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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
8 Results for "
Phosphoglycerate kinase1
" in MedChemExpress (MCE) Product Catalog:
Products (8)
8 Results for "Phosphoglycerate kinase1" in MCE Product Catalog:
16
NG 52 is a potent, cell-permeable, selective, ATP-compatible and orally active Cdc28p and Pho85p kinase inhibitor with IC50s of 7 μM and 2 μM, respectively. NG 52 also inhibits the activity of phosphoglycerate kinase 1 (PGK1) with an IC50 of 2.5 μM. NG 52 is inactive against yeast kinases Kin28p, Srb10, and Cak1p .
3
3 Cited Publications
Target:
Research Areas:
CBR-470-1 is an inhibitor of the glycolytic enzyme phosphoglycerate kinase 1 (PGK1). CBR-470-1 is also a non-covalent Nrf2 activator. CBR-470-1 protects SH-SY5Y neuronal cells against MPP +-induced cytotoxicity through activation of the Keap1-Nrf2 cascade .
Cat. No.: HY-N8540
CAS No.: 12689-26-8
Category:
Cat. No.: HY-177944
CAS No.: 2829198-49-2
Research Areas:
DC-PGKI is an orally active ATP-competitive PGK1 inhibitor(IC50 = 0.16 Μm, Kd = 99.08 nM). DC-PGKI stabilizes PGK1 in vitro and in vivo, and suppresses both glycolytic activity and the kinase function of PGK1. DC-PGKI-mediated inhibition of PGK1 leads to the accumulation of NRF2 (nuclear factor-erythroid factor 2-related factor 2, NFE2L2), which then translocates to the nucleus, binds to the proximal regions of IL-1β and IL-6 genes, and suppresses the LPS-induced expression of these genes. DC-PGKI can be used for the study of colitis .
Cat. No.: HY-P71049
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: PGK1; PGKA; Phosphoglycerate kinase 1; Epididymis Secretory Sperm Binding Protein Li 68p; Cell Migration-Inducing Gene 10 Protein; Phosphoglycerate kinase; Primer Recognition Protein 2; HEL-S-68p; PRP 2; MIG10
Species:
Human
Source:
HEK293
Cat. No.: HY-P74634
Purity: ≥ 95%, as determined by Bis-Tris PAGE.
Synonyms: PGK1; PGKA; Phosphoglycerate kinase 1; Epididymis Secretory Sperm Binding Protein Li 68p; Cell Migration-Inducing Gene 10 Protein; Phosphoglycerate kinase; Primer Recognition Protein 2; HEL-S-68p; PRP 2; MIG10
Species:
Mouse
Source:
Sf9 insect cells
Cat. No.: HY-15154R
CAS No.: 212779-48-1
Synonyms: Compound 52 (Standard)
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Research Areas:
NG 52 (Standard) is the analytical standard of NG 52. This product is intended for research and analytical applications. NG 52 is a potent, cell-permeable, selective, ATP-compatible and orally active Cdc28p and Pho85p kinase inhibitor with IC50s of 7 μM and 2 μM, respectively. NG 52 also inhibits the activity of phosphoglycerate kinase 1 (PGK1) with an IC50 of 2.5 μM. NG 52 is inactive against yeast kinases Kin28p, Srb10, and Cak1p .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
