Plant chemistry

By Targets:	COX (1) Drug Derivative (1) Parasite (1)
By Research Areas:	Cancer (1)

Cat. No.	Nombre del producto	Target	Áreas de investigación	Chemical Structure

HY-N12713

Flavoyadorinin A	Others	Others
Flavoyadorinin A is a type of flavonoid compound, and can be found in the Leaves of Viscum album Linnaeus var. coloratum Ohwi Epiphyting to Pyrus communis Linnaeus .

HY-114800

Soporidine RG4; SOP	Parasite	Others
Soporidine is an antagonist of germination of the parasitic plant Striga hermonthica. Soporidine specifically inhibits a S. hermonthica strigolactone receptor and inhibits the parasite's germination . Soporidine is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-131384

8,11,14-Eicosatriynoic acid 8,11,14-Icosatriynoic acid	COX	Others
8,11,14-Eicosatriynoic Acid, as an inhibitor of prostaglandin, leukotriene biosynthesis, and arachidonic acid-induced platelet aggregation, blocks human 12-lipoxygenase (12-LO), cyclooxygenase (COX)and 5-lipoxygenase (5-LO) with IC50 values of 0.46 μM, 14 μMand 25 μM, respectively. In addition, 8,11,14-Eicosatriynoic Acid inhibits the action of slow-reacting substances of allergic reactions, with IC50 value of 10 μM. Lipoxygenase is widely found in fungi, plants and animals. 12-LO involves in many important disease states and may play a role in oxidative glutamate toxicity. COX enzymes play complex roles in human physiology and pathology involving the neuronal, immune, renal, cardiovascular, gastrointestinal and reproductive systems. COX enzymes are blocked by aspirin and a variety of other NSAIDs, which makes them clinically important. 5-LO involves in cancer pathology. It is expressed by a variety of cancer cells, including colon, lung, breast, and prostate cancers, and promotes cancer cell growth and neovascularization . 8,11,14-Eicosatriynoic acid is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-N17822

9-Angeloylretronecine	Others	Others
9-Angeloylretronecine is a pyrrolizidine alkaloid compound. 9-Angeloylretronecine can be used in natural product chemistry, plant secondary metabolites, and research on active ingredients of Boraginaceae plants. 9-Angeloylretronecine can be extracted from the whole plant methanol extract of Echium glomeratum (a plant of the Boraginaceae family) .

HY-N9836

8,9-Dehydrothymol isobutyrate	Drug Derivative	Others
8,9-Dehydrothymol isobutyrate is a thymol (HY-N6810) derivative that can be naturally extracted from the essential oil of the trunk bark of Tetraclinis articulata (Vahl) Mast. This plant essential oil exhibits certain cytotoxicity and can be used as a research subject in the fields of natural product chemistry and the active components of plant essential oils .

HY-N13822

Trigothysoid P	Others	Others
Trigothysoid P is a daphnane-type diterpenoid compound that can be used in antiviral and natural product chemistry research. Trigothysoid P can be extracted from the dried branches and leaves of Trigonostemon thyrsoideum (a plant of the Euphorbiaceae family, genus Trigonostemon) .

HY-N1295

Serratenediol diacetate	Others	Others
Serratenediol diacetate is a serratane-type triterpenoid compound, mainly used as a derivative of natural triterpenoids in natural product chemistry research and potential bioactivity screening. Serratenediol diacetate can be prepared from serratenediol isolated from Lycopodium complanatum L. (a plant of the Lycopodiaceae family, genus Lycopodium) .

HY-N9808

Creoside III	Others	Others
Creoside III is a glycoside compound, mainly used as a component of natural product libraries for potential activity screening studies in the field of natural product chemistry. Creoside III can be naturally extracted from the dried roots of Rhodiola crenulata (a plant of the genus Rhodiola in the Crassulaceae family) through methanol reflux extraction, column chromatography separation, and high-performance liquid chromatography purification .

HY-N1788

3',5-Dihydroxy-4',5',6,7-tetramethoxyflavone	Others	Others
3',5-Dihydroxy-4',5',6,7-tetramethoxyflavone (compound 7) is a flavonoid compound that can be used in research on natural product chemistry and the screening of potential activities of flavonoid compounds. 3',5-Dihydroxy-4',5',6,7-tetramethoxyflavone can be extracted from the dried leaves of Murraya paniculata (a plant of the Murraya genus in the Rutaceae family) .

HY-N9674

Epimedonin H	Others	Cancer
Epimedonin H is a selective prenylated 2-phenoxychromone compound with no significant cytotoxicity against five human cancer cell lines, including HL-60 and SMMC-7721 (IC₅₀ > 10 μM). Epimedonin H can be used in potential activity screening studies in the field of natural product chemistry. Epimedonin H can be extracted from the dried aerial parts of Epimedium brevicornum (a plant of the genus Epimedium in the Berberidaceae family) .

Cat. No.	Nombre del producto

HY-L084

Microbial Metabolite Library	922 compounds
Nature has been a source of medicinal products for millennia, with many useful active substances developed from plant sources. In the 20th century, the discovery of the penicillin was the starting point for drug discovery from microbial sources. Microorganisms， which have been considered to be a rich source of unique bioactive compounds, play an important role in the development of the chemistry of natural products and medical therapy. Microbial metabolites have proved to be affective antimicrobial agents, anti-tumor agents, enzyme inhibitors, anti-inflammatory agents, etc. Today, many microbial-originated antibiotics are available in the mark, and a large number of bioactive metabolites are used in medicine. MCE provides a unique collection of 922 microbial metabolites, which is an important source of lead compounds and can be used for drug discovery.

Microbial Metabolite Library

922 compounds

Nature has been a source of medicinal products for millennia, with many useful active substances developed from plant sources. In the 20th century, the discovery of the penicillin was the starting point for drug discovery from microbial sources. Microorganisms， which have been considered to be a rich source of unique bioactive compounds, play an important role in the development of the chemistry of natural products and medical therapy. Microbial metabolites have proved to be affective antimicrobial agents, anti-tumor agents, enzyme inhibitors, anti-inflammatory agents, etc. Today, many microbial-originated antibiotics are available in the mark, and a large number of bioactive metabolites are used in medicine.

MCE provides a unique collection of 922 microbial metabolites, which is an important source of lead compounds and can be used for drug discovery.

Cat. No.	Nombre del producto	Type

HY-131384

8,11,14-Eicosatriynoic acid 8,11,14-Icosatriynoic acid	Biochemical Assay Reagents
8,11,14-Eicosatriynoic Acid, as an inhibitor of prostaglandin, leukotriene biosynthesis, and arachidonic acid-induced platelet aggregation, blocks human 12-lipoxygenase (12-LO), cyclooxygenase (COX)and 5-lipoxygenase (5-LO) with IC50 values of 0.46 μM, 14 μMand 25 μM, respectively. In addition, 8,11,14-Eicosatriynoic Acid inhibits the action of slow-reacting substances of allergic reactions, with IC50 value of 10 μM. Lipoxygenase is widely found in fungi, plants and animals. 12-LO involves in many important disease states and may play a role in oxidative glutamate toxicity. COX enzymes play complex roles in human physiology and pathology involving the neuronal, immune, renal, cardiovascular, gastrointestinal and reproductive systems. COX enzymes are blocked by aspirin and a variety of other NSAIDs, which makes them clinically important. 5-LO involves in cancer pathology. It is expressed by a variety of cancer cells, including colon, lung, breast, and prostate cancers, and promotes cancer cell growth and neovascularization . 8,11,14-Eicosatriynoic acid is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

8,11,14-Eicosatriynoic acid

8,11,14-Icosatriynoic acid

Biochemical Assay Reagents

8,11,14-Eicosatriynoic Acid, as an inhibitor of prostaglandin, leukotriene biosynthesis, and arachidonic acid-induced platelet aggregation, blocks human 12-lipoxygenase (12-LO), cyclooxygenase (COX)and 5-lipoxygenase (5-LO) with IC50 values of 0.46 μM, 14 μMand 25 μM, respectively. In addition, 8,11,14-Eicosatriynoic Acid inhibits the action of slow-reacting substances of allergic reactions, with IC50 value of 10 μM. Lipoxygenase is widely found in fungi, plants and animals. 12-LO involves in many important disease states and may play a role in oxidative glutamate toxicity. COX enzymes play complex roles in human physiology and pathology involving the neuronal, immune, renal, cardiovascular, gastrointestinal and reproductive systems. COX enzymes are blocked by aspirin and a variety of other NSAIDs, which makes them clinically important. 5-LO involves in cancer pathology. It is expressed by a variety of cancer cells, including colon, lung, breast, and prostate cancers, and promotes cancer cell growth and neovascularization . 8,11,14-Eicosatriynoic acid is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

Cat. No.	Nombre del producto	Category	Target	Chemical Structure

HY-N12713

Flavoyadorinin A	Structural Classification Flavonols Flavonoids Plants Orixa japonica Thunb. Salicaceae Source Classification	Others
Flavoyadorinin A is a type of flavonoid compound, and can be found in the Leaves of Viscum album Linnaeus var. coloratum Ohwi Epiphyting to Pyrus communis Linnaeus .

HY-N17822

9-Angeloylretronecine	Pyrrolizidine Alkaloids Structural Classification Alkaloids Echium glomeratum Poir. Plants Boraginaceae Source Classification	Others
9-Angeloylretronecine is a pyrrolizidine alkaloid compound. 9-Angeloylretronecine can be used in natural product chemistry, plant secondary metabolites, and research on active ingredients of Boraginaceae plants. 9-Angeloylretronecine can be extracted from the whole plant methanol extract of Echium glomeratum (a plant of the Boraginaceae family) .

HY-N9836

8,9-Dehydrothymol isobutyrate	Structural Classification Cupressaceae Ketones, Aldehydes, Acids Plants Tetraclinis articulata (Vahl) Mast. Source Classification	Drug Derivative
8,9-Dehydrothymol isobutyrate is a thymol (HY-N6810) derivative that can be naturally extracted from the essential oil of the trunk bark of Tetraclinis articulata (Vahl) Mast. This plant essential oil exhibits certain cytotoxicity and can be used as a research subject in the fields of natural product chemistry and the active components of plant essential oils .

HY-N13822

Trigothysoid P	Structural Classification Terpenoids Diterpenoids Euphorbiaceae Plants Trigonostemon thyrsoideus Stapf Source Classification	Others
Trigothysoid P is a daphnane-type diterpenoid compound that can be used in antiviral and natural product chemistry research. Trigothysoid P can be extracted from the dried branches and leaves of Trigonostemon thyrsoideum (a plant of the Euphorbiaceae family, genus Trigonostemon) .

HY-N1295

Serratenediol diacetate	Lycopodiaceae Triterpenes Structural Classification Terpenoids Diphasiastrum complanatum (L.) Holub Plants Source Classification	Others
Serratenediol diacetate is a serratane-type triterpenoid compound, mainly used as a derivative of natural triterpenoids in natural product chemistry research and potential bioactivity screening. Serratenediol diacetate can be prepared from serratenediol isolated from Lycopodium complanatum L. (a plant of the Lycopodiaceae family, genus Lycopodium) .

HY-N9808

Creoside III	Structural Classification Monophenols Rhodiola rosea Linn. Crassulaceae Phenols Plants Source Classification	Others
Creoside III is a glycoside compound, mainly used as a component of natural product libraries for potential activity screening studies in the field of natural product chemistry. Creoside III can be naturally extracted from the dried roots of Rhodiola crenulata (a plant of the genus Rhodiola in the Crassulaceae family) through methanol reflux extraction, column chromatography separation, and high-performance liquid chromatography purification .

HY-N1788

3',5-Dihydroxy-4',5',6,7-tetramethoxyflavone	Structural Classification Flavonoids Flavones Murraya paniculata (L.) Jack. Rutaceae Plants Source Classification	Others
3',5-Dihydroxy-4',5',6,7-tetramethoxyflavone (compound 7) is a flavonoid compound that can be used in research on natural product chemistry and the screening of potential activities of flavonoid compounds. 3',5-Dihydroxy-4',5',6,7-tetramethoxyflavone can be extracted from the dried leaves of Murraya paniculata (a plant of the Murraya genus in the Rutaceae family) .

HY-N9674

Epimedonin H	Structural Classification Flavonoids Epimedium brevicornu Maxim. Plants Berberidaceae Other Flavonoids Source Classification	Others
Epimedonin H is a selective prenylated 2-phenoxychromone compound with no significant cytotoxicity against five human cancer cell lines, including HL-60 and SMMC-7721 (IC₅₀ > 10 μM). Epimedonin H can be used in potential activity screening studies in the field of natural product chemistry. Epimedonin H can be extracted from the dried aerial parts of Epimedium brevicornum (a plant of the genus Epimedium in the Berberidaceae family) .

MCE Japan Authorized Agent ナミキ商事株式会社コスモ・バイオ株式会社重松貿易株式会社
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Plant chemistry

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