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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
13 Results for "
RIG-I protein
" in MedChemExpress (MCE) Product Catalog:
Products (13)
13 Results for "RIG-I protein" in MCE Product Catalog:
3
3 Cited Publications
Target:
Research Areas:
Ro 90-7501 is an amyloid β42 (Aβ42) fibril assembly inhibitor that reduces Aβ42-induced cytotoxicity (EC50 of 2 μM). Ro 90-7501 inhibits ATM phosphorylation and DNA repair. RO 90-7501 selectively enhances toll-like receptor 3 (TLR3) and RIG-I-like receptor (RLR) ligand-induced IFN-β gene expression and antiviral response . Ro 90-7501 also inhibits protein phosphatase 5 (PP5) in a TPR-dependent manner . Ro 90-7501 has significant radiosensitizing effects on cervical cancer cells .
Cat. No.: HY-P72170
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: RIGI; DExD/H-Box Helicase 58; Prev. DDX58; RNA Helicase RIG-I; Antiviral Innate Immune Response Receptor RIG-I; DKFZp434J1111; RIG-I; FLJ13599; Retinoic Acid-Inducible Gene 1 protein; RLR-1; Retinoic Acid-Inducible Gene I protein; DEAD/H (Asp-Glu-Ala-Asp/
Species:
Human
Source:
E. coli
Cat. No.: HY-P810298
Synonyms: DDX58, RIGI, Antiviral innate immune response receptor RIG-I, ATP-dependent RNA helicase DDX58, DEAD box protein 58, RIG-I-like receptor 1, RNA sensor RIG-I, Retinoic acid-inducible gene 1 protein, Retinoic acid-inducible gene I protein, RLR-1, RIG-1, RIG-I
Cat. No.: HY-P701552
Purity: ≥ 85%, as determined by reducing SDS-PAGE.
Synonyms: RNF135; RIG-I E3 Ubiquitin Ligase; Ring Finger protein 135; MGC13061; Riplet; REUL; RING Finger protein Leading To RIG-I Activation; RING Finger protein 135; RING-Type E3 Ubiquitin Transferase RNF135; MMFD; E3 Ubiquitin-protein Ligase RNF135; L13
Species:
Human
Source:
E. coli
Cat. No.: HY-P701553
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: RNF135; RIG-I E3 Ubiquitin Ligase; Ring Finger protein 135; MGC13061; Riplet; REUL; RING Finger protein Leading To RIG-I Activation; RING Finger protein 135; RING-Type E3 Ubiquitin Transferase RNF135; MMFD; E3 Ubiquitin-protein Ligase RNF135; L13
Species:
Human
Source:
E. coli
Cat. No.: HY-181165
CAS No.: 3111225-79-4
SB2960 is a receptor for activated protein C kinase 1 (RACK1) binder with a human KD of 5.65 μM. SB2960 can promote stress granule (SG) formation and exhibit potent antiviral activity across diverse viral species. SB2960 suppresses viral replication with minimal cytotoxicity by modulating host antiviral immune responses. SB2960 increases the thermal stability of RACK1 and reduces SARS-CoV-2 N protein levels. SB2960 enhances type I interferon (IFN-β) expression and inhibits RIG-I, ISG56, and RANTES expression. SB2960 can be used for the research of virus infection .
Cat. No.: HY-W682115
CAS No.: 30811-80-4
Synonyms: Polycytidylic acid
Research Areas:
Poly(C) (Polycytidylic acid) is a pleiotropic immunostimulant that specifically binds to TLR3, RIG-I and MDA5 receptors. Poly (C) recruits adaptor proteins to activate downstream signaling pathways and induce the production of type I interferons and inflammatory cytokines. Poly (C) triggers cancer cell apoptosis via the intrinsic or extrinsic caspase pathway, thereby exerting inhibitory effects on tumor growth and metastasis. Poly (C) acts as a vaccine adjuvant to modify the tumor microenvironment, regulate the expression of endothelial adhesion molecules and induce virus-like immune responses. Poly (C) can be applied to research related to melanoma, various solid tumors, hematological malignancies and autoimmune insulin-dependent diabetes mellitus .
Cat. No.: HY-103241R
CAS No.: 293762-45-5
Research Areas:
Ro 90-7501 (Standard) is the analytical standard of Ro 90-7501 (HY-103241). This product is intended for research and analytical applications. Ro 90-7501 is an amyloid β42 (Aβ42) fibril assembly inhibitor that reduces Aβ42-induced cytotoxicity (EC50 of 2 μM). Ro 90-7501 inhibits ATM phosphorylation and DNA repair. RO 90-7501 selectively enhances toll-like receptor 3 (TLR3) and RIG-I-like receptor (RLR) ligand-induced IFN-β gene expression and antiviral response . Ro 90-7501 also inhibits protein phosphatase 5 (PP5) in a TPR-dependent manner . Ro 90-7501 has significant radiosensitizing effects on cervical cancer cells .
Cat. No.: HY-189215
CAS No.: 3087067-85-1
Target:
Influenza Virus RIG-I-like receptor (RLR) Toll-like Receptor (TLR) NF-κB Interleukin Related IFNAR Apoptosis Reactive Oxygen Species (ROS)
Research Areas:
Anti-Influenza agent 12 is an orally active inhibitor of influenza A virus infection. Anti-Influenza agent 12 inhibits RIG-I-mediated innate immune signaling and TLR3-mediated signaling pathways. Anti-Influenza agent 12 inhibits NF-κB phosphorylation and downregulates the expression levels of IRF3, ASC, iNOS, IL-4, IL-6, and IFN-α inflammatory genes. Anti-Influenza agent 12 inhibits viral nucleoprotein (NP) and matrix protein 2 (M2) mRNA transcription and protein synthesis. Anti-Influenza agent 12 inhibits virus-induced apoptosis, reduces ROS and NO production, and maintains mitochondrial membrane potential. Anti-Influenza agent 12 exhibits broad-spectrum activity against H1N1 and H3N2 subtypes, reduces viral load, and alleviates lung tissue damage. Anti-Influenza agent 12 can be used for research on influenza A virus infection .
Cat. No.: HY-P87866
Synonyms: MDA5, RH116, IFIH1, Interferon-induced helicase C domain-containing protein 1, Clinically amyopathic dermatomyositis autoantigen 140 kDa, Helicase with 2 CARD domains, Interferon-induced with helicase C domain protein 1, Melanoma differentiation-associated protein 5, Murabutide down-regulated protein, RIG-I-like receptor 2, RNA helicase-DEAD box protein 116, CADM-140 autoantigen, Helicard, MDA-5, RLR-2
Cat. No.: HY-183313
CAS No.: 3038861-11-6
Research Areas:
IAV-IN-5 is an orally active inhibitor of influenza A virus (IAV). IAV-IN-5 inhibits viral replication, blocks virus-induced apoptosis, oxidative stress and cytokine storm, and regulates host immune signaling pathways. IAV-IN-5 reduces viral load and inflammatory cytokine levels in lung tissues of IAV-infected mouse models, alleviates body weight loss and pulmonary pathological damage. IAV-IN-5 can be used in studies related to influenza A virus infection .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
