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Receptor interacting protein kinase 3

" in MedChemExpress (MCE) Product Catalog:

By Targets:	RIP kinase (4) Apoptosis (1) Reference Standards (1)
By Research Areas:	Cancer (1) Cardiovascular Disease (1) Inflammation/Immunology (3)

Inhibitors & Agonists

Recombinant Proteins

Antibodies

Targets Recommended: MNK RIP kinase PIN1

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-125402

GSK-843 Maximum Cited Publications 8 Publications Verification GSK'843	RIP kinase Apoptosis	Inflammation/Immunology
GSK-843 (GSK'843) is a receptor-interacting protein kinase 3 (RIP3 or RIPK3) inhibitor, which binds RIP3 kinase domain with an IC₅₀ of 8.6 nM, and inhibits kinase activity with an IC₅₀ of 6.5 nM. GSK-843 can be used for the research of inflammation .

HY-104021

GSK840 1 Publications Verification GSK'840	RIP kinase	Inflammation/Immunology
GSK840 (GSK'840) is a receptor-interacting protein kinase 3 (RIP3 or RIPK3) inhibitor, which binds RIP3 kinase domain with an IC₅₀ of 0.9 nM, and inhibits kinase activity with an IC₅₀ of 0.3 nM .

HY-114349

HS-1371 4 Publications Verification	RIP kinase	Cardiovascular Disease Cancer
HS-1371 is a potent and ATP-competitive receptor-interacting protein kinase 3 (RIP3) inhibitor with an IC₅₀ of 20.8 nM .

HY-104021R

GSK840 (Standard) GSK'840 (Standard)	Reference Standards RIP kinase	Inflammation/Immunology
GSK840 (Standard) is the analytical standard of GSK840 (HY-104021). This product is intended for research and analytical applications. GSK840 (GSK'840) is a receptor-interacting protein kinase 3 (RIP3 or RIPK3) inhibitor, which binds RIP3 kinase domain with an IC₅₀ of 0.9 nM, and inhibits kinase activity with an IC₅₀ of 0.3 nM .

Species:	Human (3) Mouse (1)
Tag:	His (2) GST (2)
Source:	Sf9 insect cells (2) P. pastoris (2)

Cat. No.	Compare	Product Name	Species	Source	Image

HY-P71855

	RIPK3 Protein, Human (P.pastoris, His) Receptor interacting protein 3; Receptor interacting serine threonine kinase 3; RIP like protein kinase 3; RIP-3; RIP-like protein kinase 3; RIPK 3	Human	P. pastoris
	RIPK3 is a kinase that controls necroptosis and apoptosis. In necroptosis, activated by TNF-α and ZBP1, RIPK3 phosphorylates MLKL, leading to membrane damage. RIPK3 Protein, Human (P.pastoris, His) is the recombinant human-derived RIPK3 protein, expressed by P. pastoris , with N-6*His labeled tag.

HY-P705636

	RIPK3 Protein, Human (Active, sf9, GST) Receptor-interacting serine/threonine-protein kinase 3; RIP-like protein kinase 3; Receptor-interacting protein 3; RIP-3	Human	Sf9 insect cells

HY-P71853

	RIPK3 Protein, Mouse (P.pastoris, His) Ripk3; Rip3; Receptor-interacting serine/threonine-protein kinase 3; EC 2.7.11.1; RIP-like protein kinase 3; Receptor-interacting protein 3; RIP-3; mRIP3	Mouse	P. pastoris
	RIPK3 Protein, participates in programmed necrosis (necroptosis) and apoptosis, contributing to diverse cellular processes. RIPK3 Protein, Mouse (P.pastoris, His) is the recombinant mouse-derived RIPK3 protein, expressed by P. pastoris , with N-6*His labeled tag.

HY-P701698

	HIPK3 Protein, Human (Active, sf9, GST) HIPK3; Homeodomain-interacting protein kinase 3; Androgen Receptor-interacting nuclear protein kinase; ANPK; Fas-interacting serine/threonine-protein kinase; FIST; Homolog of protein kinase YAK1	Human	Sf9 insect cells
	HIPK3 is a multifaceted serine/threonine protein kinase that plays multiple roles in transcriptional regulation, apoptosis, and steroidogenic gene expression. It phosphorylates the transcription factors JUN and RUNX2, contributing to complex gene expression control. HIPK3 Protein, Human (sf9, GST) is the recombinant human-derived HIPK3 protein, expressed by sf9 insect cells , with N-GST labeled tag.

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Host:	Rabbit (3)
Reactivity:	Rat (1) Mouse (3)
Application:	ICC/IF (2) IP (1) WB (3) ELISA (1)
Isotype:	IgG (3)
Conjugation:	Non-conjugated (3)
Clonality:	Monoclonal (2)
Modification:	Phosphorylated (2) Unmodified (1)

Cat. No.	Compare	Product Name	Application	Reactivity	Image

HY-P810537

	Phospho-RIP3 (Ser232) Antibody (YA9807) Receptor interacting protein 3; Receptor interacting serine threonine kinase 3; Receptor interacting serine/threonine protein kinase 3; Receptor-interacting protein 3; Receptor-interacting serine/threonine-protein kinase 3; RIP 3; RIP like protein kinase 3; RIP-3; RIP-like protein kinase 3; RIPK 3	WB, ICC/IF	Mouse, Rat
	Phospho-RIP3 (Ser232) Antibody (YA9807) is a Rabbit-derived and non-conjugated IgG Recombinant, Monoclonal antibody, targeting to Phospho-RIP3 (Ser232).

HY-P86351

	RIP3 Antibody (YA6043) Receptor-interacting serine/threonine-protein kinase 3, RIPK3,RIP3	WB, ICC/IF, IP, ELISA	Mouse
	RIP3 Antibody (YA6043) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to RIP3.

HY-P810290

	Phospho-RIP3 (S232) Antibody (YA9633) Receptor-interacting serine/threonine-protein kinase 3, RIPK3,RIP3	WB	Mouse
	Phospho-RIP3 (S232) Antibody (YA9633) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to RIP3.

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BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.

BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

MedchemExpress Validation 03

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred

MedchemExpress Validation 04

MedchemExpress Validation

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