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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
22 Results for "
Retinal damage
" in MedChemExpress (MCE) Product Catalog:
Products (22)
22 Results for "Retinal damage" in MCE Product Catalog:
4
Category:
Rutaceae Extract Triterpenes Plant Terpenoids Disease Research Fields Citrus Extract Cancer
Target:
3
3 Cited Publications
Cat. No.: HY-W004500
CAS No.: 116-31-4
Category:
Human Gut Microbiota Metabolites Terpenoids Other Diseases Diterpenoids Microorganism Endogenous metabolite Disease Research Fields
Target:
3
3 Cited Publications
Synonyms: NMDAR/TRPM4-IN-2
Target:
Research Areas:
Brophenexin (compound 8) is a potent NMDAR/TRPM4 interaction interface inhibitor. Brophenexin shows neuroprotective activity. Brophenexin prevents NMDA-induced cell death and mitochondrial dysfunction in hippocampal neurons, with an IC50 of 2.1 μM. Brophenexin protects mice from MCAO-induced brain damage and NMDA-induced retinal ganglion cell loss .
3
3 Cited Publications
Synonyms: NMDAR/TRPM4-IN-2 free base
Target:
Research Areas:
Brophenexin free base (compound 8) is a potent NMDAR/TRPM4 interaction interface inhibitor. Brophenexin free base shows neuroprotective activity. Brophenexin free base prevents NMDA-induced cell death and mitochondrial dysfunction in hippocampal neurons, with an IC50 of 2.1 μM. Brophenexin free base protects mice from MCAO-induced brain damage and NMDA-induced retinal ganglion cell loss .
2
2 Cited Publications
Synonyms: ONO-2506; (R)-2-Propyloctanoic acid
Research Areas:
Arundic Acid (ONO-2506; (R)-2-Propyloctanoic acid) is an orally active astrocyte function modulator and neuroprotective agent. Arundic Acid increases the expression and function of astrocytic glutamate transporter EAAT1 by activating the ERK, Akt, and NF-κB pathways. Arundic Acid reduces retinal ganglion cell death in a normal-tension glaucoma model. Arundic Acid exerts neuroprotective effects in a mouse model of Parkinson's disease. Arundic Acid downregulates IL-1β, TNF-α, and ROS in a rat model of intracerebral hemorrhage, alleviating neuroinflammation, improving motor dysfunction, and reducing neuronal damage. Arundic Acid downregulates neuroinflammation and astrocyte dysfunction following status epilepticus in juvenile rats. Arundic Acid is used for research on Parkinson's disease, cerebral ischemia, glaucoma, intracerebral hemorrhage, and epilepsy .
2
2 Cited Publications
Cat. No.: HY-W040045
CAS No.: 18466-51-8
Synonyms: Pelargonidin-3-O-glucoside chloride
2
2 Cited Publications
Cat. No.: HY-P1663A
Target:
Research Areas:
ATWLPPR Peptide TFA, a heptapeptide, acts as a selective neuropilin-1 inhibitor, inhibits VEGF165 binding to NRP-1, used in the research of angiogenesis . ATWLPPR Peptide TFA has potential in reducing the early retinal damage caused by diabetes .
Cat. No.: HY-148457
CAS No.: 1613641-69-2
Synonyms: Izervay
Target:
Research Areas:
Avacincaptad pegol (Izervay) is a selective inhibitor targeting complement component C5, and is a pegylated ribonucleic acid aptamer. Avacincaptad pegol inhibits the cleavage of C5 into pro-inflammatory C5a and C5b, which forms the membrane attack complex (C5b-9), thereby reducing inflammatory cell recruitment and retinal cell damage. Avacincaptad pegol can slow the growth of geographic atrophy (GA) lesions and reduce the risk of persistent vision loss. Avacincaptad pegol can be used in research of geographic atrophy associated with age-related macular degeneration (AMD) and has been approved by the FDA .
Cat. No.: HY-N11499
CAS No.: 132679-85-7
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Cat. No.: HY-175663
Target:
Research Areas:
EYE-002 is a RPE65 inhibitor with an IC50 of 69 nM. EYE-002 promotes recovery of scotopic ERG a-/b-wave amplitudes. EYE-002 regulates the visual cycle in mice by reducing 11-cis-retinal (11cRAL) (HY-116711) synthesis and increasing all-trans-retinyl esters (atREs). EYE-002 exerts protective effects against photic retinal damage in mice. EYE-002 can be used for the study of visual cycle-associated retinopathies, such as Stargardt disease type 1 (STGD1) .
Category:
Rutaceae Extract Triterpenes Plant Terpenoids Citrus Extract
Target:
Cat. No.: HY-P991886
Target:
Research Areas:
ANX-M1 is a blood-brain barrier-permeable anti-C1q antibody. ANX-M1 can slow down the progression of retinal degeneration following photo-oxidative damage. ANX-M1 has been incorporated into nanocarriers to evaluate its brain delivery efficacy in a mouse model of Alzheimer's disease. ANX-M1 is applicable for research on age-related macular degeneration and Alzheimer's disease [1] .
Cat. No.: HY-W040045R
CAS No.: 18466-51-8
Synonyms: Pelargonidin-3-O-glucoside chloride (Standard)
Cat. No.: HY-107567
CAS No.: 56897-53-1
Synonyms: β-Alanylhistamine
Target:
Carcinine (β-Alanylhistamine) is a selective and orally active histamine H3 receptor antagonist with a Ki of 0.2939 μM. Carcinine can reduce histamine content. Carcinine exhibits anti-oxidant activity and neuroprotective effects. Carcinine shows positive inotropic effect and can reduce blood sugar and blood lipid levels. Carcinine can be used for the researches of inflammation, neurological, cardiovascular and metabolic disease, such as retinal damage, seizure and diabetes .
Synonyms: β-Alanylhistamine dihydrochloride
Target:
Carcinine (β-Alanylhistamine) dihydrochloride is the dihydrochloride salt of Carcinine (HY-107567). Carcinine is a selective and orally active histamine H3 receptor antagonist with a Ki of 0.2939 μM. Carcinine can reduce histamine content. Carcinine exhibits anti-oxidant activity and neuroprotective effects. Carcinine shows positive inotropic effect and can reduce blood sugar and blood lipid levels. Carcinine can be used for the researches of inflammation, neurological, cardiovascular and metabolic disease, such as retinal damage, seizure and diabetes .
Cat. No.: HY-107661R
CAS No.: 185517-21-9
Synonyms: ONO-2506 (Standard); (R)-2-Propyloctanoic acid (Standard)
Target:
Reference Standards ERK Akt NF-κB EAAT COX Reactive Oxygen Species (ROS) TNF Receptor Interleukin Related
Research Areas:
Arundic Acid (Standard) (ONO-2506 (Standard); (R)-2-Propyloctanoic acid (Standard)) is the analytical standard of Arundic Acid (HY-107661). This product is intended for research and analytical applications. Arundic Acid (ONO-2506; (R)-2-Propyloctanoic acid) is an orally active astrocyte function modulator and neuroprotective agent. Arundic Acid increases the expression and function of astrocytic glutamate transporter EAAT1 by activating the ERK, Akt, and NF-κB pathways. Arundic Acid reduces retinal ganglion cell death in a normal-tension glaucoma model. Arundic Acid exerts neuroprotective effects in a mouse model of Parkinson's disease. Arundic Acid downregulates IL-1β, TNF-α, and ROS in a rat model of intracerebral hemorrhage, alleviating neuroinflammation, improving motor dysfunction, and reducing neuronal damage. Arundic Acid downregulates neuroinflammation and astrocyte dysfunction following status epilepticus in juvenile rats. Arundic Acid is used for research on Parkinson's disease, cerebral ischemia, glaucoma, intracerebral hemorrhage, and epilepsy .
Cat. No.: HY-189150
CAS No.: 1643925-08-9
Research Areas:
NSP-116 is an orally active antioxidant and neuroprotective agent. NSP-116 protects corneal epithelial cells from UV-A and blue light LED-induced photo-oxidative damage. NSP-116 scavenges DPPH, superoxide anion, and hydroxyl radicals, inhibits light-induced ROS production in photoreceptor cells, and inhibits lipid peroxidation in retinal homogenates. NSP-116 prevents light-induced photoreceptor cell death and retinal degeneration, and inhibits intracellular Fe 2+ accumulation, autophagy, apoptosis, p38 phosphorylation, and microglial/macrophage activation. NSP-116 exerts neuroprotective effects in hemorrhagic stroke models. NSP-116 can be used for research on photokeratitis, dry age-related macular degeneration, and intracranial hemorrhage .
Cat. No.: HY-W319295
CAS No.: 3637-10-3
Target:
Research Areas:
TEMPOL-H is the reduced hydroxylamine form of the stable nitroxide radical Tempol (HY-100561), and serves as the active metabolite of OT-551 (HY-W556870). TEMPOL-H acts as a potent antioxidant and free radical scavenger. TEMPOL-H protects retinal pigment epithelial cells from acute light-induced damage, and protects mice from lethal whole-body radiation. TEMPOL-H inhibits lens opacification in mice, prevents glutathione loss in rat lenses under stress, blocks protein leakage in rhesus monkey lenses under stress, and maintains the 3H-choline accumulation capacity of the lens. TEMPOL-H can be used in studies related to light-induced retinal pigment epithelial degeneration and age-related cataract .
Cat. No.: HY-N18471
CAS No.: 31363-74-3
Synonyms: 5,7-DHP
Category:
Target:
Cat. No.: HY-N18471A
CAS No.: 1841081-30-8
Synonyms: 5,7-DHP hydrobromide
Target:
Research Areas:
5,7-Dihydroxytryptamine (5,7-DHT) hydrobromide is an autofluorescent (Ex ≈ 365 nm), selective neurotoxin and a transport substrate for MAO-A and 5-HT. 5,7-Dihydroxytryptamine hydrobromide can specifically target and damage central and peripheral 5-HTergic neurons, while affecting 5-HT-related pathways and neurotransmitter balance. 5,7-Dihydroxytryptamine hydrobromide can be used to establish 5-HTergic neuron injury models for studies on neural development, neurodegenerative diseases, as well as mechanisms related to platelet function and retinal neurons .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
