322639-20-3
Chemical Structure
PG-901
- CAS No.: 322639-20-3
- Formula:C53H71N13O9
- Molecular Weight:1034.21
InChIKey: JNEKRCCXHUFBPL-GLEMDPEOSA-N
SMILES: O=C([C@@H](NC([C@H](NC([C@@]1([H])N(CCC1)C([C@H](CC(NCCCC[C@H](NC2=O)C(N)=O)=O)NC([C@@H](NC(C)=O)CCCC)=O)=O)=O)CC3=CC4=C(C=CC=C4)C=C3)=O)CCCNC(N)=N)N[C@H]2CC5=CNC6=CC=CC=C56
Biological Activity: PG-901 is a full, selective MC5R agonist (EC50 = 0.072 nM for hMC5R). PG-901 is also a full antagonist at the hMC3R and the hMC4R (Kb: 1.0 nM and 0.53 nM, respectively). PG-901 significantly diminishes Cytokines (IL-1α, IL-1β, IL-6). PG-901 increases glucose tolerance, reduces blood glucose, decreases retinal damage[1][2][3].
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PG-901 | 99.35% | PG-901 is a full, selective MC5R agonist (EC50 = 0.072 nM for hMC5R). PG-901 is also a full antagonist at the hMC3R and the hMC4R (Kb: 1.0 nM and 0.53 nM, respectively). PG-901 significantly diminishes Cytokines (IL-1α, IL-1β, IL-6). PG-901 increases glucose tolerance, reduces blood glucose, decreases retinal damage. | ||||||||||||||||||||
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- [1]. Grieco P, et al. Design and synthesis of highly potent and selective melanotropin analogues of SHU9119 modified at position 6. Biochem Biophys Res Commun. 2002 Apr 12;292(4):1075-80. [Content Brief]
- [2]. Swan P, et al. α-Melanocyte Stimulating Hormone Reduces Blood Glucose Across Species. bioRxiv, 2025: 2025.03. 26.645414.
- [3]. Rossi S, et al. Activation of Melanocortin Receptors MC 1 and MC 5 Attenuates Retinal Damage in Experimental Diabetic Retinopathy. Mediators Inflamm. 2016;2016:7368389. [Content Brief]
Keywords
