322639-20-3
Chemical Structure
PG-901
- CAS No.: 322639-20-3
- Formula:C53H71N13O9
- Molecular Weight:1034.21
InChIKey: JNEKRCCXHUFBPL-GLEMDPEOSA-N
SMILES: O=C([C@@H](NC([C@H](NC([C@@]1([H])N(CCC1)C([C@H](CC(NCCCC[C@H](NC2=O)C(N)=O)=O)NC([C@@H](NC(C)=O)CCCC)=O)=O)=O)CC3=CC4=C(C=CC=C4)C=C3)=O)CCCNC(N)=N)N[C@H]2CC5=CNC6=CC=CC=C56
Biological Activity: PG-901 is a selective MC5R agonist and also an MC3R/MC4R antagonist. PG-901 activates the MC5R‑cAMP‑PKA signaling axis in skeletal muscle, mediating increased skeletal muscle glucose uptake and enhanced glycolysis. PG-901 downregulates genes related to pro-hypertrophy, cardiac remodeling, inflammation, and fibrosis, including αSMA, αSKA, TGF-β, IL-6, NOS2, Col3A1, Nppb, and CTGF, and reduces JNK/ERK phosphorylation and cAMP levels. PG-901 synergizes with insulin to increase glucose uptake in myotubes, improves glucose tolerance in wild-type mice, and lowers fasting plasma glucose in MC4R-deficient mice. PG-901 can be used in research related to diseases such as cardiac hypertrophy, heart failure, and diabetes[1][2][3][4][5].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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PG-901 | 99.35% | PG-901 is a selective MC5R agonist and also an MC3R/MC4R antagonist. PG-901 activates the MC5R‑cAMP‑PKA signaling axis in skeletal muscle, mediating increased skeletal muscle glucose uptake and enhanced glycolysis. PG-901 downregulates genes related to pro-hypertrophy, cardiac remodeling, inflammation, and fibrosis, including αSMA, αSKA, TGF-β, IL-6, NOS2, Col3A1, Nppb, and CTGF, and reduces JNK/ERK phosphorylation and cAMP levels. PG-901 synergizes with insulin to increase glucose uptake in myotubes, improves glucose tolerance in wild-type mice, and lowers fasting plasma glucose in MC4R-deficient mice. PG-901 can be used in research related to diseases such as cardiac hypertrophy, heart failure, and diabetes. | ||||||||||||||||||||
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References
- [1]. Enriori PJ, et al. α-Melanocyte stimulating hormone promotes muscle glucose uptake via melanocortin 5 receptors. Molecular metabolism. 2016 Oct;5(10):807-822.
- [2]. Saldo Rubio G. Effects of melanocortin receptor modulation on hypertrophic responses in cardiomyocytes. Master’s thesis, University of Turku; 2021.
- [3]. Suominen A, et al. α-Melanocyte-Stimulating Hormone Regulates Pathological Cardiac Remodeling by Activating Melanocortin 5 Receptor in Cardiomyocytes. bioRxiv. 2023 Apr 11:2023-04.
- [4]. Chen B, et al. Melanocortin 5 receptor signaling protects against podocyte injury in proteinuric glomerulopathies. Kidney international. 2025 May;107(5):835-851.
- [5]. Swan P, et al. α-Melanocyte Stimulating Hormone Reduces Blood Glucose Across Species. bioRxiv. 2025 Mar 29:2025-03.
