2243506-33-2
Chemical Structure
Brophenexin
Synonym(s): NMDAR/TRPM4-IN-2
- CAS No.: 2243506-33-2
- Formula:C11H19BrCl2N2
- Molecular Weight:330.09
IUPAC Name: N1-(3-bromobenzyl)-N1-ethylethane-1,2-diamine dihydrochloride
InChIKey: AQDSZKTVQVSVNC-UHFFFAOYSA-N
SMILES: NCCN(CC1=CC=CC(Br)=C1)CC.[H]Cl.[H]Cl
Biological Activity: Brophenexin (compound 8) is a potent NMDAR/TRPM4 interaction interface inhibitor. Brophenexin shows neuroprotective activity. Brophenexin prevents NMDA-induced cell death and mitochondrial dysfunction in hippocampal neurons, with an IC50 of 2.1 μM. Brophenexin protects mice from MCAO-induced brain damage and NMDA-induced retinal ganglion cell loss[1].
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Brophenexin | 98.74% | Brophenexin (compound 8) is a potent NMDAR/TRPM4 interaction interface inhibitor. Brophenexin shows neuroprotective activity. Brophenexin prevents NMDA-induced cell death and mitochondrial dysfunction in hippocampal neurons, with an IC50 of 2.1 μM. Brophenexin protects mice from MCAO-induced brain damage and NMDA-induced retinal ganglion cell loss. | ||||||||||||||||||||
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Keywords
