116-31-4
116-31-4
Chemical Structure
All-trans-retinal
- CAS No.: 116-31-4
- Formula:C20H28O
- Molecular Weight:284.44
IUPAC Name: (2E,4E,6E,8E)-3,7-dimethyl-9-(2,6,6-trimethylcyclohex-1-en-1-yl)nona-2,4,6,8-tetraenal
InChIKey: NCYCYZXNIZJOKI-OVSJKPMPSA-N
SMILES: CC(/C=C/C=C(/C=C/C1=C(CCCC(C)1C)C)C)=C\C=O
Biological Activity: All-trans-retinal is an vitamin A metabolite in the retina, and is produced following photo-isomerization of the visual chromophore 11-cis-Retinal. All-trans-retinal is cleared from photoreceptors by ATP-binding cassette transporter (ABCA4) and all-trans-retinol dehydrogenase (RDH). All-trans-retinal induces Bax activation via DNA damage to mediate retinal cell apoptosis[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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All-trans-retinal | 99.56% | All-trans-retinal is an vitamin A metabolite in the retina, and is produced following photo-isomerization of the visual chromophore 11-cis-Retinal. All-trans-retinal is cleared from photoreceptors by ATP-binding cassette transporter (ABCA4) and all-trans-retinol dehydrogenase (RDH). All-trans-retinal induces Bax activation via DNA damage to mediate retinal cell apoptosis. | ||||||||||||||||||||
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All-trans-retinal (Standard) | 99.09% | All-trans-retinal (Standard) is the analytical standard of All-trans-retinal. This product is intended for research and analytical applications. | ||||||||||||||||||||
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β-Apo-13-carotenone | 96.17% | β-Apo-13-carotenone (D'Orenone) is a naturally occurring β-apocarotenoid functioned as an antagonist of RXRα. | ||||||||||||||||||||
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11-cis-Retinal | 11-cis-Retinal (11-cis Retinaldehyde; 11-cis Vitamin A aldehyde), oxidized form of 11-cis-Retinol (HY-W587807), is a naturally occurring visual component. 11-cis-Retinal binds to opsin in the mammalian visual system as an inverse agonist forming the inactive conformation of rhodopsin. 11-cis-Retinal plays a crucial role in vision, growth and development. 11-cis-Retinal can restore visual function in moths with visual impairments. 11-cis-Retinal can restore retinal function in an early-age LCA2 retinal degeneration 12 mouse model. | |||||||||||||||||||||
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Retinoic acid (GMP) | Retinoic acid (Vitamin A acid) (GMP) is Retinoic acid (HY-14649) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. Retinoic acid is an agonist of RAR nuclear receptors. | |||||||||||||||||||||
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Isotretinoin (Standard) | 98.24% | Isotretinoin (Standard) is the analytical standard of Isotretinoin. This product is intended for research and analytical applications. Isotretinoin (13-cis-Retinoic acid) is an orally active vitamin A derivative and is often be used for the research of severe acne. Isotretinoin also shows anticancer activity. | ||||||||||||||||||||
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9-cis-Retinoic acid | 99.92% | 9-cis-Retinoic acid (ALRT1057), a vitamin A derivative, is a potent RAR/RXR agonist. 9-cis-Retinoic acid induces apoptosis, regulates cell cycle and has anticancer, anti-inflammatory and neuroprotection activities. | ||||||||||||||||||||
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Vitamin A | 99.18% | Vitamin A (Vitamin A1) is an endogenous metabolite. | ||||||||||||||||||||
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13-cis-Vitamin A | 13-cis-Vitamin A (13-cis-Vitamin A1) is the 13-cis-isomer of Vitamin A (HY-B1342), which is an active metabolite found in butter. | |||||||||||||||||||||
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9-cis-Retinal (Standard) | ≥98% | 9-cis-Retinal (Standard) is the analytical standard of 9-cis-Retinal (HY-W009310). This product is intended for research and analytical applications. 9-cis-Retinal is a natural retinoid. Dietary 9-cis-β-carotene generates 9-cis-retinoids via cleavage into 9-cis-retinal. 9-cis Retinal binds to cellular retinol-binding protein-I (CRBP-I) and CRBP-II with Kds of 8 nM and 5 nM, respectively. 9-cis-Retinal expedites differentiation and maturation of rod photoreceptors in retinal organoids. | ||||||||||||||||||||
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9-cis Retinol | 97.0% | 9-cis Retinol is an upstream precursor of 9-cis-Retinal (HY-W009310) and 9-cis-Retinoic acid (HY-15128). 9-cis Retinol serves as a reaction substrate for cRDH, ARAT and LRAT, participates in cellular uptake and isomerization processes, and can be oxidized to form 9-cis-Retinal in the biosynthetic pathway. 9-cis Retinol inhibits the activity of 9-cis retinaldehyde dehydrogenase, thereby blocking the biosynthesis of 9-cis-Retinoic acid. 9-cis Retinol is applicable for metabolism-related research. | ||||||||||||||||||||
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11-cis-Retinol | 11-cis-Retinol, a form of retinol, can bind to RDH5. 11-cis-Retinol promote dark adaptation and recovery of photoresponsiveness of red cones but not of red rods. | |||||||||||||||||||||
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