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Rho-kinase

" in MedChemExpress (MCE) Product Catalog:

By Targets:	ROCK (25) Adrenergic Receptor (1) Apoptosis (2) Aurora Kinase (1) CaMK (1) Cytochrome P450 (1) DNA/RNA Synthesis (1) Drug Intermediate (2) Isotope-Labeled Compounds (1) NF-κB (1) Organoid (2) PKA (1) PKC (1) Prostaglandin Receptor (2) Reference Standards (5) SGK (1) Small Interfering RNA (siRNA) (1) TGF-beta/Smad (1)
By Research Areas:	Cancer (14) Cardiovascular Disease (8) Infection (1) Inflammation/Immunology (8) Metabolic Disease (1) Neurological Disease (9)
Oligonucleotides:	Mouse Pre-designed siRNA Sets (1) siRNAs (1)

Inhibitors & Agonists

Fluorescent Dyes

Biochemical Assay Reagents

Peptides

Natural
Products

Isotope-Labeled Compounds

Antibodies

Oligonucleotides

GMP Molecules

Targets Recommended: ROCK

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-10583

Y-27632 dihydrochloride Maximum Cited Publications 532 Publications Verification	Organoid ROCK	Neurological Disease Cancer
Y-27632 dihydrochloride is an orally active and ATP-competitive ROCK (Rho-kinase) inhibitor (ROCK-I K_i=220 nM; ROCK-II K_i=300 nM). Y-27632 dihydrochloride shows antiepileptic effects .

HY-16563

Narciclasine 20+ Cited Publications Lycoricidinol	ROCK	Cancer
Narciclasine is a plant growth modulator. Narciclasine modulates the Rho/Rho kinase/LIM kinase/cofilin signaling pathway, greatly increasing GTPase RhoA activity as well as inducing actin stress fiber formation in a RhoA-dependent manner.

HY-10583G

Y-27632 dihydrochloride 1 Publications Verification	ROCK	Neurological Disease Cancer
Y-27632 dihydrochloride (GMP) is the GMP level of Y-27632 dihydrochloride (HY-10583). GMP guidelines are used to produce Y-27632 dihydrochloride (GMP). GMP small molecules works appropriately as an auxiliary reagent for cell research manufacture. Y-27632 dihydrochloride is an orally active and ATP-competitive ROCK (Rho-kinase) inhibitor with antiepileptic effect .

HY-10583R

Y-27632 dihydrochloride (Standard) Maximum Cited Publications 532 Publications Verification	ROCK Organoid Reference Standards	Cancer
Y-27632 dihydrochloride (Standard) is the analytical standard of Y-27632 dihydrochloride. Y-27632 dihydrochloride is an orally active and ATP-competitive ROCK (Rho-kinase) inhibitor (ROCK-I K_i=220 nM; ROCK-II K_i=300 nM). Y-27632 dihydrochloride shows antiepileptic effects .

HY-N0168A

(Rac)-Hesperetin	TGF-beta/Smad NF-κB	Infection Inflammation/Immunology Cancer
(Rac)-Hesperetin is the racemate of Hesperetin (HY-N0168), an orally active multi-target inhibitor. (Rac)-Hesperetin exhibits significant anti-tumor and anti-inflammatory activities by blocking the TGF-β1-mediated Fyn/RhoA signaling axis and the TLR4-MyD88-NF-κB inflammatory pathway. (Rac)-Hesperetin inhibits the formation of actin stress fibers and the migration and invasion of cancer cells, and is suitable for triple-negative breast cancer research. In inflammation models, (Rac)-Hesperetin effectively alleviates lung injury by reducing the release of pro-inflammatory mediators and regulating the activity of oxidative stress enzymes, and is suitable for acute lung injury research. (Rac)-Hesperetin also interferes with the entry and early replication processes of channel catfish virus, inhibits viral gene expression and progeny virus production, thereby protecting cells from virus-induced cytopathic effects .

HY-N6012

(-)-Alkannin 2 Publications Verification	Apoptosis	Inflammation/Immunology Cancer
(-)-Alkannin, found in Alkanna tinctoria, is used as a food coloring. (-)-Alkannin shows anticancer activity, arrests cell cycle, and induces apoptosis. (-)-Alkannin improves hepatic inflammation in a Rho-kinase pathway .

HY-108518

SB-772077B dihydrochloride	ROCK	Cardiovascular Disease Inflammation/Immunology
SB-772077B dihydrochloride is an orally active aminofuran-based Rho kinase ((ROCK)) inhibitor with IC₅₀ values of 5.6 nM and 6 nM for ROCK1 and ROCK2, respectively. SB-772077B dihydrochloride reduces inflammatory cytokines (TNF-α and IL-6). SB-772077B dihydrochloride relaxes aortic rings and lowers blood pressure. SB-772077B dihydrochloride can be used in the research of inflammatory diseases .

HY-112362

3-(4-Pyridyl)indole Rockout; 3-(4-Pyridinyl)-1H-indole; Rho kinase Inhibitor III, Rockout	ROCK	Inflammation/Immunology
3-(4-Pyridyl)indole (Rockout) is a Rho-kinase (ROCK) inhibitor, with an IC₅₀ of 25 μM. 3-(4-Pyridyl)indole can inhibit blebbing and cause dissolution of actin stress fibers in a wound healing assay .

HY-100270

Rho-Kinase-IN-1	ROCK	Cancer
Rho-Kinase-IN-1 is a Rho kinase (ROCK) inhibitor (K_i values of 30.5 and 3.9 nM for ROCK1 and ROCK2, respectively) extracted from US20090325960A1, compound 1.008 .

HY-19518

Latanoprostene bunod NCX116; LBN	Prostaglandin Receptor	Neurological Disease
Latanoprostene bunod (NCX116; LBN) is a nitric oxide-releasing prostaglandin F₂α analog. Latanoprostene bunod is a prodrug that, upon instillation into the eye, is hydrolyzed by corneal esterases into two active metabolites: Latanoprost (HY-B0577) and NO. Latanoprost activates the prostaglandin FP receptor to increase the outflow of aqueous humor through the uveoscleral pathway. NO increases aqueous humor drainage through the trabecular meshwork pathway, achieving synergistic enhancement targeting the dual pathways of aqueous humor outflow. Latanoprostene bunod can be used in research related to open-angle glaucoma and ocular hypertension .

HY-150640

Rho-Kinase-IN-2	ROCK	Neurological Disease Inflammation/Immunology Cancer
Rho-Kinase-IN-2 (Compound 23) is an orally active, selective, and CNS-penetrant Rho Kinase (ROCK) inhibitor (ROCK2 IC₅₀ = 3 nM). Rho-Kinase-IN-2 can be used in Huntington’s research .

HY-32951

2-Fluoropyridine-4-boronic acid	Drug Intermediate	Others
2-Fluoropyridine-4-boronic acid is a coupling reagent and chemical intermediate. 2-Fluoropyridine-4-boronic acid facilitates the synthesis of Rho kinase (ROCK) inhibitor Compound 37 .

HY-139170

CAY10746	ROCK	Metabolic Disease
CAY10746 is a selective Rho kinase (ROCK) inhibitor. CAY10746 has inhibitory activity for ROCK I, ROCK II with IC₅₀ values of 0.014 μM and 0.003 μM, respectively. CAY10746 can be used for the research of diabetic retinopathy (DR) .

HY-109191

Sovesudil PHP-201; AMA0076	ROCK	Others
Sovesudil (PHP-201) is a potent, ATP-competitive, locally acting Rho kinase (ROCK) inhibitor with IC₅₀s of 3.7 and 2.3 nM for ROCK-I and ROCK-II, respectively. Sovesudil lowers intraocular pressure (IOP) without inducing hyperemia .

HY-15720B

Glycyl H-1152 hydrochloride	ROCK Aurora Kinase CaMK	Neurological Disease
Glycyl H-1152 hydrochloride (compound 18) is a glycyl derivative of Rho-kinase inhibitors H-1152 dihydrochloride. Glycyl H-1152 hydrochloride inhibits ROCKII, Aurora A, CAMKII and PKG, with IC₅₀s of 0.0118, 2.35, 2.57 and 3.26 μM respectively. Glycyl H-1152 hydrochloride has higher selective than H-1152 hydrochloride .

HY-109191A

Sovesudil hydrochloride PHP-201 hydrochloride; AMA0076 hydrochloride	ROCK	Neurological Disease
Sovesudil (PHP-201) hydrochloride is a potent, ATP-competitive, locally acting Rho kinase (ROCK) inhibitor with IC₅₀s of 3.7 and 2.3 nM for ROCK-I and ROCK-II, respectively. Sovesudil hydrochloride lowers intraocular pressure (IOP) without inducing hyperemia .

HY-118151

Rho-Kinase-IN-3	ROCK	Cardiovascular Disease Neurological Disease
Rho-Kinase-IN-3 (compound 12) is a potent and selective Rho kinase (ROCK1) inhibitor with an IC₅₀ value of 8 nM. Rho-Kinase-IN-3 can be used in research of hypertension .

HY-16563R

Narciclasine (Standard) Lycoricidinol (Standard)	Reference Standards ROCK	Cancer
Narciclasine (Standard) is the analytical standard of Narciclasine. This product is intended for research and analytical applications. Narciclasine is a plant growth modulator. Narciclasine modulates the Rho/Rho kinase/LIM kinase/cofilin signaling pathway, greatly increasing GTPase RhoA activity as well as inducing actin stress fiber formation in a RhoA-dependent manner.

HY-N6012R

(-)-Alkannin (Standard)	Reference Standards Apoptosis	Inflammation/Immunology Cancer
(-)-Alkannin, found in Alkanna tinctoria, is used as a food coloring. (-)-Alkannin shows anticancer activity, arrests cell cycle, and induces apoptosis. (-)-Alkannin improves hepatic inflammation in a Rho-kinase pathway .

HY-122011

PF-4950834	ROCK SGK PKA PKC	Inflammation/Immunology
PF-4950834 is a potent, selective, orally bioavailable, ATP-competitive *rho kinase* inhibitor with IC₅₀ values of 8.35 nM and 33.12 nM against ROCK2 and ROCK1, respectively. PF-4950834 inhibits neutrophil migration .

HY-P5467

S6(229-239), Amide, biotinalyted	ROCK	Others
S6(229-239), Amide, biotinalyted is a biological active peptide. (substrate for Rho-Kinase II)

HY-126913

Rhodblock 6	ROCK	Cancer
Rhodblock 6 is a Rho kinase (ROCK) inhibitor that inhibits phospho-MRLC (myosin regulatory light chain) localization .

HY-100270R

Rho-Kinase-IN-1 (Standard)	ROCK Reference Standards	Cancer
Rho-Kinase-IN-1 (Standard) is the analytical standard of Rho-Kinase-IN-1 (HY-100270). This product is intended for research and analytical applications. Rho-Kinase-IN-1 is a Rho kinase (ROCK) inhibitor (Ki values of 30.5 and 3.9 nM for ROCK1 and ROCK2, respectively) extracted from US20090325960A1, compound 1.008 .

HY-RS12118

Rock2 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA) ROCK	Others
Rock2 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Rock2 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Rock2 Mouse Pre-designed siRNA Set A Rock2 Mouse Pre-designed siRNA Set A

HY-130448

8-iso Prostaglandin F1β	Prostaglandin Receptor ROCK	Cardiovascular Disease
8-iso Prostaglandin F1β is an isoprostane, that exhibits vasoconstrictive effect in neonatal porcine pulmonary arteries, pulmonary veins, and mesenteric arteries. 8-iso Prostaglandin F1β targets TXA2 receptor and exhibits the blood vessel contractile efficacy under the influence of tyrosine kinase and Rho kinase .

HY-134913

Rhodblock 1a	ROCK	Cardiovascular Disease Cancer
Rhodblock 1a is an inhibitor of the *Rho kinase* signaling pathway. It inhibits the normal formation of the cleavage furrow during cell division by interfering with the localization and function of Rho pathway proteins, causing some cells to fail to form a cleavage furrow or the formed cleavage furrow to break, resulting in binucleated cells. Rhodblock 1a can be used to study the mechanism of cell division and is expected to be used in the research of diseases such as cardiovascular diseases and cancer .

HY-145294

ROCK2-IN-5	ROCK	Neurological Disease
ROCK2-IN-5 (compound 1d) is a hybrid compound containing structural fragments of the Rho kinase inhibitor fasudil and the NRF2 inducers caffeic and ferulic acids. ROCK2-IN-5 has good multitarget profile and good tolerability. ROCK2-IN-5 has the potential for thr research of Amyotrophic lateral sclerosis (ALS) with a SOD1 mutation .

HY-W110138

Chloroxoquinoline	DNA/RNA Synthesis Cytochrome P450 ROCK	Cancer
Chloroxoquinoline is an anticancer agent. Chloroxoquinoline damages the DNA templates of cancer cells, inducing DNA breaks and cell death, and inhibits cell invasion via down-regulating Rho/Rho kinase signaling pathway. Chloroxoquinoline enhances the radiation sensitivity of Lewis lung cancer cells and xenograft tumors in tumor-bearing mouse models but decreases efficacy after long term exposure in rat models by auto-induction effects on CYP1A and CYP3A. Chloroxoquinoline has a broad-spectrum anticancer activity, such as non-small-cell lung carcinoma (NSCLC), breast cancer and gastric cancer .

HY-W047432

5-Nitro-1H-indazole-3-carbonitrile DL0805	ROCK	Cardiovascular Disease
5-Nitro-1H-indazole-3-carbonitrile (DL0805) is a *Rho kinase(ROCK)* inhibitor with an IC₅₀ of 6.67 μM for ROCK-I. 5-Nitro-1H-indazole-3-carbonitrile reduces Norepinephrine (HY-13715)-induced transient contraction and inhibits contraction induced by increasing external calcium in the endothelium-denuded rings of rat models. 5-Nitro-1H-indazole-3-carbonitrile has a vasorelaxant activity but high toxicity. 5-Nitro-1H-indazole-3-carbonitrile can be used for cardiovascular diseases, especially hypertension research .

HY-132184S

5,6-Epoxyeicosatrienoic acid-d11 5,6-EET-d₁₁; (±)5,6-EpETrE-d₁₁	Isotope-Labeled Compounds Adrenergic Receptor	Cardiovascular Disease Neurological Disease
5,6-Epoxyeicosatrienoic acid-d₁₁ (5,6-EET-d₁₁) is deuterium labeled 5,6-Epoxyeicosatrienoic acid. 5,6-Epoxyeicosatrienoic acid is one of the four major epoxyeicosatrienoic acid (EET) isomers metabolized from Arachidonic acid (HY-109590). 5,6-Epoxyeicosatrienoic acid induces peripheral vasodilation and lowers blood pressure by inhibiting T-type calcium channels (Cav3.2: IC₅₀ = 0.54 μM). 5,6-Epoxyeicosatrienoic acid causes vasoconstriction in hypoxic pulmonary blood vessels via activating *Rho* kinase in a membrane depolarization-dependent manner. 5,6-Epoxyeicosatrienoic acid induces mechanical pain by activating TRPA1. 5,6-Epoxyeicosatrienoic acid can be used in studies related to hypoxic pulmonary vasoconstriction, mechanical hyperalgesia and hypertension.

HY-182613

NSC-2888		Cardiovascular Disease
NSC-2888 is a Rho kinase II (ROCK-II) inhibitor with an IC₅₀ of 8.4 nM against human targets. NSC-2888 inhibits enzymatic activity by binding to active site amino acids via hydrogen bonds and hydrophobic interactions. NSC-2888 induces relaxation of pre-contracted rat aortic strips. NSC-2888 can be used in research related to hypertension .

HY-100062

2,4-Dibromo-5-nitropyridine	Drug Intermediate	Others
2,4-Dibromo-5-nitropyridine is a trisubstituted pyridine derivative used to prepare Rho kinase inhibitors .

HY-108518R

SB-772077B dihydrochloride (Standard)	Reference Standards ROCK	Cardiovascular Disease Inflammation/Immunology
SB-772077B dihydrochloride (Standard) is the analytical standard of SB-772077B (dihydrochloride) (HY-108518). This product is intended for research and analytical applications. SB-772077B dihydrochloride is an orally active aminofuran-based Rho K_inase ((ROCK)) inhibitor with IC₅₀ values of 5.6 nM and 6 nM for ROCK1 and ROCK2, respectively. SB-772077B dihydrochloride reduces inflammatory cytoK_ines (TNF-α and IL-6). SB-772077B dihydrochloride relaxes aortic rings and lowers blood pressure. SB-772077B dihydrochloride can be used in the research of inflammatory diseases .

Cat. No.	Product Name	Type

HY-10583G

Y-27632 dihydrochloride 1 Publications Verification	Fluorescent Dyes
Y-27632 dihydrochloride (GMP) is the GMP level of Y-27632 dihydrochloride (HY-10583). GMP guidelines are used to produce Y-27632 dihydrochloride (GMP). GMP small molecules works appropriately as an auxiliary reagent for cell research manufacture. Y-27632 dihydrochloride is an orally active and ATP-competitive ROCK (Rho-kinase) inhibitor with antiepileptic effect .

Cat. No.	Product Name	Type

HY-10583G

Y-27632 dihydrochloride 1 Publications Verification	Biochemical Assay Reagents
Y-27632 dihydrochloride (GMP) is the GMP level of Y-27632 dihydrochloride (HY-10583). GMP guidelines are used to produce Y-27632 dihydrochloride (GMP). GMP small molecules works appropriately as an auxiliary reagent for cell research manufacture. Y-27632 dihydrochloride is an orally active and ATP-competitive ROCK (Rho-kinase) inhibitor with antiepileptic effect .

HY-32951

2-Fluoropyridine-4-boronic acid	Biochemical Assay Reagents
2-Fluoropyridine-4-boronic acid is a coupling reagent and chemical intermediate. 2-Fluoropyridine-4-boronic acid facilitates the synthesis of Rho kinase (ROCK) inhibitor Compound 37 .

HY-100062

2,4-Dibromo-5-nitropyridine	Biochemical Assay Reagents
2,4-Dibromo-5-nitropyridine is a trisubstituted pyridine derivative used to prepare Rho kinase inhibitors .

S6(229-239), Amide, biotinalyted	ROCK	Others
S6(229-239), Amide, biotinalyted is a biological active peptide. (substrate for Rho-Kinase II)

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-16563

Narciclasine 20+ Cited Publications Lycoricidinol	Alkaloids Classification of Application Fields Narcissus tazetta Linn. var. chinensis M.Roemer Plants Isoquinoline Alkaloids Amaryllidaceae Disease Research Fields Source Classification Cancer Agricultural Research	ROCK
Narciclasine is a plant growth modulator. Narciclasine modulates the Rho/Rho kinase/LIM kinase/cofilin signaling pathway, greatly increasing GTPase RhoA activity as well as inducing actin stress fiber formation in a RhoA-dependent manner.

HY-N0168A

(Rac)-Hesperetin	Structural Classification Flavonoids other families Flavonones Phenols Polyphenols Plants Source Classification	TGF-beta/Smad NF-κB
(Rac)-Hesperetin is the racemate of Hesperetin (HY-N0168), an orally active multi-target inhibitor. (Rac)-Hesperetin exhibits significant anti-tumor and anti-inflammatory activities by blocking the TGF-β1-mediated Fyn/RhoA signaling axis and the TLR4-MyD88-NF-κB inflammatory pathway. (Rac)-Hesperetin inhibits the formation of actin stress fibers and the migration and invasion of cancer cells, and is suitable for triple-negative breast cancer research. In inflammation models, (Rac)-Hesperetin effectively alleviates lung injury by reducing the release of pro-inflammatory mediators and regulating the activity of oxidative stress enzymes, and is suitable for acute lung injury research. (Rac)-Hesperetin also interferes with the entry and early replication processes of channel catfish virus, inhibits viral gene expression and progeny virus production, thereby protecting cells from virus-induced cytopathic effects .

HY-N6012

(-)-Alkannin 2 Publications Verification	Alkaloids Classification of Application Fields Other Alkaloids Plants Inflammation/Immunology Disease Research Fields Boraginaceae Alkanna tinctoria L. Shikonin	Apoptosis
(-)-Alkannin, found in Alkanna tinctoria, is used as a food coloring. (-)-Alkannin shows anticancer activity, arrests cell cycle, and induces apoptosis. (-)-Alkannin improves hepatic inflammation in a Rho-kinase pathway .

HY-16563R

Narciclasine (Standard) Lycoricidinol (Standard)	Structural Classification Alkaloids Narcissus tazetta Linn. var. chinensis M.Roemer Plants Isoquinoline Alkaloids Amaryllidaceae Source Classification	Reference Standards ROCK
Narciclasine (Standard) is the analytical standard of Narciclasine. This product is intended for research and analytical applications. Narciclasine is a plant growth modulator. Narciclasine modulates the Rho/Rho kinase/LIM kinase/cofilin signaling pathway, greatly increasing GTPase RhoA activity as well as inducing actin stress fiber formation in a RhoA-dependent manner.

HY-N6012R

(-)-Alkannin (Standard)	Structural Classification Alkaloids Other Alkaloids Plants Boraginaceae Alkanna tinctoria L. Shikonin	Reference Standards Apoptosis
(-)-Alkannin, found in Alkanna tinctoria, is used as a food coloring. (-)-Alkannin shows anticancer activity, arrests cell cycle, and induces apoptosis. (-)-Alkannin improves hepatic inflammation in a Rho-kinase pathway .

Cat. No.	Product Name	Chemical Structure

HY-132184S

5,6-Epoxyeicosatrienoic acid-d11

5,6-Epoxyeicosatrienoic acid-d₁₁ (5,6-EET-d₁₁) is deuterium labeled 5,6-Epoxyeicosatrienoic acid. 5,6-Epoxyeicosatrienoic acid is one of the four major epoxyeicosatrienoic acid (EET) isomers metabolized from Arachidonic acid (HY-109590). 5,6-Epoxyeicosatrienoic acid induces peripheral vasodilation and lowers blood pressure by inhibiting T-type calcium channels (Cav3.2: IC₅₀ = 0.54 μM). 5,6-Epoxyeicosatrienoic acid causes vasoconstriction in hypoxic pulmonary blood vessels via activating Rho kinase in a membrane depolarization-dependent manner. 5,6-Epoxyeicosatrienoic acid induces mechanical pain by activating TRPA1. 5,6-Epoxyeicosatrienoic acid can be used in studies related to hypoxic pulmonary vasoconstriction, mechanical hyperalgesia and hypertension.

Host:	Rabbit (2)
Reactivity:	Human (2) Rat (2)
Application:	ICC/IF (2) WB (2)
Isotype:	IgG (2)
Conjugation:	Non-conjugated (2)
Clonality:	Monoclonal (1) Recombinant (1)
Modification:	Unmodified (1)

Cat. No.	Compare	Product Name	Application	Reactivity	Image

HY-P81922

	ROCK2 Antibody (YA1667) p164 ROCK 2; Rho kinase 2; ROCK 2; Rock II; Rock2m; ROK alpha; ROKalpha	WB, ICC/IF	Human, Rat
	ROCK2 Antibody (YA1667) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to ROCK2.

HY-P81922A

	ROCK2 Antibody (YA1667)(PBS only) p164 ROCK 2; Rho kinase 2; ROCK 2; Rock II; Rock2m; ROK alpha; ROKalpha	WB, ICC/IF	Human, Rat
	ROCK2 Antibody (YA1667) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to ROCK2.

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Targets Recommended: ROCK

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-10583G

Y-27632 dihydrochloride 1 Publications Verification	ROCK	Neurological Disease Cancer
Y-27632 dihydrochloride (GMP) is the GMP level of Y-27632 dihydrochloride (HY-10583). GMP guidelines are used to produce Y-27632 dihydrochloride (GMP). GMP small molecules works appropriately as an auxiliary reagent for cell research manufacture. Y-27632 dihydrochloride is an orally active and ATP-competitive ROCK (Rho-kinase) inhibitor with antiepileptic effect .

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Rho-kinase

Inhibitors & Agonists

Fluorescent Dyes

Biochemical Assay Reagents

Peptides

NaturalProducts

Isotope-Labeled Compounds

Antibodies

Oligonucleotides

GMP Molecules

Natural
Products