913844-45-8
Chemical Structure
Glycyl H-1152 hydrochloride
- CAS No.: 913844-45-8
- Formula:C18H26Cl2N4O3S
- Molecular Weight:449.40
IUPAC Name: (S)-2-amino-1-(3-methyl-4-((4-methylisoquinolin-5-yl)sulfonyl)-1,4-diazepan-1-yl)ethan-1-one dihydrochloride
InChIKey: ILDBNQGLZFSHQZ-UTLKBRERSA-N
SMILES: O=S(N1[C@@H](C)CN(C(CN)=O)CCC1)(C2=CC=CC3=C2C(C)=CN=C3)=O.[H]Cl.[H]Cl
Biological Activity: Glycyl H-1152 hydrochloride (compound 18) is a glycyl derivative of Rho-kinase inhibitors H-1152 dihydrochloride. Glycyl H-1152 hydrochloride inhibits ROCKII, Aurora A, CAMKII and PKG, with IC50s of 0.0118, 2.35, 2.57 and 3.26 μM respectively. Glycyl H-1152 hydrochloride has higher selective than H-1152 hydrochloride[1].
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Glycyl H-1152 hydrochloride | 99.9% | Glycyl H-1152 hydrochloride (compound 18) is a glycyl derivative of Rho-kinase inhibitors H-1152 dihydrochloride. Glycyl H-1152 hydrochloride inhibits ROCKII, Aurora A, CAMKII and PKG, with IC50s of 0.0118, 2.35, 2.57 and 3.26 μM respectively. Glycyl H-1152 hydrochloride has higher selective than H-1152 hydrochloride. | ||||||||||||||||||||
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Keywords
