Glycyl H-1152 hydrochloride
Glycyl H-1152 hydrochloride (compound 18) is a glycyl derivative of Rho-kinase inhibitors H-1152 dihydrochloride. Glycyl H-1152 hydrochloride inhibits ROCKII, Aurora A, CAMKII and PKG, with IC50s of 0.0118, 2.35, 2.57 and 3.26 μM respectively. Glycyl H-1152 hydrochloride has higher selective than H-1152 hydrochloride.
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- No. CAS: 913844-45-8
- Fòrmula: C18H26Cl2N4O3S
- Peso molecular:449.40
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Almacenamiento:
Solution, -20°C, 2 years
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Actividad biológica
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Chemical Information
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Ver todos los productos específicos de isoformas Aurora Kinase
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Actividad biológica
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ROCKII 11.8 nM (IC50) |
Aurora A 2.35 μM (IC50) |
CaMK II 2.57 μM (IC50) |
PKG 3.26 μM (IC50) |
Chemical Information
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No. CAS 913844-45-8
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Appearance Liquid
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Peso molecular 449.40
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Fòrmula C18H26Cl2N4O3S
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Color Colorless to light yellow
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SMILES
O=S(N1[C@@H](C)CN(C(CN)=O)CCC1)(C2=CC=CC3=C2C(C)=CN=C3)=O.[H]Cl.[H]Cl
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Solution, -20°C, 2 years
Pureza y Documentación
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Ficha de datos (272 KB)
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SDS (419 KB)
- English - EN (419 KB)
- Français - FR (419 KB)
- Deutsch - DE (419 KB)
- Norwegian - NO (419 KB)
- Español - ES (419 KB)
- Swedish - SV (419 KB)
- Italian - IT (419 KB)
- Portuguese - PT (419 KB)
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Instrucciones de manejo (2659 KB)
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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