30 Results for "

S. typhimurium

" in MedChemExpress (MCE) Product Catalog:
Products (30)

30 Results for "S. typhimurium" in MCE Product Catalog:

2
2 Cited Publications
Cat. No.: HY-N8060A
CAS No.: 68244-58-6
Synonyms: Orotidine monophosphate trisodium; Orotidylic acid trisodium
Orotidine 5'-monophosphate trisodium is a pyrimidine nucleotide. Orotidine 5'-monophosphate trisodium is synthesized via the de novo synthesis pathway for DNA synthesis in a large number of microorganisms including M. tuberculosis, S. cerevisiae, S. typhimurium and P. falciparum to name a few. The synthesis of orotidine 5'-monophosphate trisodium uses phosphoribosyl pyrophosphate (PRPP) and orotic acid (OA) as the substrates catalyzed by orotate phosphoribosyltransferase (OPRT) .
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Cat. No.: HY-NP134
Flagellin from S. typhimurium is a potent TLR5 agonist. Flagellin from S. typhimurium activates immune cells and inhibits the activity of melanoma cells. Flagellin from S. typhimurium activates the NF-κB pathway dependent on the TLR5/MyD88/TRAF6 signaling axis in cells. Flagellin from S. typhimurium induces a proinflammatory response in the primary chicken hepatocyte-nonparenchymal cell co-culture system by promoting IL-8 production, inhibiting IL-10 production, and increasing the IFN-γ/IL-10 ratio. Flagellin from S. typhimurium can be used for research on melanoma and inflammatory diseases .
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Cat. No.: HY-D1056C3
Synonyms: LPS, from Salmonella enterica (Serotype typhimurium)
Lipopolysaccharides, from S. enterica (Salmonella enterica) serotype typhimurium are lipopolysaccharide endotoxins and TLR4 activators derived from serotype typhimurium of Salmonella enterica, and are classified as S-type LPS. Lipopolysaccharides, from S. enterica exhibit a typical three-part structure: O-antigen, core oligosaccharide, and lipid A. Lipopolysaccharides, from S. enterica serotype typhimurium can modulate the fate of bacteria in dendritic cells (DC), determining the uptake, degradation, and activation of immune functions by DC cells against the bacteria .
It is recommended to prepare a solution with concentration ≥2 mg/mL. Vortex thoroughly for more than 10 minutes. Due to the adsorption characteristics of LPS, silanized container or low adsorption centrifuge tubes should be used for aliquoting and storage, and mix thoroughly before use.
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Cat. No.: HY-N10479
CAS No.: 617-12-9
Chorismic acid is a precursor for the biosynthesis of aromatic amino acids and vitamins, as well as a key metabolite in tRNA modification. Chorismic acid is a critical metabolite for the synthesis of cmo 5U. Deficiency of Chorismic acid inhibits the formation of cmo 5U and mcmo 5U. Chorismic acid can be used in studies of S. typhimurium and E. coli infections .\n


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Cat. No.: HY-W001189
CAS No.: 505-23-7
1,3-Dithiane is a protected formaldehyde anion equivalent and a sulfur-containing Maillard reaction product. 1,3-Dithiane is found in cooked beef extracts. 1,3-Dithiane is a potent mutagenic agent against S. typhimurium TA98 and TA100. 1,3-Dithiane can be used as a useful marker synthon .
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Cat. No.: HY-P5016A
Research Areas:  

Infection Cancer

CRAMP-18 (mouse) acetate is an antibiotic peptide without hemolytic activity. CRAMP-18 (mouse) acetate has good inhibitory activity against Gram-negative bacteria, such as S. typhimurium and P. aeruginosa. CRAMP-18 (mouse) acetate has the potential to study antifungal, antibacterial and antitumor .
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Cat. No.: HY-P5640
CAS No.: 179264-81-4
Target:  

Bacterial Parasite

Research Areas:  

Infection

Tritrpticin is a porcine-derived antimicrobial peptide with properties such as membrane disruption and hemolysis. Tritrpticin disrupts the cell membranes of bacteria, fungi and Jurkat T cell leukemia cells and induces their death. Tritrpticin also enhances the efficacy of Metronidazole (HY-B0318) against *Trichomonas vaginalis*, reduces plasma endotoxin and inflammatory cytokine levels, restricts bacterial growth in blood and visceral tissues, decreases the mortality rate of septic shock in rats and enhances the therapeutic effect of ertapenem. Tritrpticin exhibits selective cytotoxicity against Jurkat T cell leukemia cells, while showing low toxicity to normal peripheral blood mononuclear cells and red blood cells, and can serve as a template for antimicrobial peptide design. Tritrpticin can be applied to research related to bacterial infections, fungal infections, trichomoniasis, septic shock and leukemia .
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Cat. No.: HY-134013
CAS No.: 3564-96-3
Piperitenone oxide is an orally active monoterpene ketone. Piperitenone oxide can be isolated from the essential oils of plants belonging to Mentha x villosa and Ziziphora clinopodioides. Piperitenone oxide induces differentiation. Piperitenone oxide induces chromosome breakage damage, aneuploidy damage and DNA single-strand breaks. Piperitenone oxide reduces ET-1 levels. Piperitenone oxide exerts antihypertensive effects. Piperitenone oxide can be used in studies related to colon cancer .
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Cat. No.: HY-W099540
CAS No.: 5538-95-4
Target:  

Bacterial

Research Areas:  

Infection

OES2-0017 shows potent synergy with polyamines and growth-inhibitory effects at the low micromolar range. OES2-0017 inhibits spermine/spermidine acetyltransferase (SpeG) (IC50: 34.82 μM ) and other polyamine detoxification enzymes in low concentrations, perturbed the bacterial membrane in higher concentrations .
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Cat. No.: HY-P5565
CAS No.: 239114-03-5
Target:  

Bacterial

Research Areas:  

Infection Cancer

RP-1 is an antimicrobial peptide, and is active against S. aureus, S. typhimurium, E. coli, and C. albicans .
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Cat. No.: HY-P5122
CAS No.: 1135688-38-8
Target:  

Caspase

Research Areas:  

Inflammation/Immunology

Z-LEED-FMK is a caspase-13 and caspase-4 inhibitor. Z-LEED-FMK also inhibits caspase-1 processing in S. typhimurium-infected macrophages .
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Cat. No.: HY-N3616
CAS No.: 20649-42-7
trans-Coniferyl aldehyde (compound 2) is a natural compound isolated from the buds of clove (Syzygium aromaticum).trans-Coniferyl aldehyde suppresses 63% of the UV mutable gene expression at 1.20 μM, and with an ID50 value of 0.76 μM,and has the antimutagenic activities against furylfuramide, Trp-P-1, and activated Trp-P-1 .
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Cat. No.: HY-N5054
CAS No.: 1277188-85-8
(R)-5,7-Dimethoxyflavanone shows potent antimutagenic activity against MeIQ mutagenesis in Ames test using the S. typhimurium TA100 and TA98 strains . And (R)-5,7-Dimethoxyflavanone significantly and dose-dependently inhibits the inflammatory mediato .
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Cat. No.: HY-P11091
CAS No.: 2387505-19-1
Target:  

Bacterial

Research Areas:  

Infection

PA2-GNU7 is an antimicrobial peptide (AMP). PA2-GNU7 exhibits potent antimicrobial activity with minimal inhibitory concentration (MIC) against P. aeruginosa, E. coli, S. typhimurium, S. aureus, and C. albicans are 2 μM, 1 μM, 2 μM, 2 μM, and 8 μM, respectively. PA2-GNU7 rapidly and selectively kills Pseudomonas aeruginosa without affecting other commensal bacteria. PA2-GNU7 significantly improves survival of mice infected with P. aeruginosa. PA2-GNU7 can be used for the research and development of therapeutic agents against MDR Pseudomonas aeruginosa infections .
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Cat. No.: HY-P5286
CAS No.: 184870-30-2
BMAP-27 is a cationic amphipathic α-helical antimicrobial peptide with anticancer activity. BMAP-27 disrupts the integrity and permeability of cell membranes, leading to the leakage of intracellular DNA, proteins and alkaline phosphatase. BMAP-27 increases intracellular ROS levels and reduces plasma endotoxin and TNF-α concentrations. BMAP-27 can be used in studies related to Salmonella infection, breast cancer, lung cancer and obstructive jaundice .
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Cat. No.: HY-P5016
CAS No.: 256639-17-5
Research Areas:  

Infection Cancer

CRAMP-18 (mouse) is an antibiotic peptide without hemolytic activity. CRAMP-18 (mouse) has good inhibitory activity against Gram-negative bacteria, such as S. typhimurium and P. aeruginosa. CRAMP-18 (mouse) has the potential to study antifungal, antibacterial and antitumor .
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Cat. No.: HY-173077
Target:  

PD-1/PD-L1 Bacterial

Research Areas:  

Infection Inflammation/Immunology

PD-L1/LpxC-IN-1 (Conpound 12b) is the inhibitor for PD-L1 and LpxC with IC50 of 5.2 μM and 0.081 μM. PD-L1/LpxC-IN-1 inhibits the biosynthesis of bacterial lipopolysaccharide, causes the lysis and death of bacterial cells. PD-L1/LpxC-IN-1 inhibits Gram-negative bacteria, MIC for K. pneumoniae ATCC 13883, E. coli ATCC 8739, S. typhimurium ATCC 14028 and P. aeruginosa ATCC 9027 is 0.25-0.5 μg/mL. PD-L1/LpxC-IN-1 downregulates the expression of inflammatory factors IL-2 and IFN-γ, upregulates the expression of CD4+ and CD8+ cells, thereby activating the immune system and inhibiting excessive inflammatory responses. PD-L1/LpxC-IN-1 exhibits antibacterial activity in K. pneumoniae ATCC 13883 infected mouse models .
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Cat. No.: HY-120002
CAS No.: 14088-71-2
Synonyms: Kilacar; R 8284
Target:  

Parasite

Research Areas:  

Infection

Proclonol (Kilacar) is an insecticide-acaricide. Proclonol is a weak mutagen in the TA97 strain of S. typhimurium .
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Cat. No.: HY-N2980
CAS No.: 35761-54-7
Synonyms: Cabraleone
Target:  

Bacterial

Ocotillone ((24S)-20,24-Epoxy-25-hydroxydammaran-3-one) is a triterpenoids that can be isolated from the fruits of Dysoxylum richii. Ocotillone has antibacterial activities against P. aeruginosa and S. typhimurium without hemolytic activity .
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Cat. No.: HY-W844796
CAS No.: 73322-75-5
Synonyms: (S)-2-Amino-5-methylhex-5-enoic acid
Research Areas:  

Infection

2-Amino-5-methyl-5-hexenoic acid ((S)-2-Amino-5-methylhex-5-enoic acid) is a Methionine analog that competes with methionine and resulting in inhibition of cell growth. 2-Amino-5-methyl-5-hexenoic acid inhibits protein synthesis but not DNA or RNA synthesis in S. typhimurium TA1535 and E. coli K-12 . X
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