Scientific Reviews
Product Guides
Blogs
Topics
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
27 Results for "
SDF-1/CXCR4
" in MedChemExpress (MCE) Product Catalog:
Products (27)
27 Results for "SDF-1/CXCR4" in MCE Product Catalog:
13
13 Publications Verification
Target:
Research Areas:
3
3 Cited Publications
Research Areas:
WZ811 is an orally active, highly potent competitive antagonist of CXCR4. WZ811 efficiently inhibits CXCR4/SDF-1 (or CXCL12)-mediated modulation of cAMP levels (EC50=1.2 nM) and SDF-1 induced Matrigel invasion in cells (EC50=5.2 nM) [1].
2
2 Cited Publications
Cat. No.: HY-P4911A
Target:
Research Areas:
1
1 Cited Publications
Cat. No.: HY-P7061A
Target:
Research Areas:
Cat. No.: HY-P3612
CAS No.: 577782-52-6
Target:
Research Areas:
Cat. No.: HY-P10427
Target:
Research Areas:
Cat. No.: HY-122058A
CAS No.: 2253744-59-9
Research Areas:
KRH-3955 hydrochloride is an orally bioavailable CXCR4 antagonist. KRH-3955 hydrochloride inhibits SDF-1α binding to CXCR4 with an IC50 of 0.61 nM. KRH-3955 hydrochloride is also a highly potent and selective inhibitor of X4 HIV-1, with an EC50 of 0.3 to 1.0 nM [1].
Cat. No.: HY-P4109
CAS No.: 265650-93-9
Synonyms: NT21MP; V1 peptide
Target:
Research Areas:
Cat. No.: HY-P4911
CAS No.: 1268129-65-2
Target:
Research Areas:
Cat. No.: HY-P10427A
Target:
Research Areas:
Cat. No.: HY-P7061
CAS No.: 143413-49-4
Target:
Research Areas:
Cat. No.: HY-144347
CAS No.: 2177311-29-2
HF51116 is a potent antagonist of CXCR4. HF51116 strongly antagonizes SDF-1α-induced cell migration, calcium mobilization, and CXCR4 internalization. HF51116 inhibits HIV-1 infection via CXCR4. HF51116 has the potential for the research of HIV-1 infection, hematopoietic stem cell mobilization, and cancer metastasis [1].
Cat. No.: HY-P991656
CAS No.: 2125546-89-4
Cat. No.: HY-P4109A
Synonyms: NT21MP TFA; V1 peptide TFA
Target:
Research Areas:
Cat. No.: HY-P992405
Cat. No.: HY-122058
CAS No.: 1097732-62-1
KRH-3955 is a CXCR4 antagonist with good bioavailability and potent anti-HIV-1 activity. KRH-3955 can effectively inhibit the replication of X4 HIV-1, including clinical isolates from different donors. KRH-3955 also shows activity against recombinant X4 HIV-1 containing reverse transcriptase, protease and tyrosinase resistance mutations. KRH-3955 can inhibit the binding of SDF-1alpha to CXCR4 and calcium ion signaling through this receptor. KRH-3955 inhibits the binding of an antibody against CXCR4 to CXCR4, showing a potent antagonistic effect on CXCR4. KRH-3955 shows an oral bioavailability of 25.6% in rats and can inhibit the replication of X4 HIV-1 in vivo [1].
Cat. No.: HY-164682
CAS No.: 170861-77-5
AMD 3329 octahydrobromide is a potent and selective anti-HIV-1 and HIV-2 compound with activity to inhibit viral replication. AMD 3329 blocks viral invasion by binding to the chemokine receptor CXCR4. AMD 3329 exhibits EC50 values as low as 0.8 and 1.6 nM when inhibiting HIV-1 and HIV-2 replication, showing better antiviral efficacy than AMD3100. AMD 3329 significantly inhibits the binding of specific CXCR4 monoclonal antibodies and the Ca(2+) flux induced by SDF-1alpha. AMD 3329 is also able to effectively interfere with virus-induced syncytium formation, with an EC50 value of 12 nM [1].
Cat. No.: HY-P81089
Synonyms: C-X-C chemokine receptor type 4; CXC-R4; CXCR-4; Stromal cell-derived factor 1 receptor; SDF-1 receptor; Fusin; Leukocyte-derived seven transmembrane domain receptor; LESTR; CD184 antigen; CXCR4_HUMAN.
Cat. No.: HY-P991790
Cat. No.: HY-P991744
- 1
- 2
-
-
Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
