55778-02-4
55778-02-4
Chemical Structure
WZ811
- CAS No.: 55778-02-4
- Formula:C18H18N4
- Molecular Weight:290.36
IUPAC Name: N,N'-(1,4-phenylenebis(methylene))bis(pyridin-2-amine)
InChIKey: KBVFRXIGQQRMEF-UHFFFAOYSA-N
SMILES: C1(CNC2=NC=CC=C2)=CC=C(CNC3=NC=CC=C3)C=C1
Biological Activity: WZ811 is an orally active, highly potent competitive antagonist of CXCR4. WZ811 efficiently inhibits CXCR4/SDF-1 (or CXCL12)-mediated modulation of cAMP levels (EC50=1.2 nM) and SDF-1 induced Matrigel invasion in cells (EC50=5.2 nM)[1].
| Cat. No. | Nom du produit | Pureté | Description | Pricing | |||||||||||||||||||
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WZ811 | 99.80% | WZ811 is an orally active, highly potent competitive antagonist of CXCR4. WZ811 efficiently inhibits CXCR4/SDF-1 (or CXCL12)-mediated modulation of cAMP levels (EC50=1.2 nM) and SDF-1 induced Matrigel invasion in cells (EC50=5.2 nM). | ||||||||||||||||||||
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Structural Analogs
-
Similarity Score 0.75
HY-13696MSX-122 -
Similarity Score 0.74
HY-W075646N,N'-(1,4-Phenylenebis(methylene))bis(pyridin-4-amine) -
Similarity Score 0.71
HY-W075531N1,N3-Di(pyridin-2-yl)benzene-1,3-diamine -
Similarity Score 0.67
HY-17482Difenpiramide -
Similarity Score 0.67
HY-156793hRIO2 kinase ligand-1 -
Similarity Score 0.65
HY-W327677N1,N3-di(pyridin-2-yl)malonamide -
Similarity Score 0.65
HY-W034703Tris(2-pyridylmethyl)amine -
Similarity Score 0.64
HY-W856350N2,N6-Dimethyl-N2,N6-di(pyridin-2-yl)pyridine-2,6-diamine -
Similarity Score 0.64
HY-W7925621,4-Bis(pyridin-4-ylmethyl)benzene -
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