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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
12 Results for "
SOD1 protein
" in MedChemExpress (MCE) Product Catalog:
Products (12)
12 Results for "SOD1 protein" in MCE Product Catalog:
2
2 Cited Publications
Synonyms: BIIB067; ISIS-SOD1Rx; ISIS 333611
Target:
Research Areas:
Tofersen (BIIB067) is an antisense oligonucleotide and SOD1 mRNA inhibitor with an IC50 of 320 pM. Tofersen mediates RNase H-dependent degradation of SOD1 mRNA to reduce SOD1 protein levels in cerebrospinal fluid and serum. Tofersen downregulates cerebrospinal fluid neurofilament light chain, neurofilament heavy chain, amyloid-beta 1-40, amyloid-beta 1-42, neuropeptide Y, ubiquitin C-terminal hydrolase L1, neuropentraxins 1, 2, R, corticotropin-releasing hormone, IL-15, and serum neurofilament light chain, neurofilament heavy chain. Tofersen can be used for the research of superoxide dismutase 1-associated amyotrophic lateral sclerosis .
2
2 Cited Publications
Synonyms: BIIB067 SODium; ISIS-SOD1Rx SODium; ISIS 333611 SODium
Target:
Research Areas:
Tofersen (BIIB067) sodium is an antisense oligonucleotide and SOD1 mRNA inhibitor with an IC50 of 320 pM. Tofersen sodium mediates RNase H-dependent degradation of SOD1 mRNA to reduce SOD1 protein levels in cerebrospinal fluid and serum. Tofersen sodium downregulates cerebrospinal fluid neurofilament light chain, neurofilament heavy chain, amyloid-beta 1-40, amyloid-beta 1-42, neuropeptide Y, ubiquitin C-terminal hydrolase L1, neuropentraxins 1, 2, R, corticotropin-releasing hormone, IL-15, and serum neurofilament light chain, neurofilament heavy chain. Tofersen sodium can be used for the research of superoxide dismutase 1-associated amyotrophic lateral sclerosis .
Cat. No.: HY-173025
Target:
Research Areas:
Nurr1 agonist 12 (Compound 37) is the agonist for nuclear receptor-associated protein 1 (Nurr1) that activates the transcriptional activity of Nurr1 with an EC50 of 0.06 μM. Nurr1 agonist 12 activates the human response elements NBRE, NurRE, and DR5 with EC50 of 0.07 μM, 0.027 μM, and 0.014 μM, respectively. Nurr1 agonist 12 induces the expression of Nurr1-regulated neurotrophic genes, such as tyrosine hydroxylase (TH), SOD1/2, BDNF, Sestrin 3, and BIRC5 (Survivin). Nurr1 agonist 12 exhibits neuroprotective efficacy against Paraquat-induced neurotoxicity .
Target:
Research Areas:
CMB-087229 is a mutant superoxide dismutase 1 (SOD1) protein aggregation inhibitor with IC50 of 67 nM, which can be used in the research of amyotrophic lateral sclerosis .
Cat. No.: HY-132580S
Synonyms: BIIB067-d27; ISIS-SOD1Rx-d27; ISIS 333611-d27
Cat. No.: HY-P71048
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: SOD1; Superoxide Dismutase, Cystolic; Prev. ALS1; Cu/Zn Superoxide Dismutase; Prev. ALS; Alternative protein SOD1; Superoxide Dismutase [Cu-Zn]; Superoxide Dismutase; IPOA; Indophenoloxidase A; Superoxide Dismutase 1, Soluble; SOD, Soluble; Hydrogen Sulfi
Species:
Human
Source:
E. coli
Cat. No.: HY-P71048A
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: SOD1; Superoxide Dismutase, Cystolic; Prev. ALS1; Cu/Zn Superoxide Dismutase; Prev. ALS; Alternative protein SOD1; Superoxide Dismutase [Cu-Zn]; Superoxide Dismutase; IPOA; Indophenoloxidase A; Superoxide Dismutase 1, Soluble; SOD, Soluble; Hydrogen Sulfi
Species:
Human
Source:
E. coli
Cat. No.: HY-182304
CAS No.: 1338489-62-5
Research Areas:
CLR01 sodium is a blood-brain barrier-permeable anti-aggregation agent. CLR01 sodium inhibits the de novo aggregation of Amyloid-β 40/42, α-synuclein, IAPP, tau protein and SOD1. CLR01 sodium reduces amyloid plaque burden in the cortex of triple-transgenic mice and improves the memory and motor abilities of these mice. CLR01 sodium can be used in research related to Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis (ALS) .
Cat. No.: HY-P10627
CAS No.: 2760733-01-3
Target:
Research Areas:
Cat. No.: HY-D3111
CAS No.: 1240465-12-6
Target:
Research Areas:
DBHA is a long-wavelength polarity-sensitive fluorescent probe based on Nile Red. Under the catalysis of Pd (OAc)2/TPPTS, DBHA site-selectively labels protein tyrosine residues via a π-allyl palladium complex intermediate. Utilizing the property that its maximum emission wavelength blue-shifts with decreasing local polarity (650 nm in aqueous solution → 584-608 nm in hydrophobic domains), it detects changes in local polarity and conformation of protein tyrosine domains under acid/thermal denaturation conditions. DBHA can be used in studies related to SOD1-associated oxidative stress neurodegenerative diseases .
Cat. No.: HY-D3112
Target:
Research Areas:
P2-Aggregate is a polarity-sensitive fluorescent probe for protein aggregation, which is based on the Nile Red scaffold and modified with a morpholine ring to enhance water solubility. P2-Aggregate improves anti-precipitation ability in aqueous phase via morpholine ring modification, and enables site-specific labeling of target proteins by combining with HaloTag technology. Utilizing the property that its emission wavelength blue-shifts with decreasing local polarity (excited at 543 nm), P2-Aggregate quantitatively detects changes in local polarity during protein aggregation and polarity heterogeneity inside aggregates in living cells. P2-Aggregate can be used in the research of diseases associated with the aggregation of Htt-110Q and SOD1 proteins, such as Huntington's disease and amyotrophic lateral sclerosis .
Cat. No.: HY-P81228
Synonyms: ALS antibody;
ALS1 antibody;
Amyotrophic lateral sclerosis 1 adult antibody;
Cu/Zn SOD antibody;
Cu/Zn superoxide dismutase antibody;
Epididymis secretory protein Li 44 antibody;
HEL S 44 antibody;
Homodimer antibody;
hSOD1 antibody;
Indophenoloxidase A antibody;
IPOA antibody;
Mn superoxide dismutase antibody;
SOD antibody;
SOD soluble antibody;
SOD1 antibody;
SOD2 antibody;
SODC antibody;
SODC_HUMAN antibody;
Superoxide dismutase [Cu-Zn] antibody;
Superoxide dismutase 1 antibody;
Superoxide dismutase 1 soluble antibody;
Superoxide dismutase Cu Zn antibody;
Superoxide dismutase cystolic antibody;
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
