CMB-087229
Based on 1 Customer Validation
CMB-087229 is a mutant superoxide dismutase 1 (SOD1) protein aggregation inhibitor with IC50 of 67 nM, which can be used in the research of amyotrophic lateral sclerosis.
For research use only. We do not sell to patients.
- Purity: 98.05%
- CAS No.: 1227692-67-2
- Formula: C10H8Cl2N2O2
- Molecular Weight:259.09
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Storage:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| PC-12 | EC50 |
0.067 μM
Compound: 13
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Inhibition of SOD1 G93A mutant aggregation-induced cytotoxicity in rat PC12 cells incubated for 24 hrs and measured 72 hrs post compound dose by cytotoxicity protection assay
Inhibition of SOD1 G93A mutant aggregation-induced cytotoxicity in rat PC12 cells incubated for 24 hrs and measured 72 hrs post compound dose by cytotoxicity protection assay
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[PMID: 22191331] |
| PC-12 | EC50 |
0.067 μM
Compound: 5a
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Neuroprotective activity in rat PC12 cells expressing SOD1 G93A mutant assessed as increase in cell viability after 48 hrs by CalceinAM-based fluorescence assay
Neuroprotective activity in rat PC12 cells expressing SOD1 G93A mutant assessed as increase in cell viability after 48 hrs by CalceinAM-based fluorescence assay
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[PMID: 23021992] |
Chemical Information
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CAS No. 1227692-67-2
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Appearance Solid
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Molecular Weight 259.09
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Formula C10H8Cl2N2O2
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Color Off-white to light brown
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SMILES
O=C1C=C(COC2=CC(Cl)=CC(Cl)=C2)NN1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 125 mg/mL (482.46 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (268 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.8597 mL | 19.2983 mL | 38.5966 mL | 96.4916 mL |
| 5 mM | 0.7719 mL | 3.8597 mL | 7.7193 mL | 19.2983 mL | |
| 10 mM | 0.3860 mL | 1.9298 mL | 3.8597 mL | 9.6492 mL | |
| 15 mM | 0.2573 mL | 1.2866 mL | 2.5731 mL | 6.4328 mL | |
| 20 mM | 0.1930 mL | 0.9649 mL | 1.9298 mL | 4.8246 mL | |
| 25 mM | 0.1544 mL | 0.7719 mL | 1.5439 mL | 3.8597 mL | |
| 30 mM | 0.1287 mL | 0.6433 mL | 1.2866 mL | 3.2164 mL | |
| 40 mM | 0.0965 mL | 0.4825 mL | 0.9649 mL | 2.4123 mL | |
| 50 mM | 0.0772 mL | 0.3860 mL | 0.7719 mL | 1.9298 mL | |
| 60 mM | 0.0643 mL | 0.3216 mL | 0.6433 mL | 1.6082 mL | |
| 80 mM | 0.0482 mL | 0.2412 mL | 0.4825 mL | 1.2061 mL | |
| 100 mM | 0.0386 mL | 0.1930 mL | 0.3860 mL | 0.9649 mL |
CMB-087229 Related Classifications
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