31 Results for "

TRH

" in MedChemExpress (MCE) Product Catalog:
Products (31)

31 Results for "TRH" in MCE Product Catalog:

4
4 Cited Publications
Art. -Nr.: HY-P0002
CAS. Nr.: 24305-27-9
Synonyms: Thyrotropin-releasing-hormone; TRH
Protirelin is a highly conserved neuropeptide that exerts the hormonal control of thyroid-stimulating hormone (TSH) levels as well as neuromodulatory functions.
4
4 Cited Publications
Art. -Nr.: HY-P0002A
CAS. Nr.: 120876-23-5
Synonyms: Thyrotropin-releasing-hormone acetate; TRH acetate
Protirelin Acetate is a highly conserved neuropeptide that exerts the hormonal control of thyroid-stimulating hormone (TSH) levels as well as neuromodulatory functions.
2
2 Cited Publications
Art. -Nr.: HY-P1529
CAS. Nr.: 24769-58-2
Synonyms: TRH-OH
Target:  

Peptides

Forschungsgebiete:  

Neurological Disease Metabolic Disease

Thyrotropin-Releasing Hormone (TRH), Free Acid (TRH-OH) is a physiological metabolite of Thyrotropin-Releasing Hormone.
1
1 Cited Publications
Art. -Nr.: HY-B0596
CAS. Nr.: 103300-74-9
Synonyms: TA-0910
Taltirelin (TA-0910) is an orally effective analogue of thyrotropin releasing hormone (TRH) and a TRH receptor (TRH-R) superagonist (IC50 at 910 nM). Taltirelin can cross the blood-brain barrier. Taltirelin stimulates an increase in cytosolic Ca 2+ concentration (Ca 2+ release) with an EC50 value of 36 nM. Taltirelin increases cell viability and reduces apoptosis in SH-SY5Y cells and primary rat mesencephalic neurons treated with MPP+ (HY-W008719) or Rotenone (HY-B1756). Taltirelin has neuroprotective effects in both cellular and animal models of Parkinson's disease. Taltirelin alleviates fatigue-like behavior in mouse models of cancer-related fatigue .
1
1 Cited Publications
Art. -Nr.: HY-B0596A
CAS. Nr.: 1549593-23-8
Synonyms: TA-0910 acetate
Taltirelin acetate (TA-0910) is an acetate form of Taltirelin (TA-0910). Taltirelin (TA-0910) is an orally effective analogue of thyrotropin releasing hormone (TRH) and a TRH receptor (TRH-R) superagonist (IC50 at 910 nM). Taltirelin can cross the blood-brain barrier. Taltirelin stimulates an increase in cytosolic Ca 2+ concentration (Ca 2+ release) with an EC50 value of 36 nM. Taltirelin increases cell viability and reduces apoptosis in SH-SY5Y cells and primary rat mesencephalic neurons treated with MPP+ (HY-W008719) or Rotenone (HY-B1756). Taltirelin has neuroprotective effects in both cellular and animal models of Parkinson's disease. Taltirelin alleviates fatigue-like behavior in mouse models of cancer-related fatigue .
Art. -Nr.: HY-P3960
CAS. Nr.: 85541-78-2
(Glu2)-TRH, a metabolically stable analogue of Thyrotropin-releasing hormone (TRH; HY-P0002), is a negative modulator for the cholinergic effect of TRH in the mouse brain. (Glu2)-TRH significantly attenuates TRH-induced hippocampal extracellular acetylcholine release. (Glu2)-TRH is not metabolized by thyroliberinase. (Glu2)-TRH manifests neuroprotective, antidepressant, anticonvulsant in the CNS .
Art. -Nr.: HY-Y0973
CAS. Nr.: 56602-33-6
BOP hexafluorophosphate is a phosphonium-type condensing agent. BOP hexafluorophosphate activates the carboxylic acid component to form a highly reactive O-benzotriazole ester (active ester) intermediate, which then reacts with the amino component to form an amide bond (peptide bond). BOP hexafluorophosphate is applicable to solid-phase polypeptide synthesis and nucleoside modification .
Art. -Nr.: HY-P1213
CAS. Nr.: 436083-30-6
Target:  

Melanocortin Receptor

Forschungsgebiete:  

Neurological Disease

JKC363, a selective melanocortin MC4 receptor antagonist, has a 90-fold higher affinity at the MC4 receptor (IC50=0.5 nM) than at the MC3 receptor (44.9 nM). JKC-363 blocks the stimulatory effect of α-MSH on TRH release. Anti-hyperalgesic effect .
Art. -Nr.: HY-W345393
CAS. Nr.: 85344-77-0
Synonyms: TRH-glycine
Forschungsgebiete:  

Endocrinology

Trh-gly (TRH-glycine) is a precursor of thyrotropin (TSH)-releasing hormone (TRH) that can release thyrotropin and prolactin .
Art. -Nr.: HY-P10485
CAS. Nr.: 291752-43-7
Forschungsgebiete:  

Neurological Disease

Glp-Asn-Pro-AMC is an inhibitor of thyrotropin-releasing hormone degrading enzyme (TRH-DE) with a Ki value of 0.97 μM .
Art. -Nr.: HY-P4584
CAS. Nr.: 73644-58-3
Forschungsgebiete:  

Others

TRH-βNA is a substrate for determining the membrane TRH-deamidating enzyme (TRH-DE) activity and membrane pyroglutamyl aminopeptidase II (PPII) activity .
Art. -Nr.: HY-P3962
CAS. Nr.: 34783-35-2
Forschungsgebiete:  

Endocrinology

[Phe2]-TRH is a thyrotropin releasing hormone analogue, equipping a conformational similarity with Leu5-enkephalin .
Art. -Nr.: HY-15113A
CAS. Nr.: 143984-17-2
Forschungsgebiete:  

Neurological Disease Cancer

Y-29794 tosylate is a selective, orally active inhibitor for non-peptide prolyl endopeptidase (PREP), with an IC50 of 3 nM and a Ki of 0.95 nM. Y-29794 tosylate enhances the effect of thyrotropin-releasing hormone (TRH) on the release of ACh in the rat hippocampus, exhibits potential neuroprotective efficacy. Y-29794 tosylate exhibits anticancer activity through inhibition of the IRS1-AKT-mTORC1 pathway. Y-29794 tosylate penetrates the brain-blood barrier (BBB) .
Art. -Nr.: HY-P3964
CAS. Nr.: 128578-17-6
Target:  

Endogenous Metabolite

Forschungsgebiete:  

Endocrinology

TRH Precursor Peptide is a precursor peptide of thyrotropin-releasing hormone (TRH). TRH Precursor Peptide formation of TRH in rat brain and pituitary is zinc-dependent .
Art. -Nr.: HY-P1213A
Target:  

Melanocortin Receptor

Forschungsgebiete:  

Neurological Disease

JKC363 TFA, a selective melanocortin MC4 receptor antagonist, has a 90-fold higher affinity at the MC4 receptor (IC50=0.5 nM) than at the MC3 receptor (44.9 nM). JKC363 TFA blocks the stimulatory effect of α-MSH on TRH release. Anti-hyperalgesic effect .
Art. -Nr.: HY-W009673
CAS. Nr.: 53100-44-0
Synonyms: N-Boc-L-pyroglutamic acid
Boc-Pyr-OH is a Boc-protected pyroglutamic acid derivative. Boc-Pyr-OH stabilizes the amino group of pyroglutamic acid through the Boc protecting group, preventing unwanted reactions during peptide synthesis. Boc-Pyr-OH can be used in the research of thyrotropin-releasing hormone (TRH) synthesis .
Art. -Nr.: HY-P4367
CAS. Nr.: 190836-86-3
Target:  

Fluorescent Dye

Forschungsgebiete:  

Others

TRH-AMC is a fluorogenic substrate used in a coupled assay for thyrotropin-releasing hormone(TRH)-degrading ectoenzyme .
Art. -Nr.: HY-P3969
CAS. Nr.: 122018-91-1
Forschungsgebiete:  

Neurological Disease Endocrinology

Prepro-TRH-(160-169) is one of the connecting peptides of thyrotropin-releasing hormone prohormone (pro-TRH), potentiates TRH-induced thyrotropin (TSH) release .
Art. -Nr.: HY-RS15011
Forschungsgebiete:  

Others

TRH Human Pre-designed siRNA Set A contains three designed siRNAs for TRH gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

Art. -Nr.: HY-RS16699
Forschungsgebiete:  

Others

Trh Mouse Pre-designed siRNA Set A contains three designed siRNAs for Trh gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.