75 Results for "

Vitamin D receptor

" in MedChemExpress (MCE) Product Catalog:
Products (75)

75 Results for "Vitamin D receptor" in MCE Product Catalog:

77
77 Publications Verification
Cat. No.: HY-10002
CAS No.: 32222-06-3
Purity:  99.94%
Synonyms: 1,25-DihydroxyVitamin D3
Calcitriol is the most active metabolite of vitamin D and also a vitamin D receptor (VDR) agonist.
loading...
    loading...
54
54 Cited Publications
Cat. No.: HY-10001
CAS No.: 112965-21-6
Purity:  99.93%
Synonyms: MC 903; Calcipotriene
Target:  

VD/VDR

Research Areas:  

Inflammation/Immunology Cancer

Calcipotriol is a synthetic VitD3 analogue with a high affinity for the vitamin D receptor.
loading...
    loading...
54
54 Cited Publications
Cat. No.: HY-10001A
CAS No.: 147657-22-5
Purity:  99.95%
Target:  

VD/VDR

Research Areas:  

Inflammation/Immunology Cancer

Calcipotriol monohydrate is a synthetic VitD3 analogue with a high affinity for the vitamin D receptor.
loading...
    loading...
16
16 Cited Publications
Cat. No.: HY-50919
CAS No.: 131918-61-1
Target:  

VD/VDR

Research Areas:  

Metabolic Disease Cancer

Paricalcitol, a vitamin D analogue, is a vitamin D receptor agonist, used for the prevention and treatment of secondary hyperparathyroidism (excessive secretion of parathyroid hormone) associated with chronic renal failure.
loading...
    loading...
9
9 Cited Publications
Cat. No.: HY-32348
CAS No.: 54573-75-0
Synonyms: 1.alpha.-HydroxyVitamin D2
Research Areas:  

Metabolic Disease Cancer

Doxercalciferol is a Vitamin D2 analog, acts as an activator of Vitamin D receptor, and prevent renal disease.
loading...
    loading...
7
7 Cited Publications
Cat. No.: HY-32343
CAS No.: 55721-11-4
Synonyms: (24R)-24,25-DihydroxyVitamin D3
Secalciferol ((24R)-24,25-Dihydroxyvitamin D3) is the major active metabolite of Vitamin D. Secalciferol activates vitamin D receptor (VDR) with an EC50 value of 150 nM. Secalciferol is involved in a wide range of biological functions such as calcium homeostasis, cellular differentiation and proliferation processes, as well as other functions related to the immune system, which is promising for research of rickets, osteomalacia, hypercalcemia and autoimmune disorders .
loading...
    loading...
5
5 Cited Publications
Cat. No.: HY-147337
CAS No.: 1817841-22-7
Purity:  98.50%
Target:  

VD/VDR

Research Areas:  

Cancer

MeTC7 is a Vitamin-D receptor (VDR) antagonist. MeTC7 has potent VDR inhibition activity with an IC50 value of 2.9 μM. MeTC7 shows good antitumor effects .
loading...
    loading...
3
3 Cited Publications
Cat. No.: HY-32350
CAS No.: 60133-18-8
Synonyms: 1α,25-Dihydroxy Vitamin D2
Ercalcitriol (1α,25-Dihydroxy Vitamin D2) is a vitamin D receptor (VDR) agonist with high binding affinity. After binding to VDR, Ercalcitriol forms a complex with retinoid X receptor (RXR) to regulate target gene transcription. For example, Ercalcitriol induces human gingival/oral epithelial cells to produce human cat antimicrobial peptide (hCAP-18/LL-37), which has antimicrobial activity against periodontal pathogens such as Porphyromonas gingivalis. Ercalcitriol enhances the innate immune defense of the oral mucosa by promoting the expression of antimicrobial peptides, and is mainly used in the study of periodontal diseases and immune-related oral diseases .
loading...
    loading...
2
2 Cited Publications
Cat. No.: HY-12398
CAS No.: 173388-20-0
Purity:  99.88%
Target:  

VD/VDR

TEI-9647, a Vitamin D3 Lactone analogue, is a potent and specific vitamin D receptor (VDR) antagonist. TEI-9647 inhibits VDR/VDRE-mediated genomic actions of 1α,25(OH)2D3. TEI-9647 inhibits bone resorption and HL-60 cell differentiation induced by of 1α,25(OH)2D3. TEI-9647 has the potential for suppressing the excessive bone resorption and osteoclast formation in Paget's disease .
loading...
    loading...
2
2 Cited Publications
Cat. No.: HY-32341
CAS No.: 134404-52-7
Synonyms: EB 1089
Target:  

VD/VDR

Research Areas:  

Cancer

Seocalcitol is a vitamin D analog, binds vitamin D receptor protein from human osteosarcoma MG-63 cells with Kd of 0.27 nM.
loading...
    loading...
1
1 Cited Publications
Cat. No.: HY-103053
CAS No.: 1529814-60-5
Purity:  96.40%
Target:  

VD/VDR Apoptosis

Research Areas:  

Cancer

PS121912 is a selective vitamin D receptor (VDR)-coregulator inhibitor. PS121912 has acceptable metabolic stability in vivo. PS121912 can be used for the research of cancer .
loading...
    loading...
1
1 Cited Publications
Cat. No.: HY-12397
CAS No.: 156965-15-0
Purity:  99.23%
Target:  

VD/VDR

Research Areas:  

Endocrinology

ZK159222, a 25-carboxylic ester analogue of 1α,25-(OH)2D3, is a potent 1α,25-(OH)2D3 receptor (VDR) antagonist. The mechanism of ZK159222 antagonistic action is mediated by a lack of ligand-induced vitamin D receptor interaction with coactivators. ZK159222 has a partial agonistic character .
loading...
    loading...
1
1 Cited Publications
Cat. No.: HY-32344
CAS No.: 163217-09-2
Synonyms: TX 522
Target:  

VD/VDR Apoptosis

Research Areas:  

Cancer

Inecalcitol (TX 522), a unique vitamin D3 analog, is an orally active vitamin D receptor (VDR) agonist with a Kd of 0.53 nM. Inecalcitol can induce cell apoptosis and has potent anticancer activities . Inecalcitol is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
loading...
    loading...
1
1 Cited Publications
Cat. No.: HY-12398A
CAS No.: 173388-21-1
Purity:  99.30%
Target:  

VD/VDR

TEI-9648, a Vitamin D3 Lactone analogue, is a potent and specific vitamin D receptor (VDR) antagonist. TEI-9648 inhibits VDR/VDRE-mediated genomic actions of 1α,25(OH)2D3. TEI-9648 also inhibits HL-60 cell differentiation induced by of 1α,25(OH)2D3. TEI-9648 has the potential for bone metabolism research .
loading...
    loading...
1
1 Cited Publications
Cat. No.: HY-15329
CAS No.: 2070009-38-8
Purity:  99.63%
Maxacalcitol-d66 is the deuterated form of Maxacalcitol (22-Oxacalcitriol), which is a non-calcemic vitamin D3 analog and VDR ligand of VDR-like receptors.
loading...
    loading...
1
1 Cited Publications
Cat. No.: HY-P81203
Synonyms: Vitamin D3 receptor; 125 dihydroxyVitamin D3 receptor; 1 antibody 1,25-@dihydroxyVitamin D3 receptor; 125 dihydroxyVitamin D3 receptor; 25-dihydroxyVitamin D3 receptor; NR1I1; Nuclear receptor subfamily 1 group I member 1; VDR; VDR_HUMAN; Vitamin D (1,25- dihydroxyVitamin D3) receptor; Vitamin D hormone receptor; Vitamin D receptor; Vitamin D3 receptor,

Host:  

Rabbit

Application:  

IHC-P, IHC-F, ICC/IF

Reactivity:  

Human, Rat

loading...
    loading...
1
1 Cited Publications
Cat. No.: HY-P73543
Purity:  ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: VDR; Vitamin D receptor; NR1I1; Nuclear receptor Subfamily 1 Group I Member 1; 1,25-DihydroxyVitamin D3 receptor; Vitamin D3 receptor; PPP1R163; Vitamin D (1,25-DihydroxyVitamin D3) receptor; Protein Phosphatase 1, Regulatory Subunit 163; 1,25-Dihydroxyvi
Species:  
Human
Source:  
Sf9 insect cells
loading...
    loading...
Cat. No.: HY-134816
CAS No.: 9012-72-0
Purity:  ≥96.0%
D-Glucan is an orally effective Dectin-1 receptor immune activator with antioxidant properties (reducing TNF-α). D-Glucan activates macrophages and neutrophils to scavenge free radicals, inhibit oxidative stress and inflammatory responses, and improve insulin sensitivity. D-Glucan promotes glycolysis by enhancing the activity of the antioxidant enzyme glutathione, inhibiting gluconeogenesis and activating GK. D-Glucan can be used in the research of liver damage protection (antagonizing Acetaminophen (HY-66005) toxicity), radiation protection (synergistic with vitamin E) and diabetes (improving glucose metabolism) .
loading...
    loading...
Cat. No.: HY-76814
CAS No.: 78782-99-7
Calcitriol-d6 is the deuterium labeled Calcitriol. Calcitriol is the active metabolite of vitamin D3 and an agonist of the vitamin D receptor (VDR) .
loading...
    loading...
Cat. No.: HY-N10508
CAS No.: 71204-89-2
Calcitroic acid is a water-soluble terminal vitamin D metabolite and also a ligand for vitamin D receptor (VDR). Calcitroic acid binds to the ligand-binding domain of VDR, forms a retinoic X receptor complex, recruits the coactivator peptide MED1, mediates partial VDR-dependent transcription, inhibits Calcitriol (HY-10002)-induced VDR activation, and reduces the transcription level of CYP24A1 in the presence of 1α,25-dihydroxyvitamin D3. Calcitroic acid exerts selective activating effects on VDR, upregulates the expression of CYP24A1 and CYP3A4, decreases the transcription levels of iNOS and IL-1β, reduces the secretion of nitric oxide and IL-1β, and possesses metabolic stability due to its resistance to phase I oxidation and hepatic glucuronidation. Calcitroic acid can be used in research related to colon cancer, inflammatory bowel disease and rickets .
loading...
    loading...