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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
14 Results for "
WD40 domain
" in MedChemExpress (MCE) Product Catalog:
Products (14)
14 Results for "WD40 domain" in MCE Product Catalog:
9
9 Cited Publications
Apcin, a ligand of Cdc20, is a potent and competitive anaphase-promoting complex/cyclosome (APC/C(Cdc20)) E3 ligase activity inhibitor. Apcin competitively inhibits APC/C-dependent ubiquitylation by binding to Cdc20 and preventing substrate recognition. Apcin occupes the D-box-binding pocket on the side face of the WD40-domain and can prolong mitosis .
MS67 is a potent and selective WD40 repeat domain protein 5 (WDR5) degrader with a Kd of 63 nM. MS67 is inactive against other protein methyltransferases, kinases, GPCRs, ion channels, and transporters. MS67 shows potent acticancer effects .
Research Areas:
Dimethyl-F-OICR-9429-COOH a ligand for WD40 repeat domain protein 5 (WDR5) extracted from patent WO2019246570A1 intermediate 19. Dimethyl-F-OICR-9429-COOH can be used in the synthesis of PROTACs .
Cat. No.: HY-141798
CAS No.: 2407457-55-8
Research Areas:
OICR-9429-N-C2-NH2 is a ligand for Wd40 repeat domain protein 5 (WDR5) extracted from patent WO2019246570A1, intermediate 2. OICR-9429-N-C2-NH2 can be used in the synthesis of PROTACs .
Cat. No.: HY-162896
CAS No.: 3029132-46-2
Target:
Research Areas:
And1 degrader 1 is an acidic nucleoplasmic DNA-binding protein 1 (And1) molecular glue-like degrader. And1 degrader 1 binds to the WD40 domain of And1 in a 'V' conformation to induce And1 degradation via the ubiquitin-proteasome pathway. And1 degrader 1 exhibits antiproliferative activity via synthetic lethal interaction with a PARP1 inhibitor to inhibit proliferation of cancer cells. And1 degrader 1 can be used for the research of non-small cell lung cancer (NSCLC) .
Cat. No.: HY-110287R
CAS No.: 300815-04-7
Target:
Research Areas:
Apcin (Standard) is the analytical standard of Apcin (HY-110287). This product is intended for research and analytical applications. Apcin, a ligand of Cdc20, is a potent and competitive anaphase-promoting complex/cyclosome (APC/C(Cdc20)) E3 ligase activity inhibitor. Apcin competitively inhibits APC/C-dependent ubiquitylation by binding to Cdc20 and preventing substrate recognition. Apcin occupes the D-box-binding pocket on the side face of the WD40-domain and can prolong mitosis .
Cat. No.: HY-183959
CAS No.: 713099-37-7
DC_M5_2 is a WD40 repeat domain protein 5 (WDR5) inhibitor with an IC50 of 9.63 μM and a KD of 13.8 μM. DC_M5_2 binds to the WDR5 pocket that interacts with the MLL1 peptide, blocking the WDR5-MLL1 protein-protein interaction . DC_M5_2 can be used in leukemia-related research .
Cat. No.: HY-169389
OICR41114 is a WDR5 PROTAC degrader with an EC50 of 40 nM. OICR41114 binds both DCAF1 and WDR5, and its binding affinity for DCAF1 is significantly enhanced in the presence of WDR5 (KD increases from 59 nM to 5 nM). OICR41114 exerts antiproliferative effects on MV4-11 cells. OICR41114 can be used for the research of acute myeloid leukemia .
Cat. No.: HY-P702046
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: CIAO1; WD Repeat domain 39; Prev. WDR39; Cytosolic Iron-Sulfur Protein Assembly 1 Homolog; CIA1; Cytosolic Iron-Sulfur Protein Assembly 1; Probable Cytosolic Iron-Sulfur Protein Assembly Protein CIAO1; WD40 Protein Ciao1; WD Repeat-Containing Protein 39;
Species:
Human
Source:
E. coli
Cat. No.: HY-P702047
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: CIAO1; WD Repeat domain 39; Prev. WDR39; Cytosolic Iron-Sulfur Protein Assembly 1 Homolog; CIA1; Cytosolic Iron-Sulfur Protein Assembly 1; Probable Cytosolic Iron-Sulfur Protein Assembly Protein CIAO1; WD40 Protein Ciao1; WD Repeat-Containing Protein 39;
Species:
Human
Source:
E. coli
Cat. No.: HY-P703615
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: WDR5; WD Repeat domain 5; CFAP89; BIG-3; SWD3; Cilia And Flagella Associated Protein 89; WD Repeat-Containing Protein 5; BMP2-Induced 3-Kb Gene Protein; BMP-2-Induced Gene 3 Kb; BIG3; SWD3, Set1c WD40 Repeat Protein, Homolog (S. Cerevisiae); SWD3, Set1c W
Species:
Human
Source:
E. coli
Cat. No.: HY-P702880
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: WDR5; WD Repeat domain 5; CFAP89; BIG-3; SWD3; Cilia And Flagella Associated Protein 89; WD Repeat-Containing Protein 5; BMP2-Induced 3-Kb Gene Protein; BMP-2-Induced Gene 3 Kb; BIG3; SWD3, Set1c WD40 Repeat Protein, Homolog (S. Cerevisiae); SWD3, Set1c W
Species:
Human
Source:
Sf9 insect cells
Cat. No.: HY-P702881
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: WDR5; WD Repeat domain 5; CFAP89; BIG-3; SWD3; Cilia And Flagella Associated Protein 89; WD Repeat-Containing Protein 5; BMP2-Induced 3-Kb Gene Protein; BMP-2-Induced Gene 3 Kb; BIG3; SWD3, Set1c WD40 Repeat Protein, Homolog (S. Cerevisiae); SWD3, Set1c W
Species:
Human
Source:
Sf9 insect cells
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
