13 Results for "

adipocyte membrane

" in MedChemExpress (MCE) Product Catalog:
Products (13)

13 Results for "adipocyte membrane" in MCE Product Catalog:

2
2 Cited Publications
Cat. No.: HY-P1723
CAS No.: 1370290-58-6
Synonyms: Neuropeptide Q
Spexin (Neuropeptide Q) is a selective agonist of galanin receptors GAL2 and GAL3, and is a conserved peptide that functions as a neurotransmitter/neuromodulator and endocrine factor. Spexin can function through both central and peripheral actions. Spexin upregulates Beclin 1 to inhibit ferroptosis induced by excessive autophagy, reduces the uptake of long-chain fatty acids by adipocytes, and regulates energy metabolism by increasing lipid oxidation (e.g., reducing the respiratory exchange ratio in rodents). Spexin improves cardiac function in the Doxorubicin hydrochloride (HY-15142)-induced cardiotoxicity model, protects mitochondrial membrane potential, and reduces iron accumulation and lipid peroxidation. Spexin can be used to study obesity and its related metabolic disorders, cardiovascular diseases (e.g., cardioprotection), and side effects of tumor chemotherapy .
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1
1 Cited Publications
Cat. No.: HY-172241
CAS No.: 1436920-57-8
Synonyms: RZL-012; Utenpanium chloride
Research Areas:  

Metabolic Disease

Tapencarium (RZL-012; Utenpanium chloride) is an injectable fat volume-reducing agent. Tapencarium irreversibly impairs cell membrane integrity, increases membrane permeability, induces elevated cytoplasmic calcium, alters mitochondrial membrane potential, and triggers necrosis. Tapencarium induces fat necrosis, inflammatory responses and fibrous tissue formation at the injection site. Tapencarium can be used in research related to submental fat excess and Dercum's disease .
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Cat. No.: HY-W013967
CAS No.: 1720-32-7
1,6-Diphenylhexa-1,3,5-triene is a membrane intercalator and hydrophobic fluorescent probe. 1,6-Diphenylhexa-1,3,5-triene intercalates into the non-polar region of lipid bilayers of adipocyte membranes with probe/membrane equilibrium affected by temperature, probe concentration, and membrane concentration. 1,6-Diphenylhexa-1,3,5-triene’s fluorescence intensity correlating with adipocyte membrane probe incorporation (Ex/Em = 350/452 nm) .
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Cat. No.: HY-19842
CAS No.: 618380-90-8
Synonyms: CVT 3619
GS-9667 (CVT 3619), a novel N 6-5'-substituted adenosine analog, is a selective, partial agonist of the A1 adenosine receptor (A1AdoR). GS-9667 binds to adipocyte membranes with high (KH=14 nM) and low (KL=5.4 μM) affinities. GS-9667 reduces cyclic AMP content and release of nonesterified fatty acids from epididymal adipocytes with IC50 values of 6 nM and 44 nM, respectively. GS-9667 inhibits lipolysis and has the potential for Type 2 diabetes (T2DM) and dyslipidemia via lowering of free fatty acids (FFA) .
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Cat. No.: HY-119741
CAS No.: 200399-47-9
Salacinol, compound found in Salacia reticulata, is an orally active α-glucosidase/lipase inhibitor. Salacinol inhibits enzymatic activity of intestinal maltase (IC50 = 3.2 μg/mL, Ki = 0.31 μg/mL), sucrase (IC50 = 0.84 μg/mL, Ki = 0.32 μg/mL), and isomaltase (IC50 = 0.59 μg/mL, Ki = 0.47 μg/mL), and inhibits increases in serum glucose levels in sucrose-loaded rats. Salacinol also inhibits pancreatic lipase and lipoprotein lipase. Salacinol can be used for the research of diabetes mellitus .
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Cat. No.: HY-142444
CAS No.: 2647975-06-0
Target:  

VAP-1

Research Areas:  

Metabolic Disease

SSAO/VAP-1 inhibitor 1 is a potent inhibitor of SSAO/VAP-1. SSAO/VAP-1 promotes the transfer of Glucose transport 4 (GLUT 4) from adipocytes to the cell membrane, thereby regulating glucose transport. In endothelial cells, SSAO/VAP-1 can mediate the adhesion and exudation of leukocytes and endothelial cells, and participate in inflammatory responses. SSAO/VAP-1 inhibitor 1 has the potential for the research of inflammation and/or inflammation-related disease or diabetes and/or diabetes-related disease (extracted from patent WO2021102774A1, compound E3) .
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Cat. No.: HY-P1723A
Synonyms: Neuropeptide Q TFA
Spexin (Neuropeptide Q) TFA is a selective agonist of galanin receptors GAL2 and GAL3, and is a conserved peptide that functions as a neurotransmitter/neuromodulator and endocrine factor. Spexin TFA can function through both central and peripheral actions. Spexin TFA upregulates Beclin 1 to inhibit ferroptosis induced by excessive autophagy, reduces the uptake of long-chain fatty acids by adipocytes, and regulates energy metabolism by increasing lipid oxidation (e.g., reducing the respiratory exchange ratio in rodents). Spexin TFA improves cardiac function in the Doxorubicin hydrochloride (HY-15142)-induced cardiotoxicity model, protects mitochondrial membrane potential, and reduces iron accumulation and lipid peroxidation. Spexin TFA can be used to study obesity and its related metabolic disorders, cardiovascular diseases (e.g., cardioprotection), and side effects of tumor chemotherapy .
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Cat. No.: HY-P10984
CAS No.: 206536-96-1
FNIII14 is a β1-integrin inhibitory peptide. FNIII14 induces the conformational shift of β1-integrin from the active form to the inactive form, blocks integrin-mediated signaling pathways, disrupts the interaction between VLA-4 and fibronectin, inhibits the phosphorylation of FAK/Akt, suppresses cell adhesion, fibronectin fibril formation and chondrocyte proliferation, induces chondrocyte apoptosis and cartilage degeneration, upregulates the pro-apoptotic protein Bim, and binds to membrane-bound eEF1A. FNIII14 reversibly disrupts cell adhesion without reducing cell viability, accelerates adipocyte differentiation, and loosens tumor matrix architecture to enhance the permeability of nanotherapeutic agents. FNIII14 can be used in research related to neuroblastoma, pancreatic cancer, acute myeloid leukemia, colitis-associated colorectal cancer, osteoarthritis, and atherosclerosis .
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Cat. No.: HY-137934
CAS No.: 64657-20-1
Synonyms: 7-Deacetylforskolin
Deacetylforskolin is a deacetylated derivative of forskolin (HY-15371) that can be extracted from C. forskohlii. Deacetylforskolin activates rat adipocyte adenylyl cyclase (IC50 = 20 µM), inhibits glucose transport in rat adipocyte plasma membranes and exhibits antihypertensive activity .
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Cat. No.: HY-176148
CAS No.: 3068828-64-5
Research Areas:  

Metabolic Disease

ZGL-18 is an uncoupling protein 1 (UCP1)-inspired mitochondrial uncoupler. ZGL-18 activates brown adipocytes and reduces mitochondrial membrane potential .
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Cat. No.: HY-P7609
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: CLMP; adipocyte-Specific Adhesion Molecule; CXADR Like Cell Adhesion Molecule; adipocyte Adhesion Molecule; ASAM; CXADR-Like membrane Protein; ACAM; FLJ22415; Coxsackie- And Adenovirus Receptor-Like membrane Protein; CSBM; CXADR Like membrane Protein; CSB
Species:  
Human
Source:  
HEK293
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Cat. No.: HY-P72836
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: CLMP; adipocyte-Specific Adhesion Molecule; CXADR Like Cell Adhesion Molecule; adipocyte Adhesion Molecule; ASAM; CXADR-Like membrane Protein; ACAM; FLJ22415; Coxsackie- And Adenovirus Receptor-Like membrane Protein; CSBM; CXADR Like membrane Protein; CSB
Species:  
Mouse
Source:  
HEK293
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Cat. No.: HY-P72837
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: CLMP; adipocyte-Specific Adhesion Molecule; CXADR Like Cell Adhesion Molecule; adipocyte Adhesion Molecule; ASAM; CXADR-Like membrane Protein; ACAM; FLJ22415; Coxsackie- And Adenovirus Receptor-Like membrane Protein; CSBM; CXADR Like membrane Protein; CSB
Species:  
Rat
Source:  
HEK293
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