64657-20-1
Chemical Structure
Deacetylforskolin
Synonym(s): 7-Deacetylforskolin
- CAS No.: 64657-20-1
- Formula:C20H32O6
- Molecular Weight:368.46
IUPAC Name: (3R,4aR,5S,6S,6aS,10S,10aR,10bS)-5,6,10,10b-tetrahydroxy-3,4a,7,7,10a-pentamethyl-3-vinyldodecahydro-1H-benzo[f]chromen-1-one
InChIKey: WPDITXOBNLYZHH-KAACEJSMSA-N
SMILES: O[C@@]([C@@]([C@H]1O)(O[C@@]2(C)C=C)C)(C(C2)=O)[C@]([C@@](C3(C)C)([H])[C@@H]1O)([C@H](CC3)O)C
Biological Activity: Deacetylforskolin is a deacetylated derivative of forskolin (HY-15371) that can be extracted from C. forskohlii. Deacetylforskolin activates rat adipocyte adenylyl cyclase (IC50 = 20 µM), inhibits glucose transport in rat adipocyte plasma membranes and exhibits antihypertensive activity[1][2].
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Deacetylforskolin | Deacetylforskolin is a deacetylated derivative of forskolin (HY-15371) that can be extracted from C. forskohlii. Deacetylforskolin activates rat adipocyte adenylyl cyclase (IC50 = 20 µM), inhibits glucose transport in rat adipocyte plasma membranes and exhibits antihypertensive activity. | |||||||||||||||||||||
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- [1]. Joost HG, et al. Activation of adenylate cyclase and inhibition of glucose transport in rat adipocytes by forskolin analogues: structural determinants for distinct sites of action. Mol Pharmacol. 1988 Apr;33(4):449-53. [Content Brief]
- [2]. Bhat SV, et al. The antihypertensive and positive inotropic diterpene forskolin: effects of structural modifications on its activity. J Med Chem. 1983 Apr;26(4):486-92. [Content Brief]
Keywords
