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airway remodeling

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Adenosine Receptor (2) Apoptosis (1) Bacterial (3) Bcl-2 Family (1) Biochemical Assay Reagents (1) Branched Chain Amino Acid Transaminase (BCAT) (1) Cadherin (1) Caspase (1) Drug Isomer (1) Environmental Pollutants (1) ERK (1) HCV (1) Interleukin Related (3) Isotope-Labeled Compounds (1) JAK (1) JNK (1) Keap1-Nrf2 (1) MMP (1) NF-κB (2) p38 MAPK (1) Reference Standards (2) STAT (1) Transmembrane Glycoprotein (1)
By Research Areas:	Cancer (4) Infection (5) Inflammation/Immunology (7) Metabolic Disease (1)

By Targets:

Adenosine Receptor (2)

Apoptosis (1)

Bacterial (3)

Bcl-2 Family (1)

Biochemical Assay Reagents (1)

Branched Chain Amino Acid Transaminase (BCAT) (1)

Cadherin (1)

Caspase (1)

Drug Isomer (1)

Environmental Pollutants (1)

ERK (1)

HCV (1)

Interleukin Related (3)

Isotope-Labeled Compounds (1)

JAK (1)

JNK (1)

Keap1-Nrf2 (1)

MMP (1)

NF-κB (2)

p38 MAPK (1)

Reference Standards (2)

STAT (1)

Transmembrane Glycoprotein (1)

By Research Areas:

Cancer (4)

Infection (5)

Inflammation/Immunology (7)

Metabolic Disease (1)

Inhibitors & Agonists

Inhibitory Antibodies

Natural
Products

Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-D0261

Tiron 1 Publications Verification	Biochemical Assay Reagents Apoptosis	Metabolic Disease Inflammation/Immunology Cancer
Tiron is a non-toxic chelator of a variety of metals. Tiron is cell permeable analog of vitamin E and function as hydroxyl radical and superoxide scavenger. Tiron is an orally active antioxidant. Tiron can be used to alleviate acute metal overload in animals .

HY-N3519

Platycodin D3 1 Publications Verification	HCV Branched Chain Amino Acid Transaminase (BCAT) Interleukin Related NF-κB ERK p38 MAPK JNK	Infection Inflammation/Immunology
Platycodin D3 is a triterpenoid saponin that can be found in Platycodon grandiflorum. Platycodin D3 exhibits multiple activities including anti-inflammation, regulation of airway mucus secretion, improvement of asthmatic airway inflammation and remodeling, and inhibition of hepatitis C virus (HCV) replication. The IC₅₀ value of Platycodin D3 against HCV NS5B RNA-dependent RNA polymerase is 8 μg/mL. Platycodin D3 can be used in studies related to asthma, hepatitis C virus infection and inflammatory diseases .

HY-10081

GS-6201 1 Publications Verification CVT-6883	Adenosine Receptor	Inflammation/Immunology
GS-6201 (CVT-6883) is a selective adenosine A2B receptor antagonist. GS-6201 displays high affinity and selectivity for the human adenosine A2B receptors (K_i=22 nM) . GS-6201 reduces caspase-1 activity in the heart, and attenuates cardiac remodeling after acute myocardial infarction (AMI) in the mouse . GS-62013 attenuates the airway reactivity induced by NECA, AMP, or allergen in sensitized mice .

HY-P99244

Fezakinumab ILV 094	Interleukin Related JAK STAT Caspase Bcl-2 Family	Inflammation/Immunology
Fezakinumab (ILV 094) is an anti-IL-22 monoclonal antibody. Fezakinumab inhibits IL-22 signal transduction, and regulates the JAK1/STAT3 pathway as well as apoptotic proteins. Fezakinumab alleviates airway remodeling, alveolar enlargement and inflammatory cell infiltration in lung tissues. Fezakinumab reduces the levels of neutrophils, lymphocytes, eosinophils and macrophages in lung tissues. Fezakinumab can be used in the research of chronic obstructive pulmonary disease and skin diseases .

HY-W016969

2-Undecanone	Environmental Pollutants Bacterial Interleukin Related Keap1-Nrf2 NF-κB	Infection Cancer
2-Undecanone is an orally active organic ketone. 2-Undecanone exerts antibacterial effects by inhibiting bacterial chaperone systems and interfering with the refolding of heat-inactivated proteins. 2-Undecanone also ameliorates asthmatic inflammation and airway remodeling by blocking the NF-κB pathway, and activates the Nrf2 pathway to reduce oxidative damage and prevent lung cancer induced by Benzo[a]pyrene (HY-107377). 2-Undecanone can be used in research related to cancer, asthma and infections .

HY-12093A

(R)-MMP408	Drug Isomer MMP Cadherin	Inflammation/Immunology
(R)-MMP408 is an isomer of MMP408 (HY-12093). MMP408 is an orally active MMP-12 inhibitor (IC₅₀=2.0 nM for hMMP-12) that effectively interferes with the epithelial-mesenchymal transition (EMT) process. MMP408 significantly upregulates the expression of E-cadherin in nasal epithelial cells, while inhibiting mesenchymal markers such as vimentin, α-smooth muscle actin and fibronectin, thereby reversing the EMT phenotype. MMP408 is used in studies of airway remodeling-related diseases, including chronic rhinosinusitis with nasal polyps, chronic obstructive pulmonary disease (COPD) and asthma .

HY-P990126

Anti-Rat CD8α Antibody (OX-8)	Transmembrane Glycoprotein	Infection Inflammation/Immunology
Anti-Rat CD8α Antibody (OX-8) is an anti-rat CD8α IgG1 monoclonal antibody. Anti-Rat CD8α Antibody (OX-8) can deplete CD8 ⁺ T cells. Anti-Rat CD8α Antibody (OX-8) can enhance airway remodeling. Anti-Rat CD8α Antibody (OX-8) can be used for researches on allergic conditions and infections such as RHV-rn1 virus infection and asthma .

HY-W016969R

2-Undecanone (Standard)	Bacterial Reference Standards	Infection Cancer
2-Undecanone (Standard) is the analytical standard of 2-Undecanone (HY-W016969). This product is intended for research and analytical applications. 2-Undecanone is an orally active organic ketone. 2-Undecanone exerts antibacterial effects by inhibiting bacterial chaperone systems and interfering with the refolding of heat-inactivated proteins. 2-Undecanone also ameliorates asthmatic inflammation and airway remodeling by blocking the NF-κB pathway, and activates the Nrf2 pathway to reduce oxidative damage and prevent lung cancer induced by Benzo[a]pyrene (HY-107377). 2-Undecanone can be used in research related to cancer, asthma and infections .

HY-10081R

GS-6201 (Standard) CVT-6883 (Standard)	Adenosine Receptor Reference Standards	Inflammation/Immunology
GS-6201 (Standard) is the analytical standard of GS-6201 (HY-10081). This product is intended for research and analytical applications. GS-6201 (CVT-6883) is a selective adenosine A2B receptor antagonist. GS-6201 displays high affinity and selectivity for the human adenosine A2B receptors (Ki=22 nM) . GS-6201 reduces caspase-1 activity in the heart, and attenuates cardiac remodeling after acute myocardial infarction (AMI) in the mouse . GS-62013 attenuates the airway reactivity induced by NECA, AMP, or allergen in sensitized mice .

HY-W016969S

2-Undecanone-d5	Isotope-Labeled Compounds Bacterial	Infection Cancer
2-Undecanone-d₅ is the deuterium labeled 2-Undecanone (HY-W016969). 2-Undecanone is an orally active organic ketone. 2-Undecanone exerts antibacterial effects by inhibiting bacterial chaperone systems and interfering with the refolding of heat-inactivated proteins. 2-Undecanone also ameliorates asthmatic inflammation and airway remodeling by blocking the NF-κB pathway, and activates the Nrf2 pathway to reduce oxidative damage and prevent lung cancer induced by Benzo[a]pyrene (HY-107377). 2-Undecanone can be used in research related to cancer, asthma and infections .

Cat. No.	Product Name	Target	Research Area	Image

HY-P99244

Fezakinumab ILV 094	Interleukin Related JAK STAT Caspase Bcl-2 Family	Inflammation/Immunology
Fezakinumab (ILV 094) is an anti-IL-22 monoclonal antibody. Fezakinumab inhibits IL-22 signal transduction, and regulates the JAK1/STAT3 pathway as well as apoptotic proteins. Fezakinumab alleviates airway remodeling, alveolar enlargement and inflammatory cell infiltration in lung tissues. Fezakinumab reduces the levels of neutrophils, lymphocytes, eosinophils and macrophages in lung tissues. Fezakinumab can be used in the research of chronic obstructive pulmonary disease and skin diseases .

HY-P990126

Anti-Rat CD8α Antibody (OX-8)	Transmembrane Glycoprotein	Infection Inflammation/Immunology
Anti-Rat CD8α Antibody (OX-8) is an anti-rat CD8α IgG1 monoclonal antibody. Anti-Rat CD8α Antibody (OX-8) can deplete CD8 ⁺ T cells. Anti-Rat CD8α Antibody (OX-8) can enhance airway remodeling. Anti-Rat CD8α Antibody (OX-8) can be used for researches on allergic conditions and infections such as RHV-rn1 virus infection and asthma .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N3519

Platycodin D3 1 Publications Verification	Infection Triterpenes Structural Classification Classification of Application Fields Terpenoids Platycodon grandiflorus (Jacq.) A. DC. Campanulaceae Plants Disease Research Fields Source Classification	HCV Branched Chain Amino Acid Transaminase (BCAT) Interleukin Related NF-κB ERK p38 MAPK JNK
Platycodin D3 is a triterpenoid saponin that can be found in Platycodon grandiflorum. Platycodin D3 exhibits multiple activities including anti-inflammation, regulation of airway mucus secretion, improvement of asthmatic airway inflammation and remodeling, and inhibition of hepatitis C virus (HCV) replication. The IC₅₀ value of Platycodin D3 against HCV NS5B RNA-dependent RNA polymerase is 8 μg/mL. Platycodin D3 can be used in studies related to asthma, hepatitis C virus infection and inflammatory diseases .

HY-W016969

2-Undecanone	Infection Structural Classification Saururaceae Houttuynia cordata Thunb. Classification of Application Fields Phenols Plants Disease Research Fields Source Classification	Environmental Pollutants Bacterial Interleukin Related Keap1-Nrf2 NF-κB
2-Undecanone is an orally active organic ketone. 2-Undecanone exerts antibacterial effects by inhibiting bacterial chaperone systems and interfering with the refolding of heat-inactivated proteins. 2-Undecanone also ameliorates asthmatic inflammation and airway remodeling by blocking the NF-κB pathway, and activates the Nrf2 pathway to reduce oxidative damage and prevent lung cancer induced by Benzo[a]pyrene (HY-107377). 2-Undecanone can be used in research related to cancer, asthma and infections .

HY-W016969R

2-Undecanone (Standard)	Structural Classification Microorganisms Saururaceae Houttuynia cordata Thunb. Phenols Plants Source Classification	Bacterial Reference Standards
2-Undecanone (Standard) is the analytical standard of 2-Undecanone (HY-W016969). This product is intended for research and analytical applications. 2-Undecanone is an orally active organic ketone. 2-Undecanone exerts antibacterial effects by inhibiting bacterial chaperone systems and interfering with the refolding of heat-inactivated proteins. 2-Undecanone also ameliorates asthmatic inflammation and airway remodeling by blocking the NF-κB pathway, and activates the Nrf2 pathway to reduce oxidative damage and prevent lung cancer induced by Benzo[a]pyrene (HY-107377). 2-Undecanone can be used in research related to cancer, asthma and infections .

Cat. No.	Product Name	Chemical Structure

HY-W016969S

2-Undecanone-d5
2-Undecanone-d₅ is the deuterium labeled 2-Undecanone (HY-W016969). 2-Undecanone is an orally active organic ketone. 2-Undecanone exerts antibacterial effects by inhibiting bacterial chaperone systems and interfering with the refolding of heat-inactivated proteins. 2-Undecanone also ameliorates asthmatic inflammation and airway remodeling by blocking the NF-κB pathway, and activates the Nrf2 pathway to reduce oxidative damage and prevent lung cancer induced by Benzo[a]pyrene (HY-107377). 2-Undecanone can be used in research related to cancer, asthma and infections .

2-Undecanone-d5

2-Undecanone-d₅ is the deuterium labeled 2-Undecanone (HY-W016969). 2-Undecanone is an orally active organic ketone. 2-Undecanone exerts antibacterial effects by inhibiting bacterial chaperone systems and interfering with the refolding of heat-inactivated proteins. 2-Undecanone also ameliorates asthmatic inflammation and airway remodeling by blocking the NF-κB pathway, and activates the Nrf2 pathway to reduce oxidative damage and prevent lung cancer induced by Benzo[a]pyrene (HY-107377). 2-Undecanone can be used in research related to cancer, asthma and infections .

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airway remodeling

Inhibitors & Agonists

Inhibitory Antibodies

NaturalProducts

Isotope-Labeled Compounds

Natural
Products