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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
17 Results for "
ammonia metabolism
" in MedChemExpress (MCE) Product Catalog:
Products (17)
17 Results for "ammonia metabolism" in MCE Product Catalog:
10
10 Publications Verification
Cat. No.: HY-W017018
CAS No.: 3184-13-2
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1 Cited Publications
Cat. No.: HY-N10574
CAS No.: 72496-59-4
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1 Cited Publications
Cat. No.: HY-N10574A
CAS No.: 86496-18-6
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1 Cited Publications
Cat. No.: HY-W017018S4
CAS No.: 2483831-57-6
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Glutamate dehydrogenase (NAD (P)) (GLDH) is a glutamate dehydrogenase . Glutamate dehydrogenase exists in all organisms and catalyzes the oxidative deamination of L-Glutamate (HY-W337739) to α-Ketoglutarate using NAD (P) + as a coenzyme. The glutamate dehydrogenase pathway is also associated with various cellular processes, including ammonia metabolism, acid-base balance, redox homeostasis, lipid biosynthesis, and lactate production .
Cat. No.: HY-W017018S2
CAS No.: 943962-21-8
Cat. No.: HY-W017018B
CAS No.: 3184-13-2
Cat. No.: HY-W017018S
CAS No.: 347841-40-1
Cat. No.: HY-W115789
CAS No.: 1344-09-8
Cat. No.: HY-W017018S5
CAS No.: 360565-59-9
Cat. No.: HY-W017018R
CAS No.: 3184-13-2
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SC-435 is an orally effective apical sodium codependent bile acid transporter (ASBT) inhibitor. SC-435 effectively removes neurotoxic bile acids and ammonia from the blood by inhibiting intestinal ASBT, thereby alleviating liver and brain damage caused by liver failure. SC-435 can alter hepatic cholesterol metabolism and lower plasma low-density lipoprotein-cholesterol concentrations .
Cat. No.: HY-W017018S3
CAS No.: 2483831-42-9
Cat. No.: HY-W017018S1
CAS No.: 224054-19-7
Cat. No.: HY-E71661
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3-Aminobutyryl-CoA ammonia-lyase (EC 4.3.1.14) is an ammonia-lyase responsible for converting the aminoacyl-CoA intermediate-generated during lysine metabolism-into crotonoyl-CoA, which can then enter fatty acid or butyrate metabolism.
Cat. No.: HY-P2749A
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L-Glutamine Synthetase, Escherichia coli (EC 6.3.1.2) is an enzyme that plays an important role in nitrogen metabolism, catalyzing the condensation of glutamate and ammonia to produce glutamine. L-Glutamine Synthetase, Escherichia coli (EC 6.3.1.2) utilizes ammonia produced by nitrate reduction, amino acid degradation, and photorespiration.
Cat. No.: HY-L064
1,827 compounds
Glutamine is an important metabolic fuel that helps rapidly proliferating cells meet the increased demand for ATP, biosynthetic precursors, and reducing agents. Glutamine Metabolism pathway involves the initial deamination of glutamine by glutaminase(GLS), yielding glutamate and ammonia. Glutamate is converted to the TCA cycle intermediate α-ketoglutarate (α-KG) by either glutamate dehydrogenase (GDH) or by the alanine or aspartate transaminases (TAs), to produce both ATP and anabolic carbons for the synthesis of amino acids, nucleotides and lipids. During periods of hypoxia or mitochondrial dysfunction, α-KG can be converted to citrate in a reductive carboxylation reaction catalyzed by IDH2. The newly formed citrate exits the mitochondria where it is used to synthesize fatty acids and amino acids and produce the reducing agent, NADPH.
Cancer cells display an altered metabolic circuitry that is directly regulated by oncogenic mutations and loss of tumor suppressors. Mounting evidence indicates that altered glutamine metabolism in cancer cells has critical roles in supporting macromolecule biosynthesis, regulating signaling pathways, and maintaining redox homeostasis, all of which contribute to cancer cell proliferation and survival. Thus, intervention in glutamine metabolic processes could provide novel approaches to improve cancer treatment.
MCE owns a unique collection of 1,827 compounds targeting the mainly proteins and enzymes involved in glutamine metabolism pathway. Glutamine Metabolism compound library is a useful tool for intervention in glutamine metabolic processes.
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
