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Results for "

amyloid β 40

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Amyloid-β (11) Amylin Receptor (1) Aquaporin (1) Beta-secretase (2) Carbonic Anhydrase (2) Cathepsin (1) Notch (2) Reactive Oxygen Species (ROS) (2) Reference Standards (3) SOD (1) Tau Protein (1) α-synuclein (1) γ-secretase (4)
By Research Areas:	Cancer (2) Inflammation/Immunology (2) Neurological Disease (14)

Inhibitors & Agonists

Peptides

Inhibitory Antibodies

Targets Recommended: Amyloid-β

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-10009

Semagacestat 10+ Cited Publications LY450139	γ-secretase Amyloid-β Notch	Neurological Disease
Semagacestat is a γ-secretase inhibitor, inhibits *β-amyloid* (Aβ42), Aβ38 and Aβ40 with IC₅₀s of 10.9, 12 and 12.1 nM, respectively; also inhibits Notch signaling with IC₅₀ of 14.1 nM. Semagacestat can be used for the research of alzheimer's disease .

HY-W176557

TGN-073	Aquaporin	Neurological Disease
TGN-073 is a aquaporin 4 (AQP4) modulator, as well as an orally available, blood-brain barrier-permeable agent. TGN-073 increases the uptake and distribution of brain MRI tracers in the brain parenchyma and reduces the levels of insoluble amyloid-β 40 and β 42. TGN-073 can be used in research related to Alzheimer's disease, dementia, traumatic brain injury and pain .

HY-101087

Benzenesulphonamide	Carbonic Anhydrase Amyloid-β Reactive Oxygen Species (ROS)	Neurological Disease Inflammation/Immunology Cancer
Benzenesulphonamide (Compound 1) is a carbonic anhydrase inhibitor. Benzenesulphonamide exhibits CA II inhibitory activity. Benzenesulphonamide reduces ROS and improves the gene expression of *amyloid-β40* and 42. Benzenesulphonamide is beneficial for Alzheimer's disease. Benzenesulphonamide derivatives have anticancer, anti-inflammatory, and anticonvulsant activities. Benzenesulphonamide can be used in the research of Alzheimer's disease, epilepsy, inflammatory diseases, leukemia, melanoma, lung cancer, and colon cancer .

HY-P990301

Anti-Human/Mouse/Rat Amyloid-beta Antibody (MOAB-2)	Amyloid-β	Neurological Disease
Anti-Human/Mouse/Rat Amyloid-beta Antibody (MOAB-2) is a mouse-derived IgG2b λ type antibody inhibitor, targeting to *Amyloid-beta. Anti-Human/Mouse/Rat Amyloid-beta Antibody (MOAB-2) recognizes unaggregated, oligomeric or fibrillar forms of Aβ42 and unaggregated Aβ40. Anti-Human/Mouse/Rat Amyloid-beta Antibody (MOAB-2) is selective for human Aβ42 over Aβ40, but not amyloid* precursor protein (APP). Anti-Human/Mouse/Rat Amyloid-beta Antibody (MOAB-2) can immunostain human or rat and mouse tissue. Anti-Human/Mouse/Rat Amyloid-beta Antibody (MOAB-2) can be used for detections of western blot, immunohistochemistry, immunofluorescence, immunoprecipitation and ELISA .

HY-14175

Begacestat GSI-953	γ-secretase	Neurological Disease
Begacestat (GSI-953) is a selective thiophene sulfonamide inhibitor of amyloid precursor protein gamma-secretase (IC₅₀Aβ₄₀=15 nM) for the treatment of Alzheimer's disease .

HY-P1894

β-Amyloid Protein Precursor 770 (135-155)	Amyloid-β	Neurological Disease
β-Amyloid Protein Precursor 770 (135-155) is a peptide of amyloid precursor protein isoform (APP 770). APP 770 produces Aβ40/42 .

HY-P1894A

β-Amyloid Protein Precursor 770 (135-155) TFA	Amyloid-β	Neurological Disease
β-Amyloid Protein Precursor 770 (135-155) TFA is a peptide of amyloid precursor protein isoform (APP 770). APP 770 produces Aβ40/42 .

HY-P3781

(Met(O)35)-Amyloid β-Protein (1-42)	Amyloid-β	Neurological Disease
(Met(O)35)-Amyloid β-Protein (1-42) is the oxidation form of Met35 in Aβ42. (Met(O)35)-Amyloid β-Protein (1-42) can yield an oligomer size distribution characteristic of Aβ40. (Met(O)35)-Amyloid β-Protein (1-42) can be used in the research of Alzheimer’s disease (AD) .

HY-14175R

Begacestat (Standard) GSI-953 (Standard)	γ-secretase Reference Standards	Neurological Disease
Begacestat (Standard) is the analytical standard of Begacestat. This product is intended for research and analytical applications. Begacestat (GSI-953) is a selective thiophene sulfonamide inhibitor of amyloid precursor protein gamma-secretase (IC50Aβ40=15 nM) for the treatment of Alzheimer's disease .

HY-10143

LY-2434074	Beta-secretase Amyloid-β	Neurological Disease
LY-2434074 is a selective β-secretase (BACE) inhibitor with an IC₅₀ <100 nM. LY-2434074 can inhibit *amyloid-β* (Aβ₄₀ and Aβ₄₂) production. LY-2434074 can be used for the research of neurological disease, such as Alzheimer's disease .

HY-10009R

Semagacestat (Standard) LY450139 (Standard)	Reference Standards γ-secretase Amyloid-β Notch	Neurological Disease
Semagacestat (Standard) is the analytical standard of Semagacestat. This product is intended for research and analytical applications. Semagacestat is a γ-secretase inhibitor, inhibits β-amyloid (Aβ42), Aβ38 and Aβ40 with IC50s of 10.9, 12 and 12.1 nM, respectively; also inhibits Notch signaling with IC50 of 14.1 nM. Semagacestat can be used for the research of alzheimer's?disease .

HY-101087R

Benzenesulphonamide (Standard)	Reference Standards Carbonic Anhydrase Amyloid-β Reactive Oxygen Species (ROS)	Neurological Disease Inflammation/Immunology Cancer
Benzenesulphonamide (Standard) is the analytical standard of Benzenesulphonamide (HY-101087). This product is intended for research and analytical applications. Benzenesulphonamide (Compound 1) is a carbonic anhydrase inhibitor. Benzenesulphonamide exhibits CA II inhibitory activity. Benzenesulphonamide reduces ROS and improves the gene expression of *amyloid-β40* and 42. Benzenesulphonamide is beneficial for Alzheimer's disease. Benzenesulphonamide derivatives have anticancer, anti-inflammatory, and anticonvulsant activities. Benzenesulphonamide can be used in the research of Alzheimer's disease, epilepsy, inflammatory diseases, leukemia, melanoma, lung cancer, and colon cancer .

HY-182429

NB-533	Beta-secretase Cathepsin Amyloid-β	Neurological Disease
NB-533 is an orally active and brain-penetrant BACE-1 inhibitor with a human IC₅₀ of 0.002 μM. NB-533 also inhibits human cathepsin D with an IC₅₀ of 0.001 μM. NB-533 inhibits amyloidogenic amyloid precursor protein (APP) processing and reduces Aβ₄₀ release. NB-533 reduces brain levels of APP metabolite C99 and Aβ₄₀ in transgenic mice. NB-533 can be used for the research of Alzheimer’s disease .

HY-182304

CLR01 sodium	Amyloid-β α-synuclein Amylin Receptor Tau Protein SOD	Neurological Disease
CLR01 sodium is a blood-brain barrier-permeable anti-aggregation agent. CLR01 sodium inhibits the de novo aggregation of **Amyloid-β 40/42, α-synuclein, IAPP, tau protein and SOD1*. CLR01 sodium reduces amyloid* plaque burden in the cortex of triple-transgenic mice and improves the memory and motor abilities of these mice. CLR01 sodium can be used in research related to Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis (ALS) .

β-Amyloid Protein Precursor 770 (135-155)	Amyloid-β	Neurological Disease
β-Amyloid Protein Precursor 770 (135-155) is a peptide of amyloid precursor protein isoform (APP 770). APP 770 produces Aβ40/42 .

β-Amyloid Protein Precursor 770 (135-155) TFA	Amyloid-β	Neurological Disease
β-Amyloid Protein Precursor 770 (135-155) TFA is a peptide of amyloid precursor protein isoform (APP 770). APP 770 produces Aβ40/42 .

*β-Amyloid* (40-1)**	Peptides	Others
β-Amyloid (40-1) is a biological active peptide. (non-toxic reverse fragment Aβ(40–1), control of HY-P0265)

(Met(O)35)-Amyloid β-Protein (1-42)	Amyloid-β	Neurological Disease
(Met(O)35)-Amyloid β-Protein (1-42) is the oxidation form of Met35 in Aβ42. (Met(O)35)-Amyloid β-Protein (1-42) can yield an oligomer size distribution characteristic of Aβ40. (Met(O)35)-Amyloid β-Protein (1-42) can be used in the research of Alzheimer’s disease (AD) .

Cat. No.	Product Name	Target	Research Area	Image

HY-P990301

Anti-Human/Mouse/Rat Amyloid-beta Antibody (MOAB-2)	Amyloid-β	Neurological Disease
Anti-Human/Mouse/Rat Amyloid-beta Antibody (MOAB-2) is a mouse-derived IgG2b λ type antibody inhibitor, targeting to *Amyloid-beta. Anti-Human/Mouse/Rat Amyloid-beta Antibody (MOAB-2) recognizes unaggregated, oligomeric or fibrillar forms of Aβ42 and unaggregated Aβ40. Anti-Human/Mouse/Rat Amyloid-beta Antibody (MOAB-2) is selective for human Aβ42 over Aβ40, but not amyloid* precursor protein (APP). Anti-Human/Mouse/Rat Amyloid-beta Antibody (MOAB-2) can immunostain human or rat and mouse tissue. Anti-Human/Mouse/Rat Amyloid-beta Antibody (MOAB-2) can be used for detections of western blot, immunohistochemistry, immunofluorescence, immunoprecipitation and ELISA .

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BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.

BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

MedchemExpress Validation 03

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred

MedchemExpress Validation 04

MedchemExpress Validation

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