877459-36-4
Chemical Structure
TGN-073
- CAS No.: 877459-36-4
- Formula:C18H16N2O3S
- Molecular Weight:340.40
IUPAC Name: N-(3-(benzyloxy)pyridin-2-yl)benzenesulfonamide
InChIKey: JBHHMMLJGNLVNB-UHFFFAOYSA-N
SMILES: O=S(C1=CC=CC=C1)(NC2=NC=CC=C2OCC3=CC=CC=C3)=O
Biological Activity: TGN-073 is an orally active, blood-brain barrier-permeable aquaporin 4 (AQP4) modulator. TGN-073 increases the uptake and distribution of brain MRI tracers in the brain parenchyma and reduces the levels of insoluble amyloid β-40 and β-42. TGN-073 can be used in research related to Alzheimer's disease, dementia, traumatic brain injury and pain[1][2][3].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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TGN-073 | 99.53% | TGN-073 is an orally active, blood-brain barrier-permeable aquaporin 4 (AQP4) modulator. TGN-073 increases the uptake and distribution of brain MRI tracers in the brain parenchyma and reduces the levels of insoluble amyloid β-40 and β-42. TGN-073 can be used in research related to Alzheimer's disease, dementia, traumatic brain injury and pain. | ||||||||||||||||||||
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- [1]. Alghanimy A, et al. The effect of a novel AQP4 facilitator, TGN-073, on glymphatic transport captured by diffusion MRI and DCE-MRI. PLoS One. 2023;18(3):e0282955. Published 2023 Mar 15. [Content Brief]
- [2]. Ingrid L. Kwee, et al. Aquaporin4 facilitator decreases insoluble amyloid b of 5XFAD mouse brain. Alzheimer's Association. 07 December 2020.
- [3]. Vincent J. et al. Aquaporin-4 facilitator TGN-073 demonstrates novel analgesic activity. bioRxiv. October 08, 2018.
Keywords
