98-10-2
98-10-2
Chemical Structure
Benzenesulphonamide
- CAS No.: 98-10-2
- Formula:C6H7NO2S
- Molecular Weight:157.19
IUPAC Name: benzenesulfonamide
InChIKey: KHBQMWCZKVMBLN-UHFFFAOYSA-N
SMILES: O=S(C1=CC=CC=C1)(N)=O
Biological Activity: Benzenesulphonamide (Compound 1) is a carbonic anhydrase inhibitor. Benzenesulphonamide exhibits CA II inhibitory activity. Benzenesulphonamide reduces ROS and improves the gene expression of amyloid-β40 and 42. Benzenesulphonamide is beneficial for Alzheimer's disease. Benzenesulphonamide derivatives have anticancer, anti-inflammatory, and anticonvulsant activities. Benzenesulphonamide can be used in the research of Alzheimer's disease, epilepsy, inflammatory diseases, leukemia, melanoma, lung cancer, and colon cancer[1][2][3][4][5].
| Cat. No. | Nom du produit | Pureté | Description | Pricing | |||||||||||||||||||
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Benzenesulphonamide | 99.75% | Benzenesulphonamide (Compound 1) is a carbonic anhydrase inhibitor. Benzenesulphonamide exhibits CA II inhibitory activity. Benzenesulphonamide reduces ROS and improves the gene expression of amyloid-β40 and 42. Benzenesulphonamide is beneficial for Alzheimer's disease. Benzenesulphonamide derivatives have anticancer, anti-inflammatory, and anticonvulsant activities. Benzenesulphonamide can be used in the research of Alzheimer's disease, epilepsy, inflammatory diseases, leukemia, melanoma, lung cancer, and colon cancer. | ||||||||||||||||||||
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Benzenesulphonamide (Standard) | ≥98% | Benzenesulphonamide (Standard) is the analytical standard of Benzenesulphonamide (HY-101087). This product is intended for research and analytical applications. Benzenesulphonamide (Compound 1) is a carbonic anhydrase inhibitor. Benzenesulphonamide exhibits CA II inhibitory activity. Benzenesulphonamide reduces ROS and improves the gene expression of amyloid-β40 and 42. Benzenesulphonamide is beneficial for Alzheimer's disease. Benzenesulphonamide derivatives have anticancer, anti-inflammatory, and anticonvulsant activities. Benzenesulphonamide can be used in the research of Alzheimer's disease, epilepsy, inflammatory diseases, leukemia, melanoma, lung cancer, and colon cancer. | ||||||||||||||||||||
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Piloty's acid | Piloty's acid (N-Hydroxybenzenesulfonamide) is a biochemical assay reagent, that can be used for synthesis of nitroxyl (HNO). | |||||||||||||||||||||
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Phenylsulfamide | 99.90% | Phenylsulfamide (Compound 10) is a human carbonic anhydrase-II (hCA-II) inhibitor with a Kd of 45.50 μM and a Ki of 79.60 μM. | ||||||||||||||||||||
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p-Toluenesulfonamide (Standard) | ≥98% | p-Toluenesulfonamide (Standard) is the analytical standard of p-Toluenesulfonamide (HY-79602). This product is intended for research and analytical applications. p-Toluenesulfonamide is a small-molecule anticancer agent and plasticizer. p-Toluenesulfonamide exerts antitumor activity by inducing lysosomal membrane permeabilization, cathepsin B release and lysosome-mediated cell death. p-Toluenesulfonamide modulates cholesterol distribution in lipid rafts of tumor cell membranes and the Akt/mTOR/p70S6K pathway. p-Toluenesulfonamide shows activity against various cancers including hepatocellular carcinoma, non-small cell lung cancer and tongue squamous cell carcinoma; intrapleural injection effectively reduces malignant pleural effusion without causing pleural adhesion. p-Toluenesulfonamide is also the main degradation product of the disinfectant Chloramine-T (HY-B0959) in water. p-Toluenesulfonamide facilitates the localization of fluorescent probes to the endoplasmic reticulum. p-Toluenesulfonamide can be used in cancer-related research. | ||||||||||||||||||||
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p-Toluenesulfonamide-15N | p-Toluenesulfonamide-15N is the 15N-labeled p-Toluenesulfonamide (HY-79602). p-Toluenesulfonamide is a small-molecule anticancer agent and plasticizer. p-Toluenesulfonamide exerts antitumor activity by inducing lysosomal membrane permeabilization, cathepsin B release and lysosome-mediated cell death. p-Toluenesulfonamide modulates cholesterol distribution in lipid rafts of tumor cell membranes and the Akt/mTOR/p70S6K pathway. p-Toluenesulfonamide shows activity against various cancers including hepatocellular carcinoma, non-small cell lung cancer and tongue squamous cell carcinoma; intrapleural injection effectively reduces malignant pleural effusion without causing pleural adhesion. p-Toluenesulfonamide is also the main degradation product of the disinfectant Chloramine-T (HY-B0959) in water. p-Toluenesulfonamide facilitates the localization of fluorescent probes to the endoplasmic reticulum. p-Toluenesulfonamide can be used in cancer-related research. | |||||||||||||||||||||
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Sulfanilamide (Standard) | 99.83% | Sulfanilamide (Standard) is the analytical standard of Sulfanilamide. This product is intended for research and analytical applications. ulfanilamide (Sulphanilamide) is a potent and orally active sulfonamide antibiotic and can be a major intermediate of sulfamethoxazole biodegradation. Sulfanilamide also is a carbonic anhydrase inhibitor. Sulfanilamide shows inhibition on virus of lymphogranuloma venereum. | ||||||||||||||||||||
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2-Aminobenzenesulfonamide | 99.90% | 2-Aminobenzenesulfonamide is a carbonic anhydrase IX inhibitor. | ||||||||||||||||||||
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2-Methylbenzenesulfonamide (Standard) | ≥98% | 2-Methylbenzenesulfonamide (Standard) is the analytical standard of 2-Methylbenzenesulfonamide. This product is intended for research and analytical applications. | ||||||||||||||||||||
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Ethyl benzenesulfonate (Standard) | ≥98% | Ethyl benzenesulfonate (Standard) is the analytical standard of Ethyl benzenesulfonate. This product is intended for research and analytical applications. | ||||||||||||||||||||
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Benzenesulfonate sodium (Standard) | ≥98% | Benzenesulfonate (sodium) (Standard) is an analytical standard for Benzenesulfonate sodium (HY-W016510). This product is intended for research and analytical applications. Benzenesulfonate sodium is the sodium salt of Benzenesulfonic acid. Benzenesulfonate sodium facilitates the identification of -SO3H and -SO3- vibrational bands in compounds in Raman spectroscopy. Benzenesulfonate sodium was used in the synthesis of 1-Butyl-3-propanenitrile imidazolium benzenesulfonate [C2CN Bim]BS. | ||||||||||||||||||||
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Methyl phenyl sulfone (Standard) | ≥98% | (Methylsulfonyl)benzene (Standard) is the analytical standard of (Methylsulfonyl)benzene. This product is intended for research and analytical applications. | ||||||||||||||||||||
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References
- [1]. Thakur A, et al. QSAR study on benzenesulphonamide carbonic anhydrase inhibitors: topological approach using Balaban index. Bioorg Med Chem. 2004 Feb 15;12(4):789-93. [Content Brief]
- [2]. Hesar Shourkabi M, et al. Benzenesulfonamide as a novel, pharmaceutical small molecule inhibitor on Aβ gene expression and oxidative stress in Alzheimer's Wistar rats. Biochem Biophys Res Commun. 2023 Sep 24;674:154-161. [Content Brief]
- [3]. Bashir R, et al. Synthesis of some new 1,3,5-trisubstituted pyrazolines bearing benzene sulfonamide as anticancer and anti-inflammatory agents. Bioorg Med Chem Lett. 2011 Jul 15;21(14):4301-5. [Content Brief]
- [4]. Nissan YM, et al. New benzenesulfonamide scaffold-based cytotoxic agents: Design, synthesis, cell viability, apoptotic activity and radioactive tracing studies. Bioorg Chem. 2020 Mar;96:103577. [Content Brief]
- [5]. Wang Z, et al. Synthesis and Pharmacological Evaluation of Novel Benzenesulfonamide Derivatives as Potential Anticonvulsant Agents. Molecules. 2015 Sep 23;20(9):17585-600. [Content Brief]
