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Results for "

antibiotic activity

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Antibiotic (1284) 11β-HSD (1) 5-HT Receptor (2) Acetyl-CoA Carboxylase (1) ADC Payload (9) Adenosine Deaminase (2) Akt (18) Amino Acid Derivatives (1) Aminoacyl-tRNA Synthetase (4) Aminotransferases (Transaminases) (1) AMPK (2) Amyloid-β (2) Androgen Receptor (2) Apoptosis (97) Atg8/LC3 (1) ATP Synthase (1) Aurora Kinase (8) Autophagy (29) Bacterial (1210) Bcl-2 Family (5) Beclin1 (3) Beta-lactamase (53) Biochemical Assay Reagents (4) c-Myc (1) Calcium Channel (2) CaMK (1) Carbonic Anhydrase (3) Caspase (8) CDK (1) CGRP Receptor (1) Cholecystokinin Receptor (1) COX (4) Cytochrome P450 (4) Dengue Virus (1) Dihydrofolate reductase (DHFR) (2) DNA Alkylator/Crosslinker (1) DNA/RNA Synthesis (89) Dopamine Receptor (2) Drug Derivative (3) Drug Intermediate (3) Drug Metabolite (17) Drug-Linker Conjugates for ADC (1) Dynamin (2) E1/E2/E3 Enzyme (1) EAAT (6) EBV (2) Elastase (1) Endogenous Metabolite (31) Endothelin Receptor (1) Enolase (1) Environmental Pollutants (14) ERK (4) Exosomes (2) Farnesyl Transferase (2) Ferroptosis (3) FKBP (2) Fluorescent Dye (2) FOXO (2) Fungal (192) GABA Receptor (8) Glutathione S-transferase (1) Glycosidase (2) GSK-3 (8) HCV (1) Herbicide (3) Hexokinase (1) HIF/HIF Prolyl-Hydroxylase (4) Histamine Receptor (2) Histone Demethylase (2) HIV (11) HIV Integrase (2) HSP (6) HSV (18) Influenza Virus (16) Interleukin Related (13) Isotope-Labeled Compounds (82) JNK (6) Lactate Dehydrogenase (1) MDM-2/p53 (4) Microtubule/Tubulin (1) Mitochondrial Metabolism (14) Mitophagy (10) MMP (17) Molecular Glues (1) mRNA (1) mTOR (6) Na+/K+ ATPase (1) NADH Dehydrogenase (1) Necroptosis (3) NF-κB (11) NO Synthase (6) NOD-like Receptor (NLR) (4) Nuclear Factor of activated T Cells (NFAT) (1) Nuclear Hormone Receptor 4A/NR4A (1) Nucleoside Antimetabolite/Analog (4) Orthopoxvirus (22) Oxidative Phosphorylation (8) P-glycoprotein (3) p38 MAPK (5) Parasite (96) PARP (1) PDI (2) Penicillin-binding protein (PBP) (37) Phosphatase (2) Phospholipase (7) PI3K (11) PINK1/Parkin (2) PKC (3) Potassium Channel (4) PPAR (3) Prostaglandin Receptor (2) PROTACs (1) Proteasome (2) Protein Arginine Deiminase (1) Proton Pump (1) PTEN (3) Pyroptosis (3) Pyruvate Kinase (1) Ras (1) Reactive Oxygen Species (ROS) (27) Reference Standards (210) SARS-CoV (4) SOD (1) Src (1) STAT (7) TGF-beta/Smad (1) TGF-β Receptor (1) TNF Receptor (8) Toll-like Receptor (TLR) (1) Topoisomerase (68) TRP Channel (1) Tyrosinase (5) VEGFR (3) Wnt (8) β-catenin (12)
By Research Areas:	Cancer (344) Cardiovascular Disease (18) Endocrinology (12) Infection (1371) Inflammation/Immunology (144) Metabolic Disease (17) Neurological Disease (57)
Click Chemistry:	Azide (1) Alkynes (1)

1461

Inhibitors & Agonists

Screening Libraries

Fluorescent Dyes

Biochemical Assay Reagents

Peptides

Inhibitory Antibodies

631

Natural
Products

100

Isotope-Labeled Compounds

Click Chemistry

GMP Molecules

Targets Recommended: Antibiotic

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-N0565

Doxycycline 170+ Cited Publications	MMP Bacterial Antibiotic Parasite	Infection Neurological Disease Inflammation/Immunology Cancer
Doxycycline, an antibiotic, is an orally active and broad-spectrum metalloproteinase (MMP) inhibitor . Doxycycline shows antibacterial activity and anti-cancer cell proliferation activity .

HY-N0565B

Doxycycline hyclate 170+ Cited Publications Doxycycline hydrochloride hemiethanolate hemihydrate; WC2031	Antibiotic MMP Bacterial Parasite	Infection Neurological Disease Inflammation/Immunology Cancer
Doxycycline hyclate, an antibiotic, is an orally active and broad-spectrum metalloproteinase (MMP) inhibitor. Doxycycline hyclate shows antibacterial activity and anti-cancer cell proliferation activity. Doxycycline hyclate can be used to construct gene expression regulation models .

HY-N0565A

Doxycycline hydrochloride 170+ Cited Publications	MMP Bacterial Antibiotic Parasite	Infection Neurological Disease Inflammation/Immunology Cancer
Doxycycline hydrochloride, an antibiotic, is an orally active and broad-spectrum metalloproteinase (MMP) inhibitor . Doxycycline hydrochloride shows antibacterial activity and anti-cancer cell proliferation activity. Doxycycline hydrochloride can be used to construct gene expression regulation models .

HY-W016420

Fosfomycin sodium 10+ Cited Publications MK-0955 sodium	Bacterial Antibiotic	Infection Cancer
Fosfomycin (MK-0955) sodium is a blood-brain barrier penetrating, broad-spectrum antibiotic by irreversibly inhibiting an early stage in cell wall synthesis. Fosfomycin sodium shows both in vivo and in vitro activity against a wide range of bacteria, including multidrug-resistant (MDR), extensively drug-resistant (XDR), and pan-drug-resistant (PDR) bacteria .

HY-W592871

10-Hydroxy-2-decenoic acid 10-HDA; Queen Bee Acid	mTOR Apoptosis ERK MDM-2/p53 GSK-3 AMPK Interleukin Related TNF Receptor Caspase NF-κB Bacterial Fungal	Cardiovascular Disease Neurological Disease Inflammation/Immunology Cancer
10-Hydroxy-2-decenoic acid (10-HDA) is an orally active unsaturated medium-chain fatty acid with various physiological activities. 10-Hydroxy-2-decenoic acid induces ROS-mediated apoptosis in A549 cells. 10-Hydroxy-2-decenoic acid inhibits VEGF-induced angiogenesis in human venous endothelial cells. 10-Hydroxy-2-decenoic acid alleviates non-alcoholic fatty liver disease (NAFLD) by activating the AMPK-α signaling pathway. 10-Hydroxy-2-decenoic acid protects against bone loss by inhibiting NF-κB signaling downstream of FFAR4. 10-Hydroxy-2-decenoic acid is an antibiotic against many bacteria and fungi, such as Neurospora sitophila, molds and Staphylococcus aureus. 10-Hydroxy-2-decenoic acid has longevity-promoting effects in C. elegans. 10-Hydroxy-2-decenoic acid prevents osteoarthritis by targeting aspartyl β hydroxylase and inhibiting chondrocyte senescence .

HY-B1831A

Oritavancin diphosphate 2 Publications Verification LY333328 diphosphate	Bacterial Antibiotic	Infection Inflammation/Immunology
Oritavancin diphosphate (LY333328 diphosphate), a semisynthetic derivative of Vancomycin (HY-B0671), is an orally active glycopeptide *antibiotic* with bactericidal activity against gram-positive organisms. Oritavancin diphosphate shows antibacterial effect against B. anthracis, such as Ames strain with a MIC value of 0.015 g/mL. Oritavancin diphosphate inhibits cell wall synthesis and disrupts the membrane potential. Oritavancin diphosphate inhibits ArlS kinase activity thereby interfering the signal transduction. Oritavancin diphosphate enters cells by adsorptive endocytosis, which drives it to lysosomes, where it exerts antibiotic activity .

HY-B1075

Fosfomycin calcium 10+ Cited Publications MK-0955 calcium	Bacterial Antibiotic	Infection Cancer
Fosfomycin (MK-0955) calcium is a blood-brain barrier penetrating, broad-spectrum antibiotic by irreversibly inhibiting an early stage in cell wall synthesis. Fosfomycin calcium shows both in vivo and in vitro activity against a wide range of bacteria, including multidrug-resistant (MDR), extensively drug-resistant (XDR), and pan-drug-resistant (PDR) bacteria .

HY-N7112

Leucomycin 1 Publications Verification Kitasamycin	Bacterial Antibiotic	Infection
Leucomycin (Kitasamycin) is an orally active macrolide *antibiotic* produced by Streptomyces kitasatoensis. Leucomycin has broad-spectrum antibacterial activities against gram-positive and gram-negative bacteria, mycoplasma, leptospira, spirochaetes, rickettsiae and some larger viruses .

HY-133704

Pyrrolnitrin 1 Publications Verification	Bacterial Fungal Antibiotic	Infection
Pyrrolnitrin is an *antibiotic* isolated from Pseudomonas pyrrocinia. Pyrrolnitrin shows a broad spectrum of antibiotic activity against fungi, yeast and gram-positive bacteria .

HY-B1075A

Fosfomycin MK-0955	Bacterial Antibiotic	Infection Cancer
Fosfomycin (MK-0955) is a broad-spectrum antibiotic. Fosfomycin can cross blood-brain barrier penetrating, and irreversibly inhibits an early stage in cell wall synthesis. Fosfomycin shows anti-bacteria activity for a range of bacteria, including multidrug-resistant (MDR), extensively drug-resistant (XDR), and pan-drug-resistant (PDR) bacteria .

HY-B0734A

Cefotiam hydrochloride SCE-963 hydrochloride	Antibiotic Bacterial	Infection
Cefotiam (SCE-963) hydrochloride is a parenteral cephalosporin antibiotic. Cefotiam hydrochloride has broad-spectrum activity against Gram-positive and Gram-negative bacteria .

HY-B0609

Fosfomycin tromethamine 10+ Cited Publications MK-0955 tromethamine	Bacterial Antibiotic	Infection Cancer
Fosfomycin (MK-0955) tromethamine is a blood-brain barrier penetrating, broad-spectrum antibiotic by irreversibly inhibiting an early stage in cell wall synthesis. Fosfomycin tromethamine shows both in vivo and in vitro activity against a wide range of bacteria, including multidrug-resistant (MDR), extensively drug-resistant (XDR), and pan-drug-resistant (PDR) bacteria .

HY-A0071

Tildipirosin	Bacterial Antibiotic	Infection
Tildipirosin, a long-acting macrolide, has antibiotic activity.

HY-P1926

A-54556A	Antibiotic Bacterial	Infection
A-54556A (ADEP 1) is an acyldepsipeptide (ADEP) *antibiotic. A-54556A shows antibacterial activity* against a broad range of Gram-positive bacteria .

HY-P5726

Aurein 1.2	Antibiotic	Cancer
Aurein 1.2 is an active amphibian antibiotic peptide with *antibiotic* and anticancer activities .

HY-N0565AR

Doxycycline (hydrochloride) (Standard)	Reference Standards MMP Parasite Bacterial Antibiotic Apoptosis Akt PI3K	Infection Neurological Disease Inflammation/Immunology Cancer
Doxycycline hydrochloride (Standard) is the analytical standard of Doxycycline hydrochloride (HY-N0565A). This product is intended for research and analytical applications. Doxycycline hydrochloride is an orally active highly lipophilic, tissue-permeable MMP inhibitor with broad-spectrum antibacterial activity. Doxycycline hydrochloride is also a semi-synthetic antibiotic with chelating properties, which blocks bacterial protein synthesis and inhibits extracellular matrix degradation through interactions with zinc and calcium atoms. Doxycycline hydrochloride also inhibits mitochondrial biogenesis, translation, and the expression of respiratory chain proteins. Doxycycline hydrochloride induces apoptosis, inhibits autophagy and EMT, downregulates stem cell markers, and activates the PI3K-AKT pathway, thereby effectively inhibiting the viability and proliferation of cancer cells such as breast cancer cells. Doxycycline hydrochloride also promotes the survival and self-renewal of embryonic stem cells and neural stem cells, and reduces the frequency of medium changes in culture. Doxycycline hydrochloride has been applied in studies related to breast cancer, prostate cancer, bladder cancer, and other cancers .

HY-N0565R

Doxycycline (Standard)	Reference Standards MMP Parasite Bacterial Antibiotic Apoptosis Akt PI3K	Infection Neurological Disease Inflammation/Immunology Cancer
Doxycycline (Standard) is the analytical standard of Doxycycline (HY-N0565). This product is intended for research and analytical applications. Doxycycline is an orally active highly lipophilic, tissue-permeable MMP inhibitor with broad-spectrum antibacterial activity. Doxycycline is also a semi-synthetic antibiotic with chelating properties, which blocks bacterial protein synthesis and inhibits extracellular matrix degradation through interactions with zinc and calcium atoms. Doxycycline also inhibits mitochondrial biogenesis, translation, and the expression of respiratory chain proteins. Doxycycline induces apoptosis, inhibits autophagy and EMT, downregulates stem cell markers, and activates the PI3K-AKT pathway, thereby effectively inhibiting the viability and proliferation of cancer cells such as breast cancer cells. Doxycycline also promotes the survival and self-renewal of embryonic stem cells and neural stem cells, and reduces the frequency of medium changes in culture. Doxycycline has been applied in studies related to breast cancer, prostate cancer, bladder cancer, and other cancers .

HY-N0565BR

Doxycycline hyclate (Standard) Doxycycline (hydrochloride hemiethanolate hemihydrate) (Standard); WC2031 (Standard)	Reference Standards MMP Parasite Bacterial Antibiotic Apoptosis Akt PI3K	Infection Neurological Disease Inflammation/Immunology Cancer
Doxycycline hyclate (Standard) is the analytical standard of Doxycycline hyclate (HY-N0565B). This product is intended for research and analytical applications. Doxycycline hyclate is an orally active highly lipophilic, tissue-permeable MMP inhibitor with broad-spectrum antibacterial activity. Doxycycline hyclate is also a semi-synthetic antibiotic with chelating properties, which blocks bacterial protein synthesis and inhibits extracellular matrix degradation through interactions with zinc and calcium atoms. Doxycycline hyclate also inhibits mitochondrial biogenesis, translation, and the expression of respiratory chain proteins. Doxycycline hyclate induces apoptosis, inhibits autophagy and EMT, downregulates stem cell markers, and activates the PI3K-AKT pathway, thereby effectively inhibiting the viability and proliferation of cancer cells such as breast cancer cells. Doxycycline hyclate also promotes the survival and self-renewal of embryonic stem cells and neural stem cells, and reduces the frequency of medium changes in culture. Doxycycline hyclate has been applied in studies related to breast cancer, prostate cancer, bladder cancer, and other cancers .

HY-19965

UK-2A antibiotic UK 2A	Antibiotic Fungal	Infection
UK-2A (Antibiotic UK 2A) is a potent antifungal antibiotic. UK-2A shows antifungal activity .

HY-P10518

Anoplin	Bacterial	Infection
Anoplin is an antimicrobial peptide found in the venom of the solitary wasp (Anoplius samariensis). Anoplin exhibits antimicrobial activity against a wide range of bacteria, including both gram-positive and gram-negative bacteria. Anoplin can be used in the development of antibiotics .

HY-B1831

Oritavancin LY 333328; Orbactiv	Antibiotic Bacterial	Infection Inflammation/Immunology
Oritavancin (LY 333328), a semisynthetic derivative of Vancomycin (HY-B0671), is an orally active glycopeptide *antibiotic* with bactericidal activity against gram-positive organisms. Oritavancin shows antibacterial effect against B. anthracis, such as Ames strain with a MIC value of 0.015 g/mL. Oritavancin inhibits cell wall synthesis and disrupts the membrane potential. Oritavancin inhibits ArlS kinase activity thereby interfering the signal transduction. Oritavancin enters cells by adsorptive endocytosis, which drives it to lysosomes, where it exerts antibiotic activity .

HY-121405

Malonomicin antibiotic K16	Antibiotic Parasite	Infection
Malonomicin (Antibiotic K16) is an antibiotic with *anti-protozoa* and *anti-trypanosome* activities. Malonomicin also shows anti-trypanosome activity in vivo .

HY-N6705

Tropodithietic acid	Bacterial Antibiotic	Infection
Tropodithietic acid is a sulfur-containing antibiotic produced by the marine bacterium Phaeobacter inhibens. Tropodithietic acid exhibits a strong antibiotic activity against a broad spectrum of bacteria including alpha- and gammaproteobacteria, flavobacteria and actinobacteria .

HY-N10174

Tomaymycin	Antibiotic	Infection
Tomaymycin is an antitumor antibiotic. Tomaymycin has antimicrobial activity against Grampositive bacteria .

HY-15993

Posizolid AZD2563; AZD5847	Antibiotic	Infection
Posizolid (AZD2563), an oxazolidinone antibiotic, is developed by AstraZeneca for the study of bacterial infections. Posizolid shows very good *anti-mycobacterial* activity .

HY-B0734

Cefotiam SCE-963; Cefotiam Dihydrochloride	Antibiotic Bacterial	Infection
Cefotiam (SCE-963) is a parenteral cephalosporin antibiotic. Cefotiam has broad-spectrum activity against Gram-positive and Gram-negative bacteria .

HY-125117

Simocyclinone D8	DNA/RNA Synthesis Bacterial	Infection Cancer
Simocyclinone D8 is an anthracycline antibiotic with antibacterial and antitumor activity against Gram-positive bacteria. Simocyclinone D8 inhibits DNA gyrase and thus has an inhibitory effect on a variety of tumor cell lines .

HY-N16459

Albomycin δ1	Antibiotic Bacterial	Infection
Albomycin δ1 is a selective bacterial ribosome-targeted *antibiotic* (MIC: 0.0625 μg/mL against S. pneumoniae). Albomycin δ1 exerts bactericidal activity via covalent binding to 70S ribosomes and irreversible inhibition of peptidyl transferase. Albomycin δ1 is promising for research of S. pneumoniae and S. aureus infections .

HY-106922

Sanfetrinem GV104326	Antibiotic Bacterial	Infection
Sanfetrinem (GV104326) is a β-lactamase-stable antibiotic. Sanfetrinem has broad-spectrum antimicrobial activity against both Gram-positive and Gram-negative bacteria .

HY-19071

BK-218	Antibiotic Bacterial	Infection
BK-218 is an orally active cephalosporin antibiotic that binds to penicillin-binding proteins (PBPs) and has a greater inhibitory effect than Cephalexin (HY-B0200) and Cefoxitin (HY-B1825). BK-218 has similar antibacterial activity to Cefamandole (HY-B1128) and can be used in the development of antibacterial drugs .

HY-W592871R

10-Hydroxy-2-decenoic acid (Standard) 10-HDA (Standard); Queen Bee Acid (Standard)	Reference Standards mTOR	Cardiovascular Disease Neurological Disease Inflammation/Immunology Cancer
10-Hydroxy-2-decenoic acid (Standard) is an analytical standard for 10-Hydroxy-2-decenoic acid (HY-W592871). This product is intended for research and analytical applications.10-Hydroxy-2-decenoic acid (10-HDA) is an orally active unsaturated medium-chain fatty acid with various physiological activities. 10-Hydroxy-2-decenoic acid induces ROS-mediated apoptosis in A549 cells. 10-Hydroxy-2-decenoic acid inhibits VEGF-induced angiogenesis in human venous endothelial cells. 10-Hydroxy-2-decenoic acid alleviates non-alcoholic fatty liver disease (NAFLD) by activating the AMPK-α signaling pathway. 10-Hydroxy-2-decenoic acid protects against bone loss by inhibiting NF-κB signaling downstream of FFAR4. 10-Hydroxy-2-decenoic acid is an antibiotic against many bacteria and fungi, such as Neurospora sitophila, molds and Staphylococcus aureus. 10-Hydroxy-2-decenoic acid has longevity-promoting effects in C. elegans. 10-Hydroxy-2-decenoic acid prevents osteoarthritis by targeting aspartyl β hydroxylase and inhibiting chondrocyte senescence .

HY-101136

Dealanylascamycin AT-265	Antibiotic Carbonic Anhydrase Bacterial	Infection
Dealanylascamycin (AT-265) (Compound 2) is a nucleoside antibiotic. AT 265 is a carbonic anhydrase (CA) inhibitor, with K_i values of 167, 65.2, 234, and 143 nM for hCA I, hCA II, hCA IV, and hCA IX respectively. Dealanylascamycin is the active form of Ascamycin (HY-121071). Dealanylascamycin exhibits broad-spectrum antibacterial activity and is effective against pathogenic bacteria such as Xanthomonas citri (MIC = 0.4 μg/mL). Dealanylascamycin has high cytotoxicity .

HY-B1075R

Fosfomycin calcium (Standard) MK-0955 calcium (Standard)	Reference Standards Bacterial Antibiotic	Infection Cancer
Fosfomycin (calcium) (Standard) is the analytical standard of Fosfomycin (calcium). This product is intended for research and analytical applications. Fosfomycin (MK-0955) calcium is a blood-brain barrier penetrating, broad-spectrum antibiotic by irreversibly inhibiting an early stage in cell wall synthesis. Fosfomycin calcium shows both in vivo and in vitro activity against a wide range of bacteria, including multidrug-resistant (MDR), extensively drug-resistant (XDR), and pan-drug-resistant (PDR) bacteria .

HY-133056

Pseudomonic acid C	Antibiotic Bacterial	Infection
Pseudomonic acid C, an antibiotic, possesses antibacterial activity .

HY-16035

Alatrofloxacin	DNA/RNA Synthesis Antibiotic	Cancer
Alatrofloxacin, the parenteral proagent of Trovafloxacin, is a fluoronaphthyridone which contains an L-alanyl-L-alanyl salt. Alatrofloxacin functions similar to other fluoroquinolone antibiotics in that it not only has antibiotic activity to kill invading organisms by interfering with DNA synthesis, it possesses immunosuppressive activity .

HY-N14544

Orchinol	Fungal	Infection
Orchinol is an aromatic derivative of antibiotic and has antifungal activity .

HY-13644A

Gusperimus trihydrochloride Spanidin; NKT-01; BMS181173	Antibiotic	Inflammation/Immunology Cancer
Gusperimus trihydrochloride (Spanidin) is a derivative of the antitumor antibiotic spergualin with immunosuppressant activity .

HY-113582

Albothricin	Antibiotic Bacterial	Infection
Albothricin is a potent streptothricin *Antibiotic* with antimicrobial activities .

HY-113562

Laidlomycin phenylcarbamate	Antibiotic Parasite	Infection
Laidlomycin phenylcarbamate is a semisynthetic polyether *antibiotic* with antiparasitic activity .

HY-123552

RK-1441A	Antibiotic	Infection
RK-1441A is a pyrrolobenzodiazepine *antibiotic* with antibacteriophage activity .

HY-116272

A51493A	Antibiotic Bacterial	Infection
A51493A is an anthracyclinone *antibiotic* with antimicrobial activities against Gram-positive bacteria .

HY-111019A

SCH 34343 sodium	Antibiotic Bacterial	Infection
SCH 34343 sodium is a potent β-lactam *Antibiotic* with bactericidal activity against Streptococcus pneumoniae, viridans streptococci, streptococci of groups A, B, C and G, and Str. bovis .

HY-113622

Cladospirone bisepoxide Palmarumycin C13; Diepoxin ζ; antibiotic Sch53514	Fungal Antibiotic	Infection
Cladospirone bisepoxide is a metabolite that isolated from cultures of a fungus. Cladospirone bisepoxide displays selective antibiotic activity against several bacteria and fungi and inhibits germinations of Lepidium sativum at low concentrations .

HY-113602

Paldimycin B antibiotic 273 A1-beta	Antibiotic Bacterial	Infection
Paldimycin B (Antibiotic 273 A1-beta) is a powerful semi-synthetic *antibiotic* with antibacterial activity against S. aureus and coagulase-negative staphylococci .

HY-125060

Viridicatin	Antibiotic Endogenous Metabolite	Infection
Viridicatin is a fungal metabolite from Penicillium species. Viridicatin shows slight in vitro antibiotic activity against Mycobacterium tuberculosis .

HY-116168

Aldecalmycin	Antibiotic Bacterial	Infection
Aldecalmycin is an *antibiotic* showing antimicrobial activities against Gram-positive bacteria including methicillin-resistant Staphylococcus aureus (MRSA) with MICs values of 6.25-25 μg/mL .

HY-N11407

Bagougeramine B	Antibiotic Bacterial Fungal	Infection
Bagougeramine B is an orally active nucleoside *antibiotic* with antimicrobial activity, which is found in Bacillus circulans. Bagougeramine B inhibits the growth of Gram-positive and Gram-negative bacteria and some fungi .

HY-116060

RK-286D	Antibiotic PKC Bacterial Fungal	Infection
RK-286D is an *antibiotic* and a PKC inhibitor with antimicrobial activity. RK-286D shows inhibitory activities against bleb formation induced by PDBu (HY-18985) and in vitro PKC activity .

HY-138179

7-APRA	Bacterial	Infection
7-APRA is a semi-synthetic intermediate of cephalosporin antibiotics. 7-APRA has antibacterial activity and is mainly used in the synthesis of other Cefaclor (HY-B0198) and Cefprozil (HY-B0458A) .

HY-136817

Nanaomycin αA OM173-αA; Nanaomycin A methyl ester	Antibiotic	Infection
Nanaomycin αA (OM173-αA) is an antibiotic with antimicrobial activity. Nanaomycin αA can be isolated from a fermentation broth of Streptomyces hebeiensis derived from lichen .

Cat. No.	Product Name

HY-L042

Glycoside Compound Library

894 compounds

Glycosides are compounds in which a sugar group is bonded through its anomeric carbon to another group via a glycosidic bond. Many biologically active compounds are glycosides. Glycosides comprise several important classes of compounds such as hormones, sweeteners, alkaloids, flavonoids, antibiotics, etc. The glycosidic residue can be crucial for their activity or can only improve pharmacokinetic parameters. Glycosides, which exhibit anti-inflammatory, anti-infection, anti-cancer and anti-oxidative properties, play numerous important roles in living organisms, such as streptomycin, as an aminoglycoside antibiotic, has anti-infection activity. Anthracyclines possess good antibacterial and anti-cancer activities.

MCE Glycoside Compound Library contains a unique collection of 894 glycoside compounds and is a useful tool to discovery glycoside drugs.

HY-L914

Serine/Threonine Focused Covalent Fragment Library

3,208 compounds

In the research of covalent inhibitors targeting serine and threonine, scientists have found that the nucleophilicity of these hydroxyl groups is significantly enhanced due to the influence of their surrounding environment. This results in higher activity during catalytic reactions. Aspirin, which targets the non-catalytic domain serine (Ser529 in human COX1) of cyclooxygenase, exerts its anti-inflammatory effect through covalent binding. β-lactam antibiotics, which targets the catalytic domain serine of penicillin-binding proteins, interferes with bacterial cell wall synthesis.

Through careful selection, we constructed a structural filter containing over 110 electrophilic groups. By analyzing the electrophilic fragments selected by the structural filter, we removed any molecules with trivial or undesirable structural features. Ultimately, we obtained 3,300 fragment molecules which can target serine and threonine residues and can be used for fragment-based covalent drug discovery.

HY-L142

Anti-tuberculosis Compound Library

151 compounds

Tuberculosis (TB), usually caused by bacteria (Mycobacterium tuberculosis), is an infectious disease that mainly affects the lungs. According to the statistics of the World Health Organization (WHO), 10 million people suffer from tuberculosis every year, and 1.5 million people die of tuberculosis every year, which makes tuberculosis the number one killer of infectious diseases.

Tuberculosis can be cured through the standard 6-month course of treatment of four kinds of antibiotics. Common drugs include rifampicin and isoniazid. In some cases, TB bacteria do not respond to standard drugs, that is, patients with drug-resistant tuberculosis. The treatment of drug-resistant tuberculosis takes longer and is more complex. In the face of the resurgence of tuberculosis in the world and the rapid emergence of multi drug resistant tuberculosis, it is very important to develop new anti-tuberculosis drugs or new clinical treatment schemes for existing anti mycobacterium drugs.

MCE supplies a unique collection of 151 compounds with clear anti-tuberculosis activity. MCE Anti-tuberculosis Compound Library is a useful tool for anti-tuberculosis related research and anti-tuberculosis drug development

Cat. No.	Product Name	Type

HY-13067G

Celastrol

Tripterine; Tripterin

Fluorescent Dyes

Celastrol (GMP) (Tripterine (GMP)) is Celastrol (HY-10227) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. Celastrol (Tripterine;Tripterin) is a proteasome inhibitor which potently and preferentially inhibits the chymotrypsin-like activity of a purified 20S proteasome with IC₅₀ of 2.5 μM. In addition, Celastrol is also an antibiotic with potent antimicrobial activity against standard and clinical methicillin-resistant Staphylococcus aureus (MRSA) strains, inducing oxidative stress and inhibiting DNA synthesis by binding to P5CDH .

HY-N0565AG

Doxycycline (hydrochloride)

Fluorescent Dyes

Doxycycline hydrochloride GMP is Doxycycline (hydrochloride) (HY-N0565A) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. Doxycycline hydrochloride is an orally active highly lipophilic, tissue-permeable MMP inhibitor with broad-spectrum antibacterial activity. Doxycycline hydrochloride is also a semi-synthetic antibiotic with chelating properties, which blocks bacterial protein synthesis and inhibits extracellular matrix degradation through interactions with zinc and calcium atoms. Doxycycline hydrochloride also inhibits mitochondrial biogenesis, translation, and the expression of respiratory chain proteins. Doxycycline hydrochloride induces apoptosis, inhibits autophagy and EMT, downregulates stem cell markers, and activates the PI3K-AKT pathway, thereby effectively inhibiting the viability and proliferation of cancer cells such as breast cancer cells. Doxycycline hydrochloride also promotes the survival and self-renewal of embryonic stem cells and neural stem cells, and reduces the frequency of medium changes in culture. Doxycycline hydrochloride has been applied in studies related to breast cancer, prostate cancer, bladder cancer, and other cancers .

Cat. No.	Product Name	Type

HY-W011549

2'-Amino-2'-deoxyguanosine	Biochemical Assay Reagents
2'-Amino-2'-deoxyguanosine is a nucleoside antibiotic. 2'-Amino-2'-deoxyguanosine exhibits lethal activity against certain strains of Escherichia coli, with its antibacterial effect reversible by guanosine and other purine nucleosides. 2'-Amino-2'-deoxyguanosine can be used for the study of bacterial infection .

HY-W009311

Thiomichler's ketone

4,4'-Bis(dimethylamino)thiobenzophenone

Biochemical Assay Reagents

Thiomichler's ketone (4,4'-Bis (dimethylamino) thiobenzophenone) is a heavy metal complexing agent and a colorimetric/spectrophotometric reagent. Thiomichler's ketone shows selectivity for Hg ²⁺ at pH 3, and exhibits activity towards Pd ²⁺ and Ag ⁺ at pH 3.5. Thiomichler's ketone enables accurate detection of trace Pd ²⁺ by forming an extractable Hg ²⁺ complex via micelle-mediated cloud point extraction, or generating a red coordination complex including Pd (TMK)₄. Thiomichler's ketone is applicable for the determination of trace Pd ²⁺ in antibiotics and catalysts of automobile exhaust purifiers .

HY-13067G

Celastrol

Tripterine; Tripterin

Biochemical Assay Reagents

HY-131557

O-Deacetylravidomycin	Biochemical Assay Reagents
O-Deacetylravidomycin, a microbial metabolite discovered in Streptomyces, is an antibiotic. O-Deacetylravidomycin exhibits light-dependent antibacterial and anticancer activities .

HY-W740053

Meropenem sodium	Biochemical Assay Reagents
Meropenem sodium is a carbapenem antibiotic with broad-spectrum antibacterial activity. Meropenem sodium has activity against susceptible and resistant *N. gonorrhoeae* (MIC value of 0.02-0.06 mg/mL), *H. influenzae* (MIC value of 0.03-0.12 mg/mL), and *H. ducreyi* (MIC value of 0.015-0.12 mg/mL) .

HY-W353258R

Moxifloxacin hydrochloride monohydrate (Standard)

BAY 12-8039 monohydrate (Standard)

Biochemical Assay Reagents

Moxifloxacin hydrochloride (BAY 12-8039) monohydrate (Standard) is the analytical standard of Moxifloxacin hydrochloride monohydrate. This product is intended for research and analytical applications. Moxifloxacin hydrochloride monohydrate is a blood-brain barrier-permeable, orally active topoisomerase II/IV inhibitor and a fluoroquinolone antibiotic. Moxifloxacin hydrochloride monohydrate disrupts bacterial DNA replication, transcription, repair and chromosome segregation processes. Moxifloxacin hydrochloride monohydrate exhibits activity against Gram-positive bacteria, Gram-negative bacteria, anaerobes, atypical pathogens, drug-resistant respiratory pathogens, Mycobacterium tuberculosis, mycoplasmas and Ureaplasma urealyticum.

HY-N0565AG

Doxycycline (hydrochloride)

Biochemical Assay Reagents

Cat. No.	Product Name	Target	Research Area

HY-B0108

Daptomycin Maximum Cited Publications 25 Publications Verification LY146032	Bacterial Antibiotic	Infection Cancer
Daptomycin is a lipopeptide antibiotic with rapid in vitro bactericidal activity against gram-positive organisms.

HY-N6708

Alamethicin 2 Publications Verification	Antibiotic Bacterial	Infection
Alamethicin is a linear 20-amino acid *antibiotic, which can induce voltage-gated conductance in model and cell membranes. Alamethicin exhibits antimicrobial activity* against Gram-positive bacteria, but not Gram-negative bacteria. Alamethicin can form an amphipathic α-helical structure in biological membranes .

HY-106783

Polymyxin B nonapeptide 2 Publications Verification	Bacterial Antibiotic	Infection
Polymyxin B nonapeptide is a cyclic peptide obtained from Polymyxin B by proteolytic removal of its terminal amino acyl residue. Polymyxin B nonapeptide is less toxic, lacks bactericidal activity, and retains its ability to render gram-negative bacteria susceptible to several antibiotics by permeabilizing their outer membranes .

HY-P1975

Aureobasidin A 3 Publications Verification Basifungin	Antibiotic Fungal Parasite	Infection Inflammation/Immunology
Aureobasidin A (Basifungin) is a cyclic peptide antibiotic with oral activity. Aureobasidin A is an inhibitor of inositol phosphorylated ceramide synthetase AUR1. Aureobasidin A has antifungal and antiparasitic activity .

HY-P0311

LAH4	Bacterial	Infection
LAH4, an alpha-helix of the designed amphipathic peptide antibiotic, exhibits potent antimicrobial, nucleic acid transfection and cell penetration activities. LAH4 possesses high plasmid DNA delivery capacities. LAH4 has a strong affinity for anionic lipids found in the outer membrane of bacterial membranes .

HY-P1649

SPR741 3 Publications Verification NAB741	Bacterial Antibiotic	Infection
SPR741 (NAB741) is a cationic peptide derived from polymyxin B and is a potentiator molecule. SPR741 increases the permeability of the outer membrane of Gram-negative bacteria and is used to treat severe Gram-negative bacteria infections. SPR741 inhibits multidrug-resistant Gram-negative bacteria. The spectrum of activity of the antibiotic can be widened when used in combination with SPR741 .

HY-P0270

Magainin 2 Magainin II	Bacterial Antibiotic Fungal	Infection
Magainin 2 (Magainin II) is an antimicrobial peptide (AMP) isolated from the skin of the African clawed frog Xenopus laevis. Magainin 2 displays antibiotic activity against numerous gram-negative and gram-positive bacteria. Magainin 2 also is active against protozoa . Magainin 2 exerts its cytotoxicity effects by preferential interactions with anionic phospholipids abundant in bacterial membranes .

HY-P5712

Gramicidin S 1 Publications Verification Gramicidin soviet	Antibiotic Bacterial Na+/K+ ATPase	Infection
Gramicidin S (Gramicidin soviet) is a cationic cyclic peptide antibiotic that selectively targets bacterial cell membranes and has anticancer activity. Gramicidin S also exerts antibacterial activity by destroying membrane integrity and interfering with membrane protein function. Gramicidin S inserts into the phospholipid bilayer through hydrophobic amino acid residues, specifically binds to negatively charged membrane lipids and disrupts membrane structure, thereby inhibiting cell division and cell wall synthesis, and ultimately causing bacterial death. Gramicidin S also inhibits ion channels, with IC₅₀s of 41 μM, 24 μM, and 3 μM for Na ⁺/K ⁺-ATPase, tobacco leaf plasma membrane Mg ²⁺/K ⁺-ATPase, and rat heart plasma membrane Ca ²⁺-ATPase, respectively .

HY-P0092

Cecropin B 1 Publications Verification	Cytochrome P450 Bacterial Antibiotic	Infection Cancer
Cecropin B has high level of antimicrobial activity and is considered as a valuable peptide antibiotic.

HY-P3078

Amphomycin	Bacterial Antibiotic	Infection
Amphomycin is a lipopeptide antibiotic that inhibits peptidoglycan synthesis and blocks cell wall development. Amphomycin exhibits potent antibacterial activities against methicillin-resistant S. aureus (MRSA), vancomycin-resistant enterococci (VRE), penicillin-gentamicin-erythromycin-resistant S. pneumonia, and linezolid-quinupristin-dalfopristin-resistant enterococci .

HY-P1649B

SPR741 acetate 3 Publications Verification NAB741 acetate	Bacterial Antibiotic	Infection
SPR741 acetate (NAB741 acetate) is a cationic peptide derived from polymyxin B and is a potentiator molecule. SPR741 acetate increases the permeability of the outer membrane of Gram-negative bacteria and is used to treat severe Gram-negative bacteria infections. SPR741 acetate inhibits multidrug-resistant Gram-negative bacteria. The spectrum of activity of the antibiotic can be widened when used in combination with SPR741 acetate .

HY-P1926

A-54556A	Antibiotic Bacterial	Infection
A-54556A (ADEP 1) is an acyldepsipeptide (ADEP) *antibiotic. A-54556A shows antibacterial activity* against a broad range of Gram-positive bacteria .

HY-P5726

Aurein 1.2	Antibiotic	Cancer
Aurein 1.2 is an active amphibian antibiotic peptide with *antibiotic* and anticancer activities .

HY-129034

Ramoplanin	Bacterial Antibiotic	Infection
Ramoplanin is a broad-spectrum lipoglycodepsipeptide antibiotic derived from the Actinoplanes spp with with activity against gram-positive bacteria .

HY-A0248B

Polymyxin B2	Antibiotic Bacterial	Infection
Polymyxin B2 is a polypeptide antibiotic that has antibacterial activity, particularly against gram-negative bacteria. Polymyxin B2 kills the bacteria by binding to lipopolysaccharide molecules on the bacterial cell membrane, disrupting the integrity of the cell membrane and causing the cell contents to leak. Polymyxin B2 can be used in antibiotic development and treatment of drug-resistant strains .

HY-W007056

Fmoc-N-me-Trp(Boc)-OH	Amino Acid Derivatives Biochemical Assay Reagents Drug Intermediate	Infection
Fmoc-N-me-Trp(Boc)-OH is an amino acid derivative with an Fmoc protecting group, which can be used to synthesize peptide antibiotics with antibacterial activity against Pseudomonas aeruginosa .

HY-P0230

Teixobactin	Antibiotic Bacterial	Infection
Teixobactin is a potent antibiotic. Teixobactin shows antibacterial activity for gram-negative bacteria. Teixobactin inhibits cell wall synthesis by binding to a highly conserved motif of lipid II and lipid III .

HY-P0269

Magainin 1 Magainin I	Bacterial Fungal Antibiotic	Infection
Magainin 1 (Magainin I) is an antimicrobial and amphipathic peptide isolated from the skin of Xenopus laevis. Magainin 1 exhibits antibiotic activity against numerous Gram-negative and Gram-positive bacteria .

HY-P2124

Cyclo(L-Trp-L-Trp)	Antibiotic Bacterial	Infection
Cyclo(L-Trp-L-Trp) is an antibiotic, and shows antimicrobial activity. Cyclo(L-Trp-L-Trp) can inhibit A. baumannii, as well as Candida albicans, Bacillus subtilis, Micrococcus luteus, Saccharomyces cerevisiae, Aspergillus niger, Staphylococcus aureus. Cyclo(L-Trp-L-Trp) can be used in microbial infection research .

HY-P4848

Dermcidin-1L (human)	Antibiotic	Infection
Dermcidin-1L (human) is an antibiotic peptide secreted by sweat glands. Dermcidin-1L (human) has antimicrobial activity. Dermcidin-1L (human) can be used for the research of inflammatory skin disorders .

HY-W587753

Bacitracin A	Antibiotic Bacterial	Infection
Bacitracin A is an antibiotic, which exhibits antibacterial activity against gram-positive bacteria. Bacitracin A forms complex with long-chain polyisoprenyl pyrophosphates in presence of metal ions, dephosphorylates the lipid carrier intermediate Css-bactoprenyl pyrophosphate, inhibits thus the bacterial cell wall biosynthesis .

HY-106783A

Polymyxin B nonapeptide TFA 2 Publications Verification	Bacterial Antibiotic	Infection
Polymyxin B nonapeptide TFA is a cyclic peptide obtained from Polymyxin B by proteolytic removal of its terminal amino acyl residue. Polymyxin B nonapeptide TFA is less toxic, lacks bactericidal activity, and retains its ability to render gram-negative bacteria susceptible to several antibiotics by permeabilizing their outer membranes .

HY-P0311A

LAH4 TFA	Bacterial	Infection
LAH4 TFA, an alpha-helix of the designed amphipathic peptide antibiotic, exhibits potent antimicrobial, nucleic acid transfection and cell penetration activities. LAH4 TFA possesses high plasmid DNA delivery capacities. LAH4 TFA has a strong affinity for anionic lipids found in the outer membrane of bacterial membranes .

HY-P1674A

Murepavadin TFA 3 Publications Verification POL7080 TFA	Bacterial Antibiotic	Infection
Murepavadin (POL7080) (TFA), a 14-amino-acid cyclic peptide, is a highly potent, specific *antibiotic. Murepavadin exhibits a potent antimicrobial activity* for P. aeruginosa with MIC₅₀ and MIC₉₀ values both of 0.12 mg/L. Murepavadin also can target the lipopolysaccharide transport portin D. Murepavadin can be used for the research of bacterial resistance .

HY-P1674

Murepavadin POL7080	Bacterial Antibiotic	Infection
Murepavadin (POL7080), a 14-amino-acid cyclic peptide, is a highly potent, specific *antibiotic. Murepavadin exhibits a potent antimicrobial activity* for P. aeruginosa with both MIC₅₀ and MIC₉₀ values of 0.12 mg/L. Murepavadin also can target the lipopolysaccharide transport portin D. Murepavadin can be used for the research of bacterial resistance .

HY-P5016A

CRAMP-18 (mouse) acetate	Antibiotic Fungal Bacterial	Infection Cancer
CRAMP-18 (mouse) acetate is an *antibiotic* peptide without hemolytic activity. CRAMP-18 (mouse) acetate has good inhibitory activity against Gram-negative bacteria, such as S. typhimurium and P. aeruginosa. CRAMP-18 (mouse) acetate has the potential to study antifungal, antibacterial and antitumor .

HY-P5641

Pleurocidin 1 Publications Verification	Bacterial p38 MAPK NF-κB NADH Dehydrogenase Antibiotic	Infection Inflammation/Immunology
Pleurocidin is an Antimicrobial peptide. Pleurocidin is derived from the skin mucosa or intestinal secretions of Pseudopleuronectes americanus. Pleurocidin inhibits the expression of key proteins in the MAPK and NF-κB inflammatory signaling pathways. Pleurocidin alters serum inflammatory and immune cytokine levels, regulates the down-regulation of tight junction proteins, and modulates the intestinal flora. Pleurocidin exerts antibacterial activity by inducing bacterial membrane damage, hydroxyl radical formation, and NADH depletion, and also produces a synergistic effect with *Antibiotics*. Pleurocidin alleviates DSS-induced ulcerative colitis. Pleurocidin can be used for research on ulcerative colitis, bacterial infections, and bacterial biofilm-related infections .

HY-P10518

Anoplin	Bacterial	Infection
Anoplin is an antimicrobial peptide found in the venom of the solitary wasp (Anoplius samariensis). Anoplin exhibits antimicrobial activity against a wide range of bacteria, including both gram-positive and gram-negative bacteria. Anoplin can be used in the development of antibiotics .

HY-P1699

Aurantimycin A	Bacterial Antibiotic	Infection Inflammation/Immunology
Aurantimycin A (Adipogen), a depsipeptide *antibiotic, displays strong activity* against Gram-positive bacteria. Aurantimycin A is a substrate of the LieAB transporter .

HY-101399R

γ-Glu-Phe (Standard) H-γ-Glu-Phe-OH (Standard); γ-Glutamylphenylalanine (Standard)	Reference Standards Endogenous Metabolite	Others
Ceftezole (sodium) (Standard) is the analytical standard of Ceftezole (sodium). This product is intended for research and analytical applications. Ceftezole sodium (CTZ sodium) is a broad-spectrum cephem antibiotic against many species of gram-positive and gram-negative bacteria. Ceftezole sodium (CTZ sodium) is an alpha-glucosidase inhibitor with in vivo anti-diabetic activity .

HY-P10519

Brevicidine	Bacterial Reactive Oxygen Species (ROS)	Infection
Brevicidine is an antimicrobial peptide with selective bactericidal activity against Gram-negative pathogens. Brevicidine disrupts bacterial morphology by binding to lipopolysaccharide (LPS) on the bacterial cell membrane to form pores. Brevicidine causes dissipation of intracellular proton motive force, outer membrane damage, inhibition of ATP biosynthesis and reactive oxygen species accumulation in bacterial cells. As a sensitizer, Brevicidine exerts synergistic activity when combined with a variety of conventional antibiotics .

HY-W012572A

D-Histidine hydrochloride hydrate	Mitochondrial Metabolism Bacterial	Infection Metabolic Disease
D-Histidine hydrochloride hydrate is an anti-biofilm agent that targets bacterial quorum sensing systems (such as RhlI/RhlR pathway) and has antibacterial activity. D-Histidine hydrochloride hydrate works by non-covalently binding to bacterial regulatory factors or copper ion complexes, selectively inhibiting bacterial biofilm formation and motility. D-Histidine hydrochloride hydrate downregulates quorum sensing-related gene expression, reduces the synthesis of virulence factors (such as alginate and proteases), and interferes with bacterial membrane stability, inhibiting biofilm formation, promoting the disintegration of mature biofilms, and enhancing antibiotic sensitivity. D-Histidine hydrochloride hydrate is also an efficient catalyst for the salt-induced peptide formation (SIPF) reaction, which promotes the condensation of amino acids to form dipeptides (such as dialanine and dilysine) by forming a complex with copper ions (Cu ²⁺) .

HY-P5572

Aurein 2.5	Antibiotic Fungal Bacterial	Infection
Aurein 2.5 is an *antibiotic* antimicrobial peptide. Aurein 2.5 has antibacterial and antifungal activity

HY-113560

Plipastatin B1	Antibiotic Fungal Phospholipase	Infection
Plipastatin B1 is a lipopeptide antibiotic, an inhibitor of phospholipase A₂ (PLA2), which has antifungal activity .

HY-148209

Balhimycin	Antibiotic Bacterial	Infection
Balhimycin is a glycopeptide antibiotic, found from the fermentation broth of a Amycolatopsis sp. Balhimycin shows anti-bacterial activity against staphylococci and anaerobes .

HY-P10556

(KFF)3K	Bacterial	Infection
(KFF)3K is a cell penetrating peptide that can promote the absorption of other antibiotics by disrupting the outer membrane of bacteria. (KFF)3K can be introduced into a hydrocarbon scaffold to induce its antibacterial properties, making it an effective antimicrobial peptide. (KFF)3K can be used in the development of new antimicrobial agents .

HY-P4747

LL-37 GKE	Antibiotic Bacterial	Infection
LL-37 GKE is an active domain of LL-37. LL-37 GKE has antibacterial activity and has potential applications in *antibiotics* .

HY-122494

Bilanafos SF-1293	Bacterial	Infection
Bilanafos is a natural organic phosphine tripeptide antibiotic metabolized by Streptomyces hydroscopius or Streptomyces viridochromeogenes. Bialaphos has antimicrobial activity aganist Gram-negative and positive bacteria as well as some fungal plant diseases .

HY-P5561

Aurein 2.2	Antibiotic Bacterial	Infection
Aurein 2.2 is a major component of the skin secretion of L.aurea. Aurein 2.2 is an *antibiotic* with broad-spectrum antibacterial activity against Gram positive bacteria such as Staphylococcus aureus and S. epidermidis .

HY-P11027

Thiazoplanomicin	Bacterial Antibiotic	Infection
Thiazoplanomicin (Compound 1) is a thiazolyl peptide antibiotic. Thiazoplanomicin can be isolated from the leaf-litter actinomycete Actinoplanes sp. MM794L-181F6. Thiazoplanomicin has potent antimicrobial activities against gonococcal strains (especially drug-resistant strains) and Gram-positive bacterium with MICs of 31.2-125 and 0.5-15.6 ng/mL, respectively. Thiazoplanomicin has no antibacterial activity against E.coli. Thiazoplanomicin can be used for bacterial infections research .

HY-P11093

Papiliocin	Antibiotic Bacterial Fungal Apoptosis Reactive Oxygen Species (ROS) TNF Receptor NO Synthase Interleukin Related NF-κB Toll-like Receptor (TLR)	Infection Inflammation/Immunology
Papiliocin is a potent peptide antibiotic with both anti-inflammatory and antibacterial activities. Papiliocin is primarily active against Gram-negative bacteria. Papiliocin exhibits strong anti-inflammatory activity against cell, exerting its anti-inflammatory activity by inhibiting the production of NO and the secretion of TNF-α and MIP-2. Papiliocin participates in the innate defense response mechanism by inhibiting the Toll-like receptor pathway and NF-κB. Papiliocin induces apoptosis in fungal cells and increases the total level of intracellular ROS. Papiliocin acts as an effective antiseptic peptide in sepsis models. Papiliocin is useful in anti-inflammatory and antibacterial research .

HY-P1612

Hormaomycin	Antibiotic Bacterial	Infection
Hormaomycin is a potent and selective macrocyc *antibiotic* agent. Hormaomycin has broad-spectrum antibiotic activity against numerous Gram-positive .

HY-N10585

Malacidin B	Antibiotic Bacterial	Infection
Malacidin B is a macrocyclic lipopeptide antibiotic that shows antibacterial activity in a calcium-dependent manner .

HY-P5575

Aurein 3.2	Antibiotic Bacterial	Infection Cancer
Aurein 3.2 is an *antibiotic* antimicrobial peptide. Aurein 3.2 also has anticancer activity .

HY-P5576

Aurein 3.3	Antibiotic Bacterial	Infection Cancer
Aurein 3.3 is an *antibiotic* antimicrobial peptide. Aurein 3.3 also has anticancer activity .

HY-105267

LY 121019	Fungal Antibiotic	Infection
LY 121019 is a semi-synthetic antifungal antibiotic with strong anticandida activity with MIC₅₀ value of 0.625 μg/mL .

HY-W714002

Feglymycin	HIV Bacterial	Infection
Feglymycin is a HIV replication inhibitor. Feglymycin is also an *antibiotic* peptide that has antibacterial activity (MIC: 32-64 μg/mL for Staphylococcus aureus) .

HY-P11098

Peptide HV2	Antibiotic TNF Receptor Bacterial	Infection Inflammation/Immunology
Peptide HV2 is an *antibiotic* that exerts anti-inflammatory effects by inhibiting TNF-α. Peptide HV2 has antibacterial activity .

HY-P5570

Aurein 2.3	Antibiotic Bacterial	Infection
Aurein 2.3 is an *antibiotic* antimicrobial peptide. Aurein 2.3 partially inhibits E.coli ATPase activity and inhibits cell growth .

HY-W748000

Kocurin PM181104; Baringolin	Antibiotic Bacterial	Infection
Kocurin (PM181104) is a thiazolyl cyclic-peptide antibiotic. Kocurin inhibits bacterial growth by impeding bacterial protein biosynthesis during the translation phase. Kocurin has strong inhibitory activity against Gram-positive bacteria, but no activity against fungi and Gram-negative bacteria .

Cat. No.	Product Name	Target	Research Area	Image

HY-P991273

MP196	Antibiotic Bacterial	Infection
MP196 is a cationic hexapeptide *antibiotic* targeting the bacterial cytoplasmic membrane, which exerts rapid bactericidal activity by disrupting membrane integrity, inhibiting cell respiration and cell wall synthesis. MP196 is promising for research of drug-resistant bacterial infections .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-B0108

Daptomycin Maximum Cited Publications 25 Publications Verification LY146032	Infection Structural Classification Microorganisms Macrolide Antibiotics Classification of Application Fields Antibiotics Mammalian Cell Culture Antibacterial Disease Research Disease Research Fields Source Classification	Bacterial Antibiotic
Daptomycin is a lipopeptide antibiotic with rapid in vitro bactericidal activity against gram-positive organisms.

HY-W016420

Fosfomycin sodium 10+ Cited Publications MK-0955 sodium	Infection Structural Classification Natural Products Microorganisms Classification of Application Fields Disease Research Fields Source Classification	Bacterial Antibiotic
Fosfomycin (MK-0955) sodium is a blood-brain barrier penetrating, broad-spectrum antibiotic by irreversibly inhibiting an early stage in cell wall synthesis. Fosfomycin sodium shows both in vivo and in vitro activity against a wide range of bacteria, including multidrug-resistant (MDR), extensively drug-resistant (XDR), and pan-drug-resistant (PDR) bacteria .

HY-W592871

10-Hydroxy-2-decenoic acid 10-HDA; Queen Bee Acid	Animals Ketones, Aldehydes, Acids Source Classification	mTOR Apoptosis ERK MDM-2/p53 GSK-3 AMPK Interleukin Related TNF Receptor Caspase NF-κB Bacterial Fungal
10-Hydroxy-2-decenoic acid (10-HDA) is an orally active unsaturated medium-chain fatty acid with various physiological activities. 10-Hydroxy-2-decenoic acid induces ROS-mediated apoptosis in A549 cells. 10-Hydroxy-2-decenoic acid inhibits VEGF-induced angiogenesis in human venous endothelial cells. 10-Hydroxy-2-decenoic acid alleviates non-alcoholic fatty liver disease (NAFLD) by activating the AMPK-α signaling pathway. 10-Hydroxy-2-decenoic acid protects against bone loss by inhibiting NF-κB signaling downstream of FFAR4. 10-Hydroxy-2-decenoic acid is an antibiotic against many bacteria and fungi, such as Neurospora sitophila, molds and Staphylococcus aureus. 10-Hydroxy-2-decenoic acid has longevity-promoting effects in C. elegans. 10-Hydroxy-2-decenoic acid prevents osteoarthritis by targeting aspartyl β hydroxylase and inhibiting chondrocyte senescence .

HY-N7112

Leucomycin 1 Publications Verification Kitasamycin	Infection Microorganisms Macrolide Antibiotics Classification of Application Fields Antibiotics Antibacterial Disease Research Disease Research Fields Source Classification	Bacterial Antibiotic
Leucomycin (Kitasamycin) is an orally active macrolide *antibiotic* produced by Streptomyces kitasatoensis. Leucomycin has broad-spectrum antibacterial activities against gram-positive and gram-negative bacteria, mycoplasma, leptospira, spirochaetes, rickettsiae and some larger viruses .

HY-133704

Pyrrolnitrin 1 Publications Verification	Microorganisms Source Classification	Bacterial Fungal Antibiotic
Pyrrolnitrin is an *antibiotic* isolated from Pseudomonas pyrrocinia. Pyrrolnitrin shows a broad spectrum of antibiotic activity against fungi, yeast and gram-positive bacteria .

HY-108307

Micronomicin sulfate 1 Publications Verification Gentamicin C2b sulfate; antibiotic XK-62-2 sulfate; Sagamicin sulfate	Infection Microorganisms Anti-inflammation/Immunoregulatory Antibiotics Antibacterial Disease Research Disease Research Fields Other Antibiotics Source Classification	Antibiotic Bacterial
Micronomicin sulfate (Gentamicin C2b sulfate) is an aminoglycoside *antibiotic* isolated from Micromonospora. Micronomicin sulfate is a broad-spectrum antibiotic close to the gentamicin-type antibiotics, exhibits a high activity against Pseudomonas, Proteus, Klebsiella pneumoniae, Serratia, etc (MIC=0.001-8.3 μg/ml) .

HY-B1915

Micronomicin 1 Publications Verification Gentamicin C2b; antibiotic XK-62-2; Sagamicin	Infection Microorganisms Classification of Application Fields Antibiotics Disease Research Fields Source Classification	Antibiotic Bacterial
Micronomicin (Gentamicin C2b) is an aminoglycoside antibiotic, with antibacterial and bactericidal activities .

HY-19965

UK-2A antibiotic UK 2A	Natural Products Microorganisms Source Classification	Antibiotic Fungal
UK-2A (Antibiotic UK 2A) is a potent antifungal antibiotic. UK-2A shows antifungal activity .

HY-N6737

Aureothricin	Infection Microorganisms Classification of Application Fields Antibiotics Antibacterial Disease Research Disease Research Fields Other Antibiotics Source Classification	Bacterial Antibiotic
Aureothricin is a dithiolopyrrolone (DTP) antibiotic first isolated from Streptomyces and exhibits relatively broad-spectrum antibiotic activity. Aureothricin can inhibit adhesion of human umbilical vein endothelial cells (HUVECs) to vitronectin .

HY-N6705

Tropodithietic acid	Infection Microorganisms Classification of Application Fields Antibiotics Marine natural products Antibacterial Disease Research Disease Research Fields Marine microorganism Other Antibiotics Source Classification	Bacterial Antibiotic
Tropodithietic acid is a sulfur-containing antibiotic produced by the marine bacterium Phaeobacter inhibens. Tropodithietic acid exhibits a strong antibiotic activity against a broad spectrum of bacteria including alpha- and gammaproteobacteria, flavobacteria and actinobacteria .

HY-N10174

Tomaymycin	Infection Monophenols Microorganisms Classification of Application Fields Antibiotics Phenols Antibacterial Disease Research Anticancer Disease Research Fields Other Antibiotics Source Classification	Antibiotic
Tomaymycin is an antitumor antibiotic. Tomaymycin has antimicrobial activity against Grampositive bacteria .

HY-125117

Simocyclinone D8	Microorganisms Antibiotics Source Classification	DNA/RNA Synthesis Bacterial
Simocyclinone D8 is an anthracycline antibiotic with antibacterial and antitumor activity against Gram-positive bacteria. Simocyclinone D8 inhibits DNA gyrase and thus has an inhibitory effect on a variety of tumor cell lines .

HY-N16459

Albomycin δ1	Microorganisms Antibiotics Source Classification	Antibiotic Bacterial
Albomycin δ1 is a selective bacterial ribosome-targeted *antibiotic* (MIC: 0.0625 μg/mL against S. pneumoniae). Albomycin δ1 exerts bactericidal activity via covalent binding to 70S ribosomes and irreversible inhibition of peptidyl transferase. Albomycin δ1 is promising for research of S. pneumoniae and S. aureus infections .

HY-W592871R

10-Hydroxy-2-decenoic acid (Standard) 10-HDA (Standard); Queen Bee Acid (Standard)	Structural Classification Animals Ketones, Aldehydes, Acids Source Classification	Reference Standards mTOR
10-Hydroxy-2-decenoic acid (Standard) is an analytical standard for 10-Hydroxy-2-decenoic acid (HY-W592871). This product is intended for research and analytical applications.10-Hydroxy-2-decenoic acid (10-HDA) is an orally active unsaturated medium-chain fatty acid with various physiological activities. 10-Hydroxy-2-decenoic acid induces ROS-mediated apoptosis in A549 cells. 10-Hydroxy-2-decenoic acid inhibits VEGF-induced angiogenesis in human venous endothelial cells. 10-Hydroxy-2-decenoic acid alleviates non-alcoholic fatty liver disease (NAFLD) by activating the AMPK-α signaling pathway. 10-Hydroxy-2-decenoic acid protects against bone loss by inhibiting NF-κB signaling downstream of FFAR4. 10-Hydroxy-2-decenoic acid is an antibiotic against many bacteria and fungi, such as Neurospora sitophila, molds and Staphylococcus aureus. 10-Hydroxy-2-decenoic acid has longevity-promoting effects in C. elegans. 10-Hydroxy-2-decenoic acid prevents osteoarthritis by targeting aspartyl β hydroxylase and inhibiting chondrocyte senescence .

HY-N14544

Orchinol	Natural Products Orchidaceae Spiranthes sinensis (Pers.) Ames Plants Source Classification	Fungal
Orchinol is an aromatic derivative of antibiotic and has antifungal activity .

HY-167256

Gentamicin C1	Microorganisms Antibiotics Other Antibiotics Source Classification	Antibiotic Bacterial
Gentamicin C1 is a broad-spectrum aminoglycoside antibiotic with antimicrobial activity .

HY-N13259

Fluopsin C	Microorganisms Antibiotics Source Classification	Antibiotic Bacterial
Fluopsin C is a copper-containing antibiotic with strong anti-Gram-positive and negative bacteria activity and anti-tumor activity .

HY-W775100

Spectinomycin sulfate	Microorganisms Antibiotics Other Antibiotics Source Classification	Antibiotic Bacterial
Spectinomycin sulfate is an aminocyclitol aminoglycoside antibiotic derived from Streptomyces spectabilis with bacteriostatic activity .

HY-113582

Albothricin	Microorganisms Antibiotics Source Classification	Antibiotic Bacterial
Albothricin is a potent streptothricin *Antibiotic* with antimicrobial activities .

HY-123552

RK-1441A	Microorganisms Antibiotics Other Antibiotics Source Classification	Antibiotic
RK-1441A is a pyrrolobenzodiazepine *antibiotic* with antibacteriophage activity .

HY-113622

Cladospirone bisepoxide Palmarumycin C13; Diepoxin ζ; antibiotic Sch53514	Infection Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Disease Research Fields Source Classification	Fungal Antibiotic
Cladospirone bisepoxide is a metabolite that isolated from cultures of a fungus. Cladospirone bisepoxide displays selective antibiotic activity against several bacteria and fungi and inhibits germinations of Lepidium sativum at low concentrations .

HY-125060

Viridicatin	Infection Alkaloids Microorganisms Classification of Application Fields Quinoline Alkaloids Disease Research Fields Source Classification	Antibiotic Endogenous Metabolite
Viridicatin is a fungal metabolite from Penicillium species. Viridicatin shows slight in vitro antibiotic activity against Mycobacterium tuberculosis .

HY-116168

Aldecalmycin	Microorganisms Antibiotics Other Antibiotics Source Classification	Antibiotic Bacterial
Aldecalmycin is an *antibiotic* showing antimicrobial activities against Gram-positive bacteria including methicillin-resistant Staphylococcus aureus (MRSA) with MICs values of 6.25-25 μg/mL .

HY-N11407

Bagougeramine B	Microorganisms Antibiotics Other Antibiotics Source Classification	Antibiotic Bacterial Fungal
Bagougeramine B is an orally active nucleoside *antibiotic* with antimicrobial activity, which is found in Bacillus circulans. Bagougeramine B inhibits the growth of Gram-positive and Gram-negative bacteria and some fungi .

HY-136817

Nanaomycin αA OM173-αA; Nanaomycin A methyl ester	Infection Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Phenols Disease Research Fields Source Classification	Antibiotic
Nanaomycin αA (OM173-αA) is an antibiotic with antimicrobial activity. Nanaomycin αA can be isolated from a fermentation broth of Streptomyces hebeiensis derived from lichen .

HY-129252

Prothracarcin	Alkaloids Microorganisms Pyrrole Alkaloids Source Classification	Antibiotic Bacterial
Prothracarcin is an antibiotic with antitumor activity that exerts its tumor cell toxicity by covalently binding to the C-2 amino group of guanine residues in the minor groove of DNA. Prothracarcin also shows antibacterial activity against Gram-positive bacteria and some Gram-negative bacteria such as Escherichia coli .

HY-105463

Saptomycin D	Quinones Structural Classification Microorganisms Anthraquinones Source Classification	Antibiotic Bacterial
Saptomycin D is an antibiotic with antitumor activity isolated from the Streptomyces sp. HP530 strain. Saptomycin D exhibits potent inhibitory effects against Gram-positive bacteria, while demonstrating weaker inhibitory activities against certain Gram-negative bacteria and yeasts. Saptomycin D also displays remarkable antitumor properties. Saptomycin D is applicable in research within the field of oncology .

HY-125104

Mirosamicin	Microorganisms Macrolide Antibiotics Antibiotics Source Classification	Antibiotic Bacterial
Mirosamicin is an antibiotic with high antibacterial activity that targets a wide range of gram-positive bacteria and certain Gram-negative bacteria as well as mycoplasma. Mirosamicin can be used for research in the field of food safety monitoring .

HY-130224

Altromycin C	Microorganisms Antibiotics Source Classification	Antibiotic
Altromycin C is a pluramycin-like antibiotic with antibacterial activity. Altromycin C is related to pluramycin-type antibiotics but is structurally distinct. The biological activity of Altromycin C makes it an antibiotic complex worthy of attention .

HY-124111

10-Deoxymethymycin antibiotic YC 17	Microorganisms Macrolide Antibiotics Antibiotics Source Classification	Antibiotic Bacterial
10-Deoxymethymycin (Antibiotic YC 17) displays antibiotic activity against Gram positive bacteria .

HY-165272

Antibiotic SF-2132	Microorganisms Antibiotics Other Antibiotics Source Classification	Bacterial Antibiotic
Antibiotic SF-2132 is a peptide antibiotic identified in Nocardiopsis sp., which exhibits inhibitory activity against β-lactam antibiotic-resistant strains, such as Pseudomonas and Escherichia .

HY-P1612

Hormaomycin	Structural Classification Microorganisms Macrolide Antibiotics Antibiotics Source Classification	Antibiotic Bacterial
Hormaomycin is a potent and selective macrocyc *antibiotic* agent. Hormaomycin has broad-spectrum antibiotic activity against numerous Gram-positive .

HY-N13946

Pyralomicin 1a	Monophenols Microorganisms Phenols Source Classification	Antibiotic Bacterial
Pyralomicin 1a is an antibiotic with antibacterial activity .

HY-N14322

Mollisin	Quinones Structural Classification Microorganisms Antibiotics Naphthalene Quinones Source Classification	Antibiotic Fungal
Mollisin is a quinone antibiotic with antifungal activity .

HY-N13966

Pyralomicin 2a	Microorganisms Phenols Source Classification	Antibiotic Bacterial
Pyralomicin 2a is an antibiotic with antibacterial activity .

HY-N14815

Nanaomycin D	Quinones Structural Classification Microorganisms Antibiotics Naphthalene Quinones Source Classification	Antibiotic Bacterial
Nanaomycin D is an antibiotic with antibacterial activity .

HY-N13954

Pyralomicin 1d	Microorganisms Phenols Source Classification	Antibiotic Bacterial
Pyralomicin 1d is an antibiotic with antibacterial activity .

HY-N13953

Pyralomicin 1c	Microorganisms Phenols Source Classification	Antibiotic Bacterial
Pyralomicin 1c is an antibiotic with antibacterial activity .

HY-N13968

Pyralomicin 2c	Microorganisms Ketones, Aldehydes, Acids Source Classification	Antibiotic Bacterial
Pyralomicin 2c is an antibiotic with antibacterial activity .

HY-N14138

Diolmycin A1	Microorganisms Antibiotics Other Antibiotics Source Classification	Antibiotic Parasite
Diolmycin A1 is an antibiotic with anticoccidial activity .

HY-N13967

Pyralomicin 2b	Microorganisms Phenols Source Classification	Antibiotic Bacterial
Pyralomicin 2b is an antibiotic with antibacterial activity .

HY-N14799

Mycobacillin	Microorganisms Antibiotics Other Antibiotics Source Classification	Antibiotic Fungal
Mycobacillin is a peptide antibiotic with anti-antifungal activity .

HY-N14779

Mureidomycin A	Structural Classification Natural Products Microorganisms Source Classification	Antibiotic Bacterial
Mureidomycin A is an antibiotic with anti-Pseudomonas aeruginosa activity .

HY-N14067

Cytosaminomycin A	Natural Products Microorganisms Source Classification	Antibiotic Bacterial Parasite
Cytosaminomycin A is an *antibiotic* with anticoccidial and antibacterial activities .

HY-N13947

Pyralomicin 1b	Monophenols Microorganisms Phenols Source Classification	Antibiotic Bacterial
Pyralomicin 1b is an antibiotic with antibacterial activity .

HY-N14282

Ezomycin B2	Microorganisms Antibiotics Other Antibiotics Source Classification	Antibiotic Fungal
Ezomycin B2 is an *antibiotic* with antifungal activity .

HY-165483

Nothramicin	Microorganisms Antibiotics Other Antibiotics Source Classification	Antibiotic Bacterial
Nothramicin is an anthracycline antibiotic with anti-mycobacterial activity .

HY-113945

Abbeymycin	Alkaloids Microorganisms Pyrrole Alkaloids Source Classification	Antibiotic Bacterial
Abbeymycin is an *antibiotic* derived from the actinobacterium Streptomyces sp. AB-999F-52. Abbeymycin is a specifically acting antibiotic with antimicrobial activity, primarily targeting anaerobic bacteria. Abbeymycin is employed in research concerning antibiotic discovery and screening .

HY-N15053

Phenelfamycin F	Microorganisms Antibiotics Other Antibiotics Source Classification	Antibiotic Bacterial
Phenelfamycins F is an antibiotic with anti-eutrophic bacterial activity .

HY-N14790

Mureidomycin B	Structural Classification Microorganisms Antibiotics Other Antibiotics Source Classification	Antibiotic Bacterial
Mureidomycin B is an antibiotic with anti-Pseudomonas aeruginosa activity .

Cat. No.	Product Name	Chemical Structure

HY-13678S

Meropenem-d6
Meropenem-d₆ is the deuterium labeled Meropenem. Meropenem (SM 7338) is a carbapenem antibiotic with broad-spectrum antibacterial activity. Meropenem has activity against susceptible and resistant N. gonorrhoeae (MIC value of 0.02-0.06 mg/mL), H. influenzae (MIC value of 0.03-0.12 mg/mL), and H. ducreyi (MIC value of 0.015-0.12 mg/mL) .

HY-B0467S

Amoxicillin-d4
Amoxicillin-d₄ is a deuterium labeled Amoxicillin. Amoxicillin is an antibiotic with good oral absorption and broad spectrum antimicrobial activity .

HY-A0107S

Tetracycline-d6
Tetracycline-d₆ is the deuterium labeled Tetracycline. Tetracycline is a broad-spectrum antibiotic, exhibiting activity against a wide range of gram-positive and gram-negative bacteria.

HY-B0322S

Sulfamethoxazole-d4

1 Publications Verification

Sulfamethoxazole-d₄ (Ro 4-2130-d₄) is a deuterium labeled Sulfamethoxazole (HY-B0322). Sulfamethoxazole (Ro 4-2130) is a sulfonamide antibiotic with a widespread antibacterial activity. Sulfamethoxazole inhibits bacterial folate metabolism by competing with 4-Aminobenzoic acid (HY-B1008) (PABA) to act on dihydropteroate synthetase and dihydropteroate reductase. Sulfamethoxazole can be used for the study of urinary tract infections (UTIs), prostatitis, and bronchitis .

HY-17586AS

Dalbavancin-d6
Dalbavancin-d₆ is the deuterium labeled Dalbavancin . Dalbavancin (MDL-63397) is a semisynthetic lipoglycopeptide antibiotic with potent bactericidal activity against Gram-positive bacteria. Dalbavancin inhibits Staphylococcus aureus and Bacillus anthracis with MIC90s of 0.06 μg/mL and 0.25 μg/mL, respectively .

HY-B0356S1

Ciprofloxacin-d8
Ciprofloxacin-d₈ is the deuterium labeled Ciprofloxacin. Ciprofloxacin (Bay-09867) is a fluoroquinolone antibiotic, exhibiting potent antibacterial activity.

HY-B0712S

Ceftriaxone-d3 disodium
Ceftriaxone-d₃ (disodium) is the deuterium labeled Ceftriaxone. Ceftriaxone is a third-generation cephalosporin antibiotic with excellent activity against many gram-negative, and reasonable activity against most gram-positive microorganisms. Anti-inflammatory and antioxidant characteristics .

HY-N0565S1

Doxycycline-d3 (hyclate) (major)

Doxycycline-d₃ hyclate (major) is the deuterium labeled Doxycycline hyclate (HY-N0565B). Doxycycline hyclate is an orally active highly lipophilic, tissue-permeable MMP inhibitor with broad-spectrum antibacterial activity. Doxycycline hyclate is also a semi-synthetic antibiotic with chelating properties, which blocks bacterial protein synthesis and inhibits extracellular matrix degradation through interactions with zinc and calcium atoms. Doxycycline hyclate also inhibits mitochondrial biogenesis, translation, and the expression of respiratory chain proteins. Doxycycline hyclate induces apoptosis, inhibits autophagy and EMT, downregulates stem cell markers, and activates the PI3K-AKT pathway, thereby effectively inhibiting the viability and proliferation of cancer cells such as breast cancer cells. Doxycycline hyclate also promotes the survival and self-renewal of embryonic stem cells and neural stem cells, and reduces the frequency of medium changes in culture. Doxycycline hyclate has been applied in studies related to breast cancer, prostate cancer, bladder cancer, and other cancers .

HY-B0356S

Ciprofloxacin-d8 hydrochloride
Ciprofloxacin-d₈ (hydrochloride) is the deuterium labeled Ciprofloxacin. Ciprofloxacin (Bay-09867) hydrochloride is a fluoroquinolone antibiotic, exhibiting potent antibacterial activity.

HY-B0272S2

Rifampicin-d4
Rifampicin-d₄ is the deuterium labeled Rifampicin. Rifampicin is a potent and broad spectrum antibiotic against bacterial pathogens. Rifampicin has anti-influenza virus activities.

HY-B0272S1

Rifampicin-d8
Rifampicin-d8 (Rifampin-d8) is the deuterium labeled Rifampicin. Rifampicin is a potent and broad spectrum antibiotic against bacterial pathogens. Rifampicin has anti-influenza virus activities.

HY-B0220S1

Erythromycin-13C,d3

Erythromycin- ¹³C,d₃ is the ¹³C- and deuterium labeled Erythromycin. Erythromycin is a macrolide antibiotic produced by actinomycete?Streptomyces erythreus?with a broad spectrum of antimicrobial activity. Erythromycin acts by binding to bacterial 50S ribosomal subunits and inhibits?RNA-dependent protein synthesis?by blockage of transpeptidation and/or translocation reactions, without affecting synthesis of nucleic acid .

HY-B0519AS

Tylosin-d3

Tylosin-d₃ is the deuterium labeled Tylosin. Tylosin (Tylosin A) is a macrolide antibiotic found naturally as a fermentation product of Streptomyces fradiae. Tylosin exerts potent antimicrobial activity against Gram-positive bacteria. Tylosin is widely used as a feed additive for promoting animal growth. Tylosin is used for veterinary purposes against bacterial dysentery and respiratory diseases in poultry, pigs and cattle .

HY-143831S

Cefepime-d8 sulfate

Cefepime-d₈ (BMY-28142-d₈) sulfate is deuterium labeled Cefepime sulfate. Cefepime sulfate is a broad-spectrum, blood-brain barrier-permeable cephalosporin antibiotic with hPON1 inhibitory activity, with an IC₅₀ of 21.115 mM and a K_i of 35.092 mM. Cefepime sulfate inhibits hPON1 via a non-competitive mechanism and blocks GABA_A receptors. Cefepime sulfate penetrates the outer membrane of Gram-negative bacteria, inhibits the growth of Gram-positive and Gram-negative bacteria, and does not induce the production of β-lactamase.

HY-B0275S

Oxytetracycline-d6
Oxytetracycline-d₆ is deuterium labeled Oxytetracycline. Oxytetracycline is an antibiotic belonging to the tetracycline class. Oxytetracycline potent inhibits Gram-negative and Gram-positive bacteria. Oxytetracycline is a protein synthesis inhibitor and prevents the binding from aminoacil-tRNA to the complex m-ribosomal RNA. Oxytetracycline also possesses anti-HSV-1 activity .

HY-B0593S

Ceftazidime-d5
Ceftazidime-d₅ (GR20263-d₅) is the deuterium labeled Ceftazidime (HY-B0593). Ceftazidime (GR20263), an antibiotic, has a broad spectrum activity against Gram-positive and Gram-negative aerobic bacteria. Ceftazidime is also active against Enterobacteriaceae (including β-lactamase-positive strains) and is resistant to hydrolysis by most β-lactamases .

HY-B0220S2

Erythromycin-d3

Erythromycin-d₃ is the deuterium labeled Erythromycin . Erythromycin is a macrolide antibiotic produced by actinomycete Streptomyces erythreus with a broad spectrum of antimicrobial activity. Erythromycin binds to bacterial 50S ribosomal subunits and inhibits RNA-dependent protein synthesis by blockage of transpeptidation and/or translocation reactions, without affecting synthesis of nucleic acid. Erythromycin also exhibits antitumor and neuroprotective effect in different fields of research .

HY-B0322S1

Sulfamethoxazole-13C6

Sulfamethoxazole- ¹³C₆ (Ro 4-2130- ¹³C₆) is a ¹³C labeled Sulfamethoxazole (HY-B0322). Sulfamethoxazole (Ro 4-2130) is a sulfonamide antibiotic with a widespread antibacterial activity. Sulfamethoxazole inhibits bacterial folate metabolism by competing with 4-Aminobenzoic acid (HY-B1008) (PABA) to act on dihydropteroate synthetase and dihydropteroate reductase. Sulfamethoxazole can be used for the study of urinary tract infections (UTIs), prostatitis, and bronchitis .

HY-W654100

Cefepime-d3 sulfate

Cefepime-d₃ (BMY-28142-d₃) sulfate is deuterium labeled Cefepime sulfate. Cefepime sulfate is a broad-spectrum, blood-brain barrier-permeable cephalosporin antibiotic with hPON1 inhibitory activity, with an IC₅₀ of 21.115 mM and a K_i of 35.092 mM. Cefepime sulfate inhibits hPON1 via a non-competitive mechanism and blocks GABA_A receptors. Cefepime sulfate penetrates the outer membrane of Gram-negative bacteria, inhibits the growth of Gram-positive and Gram-negative bacteria, and does not induce the production of β-lactamase.

HY-B0688S2

Dapsone-13C12

Dapsone- ¹³C₁₂ is the ¹³C₁₂ labeled Dapsone (HY-B0688). Dapsone (4,4′-Diaminodiphenyl sulfone) is an orally active and blood-brain penetrant sulfonamide antibiotic with bacteriostatic, antimycobacterial and antiprotozoal activities. Dapsone exerts effective antileprosy activity and inhibits folate synthesis in cell extracts of M. leprae. Dapsone is used for dermatologic disorder research, including leprosy, dermatitis herpetiformis, acne vulgaris et al .

HY-B0275S1

Oxytetracycline-d3

Oxytetracycline-d₃ is the deuterium labeled Oxytetracycline (HY-B0275). Oxytetracycline is an antibiotic belonging to the tetracycline class. Oxytetracycline potent inhibits Gram-negative and Gram-positive bacteria. Oxytetracycline is a protein synthesis inhibitor and prevents the binding from aminoacil-tRNA to the complex m-ribosomal RNA. Oxytetracycline also possesses anti-HSV-1 activity .

HY-W653936

Cephalexin-d5 hydrate

Cephalexin-d₅ (hydrate) is deuterium labeled Cephalexin (monohydrate). Cephalexin (Cefalexin) monohydrate is a potent, orally active new semisynthetic cephalosporin antibiotic with a broad antibacterial spectrum. Cephalexin (Cefalexin) monohydrate has antibacterial activity against a wide variety of gram-positive and gram-negative bacteria. Cephalexin (Cefalexin) monohydrate targets penicillin-binding proteins (PBPs) to inhibit bacterial cell wall assembly. Cephalexin (Cefalexin) monohydrate is used for the research of pneumonia, strep throat, and bacterial endocarditis, et al .

HY-N0565AS

Doxycycline-d3 (hydrochloride)

Doxycycline-d₃ hydrochloride is deuterium labeled Doxycycline hydrochloride (HY-N0565A). Doxycycline hydrochloride is an orally active highly lipophilic, tissue-permeable MMP inhibitor with broad-spectrum antibacterial activity. Doxycycline hydrochloride is also a semi-synthetic antibiotic with chelating properties, which blocks bacterial protein synthesis and inhibits extracellular matrix degradation through interactions with zinc and calcium atoms. Doxycycline hydrochloride also inhibits mitochondrial biogenesis, translation, and the expression of respiratory chain proteins. Doxycycline hydrochloride induces apoptosis, inhibits autophagy and EMT, downregulates stem cell markers, and activates the PI3K-AKT pathway, thereby effectively inhibiting the viability and proliferation of cancer cells such as breast cancer cells. Doxycycline hydrochloride also promotes the survival and self-renewal of embryonic stem cells and neural stem cells, and reduces the frequency of medium changes in culture. Doxycycline hydrochloride has been applied in studies related to breast cancer, prostate cancer, bladder cancer, and other cancers .

HY-N0565S3

Doxycycline-13C,d3

Doxycycline- ¹³C,d₃ is ¹³C and deuterium labeled Doxycycline (HY-N0565). Doxycycline is an orally active highly lipophilic, tissue-permeable MMP inhibitor with broad-spectrum antibacterial activity. Doxycycline is also a semi-synthetic antibiotic with chelating properties, which blocks bacterial protein synthesis and inhibits extracellular matrix degradation through interactions with zinc and calcium atoms. Doxycycline also inhibits mitochondrial biogenesis, translation, and the expression of respiratory chain proteins. Doxycycline induces apoptosis, inhibits autophagy and EMT, downregulates stem cell markers, and activates the PI3K-AKT pathway, thereby effectively inhibiting the viability and proliferation of cancer cells such as breast cancer cells. Doxycycline also promotes the survival and self-renewal of embryonic stem cells and neural stem cells, and reduces the frequency of medium changes in culture. Doxycycline has been applied in studies related to breast cancer, prostate cancer, bladder cancer, and other cancers .

HY-W654101

Cefotaxime-d3
Cefotaxime-d3 is the deuterium labeled Cefotaxime (HY-A0088A). Cefotaxime is the β-lactamase stable cephalosporin and the third-generation cephalosporin antibiotic. Cefotaxime possesses broad-spectrum antibiotic activity against numerous Gram-positive and Gram-negative bacteria .

HY-N7123S

Sulfacetamide-d4
Sulfacetamide-d₄ (Sulphacetamide-d₄) is the deuterium labeled Sulfacetamide (HY-N7123). Sulfacetamide (Sulphacetamide) is a sulfonamide antibiotic that can be used for the study of ocular infections. Sulfacetamide has antifungal and antibacterial activities .

HY-B1256S

Cefuroxime-d3
Cefuroxime-d₃ is deuterium labeled Cefuroxime (sodium). Cefuroxime sodium is an orally active second-generation cephalosporin antibiotic with increased stability to β-lactamase. Cefuroxime sodium has a broad spectrum activity against Gram-positive and Gram-negative bacteria .

HY-B0946S

Sulfamonomethoxine-d4
Sulfamonomethoxine-d₄ is a deuterium labeled Sulfamonomethoxine (HY-B0946). Sulfamonomethoxine is an orally active sulfonamide antibiotic for veterinary use. Sulfamonomethoxine is also an inhibitor of dihydropteroate synthetase, which can block the synthesis of folic acid. Sulfamonomethoxine has antibacterial activity .

HY-B0688S

Dapsone-d8

Dapsone-d₈ is a deuterium labeled Dapsone. Dapsone is an orally active and blood-brain penetrant sulfonamide antibiotic with antibacterial, antigenic and anti-inflammatory activities . Dapsone?exerts effective antileprosy activity?and inhibits folate synthesis in cell extracts of?M. leprae. Dapsone can be used as an anticonvulsant and also in the research of skin and glioblastoma diseases .

HY-14956S

Nemonoxacin-d3

Nemonoxacin-d₃ is the deuterium labeled Nemonoxacin. Nemonoxacin (TG-873870) is an orally active and potent broad-spectrum antibiotic. Nemonoxacin shows good inhibitory activity against different species of staphylococci, streptococci, and enterococci, Neisseria gonorrhoeae, and Haemophilus influenza. Nemonoxacin can be used in the study of bacterial infections and community-acquired pneumonia .

HY-A0088S

Cefotaxime-d3 sodium
Cefotaxime-d₃ (sodium) is the deuterium labeled Cefotaxime (sodium salt). Cefotaxime sodium salt, a β-lactamase stable cephalosporin and a third-generation cephalosporin antibiotic, possesses broad-spectrum antibiotic activity against numerous Gram-positive and Gram-negative bacteria .

HY-B0467AS

Amoxicillin-13C6
Amoxicillin- ¹³C₆ is the ¹³C₆ labeled Amoxicillin. Amoxicillin is an antibiotic with good oral absorption and broad spectrum antimicrobial activity.

HY-13234S

Rifaximin-d6
Rifaximin-d₆ is the deuterium labeled Rifaximin. Rifaximin is an orally administered, semi-synthetic, nonsystemic antibiotic derived from rifamycin SV with antibacterial activity .

HY-A0269S

Mecillinam-d12
Mecillinam-d₁₂ is deuterium labeled Mecillinam. Mecillinam (Amdinocillin), the β-lactam antibiotic, has a broad spectrum of activity against gram-negative organisms .

HY-B0272S

Rifampicin-d3
Rifampicin-d₃ is the deuterium labeled Rifampicin. Rifampicin is a potent and broad spectrum antibiotic against bacterial pathogens. Rifampicin has anti-influenza virus activities .

HY-146535S

Daptomycin-d5 TFA
Daptomycin-d₅ (LY146032-d₅) TFA is the deuterium labeled Daptomycin TFA. Daptomycin TFA is a lipopeptide antibiotic with rapid in vitro bactericidal activity against gram-positive organisms .

HY-B0272S3

Rifampicin-d11
Rifampicin-d₁₁ (Rifampin-d₁₁; Rifamycin AMP-d₁₁) is the deuterium labeled Rifampicin (HY-B0272) . Rifampicin is a potent and broad spectrum antibiotic against bacterial pathogens. Rifampicin has anti-influenza virus activities. Rifampicin shows anti-orthopoxvirus activity .

HY-14814S

Delafloxacin-d5
Delafloxacin-d₅ is deuterium labeled Delafloxacin. Delafloxacin (RX-3341; WQ-3034; ABT492) is a broad-spectrum fluoroquinolone antibiotic. Delafloxacin has a broad spectrum of activity that includes drug-resistant Staphylococcus aureus, Streptococcus pneumoniae, and Klebsiella pneumonia .

HY-W755036

Oxytetracycline-13C,d3 hydrochloride

Oxytetracycline-13C,d3 hydrochloride is the 13C- and deuterium labeled Oxytetracycline hydrochloride (HY-B0275A). Oxytetracycline hydrochloride is an antibiotic that exhibits board-spectrum antibacterial activity. Oxytetracycline hydrochloride is a protein synthesis inhibitor and prevents the binding from aminoacil-tRNA to the complex m-ribosomal RNA. Oxytetracycline hydrochloride also possesses anti-HSV-1 activity .

HY-B0239S3

Chloramphenicol-d4
Chloramphenicol-d₄ is deuterium labeled Chloramphenicol. Chloramphenicol, a broad-spectrum antibiotic, acts as a potent inhibitor of bacterial protein biosynthesis . Chloramphenicol acts primarily on the 50S subunit of bacterial 70S rihosomes and inhibits peptide bond formation by suppressing peptidyl transferase activity .

HY-B0957S

Erythromycin ethylsuccinate-13C,d3
Erythromycin ethylsuccinate- ¹³C,d₃ is the ¹³C- and deuterium labeled Erythromycin Ethylsuccinate. Erythromycin Ethylsuccinate is an antibiotic useful for the treatment of a number of bacterial infections, has an antimicrobial spectrum similar to or slightly wider than that of penicillin. Erythromycin Ethylsuccinate has antiviral activity against HIV-1.

HY-14283S1

Luliconazole-d3
Luliconazole-d₃ (NND 502-d₃) is deuterium labeled Luliconazole. Luliconazole (NND 502)?is a topical antifungal imidazole *antibiotic* with broad-spectrum and potent antifungal activity. Luliconazole can be used for the research of skin infection, including?dermatophytosis, tinea corporis, tinea pedis?et al .

HY-B0688S1

Dapsone-d4

Dapsone-d₄ is the deuterium labeled Dapsone. Dapsone (4,4′-Diaminodiphenyl sulfone) is an orally active and blood-brain penetrant sulfonamide antibiotic with bacteriostatic, antimycobacterial and antiprotozoal activities . Dapsone?exerts effective antileprosy activity?and inhibits folate synthesis in cell extracts of?M. leprae. Dapsone is used for dermatologic disorder research, including leprosy, dermatitis herpetiformis, acne vulgaris et al .

HY-B1418S2

Tazobactam-15N,d2
Tazobactam- ¹⁵N,d₂ (CL-298741- ¹⁵N,d₂) is ¹⁵N and deuterium labeled Tazobactam. Tazobactam (CL-298741) is a potent β-lactamases inhibitor and penicillin antibiotic. Tazobactam has antibacterial activity. Tazobactam can be used for pneumonia research .

HY-B0905S

Tilmicosin-d3

Tilmicosin-d3 is the deuterium labeled Tilmicosin. Tilmicosin (LY-177370) is an orally active calcium channel antagonist and macrolide antibiotic with antimicrobial activity. Tilmicosin mainly acts on the 50S subunit of bacterial ribosomes, inhibiting protein synthesis. Tilmicosin is effective in the treatment of respiratory diseases in livestock such as cattle, sheep and pigs. In addition, Tilmicosin has immunomodulatory and anti-inflammatory effects .

HY-B1075AS

(Rac)-Fosfomycin (benzylamine)-13C3

(Rac)-Fosfomycin (benzylamine)- ¹³C₃ is the ¹³C labeled Fosfomycin . Fosfomycin (MK-0955) is a broad-spectrum antibiotic. Fosfomycin can cross blood-brain barrier penetrating, and irreversibly inhibits an early stage in cell wall synthesis. Fosfomycin shows anti-bacteria activity for a range of bacteria, including multidrug-resistant (MDR), extensively drug-resistant (XDR), and pan-drug-resistant (PDR) bacteria .

HY-W654130

Daunorubicin-13C,d3

Daunorubicin- ¹³C,d₃ is ¹³C and deuterium labeled Daunorubicin. Daunorubicin (Daunomycin) is a topoisomerase II inhibitor with potent anti-tumor activity. Daunorubicin inhibits DNA and RNA synthesis. Daunorubicin is a cytotoxin that inhibits cancer cell viability and induces apoptosis and necrosis. Daunorubicin is also an anthracycline antibiotic. Daunorubicin can be used in the research of infection and variety of cancers, including leukemia, non-Hodgkin lymphomas, Ewing's sarcoma, Wilms' tumor .

HY-B0712S1

Ceftriaxone-13C2,d3 triethylammonium salt

Ceftriaxone-13C2,d3 triethylammonium salt is 13C and deuterated labeled Ceftriaxone (HY-B0712). Ceftriaxone (Ro 13-9904 free acid) is a broad spectrum β-lactam third-generation cephalosporin antibiotic, which has good antibacterial activity against a variety of gram-negative and positive bacteria. Ceftriaxone is a covalent inhibitor of GSK3β with IC₅₀ value of 0.78 mM. Ceftriaxone is an inhibitor of Aurora B. Ceftriaxone has anti-inflammatory, antitumor and antioxidant activities. Ceftriaxone can be used in the study of bacterial infections and meningitis .

HY-B1190S

Cefadroxil-d4 hydrate

Cefadroxil-d₄ (hydrate) is the deuterium labeled Cefadroxil hydrate (HY-B1190A). Cefadroxil hydrate is an orally active broad-spectrum cephalosporin antibiotic. Cefadroxil hydrate inhibits bacterial cell wall synthesis and enhances the expression of glutamate transporter-1. Cefadroxil hydrate is dependent on the intestinal peptide transporter PepT1 for small intestinal absorption. Cefadroxil hydrate has inhibitory and bactericidal activity against a variety of Gram-positive and Gram-negative bacteria and has analgesic effects on neuropathic pain .

HY-B0239S2

Threo-Chloramphenicol-d6

Threo-Chloramphenicol-d₆ is the deuterium labeled Chloramphenicol . Chloramphenicol is an orally active, potent and broad-spectrum antibiotic. Chloramphenicol shows antibacterial activity. Chloramphenicol represses the oxygen-labile transcription factor and hypoxia inducible factor-1 alpha (HIF-1α) in hypoxic A549 and H1299 cells. Chloramphenicol suppresses the mRNA levels of vascular endothelial growth factor (VEGF) and glucose transporter 1, eventually decreasing VEGF release. Chloramphenicol can be used for anaerobic infections and lung cancer research .

Cat. No.	Product Name		Classification

HY-B2091

Azidocillin		Azide
Azidocillin, a semi-synthetic Penicillin, is an orally active β-lactam *antibiotic. Azidocillin bears an azide functionality and retains on-target activity* within bacteria. Azidocillin can be used to research osteitis caused by dental surgery, otitis media, enterococcal septicemia and other bacterial infectious diseases . Azidocillin is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

HY-169175

CN-CC-861		Alkynes
CN-CC-861 is a broad-spectrum antibiotic. CN-CC-861 shows antibiotic activities for susceptible and multidrug-resistant bacteria. CN-CC-861 shows potent bactericidal activity in vivo .

Targets Recommended: Antibiotic

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-13067G

Celastrol Tripterine; Tripterin	Endogenous Metabolite Proteasome Antibiotic Apoptosis Bacterial Autophagy Mitophagy	Infection Inflammation/Immunology Cancer
Celastrol (GMP) (Tripterine (GMP)) is Celastrol (HY-10227) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. Celastrol (Tripterine;Tripterin) is a proteasome inhibitor which potently and preferentially inhibits the chymotrypsin-like activity of a purified 20S proteasome with IC₅₀ of 2.5 μM. In addition, Celastrol is also an *antibiotic* with potent antimicrobial activity against standard and clinical methicillin-resistant Staphylococcus aureus (MRSA) strains, inducing oxidative stress and inhibiting DNA synthesis by binding to P5CDH .

HY-N0565AG

Doxycycline (hydrochloride)	Apoptosis MMP Akt PI3K	Infection Neurological Disease Inflammation/Immunology Cancer
Doxycycline hydrochloride GMP is Doxycycline (hydrochloride) (HY-N0565A) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. Doxycycline hydrochloride is an orally active highly lipophilic, tissue-permeable MMP inhibitor with broad-spectrum antibacterial activity. Doxycycline hydrochloride is also a semi-synthetic antibiotic with chelating properties, which blocks bacterial protein synthesis and inhibits extracellular matrix degradation through interactions with zinc and calcium atoms. Doxycycline hydrochloride also inhibits mitochondrial biogenesis, translation, and the expression of respiratory chain proteins. Doxycycline hydrochloride induces apoptosis, inhibits autophagy and EMT, downregulates stem cell markers, and activates the PI3K-AKT pathway, thereby effectively inhibiting the viability and proliferation of cancer cells such as breast cancer cells. Doxycycline hydrochloride also promotes the survival and self-renewal of embryonic stem cells and neural stem cells, and reduces the frequency of medium changes in culture. Doxycycline hydrochloride has been applied in studies related to breast cancer, prostate cancer, bladder cancer, and other cancers .

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