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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
22 Results for "
c-Met protein kinase
" in MedChemExpress (MCE) Product Catalog:
Products (22)
22 Results for "c-Met protein kinase" in MCE Product Catalog:
6
6 Publications Verification
Synonyms: MP470; HPK 56
Amuvatinib (MP470) is an orally bioavailable multi-targeted tyrosine kinase inhibitor with potent activity against mutant c-Kit, PDGFRα, Flt3, c-Met and c-Ret. Amuvatinib (MP470) is also a DNA repair suppressor through suppression of DNA repair protein RAD51, thereby disrupting DNA damage repair . Antineoplastic activity .
1
1 Cited Publications
Target:
Research Areas:
BAY-474 is a tyrosine-protein kinase c-Met inhibitor. BAY-474 acts as an epigenetics probe .
Cat. No.: HY-124761
CAS No.: 683808-78-8
Target:
Research Areas:
Poloppin is a potent, cell penetrant inhibitor of the mitotic Polo-like kinase (PLK) (IC50=26.9 μM) and prevents the protein-protein interaction via the Polo-box domain (PBD) (Kd= 29.5 μM). Poloppin selectively kills cells expressing mutant KRAS, enhancing death in mitosis. Poloppin is used for the study of KRAS-mutant cancers as single agents, or in combination with c-MET inhibitors .
Cat. No.: HY-P991664
Research Areas:
Cat. No.: HY-10206A
CAS No.: 1055986-67-8
Synonyms: MP470 hydrochloride; HPK 56 hydrochloride
Amuvatinib hydrochloride (MP470 hydrochloride) is an orally bioavailable multi-targeted tyrosine kinase inhibitor with potent activity against mutant c-Kit, PDGFRα, Flt3, c-Met and c-Ret. Amuvatinib hydrochloride (MP470 hydrochloride) is also a DNA repair suppressor through suppression of DNA repair protein RAD51, thereby disrupting DNA damage repair . Antineoplastic activity .
Cat. No.: HY-10206R
CAS No.: 850879-09-3
Synonyms: MP470 (Standard); HPK 56 (Standard)
Target:
Reference Standards c-Kit PDGFR RAD51 FLT3 c-Met/HGFR RET Apoptosis
Research Areas:
Amuvatinib (Standard) is the analytical standard of Amuvatinib. This product is intended for research and analytical applications. Amuvatinib (MP470) is an orally bioavailable multi-targeted tyrosine kinase inhibitor with potent activity against mutant c-Kit, PDGFRα, Flt3, c-Met and c-Ret. Amuvatinib (MP470) is also a DNA repair suppressor through suppression of DNA repair protein RAD51, thereby disrupting DNA damage repair . Antineoplastic activity .
Cat. No.: HY-179098
Multi-target kinase-IN-8 (3d) is an anti-cancer agent. Multi-target kinase-IN-8 exhibits inhibitory activity against various protein kinases (B-Raf V600E (IC50 = 0.078 µg/mL), c-Met (IC50 = 0.405 µg/mL), Pim-1 (IC50 = 1.053 µg/mL), EGFR WT (IC50 = 0.177 µg/mL), VEGFR-2 (IC50 = 0.275 µg/mL)). Multi-target kinase-IN-8 can induce cell cycle arrest and promote early and late apoptosis. Multi-target kinase-IN-8 is commonly used in cancer research .
Cat. No.: HY-149415
Multi-kinase-IN-5 (compound 15c) is a promising multi-kinase inhibitory agent. Multi-kinase-IN-5 inhibits a panel of protein kinases (RET, KIT, cMet, VEGFR1,2, FGFR1, PDGFR and BRAF), showing % inhibition of 74%, 31%, 62%, 40%, 73%, 74%, 59%, and 69%, respectively, and IC50 of 1.287, 0.117 and 1.185 μM against FGFR1, VEGFR, and RET kinases, respectively .
Cat. No.: HY-114572
CAS No.: 1635405-90-1
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Research Areas:
1D-2 is a c-Met protein kinase inhibitor, with a human-derived IC50 of 1.45 nM. 1D-2 inhibits the proliferation of cancer cells and exhibits metabolic stability in human and rat liver microsomes. 1D-2 can be used in related research on non-small cell lung cancer .
Cat. No.: HY-P80803A
Synonyms: Met; Hepatocyte growth factor receptor; HGF receptor; HGF/SF receptor; Proto-oncogene c-Met; Scatter factor receptor; SF receptor; Tyrosine-protein kinase Met
Cat. No.: HY-P705789
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: Met; Soluble Met Variant 13; Met Proto-Oncogene, Receptor Tyrosine kinase; Soluble Met Variant 14; Hepatocyte Growth Factor Receptor; Soluble Met Variant 15; DFNB97; Soluble Met Variant 1; RCCP2; Soluble Met Variant 2; HGFR; Soluble Met Variant 3; Tyrosine-protein kinase Met; Soluble Met Variant 5; Scatter Factor Receptor; Soluble Met Variant 6; Proto-Oncogene C-Met; Soluble Met Variant 7; HGF/SF Receptor; Soluble Met Variant 8; HGF Receptor; Soluble Met Variant 9; SF Receptor; Met Proto-Oncogene; Met Proto-Oncogene Variant I; Met protein; Proto-Oncogenic Met protein; AUTS9; Soluble Met Variant 10; C-Met; Soluble Met Variant 11; DA11; Soluble Met Variant 12
Species:
Human
Source:
sf9 insect cells
Cat. No.: HY-L016
1,695 compounds
Protein tyrosine kinases (PTKs) are key signaling molecules and important drug targets. Two classes of PTKs are present in cells: the transmembrane receptor PTKs (RTKs) and the nonreceptor PTKs. The RTK family includes the receptors for insulin and for many growth factors, such as EGFR, FGFR, PDGFR, VEGFR, and NGFR. RTKs are transmembrane glycoproteins that are activated by the binding of their ligands, and they transduce the extracellular signal to the cytoplasm by phosphorylating tyrosine residues on the receptors themselves (autophosphorylation) and on downstream signaling proteins. Their principal functions of PTKs involve the regulation of multicellular aspects of the organism. Cell to cell signals concerning growth, differentiation, adhesion, motility, and death are frequently transmitted through tyrosine kinases. In humans, tyrosine kinases have been demonstrated to play significant roles in the development of many disease states, including diabetes and cancers.
MCE designs a unique collection of 1,695 compounds that act as a useful tool for PTKs-related drug screening and disease research.
Cat. No.: HY-P705876
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: MST1R; S13 Avian Erythroblastosis Oncogene Homolog; Prev. PTK8; C-Met-Related Tyrosine kinase; Prev. RON; MSP Receptor; Prev. SEA; S13 Erythroblastosis (Avian) Oncogene Homolog; CDw136; S13 Erythroblastosis Oncogene Homolog; Macrophage-Stimulating protein
Species:
Human
Source:
sf9 insect cells
Cat. No.: HY-P77180A
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: MST1R; S13 Avian Erythroblastosis Oncogene Homolog; Prev. PTK8; C-Met-Related Tyrosine kinase; Prev. RON; MSP Receptor; Prev. SEA; S13 Erythroblastosis (Avian) Oncogene Homolog; CDw136; S13 Erythroblastosis Oncogene Homolog; Macrophage-Stimulating protein
Species:
Human
Source:
HEK293
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
