1 Result for "

chronic posttraumatic stress disorder

" in MedChemExpress (MCE) Product Catalog:
Products (1)

1 Results for "chronic posttraumatic stress disorder" in MCE Product Catalog:

Cat. No.: HY-12143
CAS No.: 168266-51-1
Purity:  99.11%
Synonyms: GR 205171A
Target:  

Neurokinin Receptor

Research Areas:  

Neurological Disease

Vofopitant dihydrochloride (GR 205171A) is a blood-brain barrier-permeable NK1 receptor inhibitor with a pKi of 9.02 in mice. Vofopitant dihydrochloride blocks vomiting-related responses and inhibits pseudoptyalism. Vofopitant dihydrochloride exerts anxiolytic effects, regulates 5-HT receptor function and increases central 5-HT release. Vofopitant dihydrochloride improves hyperarousal symptoms of post-traumatic stress disorder. Vofopitant dihydrochloride can be used in research related to depression, anxiety, vomiting and postoperative nausea and vomiting .
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