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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
8 Results for "
covalent binder
" in MedChemExpress (MCE) Product Catalog:
Products (8)
8 Results for "covalent binder" in MCE Product Catalog:
9
Research Areas:
Lurbinectedin (PM01183) is a DNA minor groove covalent binder with potent anti-tumour activity; inhibits RMG1 and RMG2 cell growth with IC50 values of 1.25 and 1.16 nM, respectively.
Target:
Research Areas:
RA839 is a selective Nrf2/ARE pathway agonist and non-covalent small molecule binder of Keap1 (Kd is approximately 6 μM). RA839 prevents inducible nitric oxide synthase expression and nitric oxide release. RA839 exerts anti-rotaviral and anti-inflammatory effects .
Cat. No.: HY-174226
Target:
Research Areas:
RNA binder 2 (Compound 20) is a covalent inhibitor targeting the r(CUG)exp RNA in myotonic dystrophy type 1 (DM1). RNA binder 2 binds to RNA via a Hoechst scaffold, blocking MBNL1 binding and restoring normal splicing. RNA binder 2 is promising for research of DM1 .
Cat. No.: HY-110275R
CAS No.: 1832713-02-6
Target:
Research Areas:
RA839 (Standard) is the analytical standard of RA839 (HY-110275). This product is intended for research and analytical applications. RA839 is a selective Nrf2/ARE pathway agonist and non-covalent small molecule binder of Keap1 (Kd is approximately 6 μM). RA839 prevents inducible nitric oxide synthase expression and nitric oxide release. RA839 exerts anti-rotaviral and anti-inflammatory effects .
Cat. No.: HY-189472
CAS No.: 62265-73-0
Target:
Research Areas:
KB02 is a DCAF16-recruiting ligand that covalently binds to a ligandable cysteine on DCAF16, recruiting the E3 ligase to mediate target protein degradation. KB02 serves as a DCAF16-binding fragment for the synthesis of SHP2 PROTACs .
Cat. No.: HY-181519
Research Areas:
ALR2/α-GLY-IN-1 is a potent dual-target inhibitor that targets aldose reductase ALR2 and α-glucosidase (IC50 values are 0.72 μM and 0.82 μM, respectively; Ki values are 1.67 μM and 1.37 μM, respectively). ALR2/α-GLY-IN-1 also acts as a DNA binder, which stably interacts with calf thymus double-stranded DNA through non-covalent interactions such as groove-binding mode and water-bridged hydrogen bonds. ALR2/α-GLY-IN-1 can be used in studies related to diabetes and its complications .
Cat. No.: HY-W097355
CAS No.: 5241-59-8
Synonyms: D-Phenylalanine amide; H-D-Phe-NH2
Research Areas:
(R)-2-Amino-3-phenylpropanamide (D-Phenylalanine amide) is a non-natural D-α-amino acid derivative and chiral amino acid amide. (R)-2-Amino-3-phenylpropanamide can be converted into D-Phenylalanine (HY-Y0079), which is applicable to the construction of all-D antimicrobial peptides and the synthesis of anti-HIV reagents. (R)-2-Amino-3-phenylpropanamide serves as a reagent for synthesizing benzoxaborole derivative 6, a dual covalent binder of Pseudomonas aeruginosa PBP3. (R)-2-Amino-3-phenylpropanamide is used in colon cancer-related research .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
