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Results for "

cyclin-dependent kinase 4

" in MedChemExpress (MCE) Product Catalog:

By Targets:	CDK (3) Apoptosis (2)
By Research Areas:	Cancer (3) Neurological Disease (1)

Inhibitors & Agonists

Recombinant Proteins

Antibodies

Targets Recommended: CDKL CDK

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-164129

CDK4-IN-3	CDK Apoptosis	Cancer
CDK4-IN-3 (Compound 389) is a potent irreversible cyclin-dependent kinase 4 (CDK4) inhibitor (IC₅₀=25 nM, >10-fold selective over CDK6). CDK4-IN-3 arrests the cell cycle at G₁ phase, and induces tumor cell apoptosis. CDK4-IN-3 is promising for research of solid tumors such as breast and lung cancers .

HY-146213

CDK4/6-IN-12	CDK	Cancer
CDK4/6-IN-12 is a potent cyclin-dependent kinase 4/6 (CDK4/6) inhibitor. CDK4/6-IN-12 has enzymatic inhibitory activity for CDK4 and CDK6 with IC₅₀ of 592.3 nM and 3090 nM, respectively. CDK4/6-IN-12 can be used for the research of cancer .

HY-133956

3-ATA NSC 680434	Apoptosis CDK	Neurological Disease Cancer
3-ATA (NSC 680434) is a selective inhibitor of cyclin-dependent kinase 4 (CDK4) with neuroprotective and antitumor effects. 3-ATA can alleviate kainic acid (HY-N2309)-induced apoptosis in cerebellar granule neurons, which can be used in the study of neurodegenerative diseases .

Recombinant Proteins Recommended:

Cyclin-Dependent Kinase 4 (CDK4)

Species:	Human (11)
Tag:	His (7) Tag Free (3) GST (6) Flag (4)
Source:	Sf9 insect cells (9) E. coli (2)

Cat. No.	Compare	Product Name	Species	Source	Image

HY-P70034

	CDKN2C Protein, Human (His) rHucyclin-dependent kinase 4 inhibitor C/CDKN2C, His; cyclin-dependent kinase 4 Inhibitor C; cyclin-dependent kinase 6 Inhibitor; p18-INK4c; p18-INK6; CDKN2C; CDKN6	Human	E. coli
	The CDKN2C protein (also known as p18) interacts strongly with CDK6 and weakly with CDK4. Its functional effects inhibit cell growth and proliferation and are significantly related to the presence of endogenous retinoblastoma protein RB. CDKN2C Protein, Human (His) is the recombinant human-derived CDKN2C protein, expressed by E. coli , with N-6*His labeled tag.

HY-P702684

	CDK4-CCND3 Protein, Human (Active, sf9, GST, His) CDK4; cyclin-dependent kinase 4; PSK J3; cell division protein kinase 4; CMM3; PSK-J3; MGC14458;	Human	Sf9 insect cells
	CDK4 protein, acting as a Ser/Thr kinase in the cyclin D-CDK4 complex, critically regulates the G(1)/S transition by phosphorylating and inhibiting RB family members. This activity, specifically hypophosphorylation of RB1 during early G(1) phase, releases E2F and promotes transcription of genes that drive G(1) progression. CDK4-CCND3 Protein, Human (sf9, GST, His) is the recombinant human-derived CDK4-CCND3, expressed by Sf9 insect cells, with N-His, N-GST labeled tag.

HY-P74659

	p19INK4d Protein, Human (His) cyclin-dependent kinase 4 inhibitor D; p19-INK4d; CDKN2D	Human	E. coli
	The p19INK4d protein, a potent inhibitor, strongly interacts with CDK4 and CDK6, effectively impeding their activity. Specifically interacting with CDK6, p19INK4d reinforces its role as a regulator of cyclin-dependent kinase activity. This crucial role in cell cycle regulation involves restraining CDK4 and CDK6 functions, contributing to the modulation of key cellular processes. p19INK4d Protein, Human (GST) is the recombinant human-derived p19INK4d protein, expressed by E. coli , with N-GST labeled tag.

HY-P702682

	CDK4-CCND1 Protein, Human (Active, sf9, GST, Flag, His) 1 Publications Verification CDK4; cyclin-dependent kinase 4; PSK J3; cell division protein kinase 4; CMM3; PSK-J3; MGC14458;	Human	Sf9 insect cells
	CDK4 protein, acting as a Ser/Thr kinase in the cyclin D-CDK4 complex, critically regulates the G(1)/S transition by phosphorylating and inhibiting RB family members. This activity, specifically hypophosphorylation of RB1 during early G(1) phase, releases E2F and promotes transcription of genes that drive G(1) progression. CDK4-CCND1 Protein, Human (sf9, GST, Flag, His) is the recombinant human-derived CDK4-CCND1, expressed by Sf9 insect cells, with N-His, N-GST, N-Flag labeled tag.

HY-P702683

	CDK4-CCND2 Protein, Human (Active, sf9, GST, Flag, His) CDK4; cyclin-dependent kinase 4; PSK J3; cell division protein kinase 4; CMM3; PSK-J3; MGC14458;	Human	Sf9 insect cells
	CDK4 protein, acting as a Ser/Thr kinase in the cyclin D-CDK4 complex, critically regulates the G(1)/S transition by phosphorylating and inhibiting RB family members. This activity, specifically hypophosphorylation of RB1 during early G(1) phase, releases E2F and promotes transcription of genes that drive G(1) progression. CDK4-CCND2 Protein, Human (sf9, GST, Flag, His) is the recombinant human-derived CDK4-CCND2, expressed by Sf9 insect cells, with N-His, N-GST, N-Flag labeled tag.

HY-P701374

	CDK9-CCNK Heterodimer Protein, Human (sf9) CDK9; CCNK; cyclin-dependent kinase 9; C-2K; Cell division cycle 2-like protein kinase 4; Cell division protein kinase 9; Serine/threonine-protein kinase PITALRE; Tat-associated kinase complex catalytic subunit; cyclin-K	Human	Sf9 insect cells
	The CDK9 protein plays a central role in transcriptional regulation, promoting the transition from ineffective to efficient elongation by phosphorylating POLR2A, SUPT5H, and RDBP. As part of the CDK9/cyclin-T complex, it participates in phosphorylation events affecting EP300, MYOD1, RPB1/POLR2A, AR, DSIF, and NELFE. CDK9-CCNK Heterodimer Protein, Human (sf9) is a recombinant protein dimer complex containing human-derived CDK9-CCNK Heterodimer protein, expressed by sf9 insect cells , with tag free.

HY-P701375

	CDK9-CCNK Heterodimer Protein, Human (Active, sf9, GST, FLAG) CDK9; CCNK; cyclin-dependent kinase 9; C-2K; Cell division cycle 2-like protein kinase 4; Cell division protein kinase 9; Serine/threonine-protein kinase PITALRE; Tat-associated kinase complex catalytic subunit; cyclin-K	Human	Sf9 insect cells
	The CDK9 protein plays a central role in transcriptional regulation, promoting the transition from ineffective to efficient elongation by phosphorylating POLR2A, SUPT5H, and RDBP. As part of the CDK9/cyclin-T complex, it participates in phosphorylation events affecting EP300, MYOD1, RPB1/POLR2A, AR, DSIF, and NELFE. CDK9-CCNK Heterodimer Protein, Human (sf9, GST, FLAG) is a recombinant protein dimer complex containing human-derived CDK9-CCNK Heterodimer protein, expressed by sf9 insect cells , with N-Flag, N-GST labeled tag.

HY-P701377

	CDK9-CCNT2 Heterodimer Protein, Human (sf9) CDK9; CCNT2; cyclin-dependent kinase 9; C-2K; Cell division cycle 2-like protein kinase 4; Cell division protein kinase 9; Serine/threonine-protein kinase PITALRE; Tat-associated kinase complex catalytic subunit; cyclin-T2; CycT2	Human	Sf9 insect cells
	The CDK9 protein plays a central role in transcriptional regulation, promoting the transition from ineffective to efficient elongation by phosphorylating POLR2A, SUPT5H, and RDBP. As part of the CDK9/cyclin-T complex, it participates in phosphorylation events affecting EP300, MYOD1, RPB1/POLR2A, AR, DSIF, and NELFE. CDK9-CCNT2 Heterodimer Protein, Human (sf9) is a recombinant protein dimer complex containing human-derived CDK9-CCNT2 Heterodimer protein, expressed by sf9 insect cells , with tag free.

HY-P702689

	CDK9-CCNT1 Heterodimer Protein, Human (Active, sf9, GST, His) CDK9; CCNK; cyclin-dependent kinase 9; C-2K; Cell division cycle 2-like protein kinase 4; Cell division protein kinase 9; Serine/threonine-protein kinase PITALRE; Tat-associated kinase complex catalytic subunit; cyclin-K	Human	Sf9 insect cells
	The CDK9 protein plays a central role in transcriptional regulation, promoting the transition from ineffective to efficient elongation by phosphorylating POLR2A, SUPT5H, and RDBP. As part of the CDK9/cyclin-T complex, it participates in phosphorylation events affecting EP300, MYOD1, RPB1/POLR2A, AR, DSIF, and NELFE. CDK9-CCNT1 Heterodimer Protein, Human (sf9, GST, His) is the recombinant human-derived CDK9-CCNT1, expressed by Sf9 insect cells, with N-His, N-GST labeled tag.

HY-P702690

	CDK9-CCNT2 Heterodimer Protein, Human (Active, sf9, GST, Flag, His) CDK9; CCNK; cyclin-dependent kinase 9; C-2K; Cell division cycle 2-like protein kinase 4; Cell division protein kinase 9; Serine/threonine-protein kinase PITALRE; Tat-associated kinase complex catalytic subunit; cyclin-K	Human	Sf9 insect cells
	The CDK9 protein plays a central role in transcriptional regulation, promoting the transition from ineffective to efficient elongation by phosphorylating POLR2A, SUPT5H, and RDBP. As part of the CDK9/cyclin-T complex, it participates in phosphorylation events affecting EP300, MYOD1, RPB1/POLR2A, AR, DSIF, and NELFE. CDK9-CCNT2 Heterodimer Protein, Human (sf9, GST, Flag, His) is the recombinant human-derived CDK9-CCNT2, expressed by Sf9 insect cells, with N-His, N-GST, N-Flag labeled tag.

HY-P701376

	CDK9-CCNT1 Heterodimer Protein, Human (Active, sf9) CDK9; CCNT1; cyclin-dependent kinase 9; C-2K; Cell division cycle 2-like protein kinase 4; Cell division protein kinase 9; Serine/threonine-protein kinase PITALRE; Tat-associated kinase complex catalytic subunit; cyclin-T1; CycT1; cyclin-T	Human	Sf9 insect cells
	The CDK9 protein plays a central role in transcriptional regulation, promoting the transition from ineffective to efficient elongation by phosphorylating POLR2A, SUPT5H, and RDBP. As part of the CDK9/cyclin-T complex, it participates in phosphorylation events affecting EP300, MYOD1, RPB1/POLR2A, AR, DSIF, and NELFE. CDK9-CCNT1 Heterodimer Protein, Human (sf9) is a recombinant protein dimer complex containing human-derived CDK9-CCNT1 Heterodimer protein, expressed by sf9 insect cells , with tag free.

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Host:	Mouse (3) Rabbit (5)
Reactivity:	Human (8) Rat (4) Mouse (6)
Application:	IHC-P (4) ICC/IF (5) IP (5) WB (8) ELISA (4)
Isotype:	IgG (5) IgG2b,IgG/Kappa (1)
Conjugation:	Non-conjugated (8)
Clonality:	Monoclonal (8) Recombinant (3)
Modification:	Unmodified (8)

Cat. No.	Compare	Product Name	Application	Reactivity	Image

HY-P86471

	CDK4 Antibody (YA6163) CDK4; cyclin-dependent kinase 4; Cell division protein kinase 4; PSK-J3	WB, IHC-P, ICC/IF, IP, ELISA	Human, Mouse, Rat
	CDK4 Antibody (YA6163) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to CDK4.

HY-P81003

	CDKN2C Antibody (YA3497) CDKN2C; CDKN6; cyclin-dependent kinase 4 inhibitor C; cyclin-dependent kinase 6 inhibitor; p18-INK4c; p18-INK6	WB, IHC-P, ICC/IF, IP	Human, Mouse, Rat
	CDKN2C Antibody (YA3497) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to CDKN2C.

HY-P85531

	CDK4 Antibody (YA5223) Cdk 4; cdk4; CDK4 protein; CDK4_HUMAN; Cell division kinase 4; Cell division protein kinase 4; CMM 3; CMM3; Crk3; cyclin dependent kinase 4; cyclin-dependent kinase 4; Melanoma cutaneous malignant 3; MGC14458; p34 cdk4; PSK J3; PSK-J3.	WB	Human, Mouse, Rat
	CDK4 Antibody (YA5223) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to CDK4.

HY-P86438

	CDKN2A/p16INK4a Antibody (YA6130) 1 Publications Verification cyclin-dependent kinase inhibitor 2A, isoforms 1/2/3; cyclin-dependent kinase 4 inhibitor A; CDK4I; Multiple tumor suppressor 1; MTS-1; p16-INK4a; p16-INK4; p16INK4A; p16;	WB, ICC/IF, IP, ELISA	Human, Mouse, Rat
	CDKN2A/p16INK4a Antibody (YA6130) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to CDKN2A/p16INK4a.

HY-P85830

	CDKN2A/p16INK4a Antibody (YA5522) cyclin-dependent kinase inhibitor 2A, isoforms 1/2/3; cyclin-dependent kinase 4 inhibitor A; CDK4I; Multiple tumor suppressor 1; MTS-1; p16-INK4a; p16-INK4; p16INK4A; p16;	IHC-P, WB, ICC/IF, ELISA	Human
	CDKN2A/p16INK4a Antibody (YA5522) is a Mouse-derived and non-conjugated IgG2b monoclonal antibody, targeting to CDKN2A/p16INK4a.

HY-P85098

	CDK9 Antibody (YA4790) CDK9; CDC2L4; TAK; cyclin-dependent kinase 9; C-2K; Cell division cycle 2-like protein kinase 4; Cell division protein kinase 9; Serine/threonine-protein kinase PITALRE; Tat-associated kinase complex catalytic subunit	WB, IHC-P, ICC/IF, ELISA	Human
	CDK9 Antibody (YA4790) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to CDK9.

HY-P80615

	CDKN2A/p16INK4a Antibody (YA508) 1 Publications Verification CDK4 inhibitor p16 INK4 antibody; CDK4I antibody; CDKN2 antibody; CDKN2A antibody; Cell cycle negative regulator beta antibody; CMM2 antibody; cyclin dependent kinase 4 inhibitor A antibody; cyclin dependent kinase inhibitor 2A (melanoma p16 inhibits CDK4) antibody; cyclin dependent kinase Inhibitor 2A antibody; cyclin dependent kinase inhibitor 2A isoform 4 antibody; cyclin dependent kinase inhibitor 2A isoforms 1/2/3 antibody; cyclin dependent kinase inhibitor p16 antibody; INK4 antibody; INK4A antibody; MLM antibody; MTS1 antibody; Multiple tumor suppressor 1 antibody; p14 antibody; p16 antibody; P16INK4 antibody; p16INK4a antibody; p19 antibody; p19Arf antibody; TP16 antibody;	WB, IP	Human, Mouse
	CDKN2A/p16INK4a Antibody (YA508) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to CDKN2A/p16INK4a.

HY-P80615A

	CDKN2A/p16INK4a Antibody (YA508)(PBS only) CDK4 inhibitor p16 INK4 antibody; CDK4I antibody; CDKN2 antibody; CDKN2A antibody; Cell cycle negative regulator beta antibody; CMM2 antibody; cyclin dependent kinase 4 inhibitor A antibody; cyclin dependent kinase inhibitor 2A (melanoma p16 inhibits CDK4) antibody; cyclin dependent kinase Inhibitor 2A antibody; cyclin dependent kinase inhibitor 2A isoform 4 antibody; cyclin dependent kinase inhibitor 2A isoforms 1/2/3 antibody; cyclin dependent kinase inhibitor p16 antibody; INK4 antibody; INK4A antibody; MLM antibody; MTS1 antibody; Multiple tumor suppressor 1 antibody; p14 antibody; p16 antibody; P16INK4 antibody; p16INK4a antibody; p19 antibody; p19Arf antibody; TP16 antibody;	WB, IP	Human, Mouse
	CDKN2A/p16INK4a Antibody (YA508)(PBS only) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to CDKN2A/p16INK4a.

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