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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
15 Results for "
dehydrocholesterol reductase
" in MedChemExpress (MCE) Product Catalog:
Products (15)
15 Results for "dehydrocholesterol reductase" in MCE Product Catalog:
8
Category:
Human Gut Microbiota Metabolites Other Diseases Endogenous metabolite Disease Research Fields Steroids
Target:
3
3 Cited Publications
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SH-42 is a potent and selective inhibitor of human Δ 24-dehydrocholesterol reductase (DHCR24), with an IC50 of 42 nM. SH-42 can lead to a significant increase in plasma desmosterol levels of mice .
1
1 Cited Publications
Cat. No.: HY-164561
CAS No.: 1678515-93-9
Research Areas:
TASIN-30 is a selective EBP inhibitor with an EC50 of 0.097 μM. TASIN-30 blocks the production of 7-dehydrocholesterol (7-DHC) and downstream cholesterol biosynthesis processes. TASIN-30 depletes downstream sterols, disrupts the integrity of lipid rafts in tumor cells, accelerates intracellular cholesterol consumption, and inhibits tumor cell proliferation. TASIN-30 induces ferroptosis and apoptosis by reducing 7-DHC levels and increasing phospholipid peroxidation. TASIN-30 achieves tumor suppression in nude mice with osteosarcoma. TASIN-30 can be used in cancer-related research such as colorectal cancer and osteosarcoma .
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Cat. No.: HY-113279S
CAS No.: 388622-58-0
Category:
Disease markers Metabolic Disease Nervous System Disorder Endogenous metabolite Disease Research Fields Steroids
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Cat. No.: HY-113279R
CAS No.: 434-16-2
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BM 15766 sulfate is an inhibitor of 7-dehydrocholesterol δ7-reductase and reduces plasma cholesterol levels. BM 15766 sulfate is a hypolipidemic agent .
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Previtamin D3 is an orally active, thermolabile steroidal compound that generates vitamin D3, as well as biologically inactive lumisterol and tachysterol. Previtamin D3 is synthesized in the skin of humans and rats via the UV-B-mediated photoconversion of 7-dehydrocholesterol. Previtamin D3 lacks direct anti-rachitic activity, and its in vivo activity relies on the vitamin D3 it produces. Previtamin D3 can be used in studies related to rickets and vitamin D metabolism .
Cat. No.: HY-142129
CAS No.: 10346-43-7
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Pyrocholecalciferol, a vitamin D analogue, produced by photochemical transformation of 7-dehydrocholesterol (7-DHC) .
Cat. No.: HY-E71997
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7-Dehydrocholesterol reductase (EC 1.3.1.21) is an oxidoreductase that can convert cholesterol and NADP + into 7-dehydrocholesterol, NADPH and H +.
Cat. No.: HY-W726633
CAS No.: 10355-14-3
Target:
Research Areas:
Metabolic Disease Inflammation/Immunology Endocrinology Cancer
Boxidine is an orally active DHCR7 inhibitor. Boxidine inhibits DHCR7, blocks the conversion of 7-Dehydrocholesterol (HY-113279) to Cholesterol (HY-N0322), reduces serum cholesterol levels, causes accumulation of 7-dehydrocholesterol in serum and tissues, and inhibits sterol absorption. Boxidine exhibits antiproliferative and anticancer activities, with marginal activity against mouse tumors. Boxidine can be used in research related to diseases such as tumors and adrenal cancer .
Cat. No.: HY-P702263
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: DHCR7; Delta-7-dehydrocholesterol reductase; Prev. SLOS; Delta(14)-Sterol reductase TM7SF2; Cholesterol-5,6-Epoxide Hydrolase Subunit DHCR7; Putative Sterol reductase SR-2; Sterol Delta(7)-reductase; Smith-Lemli-Opitz Syndrome; Delta7-Sterol reductase; St
Species:
Bovine
Source:
E. coli Cell-free
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
