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Results for "

embryos,

" in MedChemExpress (MCE) Product Catalog:

By Targets:	5-HT Receptor (1) Akt (8) AMPK (3) Androgen Receptor (3) Angiotensin-converting Enzyme (ACE) (1) Antibiotic (9) Antifolate (6) Apoptosis (28) Aryl Hydrocarbon Receptor (1) ATP Synthase (1) Autophagy (5) Bacterial (15) Bcl-2 Family (2) Biochemical Assay Reagents (6) Calcium Channel (1) Carbonic Anhydrase (1) Caspase (3) CDK (3) Cholinesterase (ChE) (1) COX (3) DNA Alkylator/Crosslinker (1) DNA/RNA Synthesis (10) Dopamine Receptor (1) Drug Derivative (9) Drug Intermediate (1) Drug Isomer (1) Drug Metabolite (1) DYRK (1) Endogenous Metabolite (22) Environmental Pollutants (5) Epigenetic Reader Domain (1) ERK (3) Estrogen Receptor/ERR (4) Fluorescent Dye (4) FOXO (1) Fungal (13) Gli (1) Glutathione Peroxidase (1) Glycosidase (1) HDAC (2) Hedgehog (1) Heme Oxygenase (HO) (1) Herbicide (4) Histone Acetyltransferase (2) Histone Methyltransferase (3) Influenza Virus (6) Insecticide (2) Interleukin Related (4) Isotope-Labeled Compounds (10) JNK (1) Lipoxygenase (1) MDM-2/p53 (1) Microtubule/Tubulin (1) Mitophagy (1) MMP (3) mRNA (1) mTOR (6) Na+/H+ Exchanger (NHE) (1) NF-κB (4) Nucleoside Antimetabolite/Analog (3) Opioid Receptor (1) Oxytocin Receptor (1) p38 MAPK (4) PACAP Receptor (2) Parasite (3) PARP (1) Phosphodiesterase (PDE) (1) PI3K (8) PKC (3) PPAR (2) Prostaglandin Receptor (3) Quinone Reductase (1) Reactive Oxygen Species (ROS) (20) Reference Standards (16) RIP kinase (1) Sirtuin (1) SOD (5) STAT (3) TGF-beta/Smad (1) Thyroid Hormone Receptor (3) Tie (1) TNF Receptor (2) Tyrosinase (3) VD/VDR (2) VEGFR (3) WDR5 (1) Wnt (3) β-catenin (1)
By Research Areas:	Cancer (48) Cardiovascular Disease (10) Endocrinology (8) Infection (34) Inflammation/Immunology (29) Metabolic Disease (28) Neurological Disease (21)
Click Chemistry:	Alkynes (1)
Oligonucleotides:	mRNA (1)

137

Inhibitors & Agonists

Screening Libraries

Fluorescent Dye

Biochemical Assay Reagents

Peptides

MCE Kits

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Click Chemistry

Oligonucleotides

GMP Molecules

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-D0842A

Bovine Serum Albumin (Low Endotoxin,Fatty acid free) Albumin bovine serum (Low Endotoxin,Fatty acid free); BSA (Low Endotoxin,Fatty acid free)	Biochemical Assay Reagents Nucleoside Antimetabolite/Analog	Inflammation/Immunology
Bovine Serum Albumin (Low Endotoxin,Fatty acid free) (BSA) is a 583 amino acid globular protein and oligonucleotide binding protein composed of three homologous full α domains. Bovine Serum Albumin (Low Endotoxin,Fatty acid free) (BSA) blocks the overall binding of oligonucleotides to cells. Bovine Serum Albumin (Low Endotoxin,Fatty acid free) (BSA) regulates the development of hamster embryos and induces arthritis .

HY-B0717

Tocofersolan 5+ Cited Publications TPGS; D-α-Tocopherol polyethylene glycol 1000 succinate; Vitamin E-TPGS	Drug Derivative	Neurological Disease Metabolic Disease
Tocofersolan is synthetic polyethylene glycol derivative of α-tocopherol. Tocofersolan is an orally active and water-soluble analog of vitamin E. Tocofersolan can reduce neurobehavioral deficits in zebrafish embryos exposed to moderate and high concentrations of BaP during early development. Tocofersolan shows antioxidant activity. Tocofersolan can be used to provide an orally bioavailable source of vitamin E .

HY-A0096

Iloprost 5 Publications Verification Ciloprost; ZK 36374	Prostaglandin Receptor Endogenous Metabolite	Cardiovascular Disease Endocrinology Cancer
Iloprost (ZK 36374; Ciloprost) is a prostacyclin (PGI2) analogue, involves in embryo development and inflammation improvement, and inhibits tumor metastasis. Iloprost can be used for peripheral vascular research .

HY-B0510

Trimethoprim 10+ Cited Publications	Antifolate Bacterial Antibiotic Influenza Virus	Infection Cancer
Trimethoprim is a bacteriostatic antibiotic and an orally active dihydrofolate reductase inhibitor. Trimethoprim is active against a wide range of Gram-positive and Gram-negative aerobic bacteria. Trimethoprim has the potential for the research of urinary tract infections, Shigellosis and Pneumocystis pneumonia. Trimethoprim can inhibit infection of Influenza A virus in chick embryo when combinated with zinc .

HY-134124

Glutathione ethyl ester	Reactive Oxygen Species (ROS)	Metabolic Disease
Glutathione ethyl ester is a cell-permeable GSH donor and provides an efficient supply of GSH to the oocyte. Glutathione ethyl ester shows positive effect on the in vitro production of embryos by enhancement of the antioxidative defense .

HY-107420

AY 9944 5+ Cited Publications	Endogenous Metabolite	Metabolic Disease
AY 9944 is a specific cholesterol biosynthesis inhibitor. AY 9944 inhibits the 7-dehydro cholesterol Δ7-reductase (DHCR7) enzyme with an IC₅₀ of 13 nM. AY 9944 causes hypocholesterolemia and accumulation of 7DHC. At high doses, AY 9944 inhibits also in cultured embryos sterol Δ7-Δ8 isomerase, which causes the accumulation of cholest-8-en-3β-ol .

HY-W011689

6PPD 1 Publications Verification	Reactive Oxygen Species (ROS)	Others
6PPD is a rubber antioxidant that scavenges ozone and forms nitro radicals. Exposure to 6PPD reduces the hatching rate, impairs spontaneous locomotor activity, shortens body length and causes malformations in zebrafish embryos. 6PPD also induces oxidative stress in zebrafish embryos .

HY-B0642

Isosorbide mononitrate 5 Publications Verification Isosorbide-5-mononitrate	Autophagy Endogenous Metabolite Apoptosis	Cardiovascular Disease Cancer
Isosorbide mononitrate (Isosorbide-5-mononitrate) is an orally active nitric acid compound used for angina pectoris by dilating blood vessels and lowering blood pressure. Isosorbide mononitrate increases the viability and proliferation of HUVECs by decreasing Apoptosis and elevated the expressions of vedf, kdrl, pdgfr in zebrafish embryos. Isosorbide mononitrate is promising for research of heart failure and coronary heart disease .

HY-N0770

Isoliensinine 4 Publications Verification	Apoptosis	Inflammation/Immunology Cancer
Isoliensinine is a bisbenzylisoquinoline alkaloid extracted from the seed embryo of Nelumbo nucifera, with anti-oxidant and anti-inflammatory and anti-cancer activities. Isoliensinine induces apoptosis in triple-negative human breast cancer cells .

HY-D1416

HMBR 1 Publications Verification	Fluorescent Dye	Others
HMBR is an analogue with an additional methyl group on the aromatic ring and is non-fluorescent. HMBR conjugated with Y-FAST emits yellow fluorescence under blue light excitation (Ex= 419 nm; Em= 525–539 nm). HMBR is non-toxic to zebrafish embryos. HMBR has high cell permeability .

HY-B1209

Etofylline 7-(β-Hydroxyethyl)theophylline	Phosphodiesterase (PDE)	Cardiovascular Disease Inflammation/Immunology
Etofylline (7-(β-Hydroxyethyl) theophylline) is an oral bronchodilator with anti-inflammatory effects. Etofylline inhibits phosphodiesterase and prevents the degradation of cAMP (cyclic adenosine monophosphate), leading to smooth muscle relaxation, reducing inflammatory responses and improving respiratory function. Etofylline affects the development of zebrafish embryos .

HY-N0485

Liensinine Diperchlorate Maximum Cited Publications 20 Publications Verification	Autophagy Mitophagy	Cardiovascular Disease
Liensinine Diperchlorate is a major isoquinoline alkaloid, extracted from the seed embryo of Nelumbo nucifera Gaertn. Liensinine Diperchlorate inhibits late-stage autophagy/mitophagy through blocking autophagosome-lysosome fusion. Liensinine Diperchlorate has a wide range of biological activities, including anti-arrhythmias, anti-hypertension, anti-pulmonary fibrosis, relaxation on vascular smooth muscle, etc .

HY-A0277

Cyproconazole	Environmental Pollutants Fungal	Others
Cyproconazole is a triazole fungicide used to protect crops, fruits and vegetables against a wide range of fungal pathogens. Cyproconazole can cause hepatocellular adenomas and carcinomas in CD-1 mice. Cyproconazole also exhibits low toxicity to zebrafish embryos and affects locomotor activity .

HY-N6786

Ochratoxin B	Endogenous Metabolite	Metabolic Disease
Ochratoxin B is an orally active secondary metabolite of Aspergillus ochraceus and non-chlorinated analog of the mycotoxin Ochratoxin A. Ochratoxin B reduces the toxic effects of Ochratoxin A (HY-N6788). Ochratoxin B inhibits cell division. Ochratoxin B causes craniofacial malformations in Xenopus laevis embryos .

HY-W099479

Insect repellent M 3535 Ethyl butylacetylaminopropionate; IR-3535	Environmental Pollutants Apoptosis Reactive Oxygen Species (ROS) Parasite SOD	Infection Inflammation/Immunology
Insect repellent M 3535 (Ethyl butylacetylaminopropionate) is a broad-spectrum, mild insect repellent based on the structure of β-alanine. Insect repellent M 3535 exerts repellent effects by interfering with the olfaction of mosquitoes, but it poses risks of developmental and cardiac toxicity to aquatic organisms such as zebrafish embryos in aquatic environments, and can activate oxidative stress responses .

HY-B0510C

Trimethoprim lactate 10+ Cited Publications	Antifolate Bacterial Antibiotic	Infection Cancer
Trimethoprim lactate is a bacteriostatic antibiotic and an orally active dihydrofolate reductase inhibitor. Trimethoprim lactate is active against a wide range of Gram-positive and Gram-negative aerobic bacteria. Trimethoprim lactate has the potential for the research of urinary tract infections, Shigellosis and Pneumocystis pneumonia. Trimethoprim lactate can inhibit infection of Influenza A virus in chick embryo when combinated with zinc .

HY-127170

3-Hydroxycoumarin	Lipoxygenase Tyrosinase	Metabolic Disease Inflammation/Immunology
3-Hydroxycoumarin is an inhibitor of tyrosinase and lipoxygenase with an IC₅₀ for recombinant human tyrosinase (rHT) of 26 μM, and a K_i of 3.39 μM; its IC₅₀ for LOX is 9.5 μM. 3-Hydroxycoumarin has DPPH free radical scavenging activity (IC₅₀ = 31.2 μM). 3-Hydroxycoumarin has photoprotective effects on sea urchin zygotes and embryos .

HY-12346

FH1 NSC 12407; BRD-K4477	Quinone Reductase	Others
FH1 (NSC 12407) is a NQO2 inhibitor with hepatoprotective effects. FH1 enhances hepatocyte function and promotes differentiation of induced pluripotent stem (iPS)-derived hepatocytes to a more mature phenotype and maturation of well-differentiated hepatocyte-like cell (iHeps) cultures. FH1 protects against Acetaminophen (HY-66005)-induced hepatotoxicity in both embryos and adult zebrafish .

HY-N6726

Fumonisin B3	Fungal Endogenous Metabolite	Infection Cancer
Fumonisin B3 is an orally active fumonisin Mycotoxin. Fumonisin B3 can be isolated from Fusarium moniliforme, Fusarium proliferatum and Fusarium nygamai. Fumonisin B3 induces precancerous lesions, triggers embryonic death of chicken embryos, causes severe hemorrhage in dead chicken embryos. Fumonisin B3 can be used in studies related to hepatocellular carcinoma .

HY-136355

Picoxystrobin	Environmental Pollutants Reactive Oxygen Species (ROS) Fungal SOD	Infection Inflammation/Immunology
Picoxystrobin is a strobilurin fungicide. Picoxystrobin controls plant diseases by inhibiting mitochondrial respiration. Picoxystrobin is highly toxic to zebrafish embryos, causing developmental abnormalities, oxidative stress, and immunotoxicity .

HY-147372

SJ000063181	TGF-beta/Smad	Metabolic Disease
SJ000063181 is a potent BMP signaling activator. SJ000063181 activates BMP4 and the phosphorylation of SMAD1/5/8 (p-SMAD1/5/8). SJ000063181 induces ventralization in zebrafish embryos .

HY-141894

5-Ph-IAA-AM 2 Publications Verification	Histone Acetyltransferase	Metabolic Disease
5-Ph-IAA-AM is an eggshell-permeable 5-Ph-IAA (HY-134653) analog which contains an acetoxymethyl (AM) group. 5-Ph-IAA-AM affords an enhanced protein degradation in laid embryos. 5-Ph-IAA-AM can be used to disclosure the roles of proteins in C. elegans, in particular those that are involved in embryogenesis and development, through temporally controlled protein degradation .

HY-21191

Perfluorobutanesulfonic acid PFBS	Biochemical Assay Reagents PPAR Reactive Oxygen Species (ROS)	Metabolic Disease
Perfluorobutanesulfonic acid (PFBS) is a short-chain perfluoroalkyl substance and the main replacement for perfluorooctanesulfonic acid. Perfluorobutanesulfonic acid induces fat accumulation in human HepG2 hepatoma cells. Perfluorobutanesulfonic acid promotes lipid accumulation by activating PPARγ pathway and triggering oxidative stress, endoplasmic reticulum stress and calcium dyshomeostasis. Perfluorobutanesulfonic acid impairs reproduction and causes developmental disorders in offspring of Caenorhabditis elegans. Perfluorobutanesulfonic acid disrupts pancreatic organogenesis and lipid homeostasis in zebrafish embryos. Perfluorobutanesulfonic acid can be used in environmental toxicology, lipid metabolism and developmental toxicity studies .

HY-119896

Clethodim	Environmental Pollutants Herbicide	Neurological Disease
Clethodim is a postemergence herbicide. Clethodim shows developmental toxicity and neurotoxicity in zebrafish embryos and larvae .

HY-B0510R

Trimethoprim (Standard)	Reference Standards Antifolate Bacterial Antibiotic Influenza Virus	Infection
Trimethoprim (Standard) is the analytical standard of Trimethoprim. This product is intended for research and analytical applications. Trimethoprim is a bacteriostatic antibiotic and an orally active dihydrofolate reductase inhibitor. Trimethoprim is active against a wide range of Gram-positive and Gram-negative aerobic bacteria. Trimethoprim has the potential for the research of urinary tract infections, Shigellosis and Pneumocystis pneumonia. Trimethoprim can inhibit infection of Influenza A virus in chick embryo when combinated with zinc .

HY-131492

Δ4-Dafachronic acid	Endogenous Metabolite VD/VDR	Metabolic Disease
Δ4‑Dafachronic acid is an endogenous steroid hormone, an agonist of the DAF‑12 nuclear receptor, and a key ligand for the vitamin D receptor (VDR). Δ4‑Dafachronic acid promotes the active escape developmental trajectory in Austrofundulus limnaeus embryos even under diapause‑inducing conditions. Δ4‑Dafachronic acid is suitable for research on the developmental biology .

HY-W250743

Cresyl diphenyl phosphate	Biochemical Assay Reagents	Others
Cresyl diphenyl phosphate is a compound that disrupts lipid homeostasis in zebrafish embryos, causing alterations in lipid content and lipidomic profiles, as well as affecting gene expression and energy homeostasis. \|

HY-128683

Cycloposine	Biochemical Assay Reagents	Others
Cycloposine is a steroidal alkaloid that can be found in the roots and rhizomes of Veratrum californicum. Cycloposine is also a teratogenic compound that may induce cyclopia in pregnant Mianyang embryos .

HY-139059

ERD03 1 Publications Verification	DNA Alkylator/Crosslinker	Neurological Disease
ERD03 is a potent disruptor of the EXOSC3-RNA interaction, with a K_d of 17±7 μM . ERD03 induces PCH1B-like phenotype in zebrafish embryo and can be used for neurological disorder disease research .

HY-N8492

Monascorubrin	Bacterial Calcium Channel	Infection Inflammation/Immunology Cancer
Monascorubrin is a compound that can be isolated from Monascus mycelia. Monascorubrin has activities such as anti-inflammatory, anti-tumor, antibacterial, and immunomodulatory. Monascorubrin also has certain embryotoxicity, with an ED₅₀ of 4.3 μg for chicken embryos. Monascorubrin can be used for the research of tumors and inflammatory diseases .

HY-78574

N-Benzoylcytidine	Nucleoside Antimetabolite/Analog	Others
N-Benzoylcytidine is a modified cytidine analogue that can be phosphorylated by uracil-cytidine kinase (UCK1 and UCK2). N-Benzoylcytidine can be used to synthesize 2-OH protective groups for solid-phase RNA synthesis, as well as synthetic oligonucleotides for UV induction and targeted gene silencing in zebrafish embryos .

HY-B0510B

Trimethoprim hydrochloride 10+ Cited Publications	Antifolate Bacterial Antibiotic Influenza Virus	Infection Cancer
Trimethoprim hydrochloride is a bacteriostatic antibiotic and an orally active dihydrofolate reductase inhibitor. Trimethoprim hydrochloride is active against a wide range of Gram-positive and Gram-negative aerobic bacteria. Trimethoprim hydrochloride has the potential for the research of urinary tract infections, Shigellosis and Pneumocystis pneumonia. Trimethoprim hydrochloride can inhibit infection of Influenza A virus in chick embryo when combinated with zinc .

HY-119966

CCT036477	Wnt β-catenin PPAR CDK	Cancer
CCT036477 is a Wnt/β-catenin pathway inhibitor. CCT036477 blocks transcription at β-catenin without altering its levels. CCT036477 inhibits proliferation of various cancer cells, development of embryos, and expression of Wnt target genes (PPARδ, Cyclin D1, TCF4, and ID2) .

HY-P1015

VIP(Guinea pig) Vasoactive Intestinal Peptide, guinea pig	PACAP Receptor	Neurological Disease Metabolic Disease
VIP Guinea pig (Vasoactive intestinal peptide), a trophic and mitogenic factor, stimulates growth in whole cultured embryos. VIP Guinea pig functions as a simple gastrointestinal hormone and suggest a possible neurotransmitter function .

HY-N2238

Dipsanoside A	Others	Metabolic Disease
Dipsanoside A is a novel tetrairidoid glucoside from Dipsacus asper. Dipsacus asper Wall., a perennial plant widespread in China, has been used in traditional Chinese medicine for hundreds of years as a tonic for refreshment, as a fissiparism promoter of the osseous cells, and as an embryo security agent, etc .

HY-A0096R

Iloprost (Standard) Ciloprost (Standard); ZK 36374 (Standard)	Reference Standards Prostaglandin Receptor Endogenous Metabolite	Endocrinology Cancer
Iloprost (Standard) is the analytical standard of Iloprost. This product is intended for research and analytical applications. Iloprost (ZK 36374; Ciloprost) is a prostacyclin (PGI2) analogue, involves in embryo development and inflammation improvement, and inhibits tumor metastasis. Iloprost can be used for peripheral vascular research .

HY-N2236

Dipsanoside B	Others	Infection
Dipsanoside B is a novel tetrairidoid glucoside from Dipsacus asper. Dipasandin B shows s an anti-osteoarthritis effect. Dipsacus asper Wall., a perennial plant widespread in China, has been used in traditional Chinese medicine for hundreds of years as a tonic for refreshment, as a fissiparism promoter of the osseous cells, and as an embryo security agent, etc .

HY-117617

CAY10669	Histone Acetyltransferase	Cancer
CAY10669 (compound 6d) is an anacardic acid (HY-N2020) derivative that inhibits histone acetyltransferase PCAF with an IC₅₀ of 662 μM . CAY10669 enhances the SAHA-induced acetylation in HEPG2 cells, exhibits cytotoxicity in zebrafish embryo, promotes transgene expression in CHO-K1 cells .

HY-N1738

2-Methoxystypandrone	Others	Others
2-Methoxystypandroneis a naphthoquinonethat can be found inPolygonum cuspidatum. 2-Methoxystypandrone showsantioxidantactivities. 2-Methoxystypandrone improves developmental competence of bovine embryos .

HY-N6726S

Fumonisin B3-13C34	Isotope-Labeled Compounds Fungal Endogenous Metabolite	Infection Cancer
Fumonisin B3- ¹³C₃₄ is the ¹³C labeled Fumonisin B3 (HY-N6726). Fumonisin B3 is an orally active fumonisin Mycotoxin. Fumonisin B3 can be isolated from Fusarium moniliforme, Fusarium proliferatum and Fusarium nygamai. Fumonisin B3 induces precancerous lesions, triggers embryonic death of chicken embryos, causes severe hemorrhage in dead chicken embryos. Fumonisin B3 can be used in studies related to hepatocellular carcinoma .

HY-N12201

Funiculosin	Antibiotic Fungal	Infection
Funiculosin is a neutral lipophilic antibiotic that inhibits DNA and RNA viruses. Funiculosin also has antifungal activity. Funiculosin inhibits infections caused by pathogenic fungi in primary chicken embryo fibroblasts .

HY-B1944

Dipropyl phthalate	Apoptosis FOXO	Others
Dipropyl phthalate is a plasticizer. Dipropyl phthalate induced activation of the FoxO signaling pathway, leading to abnormal proliferation of pharyngeal arch cartilage and promoting its apoptosis in a zebrafish model. Dipropyl phthalate also induced developmental defects in the craniofacial cartilage of zebrafish embryos in a zebrafish model .

HY-136439

4-Epianhydrotetracycline hydrochloride	Bacterial Antibiotic Apoptosis	Infection
4-Epianhydrotetracycline hydrochloride is a major intermediate product of Tetracycline (HY-A0107). 4-Epianhydrotetracycline hydrochloride shows lethal effects and induces cell apoptosis of zebrafish embryos. 4-Epianhydrotetracycline hydrochloride inhibits Shewanella, E. coli and P. aeruginosa with MIC values of 2, 1 and 64 mg/L, respectively .

HY-W014004

m-Carboxycinnamic acid bishydroxamide CBHA	HDAC Apoptosis	Others Cancer
m-Carboxycinnamic acid bishydroxamide (CBHA) is a histone deacetylase inhibitor. m-Carboxycinnamic acid bishydroxamide modulates histone acetylation sites, alters DNA methylation and epigenetic status, increases global histone acetylation, alleviates transcription repression, and facilitates chromatin remodelling. m-Carboxycinnamic acid bishydroxamide can be used for the research of cloned embryo development and epigenetic regulation .

HY-A0277R

Cyproconazole (Standard)	Reference Standards Fungal	Others
Cyproconazole (Standard) is the analytical standard of Cyproconazole. This product is intended for research and analytical applications. Cyproconazole is a triazole fungicide used to protect crops, fruits and vegetables against a wide range of fungal pathogens. Cyproconazole can cause hepatocellular adenomas and carcinomas in CD-1 mice. Cyproconazole also exhibits low toxicity to zebrafish embryos and affects locomotor activity .

HY-136380

Clodinafop-propargyl	Herbicide	Others
Clodinafop-propargyl, a main member of aryloxyphenoxy-propionate herbicides, is used for postemergence control of annual grasses in cereals, including Avena, Lolium, Setaria, Phalaris and Alopecurus spp . Clodinafop-propargyl is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. Clodinafop-propargyl has developmental toxicity to zebrafish embryos .

HY-D1585

BODIPY TR methyl ester	Fluorescent Dye	Others
BODIPY TR methyl ester is a lipophilic GFP Counterstain. BODIPY TR methyl ester dye readily permeates cell membranes and localizes in endomembranous organelles but not localize strongly in plasma membranes. BODIPY TR methyl ester is an excellent red fluorescent vital dye (Ex=568 nm, Em=625 nm), can be used to reveal the location and shapes of cell nuclei, the shapes of cells within embryonic tissues, as well as the bound aries of organ-forming tissues within the whole embryo .

HY-124021

Benzyl 2-naphthyl ether	Aryl Hydrocarbon Receptor	Others
Benzyl 2-naphthyl ether is a compound mentioned in the study of the effects of aromatic sensitizers on zebrafish embryos. It can cause morphological abnormalities and changes in gene expression in zebrafish embryos. Its toxicity mechanism is partly related to AHR, and there may be other mechanisms independent of AHR.

HY-108475

ProINDY	DYRK	Cancer
ProINDY, a prodrug of INDY (HY-108476), is a DYRK1A and DYRK1B inhibitor. ProINDY effectively recovers Xenopus embryos from head malformation induced by Dyrk1A overexpression .

HY-N15389

Noformicin	Influenza Virus	Infection
Noformicin has inhibitory effect on mumps virus and Newcastle disease virus in chicken embryo. Noformicin also extended the survival of mice infected with swine, influenza A (PR8) and influenza B (Lee) viruses .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-B1777

Spermine 5+ Cited Publications NSC 268508; Neuridine	Natural Products Human Gut Microbiota Metabolites Microorganisms Classification of Application Fields Metabolic Disease Endogenous metabolite Disease Research Fields Source Classification	Endogenous Metabolite Bacterial Reactive Oxygen Species (ROS) DNA/RNA Synthesis
Spermine is a natural antioxidant and anti-inflammatory agent. Spermine is known to inhibit some bacterial cultures, especially strains of Staphylococcus aureus. Spermine induces neurotoxicity in the striarum dose-dependently. Spermine can reversibly inhibits DNA synthetic response, mixed lymphocyte response and the induction of cytolytic lymphocyte response in primary cultures of murine spleen cells. Spermine tetrahydrochloride is a polyamine nitric oxide donor that can provide nitric oxide to platelets and inhibit platelet activation to a certain extent concentration-dependently. Spermine tetrahydrochloride occurs in mammalian tissues, plants, bacteria, ribosomes and bacteriophage. Spermine tetrahydrochloride inhibits primary human embryo lung fibroblasts in vitro .

HY-A0096

Iloprost 5 Publications Verification Ciloprost; ZK 36374	Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Endogenous metabolite Disease Research Fields Endocrinology Source Classification Cancer	Prostaglandin Receptor Endogenous Metabolite
Iloprost (ZK 36374; Ciloprost) is a prostacyclin (PGI2) analogue, involves in embryo development and inflammation improvement, and inhibits tumor metastasis. Iloprost can be used for peripheral vascular research .

HY-B0642

Isosorbide mononitrate 5 Publications Verification Isosorbide-5-mononitrate	Cardiovascular Disease Structural Classification Natural Products Classification of Application Fields Endogenous metabolite Disease Research Fields Source Classification Cancer	Autophagy Endogenous Metabolite Apoptosis
Isosorbide mononitrate (Isosorbide-5-mononitrate) is an orally active nitric acid compound used for angina pectoris by dilating blood vessels and lowering blood pressure. Isosorbide mononitrate increases the viability and proliferation of HUVECs by decreasing Apoptosis and elevated the expressions of vedf, kdrl, pdgfr in zebrafish embryos. Isosorbide mononitrate is promising for research of heart failure and coronary heart disease .

HY-N0770

Isoliensinine 4 Publications Verification	Alkaloids Monophenols Classification of Application Fields Phenols Nelumbo nucifera Gaertn. Plants Isoquinoline Alkaloids Nymphaeaceae Inflammation/Immunology Disease Research Fields Source Classification	Apoptosis
Isoliensinine is a bisbenzylisoquinoline alkaloid extracted from the seed embryo of Nelumbo nucifera, with anti-oxidant and anti-inflammatory and anti-cancer activities. Isoliensinine induces apoptosis in triple-negative human breast cancer cells .

HY-B1777A

Spermine tetrahydrochloride 5+ Cited Publications	Natural Products Classification of Application Fields Metabolic Disease Endogenous metabolite Disease Research Fields Source Classification	Endogenous Metabolite Bacterial Reactive Oxygen Species (ROS) DNA/RNA Synthesis
Spermine tetrahydrochloride is a polyamine nitric oxide donor that can provide nitric oxide to platelets and inhibit platelet activation to a certain extent concentration-dependently. Spermine tetrahydrochloride occurs in mammalian tissues, plants, bacteria, ribosomes and bacteriophage. Spermine tetrahydrochloride inhibits primary human embryo lung fibroblasts in vitro. Spermine is a natural antioxidant and anti-inflammatory agent. Spermine is known to inhibit some bacterial cultures, especially strains of Staphylococcus aureus. Spermine induces neurotoxicity in the striarum dose-dependently. Spermine can reversibly inhibits DNA synthetic response, mixed lymphocyte response and the induction of cytolytic lymphocyte response in primary cultures of murine spleen cells .

HY-N0735

Phellodendrine chloride 2 Publications Verification	Alkaloids Phellodendron amurense Rupr. Classification of Application Fields Rutaceae Phenols Polyphenols Plants Isoquinoline Alkaloids Disease Research Fields Source Classification Cancer	Autophagy Apoptosis AMPK mTOR STAT Interleukin Related PKC p38 MAPK NF-κB COX Reactive Oxygen Species (ROS) PI3K Akt MMP
Phellodendrine chloride is an orally active plant alkaloid. Phellodendrine chloride inhibits the proliferation of KRAS-mutated pancreatic cancer cells by suppressing macropinocytosis and glutamine metabolism, inducing ROS accumulation and mitochondrial apoptosis. Phellodendrine chloride promotes autophagy by activating the AMPK/mTOR pathway, alleviating intestinal damage in ulcerative colitis. Phellodendrine chloride can alleviate gouty arthritis by inhibiting the IL-6/STAT3 signaling pathway. Phellodendrine chloride suppresses allergic reactions by altering the conformation of MRGPRB3/MRGPRX2 protein, thereby inhibiting the activation of PKC and subsequent downstream MAPK and NF-κB signaling. Phellodendrine chloride inhibits the AKT/NF-κB pathway and down-regulates the expression of COX-2, thereby protecting zebrafish embryos from oxidative stress. Phellodendrine chloride has an anti-major depressive disorder (MDD) effect by down-regulating CHRM1, HTR1A, and the PI3K/Akt signaling pathway .

HY-N0485

Liensinine Diperchlorate Maximum Cited Publications 20 Publications Verification	Cardiovascular Disease Alkaloids Piperidine Alkaloids Classification of Application Fields Phenols Polyphenols Nelumbo nucifera Gaertn. Plants Disease Research Fields Nymphaeaceae Source Classification	Autophagy Mitophagy
Liensinine Diperchlorate is a major isoquinoline alkaloid, extracted from the seed embryo of Nelumbo nucifera Gaertn. Liensinine Diperchlorate inhibits late-stage autophagy/mitophagy through blocking autophagosome-lysosome fusion. Liensinine Diperchlorate has a wide range of biological activities, including anti-arrhythmias, anti-hypertension, anti-pulmonary fibrosis, relaxation on vascular smooth muscle, etc .

HY-N6786

Ochratoxin B	Structural Classification Monophenols Microorganisms Classification of Application Fields Coumarins Phenols Phenylpropanoids Disease Research Fields Source Classification Cancer	Endogenous Metabolite
Ochratoxin B is an orally active secondary metabolite of Aspergillus ochraceus and non-chlorinated analog of the mycotoxin Ochratoxin A. Ochratoxin B reduces the toxic effects of Ochratoxin A (HY-N6788). Ochratoxin B inhibits cell division. Ochratoxin B causes craniofacial malformations in Xenopus laevis embryos .

HY-127170

3-Hydroxycoumarin	Structural Classification other families Classification of Application Fields Other Diseases Coumarins Phenylpropanoids Plants Disease Research Fields Source Classification	Lipoxygenase Tyrosinase
3-Hydroxycoumarin is an inhibitor of tyrosinase and lipoxygenase with an IC₅₀ for recombinant human tyrosinase (rHT) of 26 μM, and a K_i of 3.39 μM; its IC₅₀ for LOX is 9.5 μM. 3-Hydroxycoumarin has DPPH free radical scavenging activity (IC₅₀ = 31.2 μM). 3-Hydroxycoumarin has photoprotective effects on sea urchin zygotes and embryos .

HY-N6726

Fumonisin B3	Infection Structural Classification Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Disease Research Fields Source Classification	Fungal Endogenous Metabolite
Fumonisin B3 is an orally active fumonisin Mycotoxin. Fumonisin B3 can be isolated from Fusarium moniliforme, Fusarium proliferatum and Fusarium nygamai. Fumonisin B3 induces precancerous lesions, triggers embryonic death of chicken embryos, causes severe hemorrhage in dead chicken embryos. Fumonisin B3 can be used in studies related to hepatocellular carcinoma .

HY-N0427

Phellodendrine	Alkaloids Phellodendron amurense Rupr. Classification of Application Fields Rutaceae Phenols Polyphenols Quinoline Alkaloids Plants Inflammation/Immunology Disease Research Fields Source Classification	Akt NF-κB AMPK mTOR PKC STAT Interleukin Related p38 MAPK COX Reactive Oxygen Species (ROS) Apoptosis Autophagy PI3K MMP
Phellodendrine is an orally active plant alkaloid. Phellodendrine inhibits the proliferation of KRAS-mutated pancreatic cancer cells by suppressing macropinocytosis and glutamine metabolism, inducing ROS accumulation and mitochondrial apoptosis. Phellodendrine promotes autophagy by activating the AMPK/mTOR pathway, alleviating intestinal damage in ulcerative colitis. Phellodendrine can alleviate gouty arthritis by inhibiting the IL-6/STAT3 signaling pathway. Phellodendrine suppresses allergic reactions by altering the conformation of MRGPRB3/MRGPRX2 protein, thereby inhibiting the activation of PKC and subsequent downstream MAPK and NF-κB signaling. Phellodendrine inhibits the AKT/NF-κB pathway and down-regulates the expression of COX-2, thereby protecting zebrafish embryos from oxidative stress. Phellodendrine has an anti-major depressive disorder (MDD) effect by down-regulating CHRM1, HTR1A, and the PI3K/Akt signaling pathway .

HY-128683

Cycloposine	Liliaceae Classification of Application Fields Other Diseases Veratrum californicum Durand Plants Disease Research Fields Steroids	Biochemical Assay Reagents
Cycloposine is a steroidal alkaloid that can be found in the roots and rhizomes of Veratrum californicum. Cycloposine is also a teratogenic compound that may induce cyclopia in pregnant Mianyang embryos .

HY-N8492

Monascorubrin	Infection Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Disease Research Fields Source Classification	Bacterial Calcium Channel
Monascorubrin is a compound that can be isolated from Monascus mycelia. Monascorubrin has activities such as anti-inflammatory, anti-tumor, antibacterial, and immunomodulatory. Monascorubrin also has certain embryotoxicity, with an ED₅₀ of 4.3 μg for chicken embryos. Monascorubrin can be used for the research of tumors and inflammatory diseases .

HY-N2238

Dipsanoside A	Iridoids Classification of Application Fields Terpenoids Dipsacaceae Metabolic Disease Dipsacus asper Wall. Plants Disease Research Fields Source Classification	Others
Dipsanoside A is a novel tetrairidoid glucoside from Dipsacus asper. Dipsacus asper Wall., a perennial plant widespread in China, has been used in traditional Chinese medicine for hundreds of years as a tonic for refreshment, as a fissiparism promoter of the osseous cells, and as an embryo security agent, etc .

HY-A0096R

Iloprost (Standard) Ciloprost (Standard); ZK 36374 (Standard)	Structural Classification Ketones, Aldehydes, Acids Endogenous metabolite Source Classification	Reference Standards Prostaglandin Receptor Endogenous Metabolite
Iloprost (Standard) is the analytical standard of Iloprost. This product is intended for research and analytical applications. Iloprost (ZK 36374; Ciloprost) is a prostacyclin (PGI2) analogue, involves in embryo development and inflammation improvement, and inhibits tumor metastasis. Iloprost can be used for peripheral vascular research .

HY-N2236

Dipsanoside B	Infection Structural Classification Iridoids Classification of Application Fields Terpenoids Dipsacaceae Dipsacus asper Wall. Plants Disease Research Fields Source Classification	Others
Dipsanoside B is a novel tetrairidoid glucoside from Dipsacus asper. Dipasandin B shows s an anti-osteoarthritis effect. Dipsacus asper Wall., a perennial plant widespread in China, has been used in traditional Chinese medicine for hundreds of years as a tonic for refreshment, as a fissiparism promoter of the osseous cells, and as an embryo security agent, etc .

HY-N1738

2-Methoxystypandrone	Quinones Polygonaceae Reynoutria japonica Houtt. Plants Naphthalene Quinones Source Classification	Others
2-Methoxystypandroneis a naphthoquinonethat can be found inPolygonum cuspidatum. 2-Methoxystypandrone showsantioxidantactivities. 2-Methoxystypandrone improves developmental competence of bovine embryos .

HY-N12201

Funiculosin	Microorganisms Antibiotics Other Antibiotics Source Classification	Antibiotic Fungal
Funiculosin is a neutral lipophilic antibiotic that inhibits DNA and RNA viruses. Funiculosin also has antifungal activity. Funiculosin inhibits infections caused by pathogenic fungi in primary chicken embryo fibroblasts .

HY-N15389

Noformicin	Microorganisms Antibiotics Other Antibiotics Source Classification	Influenza Virus
Noformicin has inhibitory effect on mumps virus and Newcastle disease virus in chicken embryo. Noformicin also extended the survival of mice infected with swine, influenza A (PR8) and influenza B (Lee) viruses .

HY-N10802

6-O-Isobutyrylbritannilactone	Terpenoids Orchidaceae Andira inermis (W.Wright) DC. Plants Compositae Source Classification	ERK Akt PI3K Epigenetic Reader Domain
6-O-Isobutyrylbritannilactone is a natural melanogenesis inhibitor. 6-O-Isobutyrylbritannilactone, a sesquiterpene, can be isolated from the flowers of Inula britannica. 6-O-Isobutyrylbritannilactone inhibits IBMX (HY-12318)-induced melanin production in B16F10 cells. 6-O-Isobutyrylbritannilactone also regulates ERK, PI3K/AKT, and CREB, shows antimelanogenic activity in zebrafish embryos models .

HY-N0735R

Phellodendrine chloride (Standard)	Alkaloids Structural Classification Phellodendron amurense Rupr. Rutaceae Phenols Polyphenols Plants Isoquinoline Alkaloids Source Classification	Reference Standards Autophagy mTOR AMPK Apoptosis STAT Interleukin Related PKC p38 MAPK NF-κB COX Reactive Oxygen Species (ROS) PI3K Akt MMP
Phellodendrine chloride (Standard) is the analytical standard of Phellodendrine chloride (HY-N0735). Phellodendrine chloride is an orally active plant alkaloid. Phellodendrine chloride inhibits the proliferation of KRAS-mutated pancreatic cancer cells by suppressing macropinocytosis and glutamine metabolism, inducing ROS accumulation and mitochondrial apoptosis. Phellodendrine chloride promotes autophagy by activating the AMPK/mTOR pathway, alleviating intestinal damage in ulcerative colitis. Phellodendrine chloride can alleviate gouty arthritis by inhibiting the IL-6/STAT3 signaling pathway. Phellodendrine chloride suppresses allergic reactions by altering the conformation of MRGPRB3/MRGPRX2 protein, thereby inhibiting the activation of PKC and subsequent downstream MAPK and NF-κB signaling. Phellodendrine chloride inhibits the AKT/NF-κB pathway and down-regulates the expression of COX-2, thereby protecting zebrafish embryos from oxidative stress. Phellodendrine chloride has an anti-major depressive disorder (MDD) effect by down-regulating CHRM1, HTR1A, and the PI3K/Akt signaling pathway.

HY-N6726R

Fumonisin B3 (Standard)	Structural Classification Microorganisms Ketones, Aldehydes, Acids Source Classification	Reference Standards Fungal Endogenous Metabolite
Fumonisin B3 (Standard) is the analytical standard of Fumonisin B3. This product is intended for research and analytical applications. Fumonisin B3 is an orally active fumonisin Mycotoxin. Fumonisin B3 can be isolated from Fusarium moniliforme, Fusarium proliferatum and Fusarium nygamai. Fumonisin B3 induces precancerous lesions, triggers embryonic death of chicken embryos, causes severe hemorrhage in dead chicken embryos. Fumonisin B3 can be used in studies related to hepatocellular carcinoma .

HY-N0770R

Isoliensinine (Standard)	Alkaloids Structural Classification Monophenols Phenols Nelumbo nucifera Gaertn. Plants Isoquinoline Alkaloids Nymphaeaceae Source Classification	Reference Standards Apoptosis
Isoliensinine is a bisbenzylisoquinoline alkaloid extracted from the seed embryo of Nelumbo nucifera, with anti-oxidant and anti-inflammatory and anti-cancer activities. Isoliensinine induces apoptosis in triple-negative human breast cancer cells .

HY-N7821

Aphidicolin 17-acetate Aphidicolin 17-monoacetate	Structural Classification Natural Products Microorganisms Source Classification	DNA/RNA Synthesis
Aphidicolin 17-acetate is a selective eukaryotic DNA polymerase α inhibitor. Aphidicolin 17-acetate does not inhibit DNA polymerase β and γ. Aphidicolin 17-acetate markedly inhibits the in vivo DNA synthesis of sea urchin embryos and HeLa cells but not RNA and protein syntheses .

HY-N6786R

Ochratoxin B (Standard)	Structural Classification Monophenols Microorganisms Coumarins Phenols Phenylpropanoids Source Classification	Endogenous Metabolite Reference Standards
Ochratoxin B (Standard) is the analytical standard of Ochratoxin B (HY-N6786). This product is intended for research and analytical applications. Ochratoxin B is an orally active secondary metabolite of Aspergillus ochraceus and non-chlorinated analog of the mycotoxin Ochratoxin A. Ochratoxin B reduces the toxic effects of Ochratoxin A (HY-N6788). Ochratoxin B inhibits cell division. Ochratoxin B causes craniofacial malformations in Xenopus laevis embryos .

HY-B1777AR

Spermine tetrahydrochloride (Standard)	Structural Classification Natural Products Endogenous metabolite Source Classification	Reference Standards Endogenous Metabolite Bacterial Reactive Oxygen Species (ROS) DNA/RNA Synthesis
Spermine (tetrahydrochloride) (Standard) is the analytical standard of Spermine (tetrahydrochloride). This product is intended for research and analytical applications. Spermine tetrahydrochloride is a polyamine nitric oxide donor that can provide nitric oxide to platelets and inhibit platelet activation to a certain extent concentration-dependently. Spermine tetrahydrochloride occurs in mammalian tissues, plants, bacteria, ribosomes and bacteriophage. Spermine tetrahydrochloride inhibits primary human embryo lung fibroblasts in vitro. Spermine is a natural antioxidant and anti-inflammatory agent. Spermine is known to inhibit some bacterial cultures, especially strains of Staphylococcus aureus. Spermine induces neurotoxicity in the striarum dose-dependently. Spermine can reversibly inhibits DNA synthetic response, mixed lymphocyte response and the induction of cytolytic lymphocyte response in primary cultures of murine spleen cells .

HY-N13111

Neoliensinine	Monophenols Phenols Nelumbo nucifera Gaertn. Plants Nymphaeaceae Source Classification	Others
Neoliensinine is a benzylisoquinoline that effectively inhibits KCl (124 mM)-induced contraction of isolated mesenteric vascular smooth muscle (MVSM) with an IC₅₀ value of 2.407 μM. Neoliensinine can be isolated from the embryo of Nelumbo nucifera Gaertn., a traditional Chinese medicine.

HY-N19880

Oleanoglycotoxin A	Structural Classification Ketones, Aldehydes, Acids Phytolacca dodecandra L'Hér. Plants Phytolaccaceae Source Classification	Drug Derivative
Oleanoglycotoxin A is a saponin present in the berries of Phytolacca dodecandra, with antifertility and molluscicidal activities. Oleanoglycotoxin A prevents pregnancy, reduces the number of embryos, inhibits implantation, terminates established pregnancy, and kills Biomphalaria glabrata. Oleanoglycotoxin A can be used in studies related to schistosomiasis .

HY-N16734

Norviburtinal	Structural Classification Rehmannia glutinosa (Gaertn.) Libosch. ex Fisch. & C. A. Mey. Iridoids Terpenoids Orobanchaceae Plants Source Classification	Others
Norviburtinal is a non-selective cytotoxic and pro-angiogenic agent. Norviburtinal has an IC₅₀ of 3.25 μg/mL on G361 melanoma cells and an effective concentration of 50 μg/mL on zebrafish embryos. Norviburtinal promotes capillary sprout formation in zebrafish subintestinal vessels (SIV) and has both cytotoxic and pro-angiogenic activities. Norviburtinal can be used in research on promoting angiogenesis related to melanoma, lung cancer, and wound healing .

HY-N18470

Gadusol	Structural Classification Natural Products Animals Source Classification	DNA/RNA Synthesis Apoptosis Reactive Oxygen Species (ROS)
Gadusol is a potent, maternally supplied natural sunscreen. Gadusol is synthesized by the mother during oogenesis and stored in eggs, representing the primary sunscreen mechanism during the early developmental stages of fish. Gadusol directly prevents UVB-induced DNA damage and reduces the generation of ROS thereby avoiding cellular stress and apoptosis. Gadusol does not exert antioxidant functions in zebrafish embryos. Gadusol can be used in studies related to topical photoprotective cosmetics .

HY-117733

Zerumin A	Structural Classification Arecaceae Bercht. & J. Presl Ketones, Aldehydes, Acids Terpenoids Arecaceae Diterpenoids Plants Source Classification Zingiberaceae	Tie VEGFR
Zerumin A is an anti-angiogenic agent that acts on multiple molecular targets related to angiogenesis (including kdr/VEGFR2, angpt1, angpt2, tie1, and tie2). Zerumin A specifically inhibits the proliferation and migration of human umbilical vein endothelial cells (HUVECs) by regulating the VEGF-VEGFR and ANGPT-TIE signaling pathways, and dose-dependently inhibits angiogenesis (10-20 μM significantly inhibits zebrafish embryo angiogenesis). Zerumin A can be used in the research of cancer and angiogenesis-related inflammatory diseases. Zerumin A can be naturally extracted from the 95% ethanol extract of the fruits, seeds, and pericarp of Alpinia caerulea (R.Br.) Bentham (a plant of the Alpinia genus in the Zingiberaceae family) .

Cat. No.	Product Name	Chemical Structure

HY-B1777AS

Spermine-d8 tetrahydrochloride

Spermine-d₈ (tetrahydrochloride) is the deuterium labeled Spermine tetrahydrochloride. Spermine tetrahydrochloride is a polyamine nitric oxide donor that can provide nitric oxide to platelets and inhibit platelet activation to a certain extent concentration-dependently. Spermine tetrahydrochloride occurs in mammalian tissues, plants, bacteria, ribosomes and bacteriophage. Spermine tetrahydrochloride inhibits primary human embryo lung fibroblasts in vitro. Spermine is a natural antioxidant and anti-inflammatory agent. Spermine is known to inhibit some bacterial cultures, especially strains of Staphylococcus aureus. Spermine induces neurotoxicity in the striarum dose-dependently. Spermine can reversibly inhibits DNA synthetic response, mixed lymphocyte response and the induction of cytolytic lymphocyte response in primary cultures of murine spleen cells .

HY-W011927S

4,4'-Sulfonyldiphenol-d8

1 Publications Verification

4,4'-Sulfonyldiphenol-d₈ (Bisphenol S (4,4'-Sulfonyldiphenol)-d₈) is the deuterium labeled 4,4'-Sulfonyldiphenol (HY-W011927).4,4'-Sulfonyldiphenol (Bisphenol S; Bis(4-hydroxyphenyl) sulfone), a substitute for Bisphenol A (HY-18260), is widely used in industrial and consumer products. 4,4'-Sulfonyldiphenol is an estrogen receptor (ER) agonist and can competitively bind to thyroid hormone receptors (TR) with IC₅₀ values for TRα and TRβ are 2650 μM and 2294 μM respectively, thereby affecting breast development and reducing the expression of androgen receptor (AR) in fetal testes. 4,4'-Sulfonyldiphenol promotes the progression of glioblastoma by upregulating the EZH2 mediated PI3K/AKT/mTOR pathway. Under chronic exposure, 4,4'-Sulfonyldiphenol can cause significant lipid deposition and dyslipidemia in the mouse liver by upregulating JunB and Atf3, and has a role in causing obesity at low doses. 4,4'-Sulfonyldiphenol induces intestinal inflammation by altering the intestinal microbiome. 4,4'-Sulfonyldiphenol accelerates the progression of atherosclerosis in zebrafish embryo larvae.

HY-N6726S

Fumonisin B3-13C34

Fumonisin B3- ¹³C₃₄ is the ¹³C labeled Fumonisin B3 (HY-N6726). Fumonisin B3 is an orally active fumonisin Mycotoxin. Fumonisin B3 can be isolated from Fusarium moniliforme, Fusarium proliferatum and Fusarium nygamai. Fumonisin B3 induces precancerous lesions, triggers embryonic death of chicken embryos, causes severe hemorrhage in dead chicken embryos. Fumonisin B3 can be used in studies related to hepatocellular carcinoma .

HY-123230S

Trifloxystrobin-d6
Trifloxystrobin-d₆ is the deuterium labeled Trifloxystrobin. Trifloxystrobin (CGA 279202) is a fungicide, with EC₅₀s of 23.0 μg/L and 1.7 μg/L for Daphnia magna neonate and embryos, respectively, after treatment for 48 h .

HY-B0510S3

Trimethoprim-13C3

Trimethoprim- ¹³C₃ is the deuterium labeled Trimethoprim (HY-B0510) . Trimethoprim is a bacteriostatic antibiotic and an orally active dihydrofolate reductase inhibitor. Trimethoprim is active against a wide range of Gram-positive and Gram-negative aerobic bacteria. Trimethoprim has the potential for the research of urinary tract infections, Shigellosis and Pneumocystis pneumonia. Trimethoprim can inhibit infection of Influenza A virus in chick embryo when combinated with zinc .

HY-B1777S

Spermine-15N2

Spermine- ¹⁵N₂ (NSC 268508- ¹⁵N₂) is the ¹⁵N-labeled Spermine (HY-B1777). Spermine is a natural antioxidant and anti-inflammatory agent. Spermine is known to inhibit some bacterial cultures, especially strains of Staphylococcus aureus. Spermine induces neurotoxicity in the striarum dose-dependently. Spermine can reversibly inhibits DNA synthetic response, mixed lymphocyte response and the induction of cytolytic lymphocyte response in primary cultures of murine spleen cells. Spermine tetrahydrochloride is a polyamine nitric oxide donor that can provide nitric oxide to platelets and inhibit platelet activation to a certain extent concentration-dependently. Spermine tetrahydrochloride occurs in mammalian tissues, plants, bacteria, ribosomes and bacteriophage. Spermine tetrahydrochloride inhibits primary human embryo lung fibroblasts in vitro .

HY-N6726S1

Fumonisin B3-13C34-1

Fumonisin B3-13C34-1 is the isotopic internal standard of Fumonisin B3 (HY-N6726). Fumonisin B3 is an orally active fumonisin Mycotoxin. Fumonisin B3 can be isolated from Fusarium moniliforme, Fusarium proliferatum and Fusarium nygamai. Fumonisin B3 induces precancerous lesions, triggers embryonic death of chicken embryos, causes severe hemorrhage in dead chicken embryos. Fumonisin B3 can be used in studies related to hepatocellular carcinoma .

HY-136355S

Picoxystrobin-d3
Picoxystrobin-d₃ is the deuterium labeled Picoxystrobin (HY-136355). Picoxystrobin is a strobilurin fungicide. Picoxystrobin controls plant diseases by inhibiting mitochondrial respiration. Picoxystrobin is highly toxic to zebrafish embryos, causing developmental abnormalities, oxidative stress, and immunotoxicity .

HY-N6786S

Ochratoxin B-13C20
Ochratoxin B- ¹³C₂₀ is ¹³C-labeled Ochratoxin B (HY-N6786). Ochratoxin B is an orally active secondary metabolite of Aspergillus ochraceus and non-chlorinated analog of the mycotoxin Ochratoxin A. Ochratoxin B reduces the toxic effects of Ochratoxin A (HY-N6788). Ochratoxin B inhibits cell division. Ochratoxin B causes craniofacial malformations in Xenopus laevis embryos .

HY-131492S

Δ4-Dafachronic Acid-d3

Δ4-Dafachronic Acid-d₃ is deuterium labeled Δ4-Dafachronic acid (HY-131492). Δ4‑Dafachronic acid is an endogenous steroid hormone, an agonist of the DAF‑12 nuclear receptor, and a key ligand for the vitamin D receptor (VDR). Δ4‑Dafachronic acid promotes the active escape developmental trajectory in Austrofundulus limnaeus embryos even under diapause‑inducing conditions. Δ4‑Dafachronic acid is suitable for research on the developmental biology .

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-16658BG

Z-VAD-FMK	Caspase Apoptosis	Cancer
Z-VAD-FMK is a pan-caspase inhibitor and also an ICE-like protease inhibitor, which inhibits apoptosis by preventing the processing of CPP32 to its active form. Z-VAD-FMK sensitivity varies primarily due to differential expression of receptor-interacting protein 1 (RIP1). Z-VAD-FMK limits the cryopreservation-induced apoptosis by reducing caspase-3 activity of in vitro produced bovine embryos. Z-VAD-FMK is immunosuppressive in vitro and inhibits T cell proliferation without blocking the processing of caspase-8 and caspase-3. Z-VAD-FMK leads to a decrease in intracellular glutathione (GSH) with a concomitant increase in reactive oxygen species (ROS) levels in activated T cells. Z-VAD-FMK is due to oxidative stress via the depletion of GSH. Z-VAD-FMK can be used for the study of acute pancreatitis .

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