16051-77-7
Chemical Structure
Isosorbide mononitrate
Synonym(s): Isosorbide-5-mononitrate
- CAS. Nr.: 16051-77-7
- Formula:C6H9NO6
- Molecular Weight:191.14
IUPAC Name: (3R,3aS,6S,6aR)-6-hydroxyhexahydrofuro[3,2-b]furan-3-yl nitrate
InChIKey: YWXYYJSYQOXTPL-SLPGGIOYSA-N
SMILES: O=[N+]([O-])O[C@H]1[C@](OC[C@@H]2O)([H])[C@]2([H])OC1
Biological Activity: Isosorbide mononitrate (Isosorbide-5-mononitrate) is an orally active nitric acid compound used for angina pectoris by dilating blood vessels and lowering blood pressure. Isosorbide mononitrate increases the viability and proliferation of HUVECs by decreasing Apoptosis and elevated the expressions of vedf, kdrl, pdgfr in zebrafish embryos. Isosorbide mononitrate is promising for research of heart failure and coronary heart disease[1][2][3][4].
| Art. -Nr. | Produktname | Reinheit | Beschreibung | Pricing | |||||||||||||||||||
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Isosorbide mononitrate | 99.95% | Isosorbide mononitrate (Isosorbide-5-mononitrate) is an orally active nitric acid compound used for angina pectoris by dilating blood vessels and lowering blood pressure. Isosorbide mononitrate increases the viability and proliferation of HUVECs by decreasing Apoptosis and elevated the expressions of vedf, kdrl, pdgfr in zebrafish embryos. Isosorbide mononitrate is promising for research of heart failure and coronary heart disease. | ||||||||||||||||||||
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Isosorbide mononitrate (Standard) | 99.98% | Isosorbide mononitrate (Standard) is the analytical standard of Isosorbide mononitrate. This product is intended for research and analytical applications. Isosorbide mononitrate (Isosorbide-5-mononitrate) is a nitric acid compound used for angina pectoris by dilating blood vessels and lowering blood pressure. | ||||||||||||||||||||
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Isosorbide mononitrate-13C6 | Isosorbide mononitrate-13C6 (Isosorbide-5-mononitrate-13C6) is 13C-labeled Isosorbide mononitrate (HY-B0642). | |||||||||||||||||||||
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- [1]. Redfield MM, et al. Isosorbide Mononitrate in Heart Failure with Preserved Ejection Fraction. N Engl J Med. 2015 Dec 10;373(24):2314-24. [Content Brief]
- [2]. Abshagen UW. Pharmacokinetics of isosorbide mononitrate. Am J Cardiol. 1992 Nov 27;70(17):61G-66G. [Content Brief]
- [3]. Pipili-Synetos E, et al. Inhibition of angiogenesis, tumour growth and metastasis by the NO-releasing vasodilators, isosorbide mononitrate and dinitrate. Br J Pharmacol. 1995 Sep;116(2):1829-34. [Content Brief]
- [4]. Lv H, et al. Isosorbide mononitrate promotes angiogenesis in embryonic development of zebrafish. Genet Mol Biol. 2020 Jul 24;43(3):20190233. [Content Brief]
