2990123-10-7
Chemical Structure
5-Ph-IAA-AM
- CAS No.: 2990123-10-7
- Formula:C19H17NO4
- Molecular Weight:323.34
IUPAC Name: acetoxymethyl 2-(5-phenyl-1H-indol-3-yl)acetate
InChIKey: FGVMSTLYCNILJO-UHFFFAOYSA-N
SMILES: O=C(OCOC(C)=O)CC1=CNC2=C1C=C(C=C2)C3=CC=CC=C3
Biological Activity:
5-Ph-IAA-AM is an eggshell-permeable 5-Ph-IAA (HY-134653) analog which contains an acetoxymethyl (AM) group. 5-Ph-IAA-AM affords an enhanced protein degradation in laid embryos. 5-Ph-IAA-AM can be used to disclosure the roles of proteins in C. elegans, in particular those that are involved in embryogenesis and development, through temporally controlled protein degradation[1][2][3].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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5-Ph-IAA-AM | 98.21% | 5-Ph-IAA-AM is an eggshell-permeable 5-Ph-IAA (HY-134653) analog which contains an acetoxymethyl (AM) group. 5-Ph-IAA-AM affords an enhanced protein degradation in laid embryos. 5-Ph-IAA-AM can be used to disclosure the roles of proteins in C. elegans, in particular those that are involved in embryogenesis and development, through temporally controlled protein degradation. |
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- [1]. Negishi T, et al. The auxin-inducible degron 2 (AID2) system enables controlled protein knockdown during embryogenesis and development in Caenorhabditis elegans. Genetics. 2022 Feb 4;220(2):iyab218. [Content Brief]
- [2]. Goldner AN, et al. Evidence that tissue recoil in the early Drosophila embryo is a passive not active process[J]. Mol Biol Cell. 2023 Sep 1;34(10):br16. [Content Brief]
- [3]. Eijlers P, et al. A nematode-specific ribonucleoprotein complex mediates interactions between the major nematode spliced leader snRNP and its target pre-mRNAs. Nucleic Acids Res. 2024 Jul 8;52(12):7245-7260. [Content Brief]
Keywords
