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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
33 Results for "
extrinsic pathways
" in MedChemExpress (MCE) Product Catalog:
Products (33)
33 Results for "extrinsic pathways" in MCE Product Catalog:
8
8 Publications Verification
Cat. No.: HY-N0213
CAS No.: 18059-10-4
Synonyms: Verticinone; Raddeanine
2
2
2 Cited Publications
Target:
Domaines de recherche:
VII-31 is a potent NEDDylation pathway activator to inhibit the tumor progression in vitro and in vivo. VII-31 induces apoptosis via intrinsic and extrinsic pathways .
2
2 Cited Publications
Cat. No.: HY-N7043
CAS No.: 142796-21-2
1
Domaines de recherche:
ARC19499 sodium is an aptamer that inhibits tissue factor pathway inhibitor (TFPI) , thereby enabling clot initiation and propagation via the extrinsic pathway. The core aptamer binds tightly and specifically to TFPI. ARC19499 sodium blocks TFPI inhibition of both factor Xa and the TF/factor VIIa complex. ARC19499 sodium corrects thrombin generation in hemophilia A and B plasma and restores clotting in FVIII-neutralized whole blood.
Synonyms: Erinacine A
Category:
Cat. No.: HY-N2281
CAS No.: 97938-31-3
Category:
Flavonoids Leguminosae Flavonones Phenols Polyphenols Plants Sophora flavescens Aiton Disease Research Fields Inflammation/Immunology
Target:
Cat. No.: HY-153480
CAS No.: 1350667-54-7
Synonyms: BAX499
Domaines de recherche:
ARC19499 is an aptamer that inhibits tissue factor pathway inhibitor (TFPI) , thereby enabling clot initiation and propagation via the extrinsic pathway. The core aptamer binds tightly and specifically to TFPI. ARC19499 blocks TFPI inhibition of both factor Xa and the TF/factor VIIa complex. ARC19499 corrects thrombin generation in hemophilia A and B plasma and restores clotting in FVIII-neutralized whole blood.
Cat. No.: HY-172400
CAS No.: 3046390-69-3
Target:
Domaines de recherche:
FXIa-IN-16 is an orally active selective FXIa inhibitor with an IC50 of 0.19 nM. FXIa-IN-16 exerts highly selective competitive inhibition on endogenous FXIa, blocks the thrombin amplification loop to inhibit thrombosis, while preserving exogenous physiological hemostatic function. FXIa-IN-16 can be used in thrombosis-related research .
Cat. No.: HY-N7071
CAS No.: 79356-08-4
Synonyms: Maduramycin
Target:
Cat. No.: HY-P10833
Cat. No.: HY-179124
Apoptosis inducer 52 is a derivative of flutamide that induces apoptosis in prostate cancer cells. Apoptosis inducer 52 promotes apoptosis by activating both intrinsic and extrinsic apoptotic pathways, without generating reactive oxygen species (ROS). Apoptosis inducer 52 triggers caspase 3/7 activity and the externalization of phosphatidylserine, leading to cell cycle arrest at the G0/G1 phase. Apoptosis inducer 52 can be used for the research of androgen receptor (AR)-dependent and -independent prostate cancers and leukemia .
Cat. No.: HY-172905
CAS No.: 885684-79-7
Target:
Domaines de recherche:
BCX-3607 is an orally active tissue factor/factor VIIa (TF-FVIIa) inhibitor (IC50: 4 nM). BCX-3607 blocks the extrinsic coagulation pathway by inhibiting the TF-FVIIa complex and significantly prolongs the prothrombin time (PT). BCX-3607 has a higher selectivity for TF-FVIIa than other serine proteases (such as thrombin, FXa, etc.). BCX-3607 can reduce thrombus weight and inflammatory response, and has both anti-thrombotic and anti-inflammatory effects. BCX-3607 can be used in the study of thrombosis-related diseases .
Cat. No.: HY-178099
Target:
Domaines de recherche:
Apoptosis inducer 45 is an apoptosis inducer. Apoptosis inducer 45 is cytotoxically active against the MCF-7 cell line. Apoptosis inducer 45 elicits MCF-7 cell apoptosis via the mitochondrial pathway (increases the Bax/Bcl-2 ratio) by activating cleavage of caspase-9, thereby inducing the fragmentation of DNA repair protein PARP. Apoptosis inducer 45 also can induce caspase-8 cleavage, subsequently initiating cleavage of caspase-3 and its downstream protein PARP to culminate in the extrinsic apoptosis. Apoptosis inducer 45 can be used in the research of breast cancer .
Cat. No.: HY-P990901
CAS No.: 2796349-94-3
Synonyms: IGM-8444
Target:
Domaines de recherche:
Cat. No.: HY-164489
CAS No.: 1260401-93-1
KU004 is a potent dual EGFR/HER2 inhibitor with anticancer effects. KU004 inhibits the proliferation of human breast cancer SKBR3 cells by inducing G1 phase arrest. KU004 blocks the activation of HER2, EGFR and downstream Akt and Erk pathways and induces cell Apoptosis mainly via the extrinsic pathway. KU004 is a quinazoline derivative .
Cat. No.: HY-N10018
CAS No.: 154822-57-8
Synonyms: 25-Anhydrocimigenol xyloside
Target:
Cat. No.: HY-N7043R
CAS No.: 142796-21-2
Cat. No.: HY-N7071AR
CAS No.: 84878-61-5
Synonyms: Maduramycin ammonium (Standard)
Category:
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
