491-74-7
491-74-7
Chemical Structure
Iridin
- CAS No.: 491-74-7
- Formula:C24H26O13
- Molecular Weight:522.46
IUPAC Name: 5-hydroxy-3-(3-hydroxy-4,5-dimethoxyphenyl)-6-methoxy-7-(((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)-4H-chromen-4-one
InChIKey: LNQCUTNLHUQZLR-OZJWLQQPSA-N
SMILES: O=C1C2=C(O)C(OC)=C(O[C@@H]3O[C@@H]([C@@H](O)[C@H](O)[C@H]3O)CO)C=C2OC=C1C4=CC(OC)=C(OC)C(O)=C4
Biological Activity: Iridin is an orally active natural isoflavone. Iridin inhibits the PI3K/AKT and PKM2 signaling pathways, and downregulates the JAK/STAT and NF-κB pathways. Iridin induces Fas-mediated extrinsic apoptosis, G2/M cell cycle arrest, and inhibits cell proliferation. Iridin reduces inflammation, inhibits ROS production, suppresses glycolysis, and also exhibits antioxidant and antidiabetic activities. Iridin can be used in research related to gastric cancer and acute lung injury[1][2][3].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Iridin | 99.72% | Iridin is an orally active natural isoflavone. Iridin inhibits the PI3K/AKT and PKM2 signaling pathways, and downregulates the JAK/STAT and NF-κB pathways. Iridin induces Fas-mediated extrinsic apoptosis, G2/M cell cycle arrest, and inhibits cell proliferation. Iridin reduces inflammation, inhibits ROS production, suppresses glycolysis, and also exhibits antioxidant and antidiabetic activities. Iridin can be used in research related to gastric cancer and acute lung injury. | ||||||||||||||||||||
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Iridin (Standard) | ≥98% | Iridin (Standard) is the analytical standard of Iridin. This product is intended for research and analytical applications. Iridin is an orally active natural isoflavone. Iridin inhibits the PI3K/AKT and PKM2 signaling pathways, and downregulates the JAK/STAT and NF-κB pathways. Iridin induces Fas-mediated extrinsic apoptosis, G2/M cell cycle arrest, and inhibits cell proliferation. Iridin reduces inflammation, inhibits ROS production, suppresses glycolysis, and also exhibits antioxidant and antidiabetic activities. Iridin can be used in research related to gastric cancer and acute lung injury. | ||||||||||||||||||||
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Tectoridin | 99.52% | Tectoridin is a isoflavone isolated from Maackia amurensis. Tectoridin is a phytoestrogen and activates estrogen and thyroid hormone receptors. Tectoridin exerts the estrogenic effects via ER-dependent genomic pathway and GPR30-dependent nongenomic pathway. | ||||||||||||||||||||
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Cirsiliol 4′-glucoside | Cirsiliol 4′-glucoside is a free radical scavenger, found from Ruellia tuberosa L. Cirsiliol 4′-glucoside shows potential anti-diabetic activity. | |||||||||||||||||||||
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Centaurein | Centaurein, a flavonoid, is an IFN-γ promoter enhancer. Centaurein up-regulates the activity of NFAT and NF-κB enhancers. Centaurein increases the IFN-γ expression in T and NK cells and the serum IFN-γ level in mice. Centaureidin completely relaxes the contractions in intact rat aortic rings. Centaurein effectively protects mice against Listeria infection. | |||||||||||||||||||||
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3′-Hydroxytectorigenin-7-O-β-D-xylosyl-(1→6)-β-D-glucopyranoside | 3′-Hydroxytectorigenin-7-O-β-D-xylosyl-(1→6)-β-D-glucopyranoside is an antioxidant that can be found in Pueraria montana var. lobata. It exhibits DPPH radical scavenging activity, with an IC50 value of 42 μg/mL. | |||||||||||||||||||||
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4'-Methoxy-5,6-dihydroxyisoflavone-7-O-β-D-glucopyranoside | 4'-Methoxy-5,6-dihydroxyisoflavone-7-O-β-D-glucopyranoside is an isoflavonoid compound found in the rhizomes of Belamcanda chinensis with anti-inflammatory activity. | |||||||||||||||||||||
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Irisolidone 7-O-β-D-glucopyranoside | Irisolidone 7-O-β-D-glucopyranoside is an active compound. | |||||||||||||||||||||
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3′-Hydroxytectoridin | 3'-Hydroxytectoridin is a flavonoid that can be isolated from Belamcandae Rhizoma. | |||||||||||||||||||||
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Iristectorin B | 99.94% | Iristectorin B is an isoflavone from Iris tectorum, has anti-cancer activities in breast cancer. | ||||||||||||||||||||
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Iristectorin A | 99.24% | Iristectorin A, a natural product from Iris tectorum, has anti-cancer activities in breast cancer. | ||||||||||||||||||||
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Pratensein-7-O-β-D-glucopyranoside | 99.46% | Pratensein-7-O-β-D-glucopyranoside is a new isoflavone. | ||||||||||||||||||||
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References
- [1]. Won Y, et al. The Effects of Iridin and Irigenin on Cancer: Comparison with Well-Known Isoflavones in Breast, Prostate, and Gastric Cancers. Int J Mol Sci. 2025;26(6):2390. Published 2025 Mar 7. [Content Brief]
- [2]. Bhosale PB, et al. Iridin Induces G2/M Phase Cell Cycle Arrest and Extrinsic Apoptotic Cell Death through PI3K/AKT Signaling Pathway in AGS Gastric Cancer Cells. Molecules. 2021;26(9):2802. Published 2021 May 10. [Content Brief]
- [3]. Ying ZH, et al. Iridin Prevented Against Lipopolysaccharide-Induced Inflammatory Responses of Macrophages via Inactivation of PKM2-Mediated Glycolytic Pathways. J Inflamm Res. 2021;14:341-354. Published 2021 Feb 5. [Content Brief]
