Centaurein
Centaurein, a flavonoid, is an IFN-γ promoter enhancer. Centaurein up-regulates the activity of NFAT and NF-κB enhancers. Centaurein increases the IFN-γ expression in T and NK cells and the serum IFN-γ level in mice. Centaureidin completely relaxes the contractions in intact rat aortic rings. Centaurein effectively protects mice against Listeria infection[1][2][3][4].
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- CAS No.: 35595-03-0
- 화학식: C24H26O13
- 분자량:522.46
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보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- 순도&문서
- References
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Help & FAQs
Biological Activity
Centaurein (5-100 μg/mL, 24-72 h) can stimulate IFN-γ transcription in a T cell line (Jurkat cells) and splenocytes and up-regulates the activity of NFAT and NF-κB enhancers[1][2][3].
Centaurein (100 μg/mL, 24 h) up-regulates the transcription of T-bet and IFN-γ but not GATA-3 and IL-4 in T cells[2].
Centaurein (6 h) pretreatment reduces Listeria infection in macrophages from 46% to 15%, an effect partially reversed (34% infection) by IFN-γ-neutralizing antibody[2].
Centaureidin (10-100 μM) completely relaxes the contractions induced by Norepinephrine (NA) (HY-13715) (IC50 = 16.7 μM) or by a high K concentration (IC50 =16.1 μM) in intact rat aortic rings concentration-dependently[4].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:T cells
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Concentration:100 μg/mL
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Incubation Time:24 h
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Result:Increased the expression of T-bet by 5-fold.
Enhanced the transcription of IFN-γ but not IL-4 or GATA-3.
Centaurein (20 μg/mouse, i.p., single dose) augments the serum IFN-γ level in mice, which peaked 24 h post-injection[2].
Centaurein (20 μg/mouse, i.p., single dose) protects against and treats Listeriainfection in mice via up-regulation of IFN-γ and macrophage activation[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Listeria infection model established in 6-8 weeks C57BL/6J mice and IFN-γ−/− C57BL/6J mice[2]
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Dosage:20 μg/mouse
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Administration:i.p. for single dose
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Result:Protected mice against Listeria infection in a dose-dependent fashion.
Did not protect IFN-γ-knockout mice against Listeria infection, but Ampicillin (HY-B0522) at 1000 μg/mL could protect against Listeria infection.
Rescued 30% of the mice infected with a lethal dose of Listeria (2 × 10 6 CFU).
Rescued 70% of the mice that received the lethal dose of Listeria in combination with antibiotics (5 μg/mouse, 2 times/day for 3 days)
Chemical Information
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CAS No. 35595-03-0
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분자량 522.46
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화학식 C24H26O13
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SMILES
O=C1C2=C(O)C(OC)=C(O[C@@H]3O[C@@H]([C@H]([C@@H]([C@H]3O)O)O)CO)C=C2OC(C4=CC(O)=C(C=C4)OC)=C1OC
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Structure Classification
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Initial Source
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
[1]. Chang SL, et al. Flavonoids, centaurein and centaureidin, from Bidens pilosa, stimulate IFN-gamma expression. J Ethnopharmacol. 2007 Jun 13;112(2):232-6. [Content Brief]
[2]. Chang SL, Yeh HH, Lin YS, Chiang YM, Wu TK, Yang WC. The effect of centaurein on interferon-gamma expression and Listeria infection in mice. Toxicol Appl Pharmacol. 2007 Feb 15;219(1):54-61. [Content Brief]
[3]. Nikiema WA, et al. Systematic Review of Chemical Compounds with Immunomodulatory Action Isolated from African Medicinal Plants. Molecules. 2024 Apr 26;29(9):2010. [Content Brief]
[4]. Orallo F, et al. Preliminary study of the potential vasodilator effects on rat aorta of centaurein and centaureidin, two flavonoids from Centaurea corcubionensis. Planta Med. 1998 Mar;64(2):116-9. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Centaurein Related Classifications
HY-N13614 Related Classifications
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