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flea

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Apoptosis (5) Bcl-2 Family (2) Chloride Channel (1) Cytochrome P450 (2) Drug Derivative (1) Endogenous Metabolite (1) Environmental Pollutants (5) GABA Receptor (3) Insecticide (2) Isotope-Labeled Compounds (1) Parasite (14) Reactive Oxygen Species (ROS) (1) Reference Standards (4) SOD (1)
By Research Areas:	Cancer (2) Infection (14) Inflammation/Immunology (1) Metabolic Disease (1) Neurological Disease (6)

Inhibitors & Agonists

Natural
Products

Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-B0978

Diethyltoluamide DEET; N,N-Diethyl-m-toluamide	Environmental Pollutants Parasite	Infection Neurological Disease
Diethyltoluamide (DEET) is the most common active ingredient in insect repellents. It is intended to provide protection against mosquitoes, ticks, fleas, chiggers, leeches, and many other biting insects. Diethyltoluamide is toxic to hepatocytes and can lead to many physiological, pharmacological, and behavioral abnormalities, particularly motor deficits and learning and memory dysfunction .

HY-115584

Lufenuron	Environmental Pollutants Parasite	Infection
Lufenuron is an orally active lipophilic benzoylurea insecticide and a chitin synthesis inhibitor that can used for flea and fish lice control. Lufenuron inhibits moulting of arthropods. Lufenuron induces reproductive toxicity, genotoxic effects and oxidative stresses in pregnant albino rats and their fetuses .

HY-B0822

Fipronil	Environmental Pollutants Cytochrome P450 GABA Receptor Apoptosis	Neurological Disease
Fipronil is a broad-spectrum insecticide effective against Lepidoptera species as well as thrips, locusts, ants, cockroaches, fleas and ticks. Fipronil selectively inhibits GABA receptor with IC₅₀s of 30 nM and 1600 nM for cockroach and rat GABA receptors, respectively. Glutamate-gated chloride channels (GluCls), which are present in cockroaches but not in mammals, are sensitive to the blocking effect of Fipronil. Fipronil also induces apoptosis in HepG2 cells and promotes the expression of CYP1A1 and CYP3A4 mRNA in human hepatocytes .

HY-W099479

Insect repellent M 3535 Ethyl butylacetylaminopropionate; IR-3535	Environmental Pollutants Apoptosis Reactive Oxygen Species (ROS) Parasite SOD	Infection Inflammation/Immunology
Insect repellent M 3535 (Ethyl butylacetylaminopropionate) is a broad-spectrum, mild insect repellent based on the structure of β-alanine. Insect repellent M 3535 exerts repellent effects by interfering with the olfaction of mosquitoes, but it poses risks of developmental and cardiac toxicity to aquatic organisms such as zebrafish embryos in aquatic environments, and can activate oxidative stress responses .

HY-16730

Sarolaner 1 Publications Verification PF-6450567	Parasite	Infection
Sarolaner (PF-6450567) is an orally active and broad-spectrum ectoparasiticide. Sarolaner is an isoxazoline compound which shows efficacy against fleas and ticks on dogs, with a LC₈₀ value of 0.3 μg/mL against C. felis and a LC₁₀₀ value of 0.003 μg/mL against O. turicata .

HY-109077

Tigolaner BAY-1272858	GABA Receptor Parasite Chloride Channel	Infection Neurological Disease
Tigolaner (BAY-1272858) acts on γ-aminobutyric acid (GABA) and glutamate-gated chloride channels. Tigolaner has antiparasitic activity .

HY-B0822R

Fipronil (Standard)	Reference Standards GABA Receptor Cytochrome P450 Apoptosis	Neurological Disease
Fipronil (Standard) is the analytical standard of Fipronil. This product is intended for research and analytical applications. Fipronil is a broad-spectrum insecticide effective against Lepidoptera species as well as thrips, locusts, ants, cockroaches, fleas and ticks. Fipronil selectively inhibits GABA receptor with IC₅₀s of 30 nM and 1600 nM for cockroach and rat GABA receptors, respectively. Glutamate-gated chloride channels (GluCls), which are present in cockroaches but not in mammals, are sensitive to the blocking effect of Fipronil. Fipronil also induces apoptosis in HepG2 cells and promotes the expression of CYP1A1 and CYP3A4 mRNA in human hepatocytes .

HY-B0978R

Diethyltoluamide (Standard) DEET (Standard); N,N-Diethyl-m-toluamide (Standard)	Reference Standards Parasite	Infection Neurological Disease
Diethyltoluamide (Standard) is the analytical standard of Diethyltoluamide. This product is intended for research and analytical applications. Diethyltoluamide (DEET) is the most common active ingredient in insect repellents. It is intended to provide protection against mosquitoes, ticks, fleas, chiggers, leeches, and many other biting insects. Diethyltoluamide is toxic to hepatocytes and can lead to many physiological, pharmacological, and behavioral abnormal ities, particularly motor deficits and learning and memory dysfunction .

HY-107835

Flumethrin FCR 2769	Environmental Pollutants Apoptosis Bcl-2 Family Parasite Insecticide	Infection Cancer
Flumethrin (FCR 2769) is a pyrethroid insecticide and acaricide . Flumethrin targets voltage-gated sodium channels and estrogen receptor α (ERα). Flumethrin induces cytotoxicity, apoptosis, genotoxicity and DNA damage in breast cancer cells by regulating the expression of BCL2, BAX, TP53 and P21 genes. Flumethrin is applicable to relevant studies on ectoparasite infections (tick and flea burdens) in dogs and cats, as well as breast cancer .

HY-115584R

Lufenuron (Standard)	Parasite Reference Standards	Infection
Lufenuron (Standard) is the analytical standard of Lufenuron. This product is intended for research and analytical applications. Lufenuron is a lipophilic benzoylurea insecticide and a chitin synthesis inhibitor that can used for flea and fish lice control. Lufenuron inhibits moulting of arthropods .

HY-B0978S1

Diethyltoluamide-d7 DEET-d₇; N,N-Diethyl-m-toluamide-d₇	Parasite	Infection
Diethyltoluamide-d₇ is the deuterium labeled Diethyltoluamide . Diethyltoluamide is the most common active ingredient in insect repellents. It is intended to provide protection against mosquitoes, ticks, fleas, chiggers, leeches, and many other biting insects .

HY-172346

N-Hydroxy MDMA hemioxalate N-OH MDMA hemioxalate; flea hemioxalate	Drug Derivative	Neurological Disease Metabolic Disease
N-Hydroxy MDMA (N-OH MDMA) hemioxalate is an N-hydroxy analogue of 3,4-methylenedioxymethamphetamine (MDMA). N-Hydroxy MDMA hemioxalate can be rapidly metabolized to MDMA and MDA in rats, which are mainly excreted in urine, and can also be detected in hair .

HY-115584S

Lufenuron-13C6	Isotope-Labeled Compounds Parasite	Infection
Lufenuron- ¹³C₆ is a ¹³C-labeled Lufenuron. Lufenuron is a lipophilic benzoylurea insecticide and a chitin synthesis inhibitor that can used for flea and fish lice control. Lufenuron inhibits moulting of arthropods .

HY-B0978S

Diethyltoluamide-d10 DEET-d₁₀; N,N-Diethyl-m-toluamide-d₁₀	Parasite	Infection
Diethyltoluamide-d₁₀ is the deuterium labeled Diethyltoluamide . Diethyltoluamide is the most common active ingredient in insect repellents. It is intended to provide protection against mosquitoes, ticks, fleas, chiggers, leeches, and many other biting insects .

HY-W108381

Pyriprole	Parasite	Others
Pyriprole can be used against cat flea. Pyriprole disrupts the flea life cycle through killing of adult fleas before they lay eggs. Pyriprole has residual effect on debris from dog, which results in a decreased ability of cat flea larvae to complete development to the adult stage .

HY-115584B

Lufenuron, (-)-	Parasite	Infection
Lufenuron, (-)- is an active isomer form of Lufenuron. Lufenuron is a lipophilic benzoyl urea insecticide and chitin synthesis inhibitor that can be used for flea and fish lice control. Lufenuron inhibits the molting of arthropods .

HY-118839

trans-Phenothrin	Endogenous Metabolite	Infection
Trans-Phenothrin is a synthetic pyrethroid with activity against adult fleas and ticks. Trans-Phenothrin has shown significant differences in biological activity between its different enantiomers in comparison with fenvalerate and d-trans-phenothrin. Trans-Phenothrin is used in agriculture for its potential insecticide activity against pests such as Plutella xylostella .

HY-107835R

Flumethrin (Standard) FCR 2769 (Standard)	Reference Standards Insecticide Parasite Apoptosis Bcl-2 Family	Infection Cancer
Flumethrin (Standard) (FCR 2769 (Standard)) is the analytical standard of Flumethrin (HY-107835). This product is intended for research and analytical applications. Flumethrin (FCR 2769) is a pyrethroid insecticide and acaricide. Flumethrin targets voltage-gated sodium channels and estrogen receptor α (ERα). Flumethrin induces cytotoxicity, apoptosis, genotoxicity and DNA damage in breast cancer cells by regulating the expression of BCL2, BAX, TP53 and P21 genes. Flumethrin is applicable to relevant studies on ectoparasite infections (tick and flea burdens) in dogs and cats, as well as breast cancer.

HY-N17847

Quercetin-3-O-β-D-xylosyl-(1→2)-β-D-galactoside	Others	Others
Quercetin-3-O-β-D-xylosyl-(1→2)-β-D-galactoside (compound 2) is a flavonol glycoside. Quercetin-3-O-β-D-xylosyl-(1→2)-β-D-galactoside occurs in the leaves of horseradish Armoracia rusticana. Quercetin-3-O-β-D-xylosyl-(1→2)-β-D-galactoside serves as one of the feeding stimulants for the flea beetle Phyllotreta armoraciae .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N17847

Quercetin-3-O-β-D-xylosyl-(1→2)-β-D-galactoside	Structural Classification Flavonols Flavonoids Plants Brassicaceae Armoracia rusticana G. Gaertn., B. Mey. & Scherb. Source Classification	Others
Quercetin-3-O-β-D-xylosyl-(1→2)-β-D-galactoside (compound 2) is a flavonol glycoside. Quercetin-3-O-β-D-xylosyl-(1→2)-β-D-galactoside occurs in the leaves of horseradish Armoracia rusticana. Quercetin-3-O-β-D-xylosyl-(1→2)-β-D-galactoside serves as one of the feeding stimulants for the flea beetle Phyllotreta armoraciae .

Cat. No.	Product Name	Chemical Structure

HY-B0978S1

Diethyltoluamide-d7
Diethyltoluamide-d₇ is the deuterium labeled Diethyltoluamide . Diethyltoluamide is the most common active ingredient in insect repellents. It is intended to provide protection against mosquitoes, ticks, fleas, chiggers, leeches, and many other biting insects .

HY-115584S

Lufenuron-13C6
Lufenuron- ¹³C₆ is a ¹³C-labeled Lufenuron. Lufenuron is a lipophilic benzoylurea insecticide and a chitin synthesis inhibitor that can used for flea and fish lice control. Lufenuron inhibits moulting of arthropods .

HY-B0978S

Diethyltoluamide-d10
Diethyltoluamide-d₁₀ is the deuterium labeled Diethyltoluamide . Diethyltoluamide is the most common active ingredient in insect repellents. It is intended to provide protection against mosquitoes, ticks, fleas, chiggers, leeches, and many other biting insects .

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flea

Inhibitors & Agonists

NaturalProducts

Isotope-Labeled Compounds

Natural
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