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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
4 Results for "
fructose-1,6-bisphosphatase (FBPase-1)
" in MedChemExpress (MCE) Product Catalog:
Products (4)
4 Results for "fructose-1,6-bisphosphatase (FBPase-1)" in MCE Product Catalog:
7
7 Cited Publications
Cat. No.: HY-16307
CAS No.: 261365-11-1
Target:
Research Areas:
MB05032 is a fructose-1,6-bisphosphatase (FBP1/FBPase) inhibitor with an IC50 value of 16 nM. MB05032 blocks FBP1-mediated glycolysis inhibition in NK cells, restores NK cell glucose uptake, lactate production, degranulation, perforin production, and cytotoxicity against gastric cancer cells. MB05032 elevates ATP/ADP ratios, increases glucose utilization, and enhances insulin secretion in pancreatic β-cells. MB05032 increases neutrophil adhesion, phagocytosis, and mRNA abundance of HKII, ITGA9, CD36 in subclinically hypocalcemic dairy cows. MB05032 inhibits gluconeogenesis in hepatocytes, acts as the active metabolite of prodrug Managlinat dialanetil (MB06322) (HY-14955). MB05032 can be used for the research of gastric cancer, type 2 diabetes, subclinical hypocalcemia, and insulin resistance [1] .
2
2 Cited Publications
Cat. No.: HY-P70275
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: FBP1; Liver FBPase; Prev. FBP; Growth-Inhibiting Protein 17; fructose-1,6-bisphosphatase 1; fructose-bisphosphatase; D-fructose-1,6-Bisphosphate 1-Phosphohydrolase 1; fructose-bisphosphatase 1; FBPase 1
Species:
Human
Source:
HEK293
Target:
Research Areas:
FBPase-IN-1 is a potent FBPase (Fructose-1,6-bisphosphatase) inhibitor for Type 2 diabetes (T2D) study with an IC50 of 0.22 μM. FBPase-IN-1 can reduce blood glucose levels and ameliorate glucose tolerance. FBPase-IN-1 modifies the C128 site, regulates the N125-S124-S123 allosteric pathway of FBPase and affects the catalytic activity of FBPase .
Cat. No.: HY-P81519
Synonyms: 6-bisphosphatase 1 antibody;
6-bisphosphate 1-phosphohydrolase 1 antibody;
D fructose 1 6 bisphosphate 1 phosphohydrolase 1 antibody;
D-fructose-1 antibody;
EC 3.1.3.11 antibody;
F16P1_HUMAN antibody;
FBP antibody;
FBP 1 antibody;
FBP1 antibody;
FBPase 1 antibody;
fructose 1 6 bisphosphatase 1 antibody;
fructose bisphosphatase 1 antibody;
fructose-1 antibody;
Growth inhibiting protein 17 antibody;
Liver fructose bisphosphatase antibody;
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
