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FBPase-IN-1 

Cat. No.: HY-146725
Handling Instructions

FBPase-IN-1 is a potent FBPase (Fructose-1,6-bisphosphatase) inhibitor for Type 2 diabetes (T2D) study with an IC50 of 0.22 μM. FBPase-IN-1 can reduce blood glucose levels and ameliorate glucose tolerance. FBPase-IN-1 modifies the C128 site, regulates the N125-S124-S123 allosteric pathway of FBPase and affects the catalytic activity of FBPase.

For research use only. We do not sell to patients.

FBPase-IN-1 Chemical Structure

FBPase-IN-1 Chemical Structure

CAS No. : 20362-54-3

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Description

FBPase-IN-1 is a potent FBPase (Fructose-1,6-bisphosphatase) inhibitor for Type 2 diabetes (T2D) study with an IC50 of 0.22 μM. FBPase-IN-1 can reduce blood glucose levels and ameliorate glucose tolerance. FBPase-IN-1 modifies the C128 site, regulates the N125-S124-S123 allosteric pathway of FBPase and affects the catalytic activity of FBPase[1].

IC50 & Target

IC50: 0.22 μM (FBPase)[1]

In Vitro

FBPase-IN-1 (compund 3a) (1.5625-200 μM, 48 hours) shows a low cytotoxicity with an IC50 of 75.08 μM[1].
FBPase-IN-1 (0-45 min) inhibits FBPase in a time-dependent manner, with IC50 decreasing from 0.28 to 0.09 μM, shows FBPase-IN-1 is an irreversible covalent inhibitor of FBPase[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

FBPase-IN-1 (12 h-fasted ICR mouse, n = 6, male, 25 mg/kg, IP) shows good FBPase inhibitory activity (IC50 = 0.22 μM), satisfying glucose-lowering effect in vivo (54% reduction in blood glucose at 25 mg/kg)[1].
FBPase-IN-1 (6 or 7 weeks, ICR mice, n = 6, male, 25 mg/kg, IP for 4 hours, once) reduces blood glucose levels by targeting FBPase and inhibiting the GNG process[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: ICR mouse (12 h-fasted, n = 6, male)[1]
Dosage: 25 mg/kg
Administration: IP, once
Result: Lowered glucose.
Animal Model: ICR mice (6 or 7 weeks, n = 6, male)[1]
Dosage: 25 mg/kg
Administration: IP, for 4 h, once
Result: Reduced blood glucose levels by targeting FBPase and inhibiting the GNG process.
Molecular Weight

232.37

Formula

C6H4N2S4

CAS No.
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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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FBPase-IN-1
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HY-146725
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