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Results for "

fungicide active

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Akt (2) AMPK (2) Androgen Receptor (4) Angiotensin Receptor (2) Apoptosis (10) Autophagy (2) Bacterial (7) Bcl-2 Family (2) Caspase (2) Cholinesterase (ChE) (2) Cytochrome P450 (5) Dihydrofolate reductase (DHFR) (1) DNA/RNA Synthesis (4) Drug Derivative (1) Drug Metabolite (2) Endogenous Metabolite (2) Environmental Pollutants (14) Fatty Acid Synthase (FASN) (1) Ferroptosis (2) Fungal (48) Herbicide (1) Isotope-Labeled Compounds (7) JNK (4) Microtubule/Tubulin (2) Mitochondrial Metabolism (2) Mitosis (1) MyD88 (2) p38 MAPK (2) Parasite (6) PERK (2) Phosphatase (2) Reactive Oxygen Species (ROS) (8) Reference Standards (16) Toll-like Receptor (TLR) (2) Virus Protease (2)
By Research Areas:	Cancer (7) Cardiovascular Disease (2) Endocrinology (4) Infection (49) Inflammation/Immunology (7) Metabolic Disease (5) Neurological Disease (4)

By Targets:

Akt (2)

AMPK (2)

Androgen Receptor (4)

Angiotensin Receptor (2)

Apoptosis (10)

Autophagy (2)

Bacterial (7)

Bcl-2 Family (2)

Caspase (2)

Cholinesterase (ChE) (2)

Cytochrome P450 (5)

Dihydrofolate reductase (DHFR) (1)

DNA/RNA Synthesis (4)

Drug Derivative (1)

Drug Metabolite (2)

Endogenous Metabolite (2)

Environmental Pollutants (14)

Fatty Acid Synthase (FASN) (1)

Ferroptosis (2)

Fungal (48)

Herbicide (1)

Isotope-Labeled Compounds (7)

JNK (4)

Microtubule/Tubulin (2)

Mitochondrial Metabolism (2)

Mitosis (1)

MyD88 (2)

p38 MAPK (2)

Parasite (6)

PERK (2)

Phosphatase (2)

Reactive Oxygen Species (ROS) (8)

Reference Standards (16)

Toll-like Receptor (TLR) (2)

Virus Protease (2)

By Research Areas:

Cancer (7)

Cardiovascular Disease (2)

Endocrinology (4)

Infection (49)

Inflammation/Immunology (7)

Metabolic Disease (5)

Neurological Disease (4)

Inhibitors & Agonists

Screening Libraries

Natural
Products

Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-B0852

Tebuconazole 3 Publications Verification	Environmental Pollutants Apoptosis Cytochrome P450 Fungal	Infection
Tebuconazole is an orally active agricultural azole fungicide which can also inhibit CYP51 with IC₅₀s of 0.9 and 1.3 μM for Candida albicans CYP51 (CaCYP51) and truncated Homo sapiens CYP51 (Δ60HsCYP51), respectively. Tebuconazole induces lipid accumulation and oxidative stress in HepG2 Cells. Tebuconazole decreases MAC-T cells viability and proliferation, induces ER-stress-mediated apoptosis and increases oxidative stress levels in MAC-T cells .

HY-13582

Carbendazim Maximum Cited Publications 6 Publications Verification	Environmental Pollutants Fungal Parasite	Infection Cancer
Carbendazim is a potent and orally active broad-spectrum benzimidazole *fungicide* and can be acts as a pesticide for fungal diseases research, such as Seproria, Fusarium and Sclerotina . Carbendazim is a benzimidazole (HY-Y1825) derivative with antitumor activity and used for cancer research, especially advanced solid tumors and lymphoma .

HY-B0849

Azoxystrobin 3 Publications Verification	Environmental Pollutants Reactive Oxygen Species (ROS) Fungal Apoptosis Bacterial Phosphatase	Infection
Azoxystrobin is an orally active, broad-spectrum β-methoxyacrylate *fungicide. Azoxystrobin inhibits mitochondrial respiration by binding to the Qo site of the cytochrome bc1 complex and inhibiting electron transfer. Azoxystrobin induces the production of reactive oxygen species (ROS)* and induces cell apoptosis .

HY-B1839

Fluazinam	Environmental Pollutants JNK Fungal p38 MAPK Bcl-2 Family Caspase Autophagy Apoptosis	Infection
Fluazinam is an orally active dinitroaniline *fungicide. Fluazinam induces phosphorylation of JNK, activates p38* pathway, decreases Bcl-2, activates caspase-3, decreases complex I activity, increases Autophagy and Apoptosis. Fluazinam has strong antifungal activity against F. fujikuroi and B. maydis. Fluazinam has a negative impact on Brachydanio rerio and worker bees .

HY-B0847

Propiconazole 2 Publications Verification	Environmental Pollutants Reactive Oxygen Species (ROS) Fungal	Infection
Propiconazole is an orally active N-substituted triazole used as a fungicide. Propiconazole is a mouse liver hepatotoxicant and a hepatocarcinogen that has adverse reproductive and developmental toxicities in experimental animals .

HY-B1978

Iprodione	Environmental Pollutants Fungal Reactive Oxygen Species (ROS) Androgen Receptor	Infection
Iprodione is an orally active diformimide fungicide. Iprodione can specifically cause oxidative damage by producing free radicals (ROS). Iprodione is also an antiandrogen agent that delays adolescent development in rats and reduces sexual behavior and reproductive ability in rats .

HY-123037

Triadimefon	Environmental Pollutants AMPK Akt PERK Fungal	Infection Neurological Disease Metabolic Disease Endocrinology
Triadimefon is an orally active *fungicide. Triadimefon significantly reduces the phosphorylation of AKT1* and ERK1/2. Triadimefon significantly increases pAMPK levels, but does not affect total AMPK levels. Triadimefon inhibits the growth of Saccharomyces cerevisiae, disrupts hormone homeostasis (affecting the synthesis of testosterone, etc.), inhibits fetal adrenal development in rats, induces metabolic shifts in hepatocytes, and impairs spatial learning and memory .

HY-12396

Aminothiazole 2 Publications Verification 2-Aminothiazole; 2-Thiazolylamine	Bacterial Fungal Virus Protease	Infection
Aminothiazole (2-Aminothiazole), a typical heterocyclic amine, is a precursor for the synthesis of biologically active molecules including sulfur agents, biocides, fungicides, antibiotics, dyes and chemical reaction accelerators .

HY-B0935

Benzyl benzoate 1 Publications Verification Phenylmethyl benzoate	Environmental Pollutants Angiotensin Receptor Endogenous Metabolite Fungal Bacterial Parasite	Infection Cardiovascular Disease Inflammation/Immunology
Benzyl benzoate (Phenylmethyl benzoate) is an orally active anti-scabies agent, acaricide (EC₅₀= 0.06 g/m ²) and fungicide. Benzyl benzoate is an angiotensin II (Ang II) inhibitor with antihypertensive effects. Benzyl benzoate can be used in perfumes, pharmaceuticals and the food industry .

HY-B0843A

Metalaxyl-M (R)-Metalaxyl	Environmental Pollutants Fungal DNA/RNA Synthesis	Infection Inflammation/Immunology
Metalaxyl-M ((R)-Metalaxyl) is an orally active and selective inhibitor of fungal RNA polymerase, which exerts fungicidal activity by selectively interfering with the synthesis of fungal ribosomal RNA. Metalaxyl-M can also be used to induce inflammation in hepatocytes and regulate tryptophan metabolism. Metalaxyl-M can be used in ecotoxicology studies .

HY-Y0278

Chloranil Tetrachloro-p-benzoquinone; TCBQ	Environmental Pollutants JNK Fungal Toll-like Receptor (TLR) Reactive Oxygen Species (ROS) Apoptosis MyD88 Ferroptosis	Infection Neurological Disease Metabolic Disease Inflammation/Immunology
Chloranil (Tetrachloro-p-benzoquinone), an orally active metabolite of pentachlorophenol and hexachlorobenzene, is a widely used fungicide. Chloranil can induce ROS production. Chloranil induces neutrophil extracellular traps through the ROS-JNK-NOX2 pathway. Chloranil induces ferroptosis and neuroinflammation. Chloranil induces apoptosis of mouse embryonic stem cells .

HY-B2008

Famoxadone DPX-JE874	Environmental Pollutants Fungal	Infection
Famoxadone is a fungicide active against various oomycetes. Famoxadone induces rapid lysis of zoospores of P. viticola and P. infestans, and inhibits sporangial differentiation, zoospore release, sporangial germination and mycelial growth. Famoxadone exerts a preventive control effect on plant diseases. Famoxadone can be used in research related to grape downy mildew, potato late blight, tomato late blight and plant oomycete diseases .

HY-W020043

Pyribencarb	Fungal	Infection
Pyribencarb is a benzylcarbamate-type fungicide, which is active against a wide range of plant pathogenic fungi. Pyribencarb is a potent Qo inhibitor of cytochrome b. Pyribencarb is especially active against *Botrytis cinerea* and *Sclerotinia sclerotirum* .

HY-13582R

Carbendazim (Standard) Maximum Cited Publications 6 Publications Verification	Parasite Fungal Reference Standards	Infection Cancer
Carbendazim (Standard) is the analytical standard of Carbendazim. This product is intended for research and analytical applications. Carbendazim is a potent and orally active broad-spectrum benzimidazole *fungicide* and can be acts as a pesticide for fungal diseases research, such as Seproria, Fusarium and Sclerotina . Carbendazim is a benzimidazole (HY-Y1825) derivative with antitumor activity and used for cancer research, especially advanced solid tumors and lymphoma .

HY-B0852R

Tebuconazole (Standard)	Reference Standards Cytochrome P450 Fungal Apoptosis	Infection
Tebuconazole (Standard) is the analytical standard of Tebuconazole. This product is intended for research and analytical applications. Tebuconazole is an orally active agricultural azole fungicide which can also inhibit CYP51 with IC₅₀s of 0.9 and 1.3 μM for Candida albicans CYP51 (CaCYP51) and truncated Homo sapiens CYP51 (Δ60HsCYP51), respectively. Tebuconazole induces lipid accumulation and oxidative stress in HepG2 Cells. Tebuconazole decreases MAC-T cells viability and proliferation, induces ER-stress-mediated apoptosis and increases oxidative stress levels in MAC-T cells .

HY-116568

Prothioconazole JAU-6476	Fungal Cytochrome P450 Microtubule/Tubulin Mitochondrial Metabolism DNA/RNA Synthesis Apoptosis Fatty Acid Synthase (FASN)	Infection Metabolic Disease Endocrinology
Prothioconazole is an orally active broad-spectrum fungicide. Prothioconazole weakly inhibits CaCYP51 activity in Candida albicans, with an apparent IC₅₀ of approximately 120 μM. Prothioconazole disrupts Microtubule stability by reducing the acetylation level of α-tubulin. Prothioconazole induces Mitochondrial dysfunction, oxidative stress, DNA damage, and Apoptosis. Prothioconazole accumulates ¹⁴-methylated sterols and depletes ergosterol in cells, culture media, plants, and animals. Prothioconazole interferes with pyruvate metabolism and glycolysis/gluconeogenesis processes in mouse liver, downregulates Fasn mRNA expression, and induces hepatotoxicity and renal metabolic disorders. Prothioconazole reduces the fertility of female mice. Prothioconazole inhibits body weight gain and increases liver/kidney indices in mice. Prothioconazole can be used in studies related to candidiasis .

HY-W010593

Ethylenethiourea	Environmental Pollutants Drug Metabolite	Cancer
Ethylenethiourea is a degradation product of the ethylenebisthiocarbamate group of fungicides. Ethylenethiourea is tumorigenic and teratogenic. Ethylenethiourea is orally active .

HY-W017445

Homogentisic acid lactone	Fungal	Infection
Homogentisic acid lactone (Compound 1) is a fungal metabolite with fungicidal activity, which is found in the fungus WF5. Homogentisic acid lactone is active against the plant pathogenic fungus F. graminearum. Homogentisic acid lactone can be used as a substrate in the determination of serum paraoxonase/arylesterase 1 (PON1) activity .

HY-B0843AR

Metalaxyl-M (Standard) (R)-Metalaxyl (Standard)	DNA/RNA Synthesis Fungal	Infection Inflammation/Immunology
Metalaxyl-M ((R)-Metalaxyl) (Standard) is the analytical standard of Metalaxyl-M (HY-B0843A). This product is intended for research and analytical applications. Metalaxyl-M ((R)-Metalaxyl) is an orally active and selective inhibitor of fungal RNA polymerase, which exerts fungicidal activity by selectively interfering with the synthesis of fungal ribosomal RNA. Metalaxyl-M can also be used to induce inflammation in hepatocytes and regulate tryptophan metabolism. Metalaxyl-M can be used in ecotoxicology studies .

HY-B1839R

Fluazinam (Standard)	Reference Standards Fungal JNK p38 MAPK Bcl-2 Family Caspase Autophagy Apoptosis	Infection
Fluazinam (Standard) is the analytical standard of Fluazinam (HY-B1839). This product is intended for research and analytical applications. Fluazinam is a broad spectrum pyridinamine fungal inhibitor. Fluazinam is an orally active dinitroaniline *fungicide. Fluazinam induces phosphorylation of JNK, activates p38* pathway, decreases Bcl-2, activates caspase-3, decreases complex I activity, increases Autophagy and Apoptosis. Fluazinam has strong antifungal activity against F. fujikuroi and B. maydis. Fluazinam has a negative impact on Brachydanio rerio and worker bees .

HY-136425

Fosetyl-aluminum Fosetyl-Al	Fungal	Infection
Fosetyl-aluminum (Fosetyl-Al) is an active ingredient in many fungicides against downy mildew. Fosetyl-aluminum is used to control many diseases caused by Phytophthora spp. on agricultural and horticultural crops .

HY-B1863

Iprobenfos	Environmental Pollutants Cholinesterase (ChE) Fungal	Infection
Iprobenfos is an organophosphorus fungicide and is widely used to control the rice blast fungus. Iprobenfos can phosphorylate the -OH group on the serine residue in the active (esteratic) site of ChEs and so inhibit both AChE and BChE activity .

HY-B0847R

Propiconazole (Standard)	Reference Standards Fungal Reactive Oxygen Species (ROS)	Infection
Propiconazole (Standard) is the analytical standard of Propiconazole. This product is intended for research and analytical applications. Propiconazole is an orally active N-substituted triazole used as a fungicide. Propiconazole is a mouse liver hepatotoxicant and a hepatocarcinogen that has adverse reproductive and developmental toxicities in experimental animals .

HY-W762060

Metiram	Fungal	Infection
Metiram is a polymeric dithiocarbamate pesticide active as a fungicide. Metiram is widely used to protect crops such as tomatoes, potatoes, apples, grapevines, etc. Human and environmental exposure from the representative use of Metiram on potatoes is considered non-negligible. Metiram is considered necessary in the control of serious threats to plant health that cannot be suppressed by other available means, including non-chemical methods .

HY-13582S

Carbendazim-d4	Isotope-Labeled Compounds Fungal	Infection Cancer
Carbendazim-d₄ is the deuterium labeled Carbendazim. Carbendazim is a potent and orally active broad-spectrum?benzimidazole fungicide and can be acts as a pesticide for fungal diseases research, such as Seproria,?Fusarium?and?Sclerotina . Carbendazim is a benzimidazole (HY-Y1825) derivative with antitumor activity and used for cancer research, especially advanced solid tumors and lymphoma .

HY-W019803

Diclobutrazol	Fungal	Infection Others
Diclobutrazol, a systemic fungicide, is highly active against rusts, powdery mildews, and other fungal phytopathogens. Diclobutrazol can be used as a pesticide to control of various crop diseases .

HY-B1978R

Iprodione (Standard)	Reference Standards Fungal Reactive Oxygen Species (ROS) Androgen Receptor	Infection
Iprodione (Standard) is the analytical standard of Iprodione. This product is intended for research and analytical applications. Iprodione is an orally active diformimide fungicide. Iprodione can specifically cause oxidative damage by producing free radicals (ROS). Iprodione is also an antiandrogen agent that delays adolescent development in rats and reduces sexual behavior and reproductive ability in rats .

HY-B2058

Triticonazole	Fungal Androgen Receptor	Infection
Triticonazole is an orally active triazole fungicide and androgen receptor antagonist. Triticonazole inhibits testosterone-induced androgen receptor activation and reduces basal testosterone secretion. Prenatal exposure to Triticonazole causes shortened anogenital distance in male rat fetuses and induces organ-specific histopathological changes in pigs. Triticonazole can be used for detoxification of seeds contaminated with fungal pathogens, but there is a risk of animal poisoning if the treated seeds are used as animal feed .

HY-123037R

Triadimefon (Standard)	Reference Standards Fungal Akt PERK AMPK	Infection Neurological Disease Metabolic Disease Endocrinology
Triadimefon (Standard) is the analytical standard of Triadimefon (HY-123037). This product is intended for research and analytical applications. Triadimefon is an orally active *fungicide. Triadimefon significantly reduces the phosphorylation of AKT1* and ERK1/2. Triadimefon significantly increases pAMPK levels, but does not affect total AMPK levels. Triadimefon inhibits the growth of Saccharomyces cerevisiae, disrupts hormone homeostasis (affecting the synthesis of testosterone, etc.), inhibits fetal adrenal development in rats, induces metabolic shifts in hepatocytes, and impairs spatial learning and memory .

HY-131134S

Fosetyl-aluminum-d15 Fosetyl-Al-d₁₅	Fungal Isotope-Labeled Compounds	Infection
Fosetyl-aluminum-d₁₅ (Fosetyl-Al-d₁₅) is the deuterium labeled Fosetyl-aluminum. Fosetyl-aluminum (Fosetyl-Al) is an active ingredient in many fungicides against downy mildew. Fosetyl-aluminum is used to control many diseases caused by Phytophthora spp. on agricultural and horticultural crops .

HY-B0935R

Benzyl benzoate (Standard) Phenylmethyl benzoate (Standard)	Reference Standards Parasite Endogenous Metabolite Angiotensin Receptor Bacterial Fungal	Infection Cardiovascular Disease Inflammation/Immunology
Benzyl benzoate (Standard) is the analytical standard of Benzyl benzoate. This product is intended for research and analytical applications. Benzyl benzoate (Phenylmethyl benzoate) is an orally active anti-scabies agent, acaricide (EC₅₀= 0.06 g/m ²) and fungicide. Benzyl benzoate is an angiotensin II (Ang II) inhibitor with antihypertensive effects. Benzyl benzoate can be used in perfumes, pharmaceuticals and the food industry .

HY-136425R

Fosetyl-aluminum (Standard) Fosetyl-Al (Standard)	Reference Standards Fungal	Infection
Fosetyl-aluminum (Standard) is the analytical standard of Fosetyl-aluminum. This product is intended for research and analytical applications. Fosetyl-aluminum (Fosetyl-Al) is an active ingredient in many fungicides against downy mildew. Fosetyl-aluminum is used to control many diseases caused by Phytophthora spp. on agricultural and horticultural crops .

HY-106923

BMS-181184	Fungal Drug Derivative	Infection
BMS-181184 is a new Pradimicin derivative and *fungicide. BMS-181184 exhibits fungicidal* activity against yeasts, dermatophytes, and most Aspergillus fumigatus strains. BMS-181184 is active against Sporothrix schenckii, dematiaceous fungi, and some members of the non-Aspergillus hyaline hyphomycetes .

HY-122451

Ofurace Milfuram; RE 20615	Fungal	Infection
Ofurace is a fungicide that is extremely active against Pythium ultima, Phytophthora tabacum and Phytophthora palmi. Ofurace has a greater effect on sporangia formation than on mycelium growth .

HY-W010593R

Ethylenethiourea (Standard)	Drug Metabolite Reference Standards	Cancer
Ethylenethiourea (Standard) is the analytical standard of Ethylenethiourea. This product is intended for research and analytical applications. Ethylenethiourea is a degradation product of the ethylenebisthiocarbamate group of fungicides. Ethylenethiourea is tumorigenic and teratogenic. Ethylenethiourea is orally active .

HY-114913

Fenarimol EL 222	Androgen Receptor Bacterial	Infection Endocrinology
Fenarimol (EL 222) is a potent and orally active fungicide. Fenarimol also is a androgen receptor inhibitor with an IC₅₀ value of 19 µM. Fenarimol decreases the mRNA expression of PBP C3, ODC, IGF-1 .

HY-W020043R

Pyribencarb (Standard)	Reference Standards Fungal	Infection
Pyribencarb (Standard) is the analytical standard of Pyribencarb. This product is intended for research and analytical applications. Pyribencarb is a benzylcarbamate-type fungicide, which is active against a wide range of plant pathogenic fungi. Pyribencarb is a potent Qo inhibitor of cytochrome b. Pyribencarb is especially active against Botrytis cinerea and Sclerotinia sclerotirum .

HY-122451R

Ofurace (Standard) Milfuram (Standard); RE 20615 (Standard)	Reference Standards Fungal	Infection
Ofurace (Standard) is the analytical standard of Ofurace. This product is intended for research and analytical applications. Ofurace is a fungicide that is extremely active against Pythium ultima, Phytophthora tabacum and Phytophthora palmi. Ofurace has a greater effect on sporangia formation than on mycelium growth .

HY-W019803R

Diclobutrazol (Standard)	Reference Standards Fungal	Infection Others
Diclobutrazol (Standard) is the analytical standard of Diclobutrazol. This product is intended for research and analytical applications. Diclobutrazol, a systemic fungicide, is highly active against rusts, powdery mildews, and other fungal phytopathogens. Diclobutrazol can be used as a pesticide to control of various crop diseases .

HY-121801

Zarilamid	Fungal Microtubule/Tubulin Mitosis	Infection
Zarilamid is a fungicide which is active against a broad spectrum of Oomycete fungi. Zarilamid inhibits nuclear division in germinating zoospore cysts of Phytophthora capsici. Zarilamide inhibits growth of tobacco roots and causes swelling of the root tips, destructs microtubule cytoskeleton and inhibits mitosis .

HY-12396R

Aminothiazole (Standard)	Bacterial Fungal Virus Protease Reference Standards	Infection
Aminothiazole (Standard) is the analytical standard of Aminothiazole. This product is intended for research and analytical applications. Aminothiazole (2-Aminothiazole), a typical heterocyclic amine, is a precursor for the synthesis of biologically active molecules including sulfur agents, biocides, fungicides, antibiotics, dyes and chemical reaction accelerators .

HY-13582A

Carbendazim hydrochloride	Fungal Parasite	Infection Cancer
Carbendazim hydrochloride is a potent and orally active broad-spectrum?benzimidazole *fungicide* and can be acts as a pesticide for fungal diseases research, such as Seproria,?Fusarium?and?Sclerotina . Carbendazim hydrochloride is a benzimidazole (HY-Y1825) derivative with antitumor activity and used for cancer research, especially advanced solid tumors and lymphoma .

HY-B0849A

(Z)-Azoxystrobin	Fungal Reactive Oxygen Species (ROS) Apoptosis Bacterial Phosphatase	Infection
(Z)-Azoxystrobin is an enantiomer of Azoxystrobin. Azoxystrobin is an orally active, broad-spectrum β-methoxyacrylate fungicide. Azoxystrobin inhibits mitochondrial respiration by binding to the Qo site of the cytochrome bc1 complex and inhibiting electron transfer. Azoxystrobin induces the production of reactive oxygen species (ROS) and induces cell apoptosis .

HY-B1863R

Iprobenfos (Standard)	Reference Standards Fungal Cholinesterase (ChE)	Infection
Iprobenfos (Standard) is the analytical standard of Iprobenfos (HY-B1863). This product is intended for research and analytical applications. Iprobenfos is an organophosphorus fungicide and is widely used to control the rice blast fungus. Iprobenfos can phosphorylate the -OH group on the serine residue in the active (esteratic) site of ChEs and so inhibit both AChE and BChE activity .

HY-13582S1

Carbendazimb-d3	Isotope-Labeled Compounds Fungal Parasite	Others
Carbendazimb-d₃ is the deuterium labeled Carbendazimb (HY-13582). Carbendazim is a potent and orally active broad-spectrum?benzimidazole fungicide and can be acts as a pesticide for fungal diseases research, such as Seproria,?Fusarium?and?Sclerotina . Carbendazim is a benzimidazole (HY-Y1825) derivative with antitumor activity and used for cancer research, especially advanced solid tumors and lymphoma .

HY-Y0278R

Chloranil (Standard) Tetrachloro-p-benzoquinone (Standard); TCBQ (Standard)	Reference Standards Toll-like Receptor (TLR) MyD88 Apoptosis Ferroptosis JNK Reactive Oxygen Species (ROS) Fungal	Infection Neurological Disease Metabolic Disease Inflammation/Immunology
Chloranil (Standard) is the analytical standard of Chloranil. This product is intended for research and analytical applications. Chloranil, an orally active metabolite of pentachlorophenol and hexachlorobenzene, is a widely used fungicide. Chloranil can induce ROS production. Chloranil induces neutrophil extracellular traps through the ROS-JNK-NOX2 pathway. Chloranil induces ferroptosis and neuroinflammation. Chloranil induces apoptosis of mouse embryonic stem cells .

HY-161010

DHFR-IN-13	Dihydrofolate reductase (DHFR)	Infection
DHFR-IN-13 (Compd Hit8) is an active R. solani DHFR inhibitor with an IC₅₀ value of 10.2 μM. DHFR-IN-13 has selectivity of inhibition against human DHFR with an IC₅₀ value of 227.7 μM. DHFR-IN-13 also is a fungicide. DHFR-IN-13 has high antifungal activity against R. solani with EC₅₀ value of 38.2 mg/L .

HY-B0843AS

Metalaxyl-M-d6	Isotope-Labeled Compounds DNA/RNA Synthesis Fungal	Infection Inflammation/Immunology
Metalaxyl-M-d₆ ((R)-Metalaxyl-d₆) is the deuterium labeled Metalaxyl-M (HY-B0843A). Metalaxyl-M ((R)-Metalaxyl) is an orally active and selective inhibitor of fungal RNA polymerase, which exerts fungicidal activity by selectively interfering with the synthesis of fungal ribosomal RNA. Metalaxyl-M can also be used to induce inflammation in hepatocytes and regulate tryptophan metabolism. Metalaxyl-M can be used in ecotoxicology studies .

HY-B2008R

Famoxadone (Standard) DPX-JE874 (Standard)	Reference Standards Fungal	Infection
Famoxadone (Standard) is the analytical standard of Famoxadone. This product is intended for research and analytical applications. Famoxadone is a fungicide active against various oomycetes. Famoxadone induces rapid lysis of zoospores of P. viticola and P. infestans, and inhibits sporangial differentiation, zoospore release, sporangial germination and mycelial growth. Famoxadone exerts a preventive control effect on plant diseases. Famoxadone can be used in research related to grape downy mildew, potato late blight, tomato late blight and plant oomycete diseases .

HY-B0852S2

Tebuconazole-d6	Isotope-Labeled Compounds Cytochrome P450 Fungal	Infection
Tebuconazole-d₆ is a deuterium labeled Tebuconazole (HY-B0852). Tebuconazole is an orally active agricultural azole fungicide which can also inhibit CYP51 with IC₅₀s of 0.9 and 1.3 μM for Candida albicans CYP51 (CaCYP51) and truncated Homo sapiens CYP51 (Δ60HsCYP51), respectively. Tebuconazole induces lipid accumulation and oxidative stress in HepG2 Cells. Tebuconazole decreases MAC-T cells viability and proliferation, induces ER-stress-mediated apoptosis and increases oxidative stress levels in MAC-T cells .

Cat. No.	Product Name

HY-L938

Antifungal Lead-like compound library

8350 compounds

Currently,the incidence and mortality rates of clinical fungal infections remain high. Existing antifungal drugs are limited in variety and associated with numerous adverse effects, creating an urgent demand for the development of novel antifungal agents. Antifungal compound libraries can support the screening and development of new antifungal drugs.

The mechanisms of action of antifungal drugs cover key processes such as fungal cell membrane synthesis, cell wall synthesis, and cell division. They exert fungicidal or fungistatic effects by specifically targeting different molecular pathways. This library includes a variety of core analogs of antifungal drugs, making it adaptable to antifungal research in diverse scenarios. It can be used for the high-throughput screening of novel antifungal drug candidates, enabling the rapid identification of compounds with potential antifungal activity and facilitating the elucidation of drug-target interactions and resistance mechanisms. Additionally, it supports the screening of compounds and combinations that reverse drug resistance, thereby uncovering the novel antifungal potential of existing compounds.

The library comprises 8350 compounds with a well-defined screening strategy. The core sources of the compounds include analogs of known antifungal active moleculeswith a similarity score of ≥ 0.6 MCE has collected more than 500 antifungal molecules.All screened compounds conform to lead-like physicochemical properties, exhibiting both structural diversity and drug-like characteristics, and providing valuable support for the research and development of novel antifungal drugs.

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-B0935

Benzyl benzoate 1 Publications Verification Phenylmethyl benzoate	Infection Structural Classification Natural Products Classification of Application Fields Uvaria grandiflora Roxb. Essence, Fragrance Cosmetic Research Plants Annonaceae Disease Research Fields Source Classification	Environmental Pollutants Angiotensin Receptor Endogenous Metabolite Fungal Bacterial Parasite
Benzyl benzoate (Phenylmethyl benzoate) is an orally active anti-scabies agent, acaricide (EC₅₀= 0.06 g/m ²) and fungicide. Benzyl benzoate is an angiotensin II (Ang II) inhibitor with antihypertensive effects. Benzyl benzoate can be used in perfumes, pharmaceuticals and the food industry .

HY-W017445

Homogentisic acid lactone	Monophenols Microorganisms Phenols Source Classification	Fungal
Homogentisic acid lactone (Compound 1) is a fungal metabolite with fungicidal activity, which is found in the fungus WF5. Homogentisic acid lactone is active against the plant pathogenic fungus F. graminearum. Homogentisic acid lactone can be used as a substrate in the determination of serum paraoxonase/arylesterase 1 (PON1) activity .

HY-B0935R

Benzyl benzoate (Standard) Phenylmethyl benzoate (Standard)	Structural Classification Natural Products Uvaria grandiflora Roxb. Plants Annonaceae Source Classification	Reference Standards Parasite Endogenous Metabolite Angiotensin Receptor Bacterial Fungal
Benzyl benzoate (Standard) is the analytical standard of Benzyl benzoate. This product is intended for research and analytical applications. Benzyl benzoate (Phenylmethyl benzoate) is an orally active anti-scabies agent, acaricide (EC₅₀= 0.06 g/m ²) and fungicide. Benzyl benzoate is an angiotensin II (Ang II) inhibitor with antihypertensive effects. Benzyl benzoate can be used in perfumes, pharmaceuticals and the food industry .

Cat. No.	Product Name	Chemical Structure

HY-13582S

Carbendazim-d4
Carbendazim-d₄ is the deuterium labeled Carbendazim. Carbendazim is a potent and orally active broad-spectrum?benzimidazole fungicide and can be acts as a pesticide for fungal diseases research, such as Seproria,?Fusarium?and?Sclerotina . Carbendazim is a benzimidazole (HY-Y1825) derivative with antitumor activity and used for cancer research, especially advanced solid tumors and lymphoma .

HY-131134S

Fosetyl-aluminum-d15
Fosetyl-aluminum-d₁₅ (Fosetyl-Al-d₁₅) is the deuterium labeled Fosetyl-aluminum. Fosetyl-aluminum (Fosetyl-Al) is an active ingredient in many fungicides against downy mildew. Fosetyl-aluminum is used to control many diseases caused by Phytophthora spp. on agricultural and horticultural crops .

HY-13582S1

Carbendazimb-d3

Carbendazimb-d₃ is the deuterium labeled Carbendazimb (HY-13582). Carbendazim is a potent and orally active broad-spectrum?benzimidazole fungicide and can be acts as a pesticide for fungal diseases research, such as Seproria,?Fusarium?and?Sclerotina . Carbendazim is a benzimidazole (HY-Y1825) derivative with antitumor activity and used for cancer research, especially advanced solid tumors and lymphoma .

HY-B0843AS

Metalaxyl-M-d6

Metalaxyl-M-d₆ ((R)-Metalaxyl-d₆) is the deuterium labeled Metalaxyl-M (HY-B0843A). Metalaxyl-M ((R)-Metalaxyl) is an orally active and selective inhibitor of fungal RNA polymerase, which exerts fungicidal activity by selectively interfering with the synthesis of fungal ribosomal RNA. Metalaxyl-M can also be used to induce inflammation in hepatocytes and regulate tryptophan metabolism. Metalaxyl-M can be used in ecotoxicology studies .

HY-B0852S2

Tebuconazole-d6

Tebuconazole-d₆ is a deuterium labeled Tebuconazole (HY-B0852). Tebuconazole is an orally active agricultural azole fungicide which can also inhibit CYP51 with IC₅₀s of 0.9 and 1.3 μM for Candida albicans CYP51 (CaCYP51) and truncated Homo sapiens CYP51 (Δ60HsCYP51), respectively. Tebuconazole induces lipid accumulation and oxidative stress in HepG2 Cells. Tebuconazole decreases MAC-T cells viability and proliferation, induces ER-stress-mediated apoptosis and increases oxidative stress levels in MAC-T cells .

HY-W010593S

Ethylenethiourea-d4
Ethylenethiourea-d₄ is the deuterium labeled Ethylenethiourea . Ethylenethiourea is a degradation product of the ethylenebisthiocarbamate group of fungicides. Ethylenethiourea is tumorigenic and teratogenic. Ethylenethiourea is orally active .

HY-W724326

Tebuconazole-d4

Tebuconazole-d₄ is the deuterium labeled Tebuconazole (HY-B0852). Tebuconazole is an orally active agricultural azole fungicide which can also inhibit CYP51 with IC₅₀s of 0.9 and 1.3 μM for Candida albicans CYP51 (CaCYP51) and truncated Homo sapiens CYP51 (Δ60HsCYP51), respectively. Tebuconazole induces lipid accumulation and oxidative stress in HepG2 Cells. Tebuconazole decreases MAC-T cells viability and proliferation, induces ER-stress-mediated apoptosis and increases oxidative stress levels in MAC-T cells .

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