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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
23 Results for "
glutaminolysis
" in MedChemExpress (MCE) Product Catalog:
Products (23)
23 Results for "glutaminolysis" in MCE Product Catalog:
11
11 Publications Verification
Synonyms: Compound 968
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Glutaminase C-IN-1 (Compound 968) is an allosteric inhibitor of Glutaminase C that inhibits cancer cell growth without affecting their normal cellular counterparts .
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4 Cited Publications
Cat. No.: HY-P2336A
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1 Cited Publications
Cat. No.: HY-121970
CAS No.: 27031-00-1
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Phosphoglycerate Dehydrogenase (PHGDH) Reactive Oxygen Species (ROS) HIF/HIF Prolyl-Hydroxylase
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iGP-1 is a cell-permeable, selective mixed inhibitor of mitochondrial sn-glycerol-3-phosphate dehydrogenase (mGPDH), with IC50s of 6.3 μM and 13.6 μM for rat mGPDH activity and H2O2 production, respectively. iGP-1 specifically blocks the mitochondrial component of the glycerophosphate shuttle without affecting cytosolic GPDH. iGP-1 not only inhibits cell proliferation and glutaminolysis, and enhances glycolysis, but also significantly alters key cellular physiological processes such as apoptosis, ROS production, HIF-1α stability and mitochondrial membrane potential. iGP-1 remains active in neutrophil cultures under both normoxic and hypoxic conditions, and serves as an ideal probe for glycerol-3-phosphate metabolic mechanisms. iGP-1 has been applied to studies on prostate cancer and related metabolic pathways .
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1 Cited Publications
Category:
Natural Products Animals Marine natural products Other marine organisms Disease Research Fields Cancer
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Cat. No.: HY-P4070
CAS No.: 1188379-43-2
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Cat. No.: HY-P5362
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Pyruvate carboxylase is a key mitochondrial anaplerotic enzyme that catalyzes the conversion of pyruvate to oxaloacetate. Pyruvate carboxylase not only maintains tricarboxylic acid cycle activity and redox homeostasis, but also drives hepatic gluconeogenesis and fatty acid synthesis. The activity of Pyruvate carboxylase is upregulated in insulin-resistant states, exacerbating hepatic glucose production. Pyruvate carboxylase also shows significantly enhanced expression in early-stage non-small cell lung cancer (NSCLC). Pyruvate carboxylase promotes tumor proliferation by supporting nucleotide and lipid synthesis, and its functional deficiency cannot be compensated by glutaminolysis. Pyruvate carboxylase can be used in the research of prediabetes type 2 and NSCLC .
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Glutaminase (GLS) is a metabolic enzyme. Glutaminase catalyzes the conversion of glutamine to glutamate, which is a key step in glutaminolysis. The glutaminase isoenzymes GLS and GLS2 differ in their expression patterns and functional roles: GLS exhibits oncogenic properties, whereas GLS2 is regarded as a tumor suppressor. Glutaminase expression levels correlate with the degree of tumor malignancy .
Cat. No.: HY-P10341
CAS No.: 1345835-12-2
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Cat. No.: HY-P11004
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Cat. No.: HY-P10472
CAS No.: 134457-28-6
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Cat. No.: HY-P4757
CAS No.: 108081-77-2
Cat. No.: HY-P11243
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Cat. No.: HY-P2434
CAS No.: 846569-60-6
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Cat. No.: HY-P5362A
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Cat. No.: HY-105168
CAS No.: 157380-72-8
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Cat. No.: HY-P2075
CAS No.: 126784-34-7
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Cat. No.: HY-P10876
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Cat. No.: HY-181890
CAS No.: 3080792-24-8
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TRG-192 is a potent and selective glutaminase (GLS) inhibitor with an IC50 of 68 nM. TRG-192 inhibits intracellular glutamate levels. TRG-192 is applicable to related research on non-small cell lung cancer .
Cat. No.: HY-P11901
KH-1 is a KRAS G12D/HDAC2 dual-target inhibitor with Kd values of 11.63 nM and 20.17 nM, respectively. KH-1 induces pancreatic cell apoptosis, cell cycle arrest, and inhibits cell proliferation, invasion and migration, as well as suppresses tumor growth in pancreatic cancer xenograft models. KH-1 can be used for the research of pancreatic cancer .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
