311795-38-7
311795-38-7
Chemical Structure
Glutaminase C-IN-1
Synonym(s): Compound 968
- CAS No.: 311795-38-7
- Formula:C27H27BrN2O
- Molecular Weight:475.42
IUPAC Name: 5-(3-bromo-4-(dimethylamino)phenyl)-2,2-dimethyl-2,3,5,6-tetrahydrobenzo[a]phenanthridin-4(1H)-one
InChIKey: NVFRRJQWRZFDLM-UHFFFAOYSA-N
SMILES: O=C1C(C(C2=CC=C(N(C)C)C(Br)=C2)NC3=C4C5=CC=CC=C5C=C3)=C4CC(C)(C)C1
Biological Activity: Glutaminase C-IN-1 (Compound 968) is an allosteric inhibitor of Glutaminase C that inhibits cancer cell growth without affecting their normal cellular counterparts[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Glutaminase C-IN-1 | 99.89% | Glutaminase C-IN-1 (Compound 968) is an allosteric inhibitor of Glutaminase C that inhibits cancer cell growth without affecting their normal cellular counterparts. | ||||||||||||||||||||
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Structural Analogs
-
Similarity Score 0.52
HY-W274194Antioxidant agent-7 -
Similarity Score 0.45
HY-107682TQS -
Similarity Score 0.45
HY-146027Androgen receptor antagonist 4 -
Similarity Score 0.45
HY-116624MAZ51 -
Similarity Score 0.44
HY-146026Androgen receptor antagonist 3 -
Similarity Score 0.43
HY-118151Rho-Kinase-IN-3 -
Similarity Score 0.43
HY-19944Dimethylenastron -
Similarity Score 0.42
HY-1390436-B345TTQ -
Similarity Score 0.42
HY-123464RBC10 -
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References
- [1]. Wang JB, et al. Targeting mitochondrial glutaminase activity inhibits oncogenic transformation. Cancer Cell. 2010 Sep 14;18(3):207-19. [Content Brief]
- [2]. Stalnecker CA, et al. Mechanism by which a recently discovered allosteric inhibitor blocks glutamine metabolism in transformed cells. Proc Natl Acad Sci U S A. 2015 Jan 13;112(2):394-9. [Content Brief]
