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heme synthesis

" in MedChemExpress (MCE) Product Catalog:

8

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Biochemical Assay Reagents

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Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-137808
    Succinyl-Coenzyme A sodium
    3 Publications Verification

    Succinyl-CoA sodium

    		 Endogenous Metabolite Neurological Disease Metabolic Disease
    Succinyl CoA (Succinyl-coenzyme A) sodium is a pivotal intermediate metabolite in the tricarboxylic acid cycle and a key coenzyme A metabolite. Succinyl CoA sodium is biosynthesized from α-ketoglutarate or propionyl-CoA. Succinyl CoA sodium acts as a critical precursor and substrate for heme biosynthesis and gluconeogenesis. Succinyl CoA sodium insufficiency caused by cobalamin deficiency is directly linked to growth retardation, impaired heme synthesis, tissue glycine accumulation and neurological abnormalities. Succinyl CoA sodium can be used in research on metabolic, neurological, and hematological abnormalities (such as porphyria) caused by nutritional vitamin B12 deficiency (leading to a lack of Succinyl-Coenzyme A synthesis) .
    Succinyl-Coenzyme A sodium
  • HY-139838
    Epyrifenacil

    		Herbicide Others Cancer
    Epyrifenacil is a protoporphyrinogen oxidase (PPO) inhibiting herbicide, potently targeting the PPO2 isoform from weeds such as Amaranthus palmeri with an IC50 of 0.637 nM. Epyrifenacil also inhibits liver mitochondrial PPO across species, with IC50 values of 2.2 nM (mouse), 2.6 nM (rat), 12.1 nM (rabbit), 7.6 nM (dog), and 10.2 nM (human). Epyrifenacil induces liver tumor development in mice. Epyrifenacil can be used for weed control, and also used as a tool compound in toxicological research to study the mechanism of PPO inhibition, chemical-induced hepatotoxicity, and the mode of action of non-genotoxic carcinogens in rodents [3].
    Epyrifenacil
  • HY-W073080
    Coproporphyrin I dihydrochloride

    		MOFs Others
    Coproporphyrin I dihydrochlorideIt is an organic compound belonging to the class of porphyrins. It is a derivative of heme, an iron-containing molecule found in hemoglobin and other proteins. Coproporphyrin I dihydrochlorideOften used as a biomarker in the assessment of certain liver and metabolic diseases, especially those related to bile synthesis and transport. It can also be used as a reference standard for analytical chemistry and pharmacological research.
    Coproporphyrin I dihydrochloride
  • HY-148285
    Succinyl CoA

    Succinyl-coenzyme A; S-(Hydrogen succinyl)coenzyme A

    		 Endogenous Metabolite Metabolic Disease
    Succinyl CoA (Succinyl-coenzyme A) is a pivotal intermediate metabolite in the tricarboxylic acid cycle and a key coenzyme A metabolite. Succinyl CoA is biosynthesized from α-ketoglutarate or propionyl-CoA. Succinyl CoA acts as a critical precursor and substrate for heme biosynthesis and gluconeogenesis. Succinyl CoA insufficiency caused by cobalamin deficiency is directly linked to growth retardation, impaired heme synthesis, tissue glycine accumulation and neurological abnormalities. Succinyl CoA can be used in research on metabolic, neurological, and hematological abnormalities (such as porphyria) caused by nutritional vitamin B12 deficiency (leading to a lack of Succinyl-Coenzyme A synthesis) .
    Succinyl CoA
  • HY-W854721
    Mn(III) Protoporphyrin IX chloride

    Manganese(III) Protoporphyrin IX Chloride

    		 Heme Oxygenase (HO) Metabolic Disease
    Mn(III) protoporphyrin IX chloride is a metalloporphyrin. It induces mRNA expression of the genes encoding δ-aminolevulinate synthase and heme oxygenase (HO), enzymes that catalyze the rate-limiting steps of heme biosynthesis and degradation, respectively, in chick embryo liver cells when used at a concentration of 10 μM. Mn(III) protoporphyrin IX chloride-containing nanobialys have been used in magnetic resonance imaging (MRI) of fibrin clots in vitro. It has also been used in the synthesis of Mn(III) protoporphyrin IX-6(7)-glycyl-glycyl-L-histidine methyl ester (MnGGH), a metalloporphyrin conjugate with microperoxidase activity.
    Mn(III) Protoporphyrin IX chloride
  • HY-148285A
    Succinyl CoA disodium

    Succinyl-coenzyme A disodium; S-(Hydrogen succinyl)coenzyme A disodium

    		 Endogenous Metabolite Metabolic Disease
    Succinyl CoA (Succinyl-coenzyme A) disodium is a pivotal intermediate metabolite in the tricarboxylic acid cycle and a key coenzyme A metabolite. Succinyl CoA disodium is biosynthesized from α-ketoglutarate or propionyl-CoA. Succinyl CoA disodium acts as a critical precursor and substrate for heme biosynthesis and gluconeogenesis. Succinyl CoA disodium insufficiency caused by cobalamin deficiency is directly linked to growth retardation, impaired heme synthesis, tissue glycine accumulation and neurological abnormalities. Succinyl-Coenzyme A sodium can be used in research on metabolic, neurological, and hematological abnormalities (such as porphyria) caused by nutritional vitamin B12 deficiency (leading to a lack of Succinyl-Coenzyme A synthesis) .
    Succinyl CoA disodium
  • HY-157160
    PPO-IN-5

    		Herbicide Others
    PPO-IN-5 (compound 9) is a herbicide based on PPO inhibitors. PPO, protoporphyrinogen oxidase, participates in the biosynthetic pathway of heme and chlorophyll synthesis. PPO-IN-5 is tolerant in cereal crops such as wheat, corn, and rice, and is a potential herbicide in wheat fields .
    PPO-IN-5
  • HY-W728891
    Pentoxazone

    		Herbicide Others
    Pentoxazone is a protoporphyrinogen IX oxidase (PPO)-inhibiting herbicide. Pentoxazone inhibits chlorophyll and heme synthesis, drives protoporphyrinogen IX accumulation and oxidation, and generates singlet oxygen to oxidize cell membranes and induce cell damage.Pentoxazone suppresses fresh weight growth of multiple weed species and shows low activity against weedy rice. Pentoxazone can be used for the research of direct-seeding rice field weed management .
    Pentoxazone

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