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heterobifunctional crosslinker

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Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-D0975
    Sulfo-SMCC sodium
    5 Publications Verification

    ADC Linker Cancer
    Sulfo-SMCC sodium is a commonly used hetero-bifunctional, noncleavable ADC crosslinker bearing N-hydroxysuccinimide (NHS) ester and maleimide groups to react with primary amines and sulfhydryl groups, respectively.
    Sulfo-SMCC sodium
  • HY-128925
    AMAS
    1 Publications Verification

    ADC Linker Cancer
    AMAS is a nonclaevable heterobifunctional crosslinker with NHS ester and maleimide groups that allows covalent conjugation of amine- and sulfhydryl-containing molecules.
    AMAS
  • HY-174892

    Biochemical Assay Reagents Others
    Biotin-PEG5-NHS ester is a heterobifunctional crosslinker as well as a polyethylene glycol-containing bioconjugation reagent. Biotin-PEG5-NHS ester is widely used in scientific research fields such as the construction of highly sensitive biosensors, the development of targeted drug delivery systems (e.g., liposome modification), immunofluorescence imaging, and protein affinity purification, and serves as an important tool for achieving precise labeling and functionalization of biomolecules .
    Biotin-PEG5-NHS ester
  • HY-W041994

    Fructose-1,6-bisphosphate aldolase Biochemical Assay Reagents Cancer
    GMBS is a heterobifunctional crosslinker targeting primary amines and sulfhydryl groups. GMBS can be used for chemical crosslinking of proteins and crosslinking mass spectrometry (CXMS) to study protein folding and map interfaces between interacting proteins .
    GMBS
  • HY-W1048555A

    Biochemical Assay Reagents Others
    Mal-PEG2000-SCM is a heterobifunctional PEG crosslinker bearing maleimide and succinimidyl carboxymethyl ester functional groups. MMal-PEG2000-SCM conjugates the F3 peptide to nanoparticles: the SCM group reacts with amino groups on the nanoparticle surface to form amide groups, while the MAL group reacts with thiol groups of the F3 peptide to form carbon-sulfur bonds. Mal-PEG-SCM enables unidirectional addition of linkers, ensuring that appropriate functional groups are available for RGD incorporation. Mal-PEG2000-SCM can be used in the development of nanoparticles targeting specific tumor cells .
    Mal-PEG2000-SCM
  • HY-140339

    Biochemical Assay Reagents Others Cancer
    ANB-NOS is a heterobifunctional crosslinker with lipophilic, uncharged properties suitable for intracellular conjugation. ANB-NOS contains an amine-reactive Nhydroxysuccinimide (NHS) ester and a photoactivatable nitrophenyl azide. ANB-NOS can be used for the research of fibrosarcoma and mammary adenocarcinoma .
    ANB-NOS
  • HY-W1049061

    Biochemical Assay Reagents Others
    Boc-NH-PEG2000-COOH is a linear hetero-bifunctional PEG product with one Boc-protected amine and one carboxyl group. Boc-NH-PEG2000-COOH is an important cross-linker with PEG chains .
    Boc-NH-PEG2000-COOH
  • HY-140232B

    Biochemical Assay Reagents Others
    BOC-NH-PEG2000-NH2 is a linear hetero-bifunctional PEG product with one Boc-protected amine and one amino group. BOC-NH-PEG2000-NH2 is an important cross-linker with PEG chains .
    BOC-NH-PEG2000-NH2
  • HY-129377

    ADC Linker Cancer
    Sulfo-SPP is a heterobifunctional, thiol-cleavable and membrane impermeable crosslinker.
    Sulfo-SPP
  • HY-126495

    ADC Linker Cancer
    Sulfo-LC-SPDP is a heterobifunctional, thiol-cleavable and membrane impermeable crosslinker.
    Sulfo-LC-SPDP
  • HY-W1048572D

    Azide-PEG3400-Amine

    PROTAC Linkers Others
    N3-PEG3400-NH2 (Azide-PEG3400-Amine) is a hetero-bifunctional PEG product with an azide and an amine group at the PEG terminus. N3-PEG3400-NH2 is an important cross-linker with PEG chains. The azide can be used for molecular conjugation through chemical reactions, and the amine can react with carboxylic acid or NHS ester .
    N3-PEG3400-NH2
  • HY-140232D

    Biochemical Assay Reagents Others
    BOC-NH-PEG5000-NH2 is a linear hetero-bifunctional PEG product with one Boc-protected amine and one amino group. BOC-NH-PEG5000-NH2 is an important cross-linker with PEG chains .
    BOC-NH-PEG5000-NH2
  • HY-W1048555B

    Biochemical Assay Reagents Others
    Mal-PEG3400-SCM is a linear hetero-bifunctional PEG product with maleimide and succinimidyl NHS ester groups. Mal-PEG3400-SCM is an important cross-linker with PEG chains. Maleimide reacts with thiols, SH, sulfhydryls or sulfhydryls, and SCM stands for succinimidyl carboxymethyl ester, which reacts with primary amines. Maleimide contains a reactive C=C double bond and is sensitive to light or oxygen .
    Mal-PEG3400-SCM
  • HY-W1048572C

    Azide-PEG1000-Amine

    Biochemical Assay Reagents Others
    N3-PEG1000-NH2 (Azide-PEG1000-Amine) is a hetero-bifunctional PEG product with an azide and an amine group at the PEG terminus. N3-PEG1000-NH2 is an important cross-linker with PEG chains. The azide can be used for molecular conjugation through chemical reactions, and the amine can react with carboxylic acid or NHS ester .
    N3-PEG1000-NH2
  • HY-W1048547J

    HOOC-PEG40000-Amine

    PROTAC Linkers Others
    HOOC-PEG40000-NH2 (HOOC-PEG40000-Amine) is a heterobifunctional PEG crosslinker that can be used to attach functional PEG to biomolecules, particles, and other surface materials. The carboxyl group reacts with the amine group to form a stable amide bond. It can also react with the hydroxyl group to form an unstable ester bond. On the other hand, the amine group can be used to react with many amine-reactive groups, such as succinimidyl NHS esters, aldehydes, etc .
    HOOC-PEG40000-NH2
  • HY-129377A

    ADC Linker Cancer
    Sulfo-SPP sodium a heterobifunctional, thiol-cleavable and membrane impermeable crosslinker.
    Sulfo-SPP sodium
  • HY-W1049071D

    Biochemical Assay Reagents Others
    HO-PEG40000-SCM is a hetero-bifunctional hydroxy PEG succinimidyl carboxymethyl ester product, which is commonly used as a cross-linker or spacer between two different chemical entities.
    HO-PEG40000-SCM
  • HY-137251

    Biochemical Assay Reagents Others
    Sulfo-MBS sodium is a heterobifunctional crosslinker with a maleimide group and an N-hydroxysuccinimide (NHS) ester group, which can react with cysteine residues and lysine residues on proteins. Sulfo-MBS sodium be used for protein cross-linking studies .
    Sulfo-MBS sodium
  • HY-174364E

    Biochemical Assay Reagents Others
    Alkyne-PEG20000-COOH is a heterobifunctional PEG crosslinker that can be used to attach functional PEG to biomolecules, particles, and other material surfaces. The carboxyl group can react with the amine group to form a stable amide bond .
    Alkyne-PEG20000-COOH
  • HY-174364C

    Biochemical Assay Reagents Others
    Alkyne-PEG5000-COOH is a heterobifunctional PEG crosslinker that can be used to attach functional PEG to biomolecules, particles, and other material surfaces. The carboxyl group can react with the amine group to form a stable amide bond .
    Alkyne-PEG5000-COOH
  • HY-W1049061E

    Biochemical Assay Reagents Others
    Boc-NH-PEG1000-COOH is a linear hetero-bifunctional PEG product with one Boc-protected amine and one carboxyl group. Boc-NH-PEG1000-COOH is an important cross-linker with PEG chains .
    Boc-NH-PEG1000-COOH
  • HY-W1049061D

    Biochemical Assay Reagents Others
    Boc-NH-PEG40000-COOH is a linear hetero-bifunctional PEG product with one Boc-protected amine and one carboxyl group. Boc-NH-PEG40000-COOH is an important cross-linker with PEG chains .
    Boc-NH-PEG40000-COOH
  • HY-W1049061A

    Biochemical Assay Reagents Others
    Boc-NH-PEG5000-COOH is a linear hetero-bifunctional PEG product with one Boc-protected amine and one carboxyl group. Boc-NH-PEG5000-COOH is an important cross-linker with PEG chains .
    Boc-NH-PEG5000-COOH
  • HY-W1049061H

    Biochemical Assay Reagents Others
    Boc-NH-PEG3400-COOH is a linear hetero-bifunctional PEG product with one Boc-protected amine and one carboxyl group. Boc-NH-PEG3400-COOH is an important cross-linker with PEG chains .
    Boc-NH-PEG3400-COOH
  • HY-140232C

    Biochemical Assay Reagents Others
    BOC-NH-PEG3400-NH2 is a linear hetero-bifunctional PEG product with one Boc-protected amine and one amino group. BOC-NH-PEG3400-NH2 is an important cross-linker with PEG chains .
    BOC-NH-PEG3400-NH2
  • HY-140232A

    Boc-NH-PEG1000-Amine

    Biochemical Assay Reagents Others
    BOC-NH-PEG1000-NH2 (Boc-NH-PEG1000-Amine) is a linear hetero-bifunctional PEG product with one Boc-protected amine and one amino group. BOC-NH-PEG1000-NH2 is an important cross-linker with PEG chains .
    BOC-NH-PEG1000-NH2
  • HY-140232H

    Boc-NH-PEG20000-Amine

    Biochemical Assay Reagents Others
    BOC-NH-PEG20000-NH2 (Boc-NH-PEG20000-Amine) is a linear hetero-bifunctional PEG product with one Boc-protected amine and one amino group. BOC-NH-PEG20000-NH2 is an important cross-linker with PEG chains .
    BOC-NH-PEG20000-NH2
  • HY-140232E

    Boc-NH-PEG10000-Amine

    Biochemical Assay Reagents Others
    BOC-NH-PEG10000-NH2 (Boc-NH-PEG10000-Amine) is a linear hetero-bifunctional PEG product with one Boc-protected amine and one amino group. BOC-NH-PEG10000-NH2 is an important cross-linker with PEG chains .
    BOC-NH-PEG10000-NH2
  • HY-140232I

    Boc-NH-PEG40000-Amine

    Biochemical Assay Reagents Others
    BOC-NH-PEG40000-NH2 (Boc-NH-PEG40000-Amine) is a linear hetero-bifunctional PEG product with one Boc-protected amine and one amino group. BOC-NH-PEG40000-NH2 is an important cross-linker with PEG chains .
    BOC-NH-PEG40000-NH2
  • HY-W1048555D

    Biochemical Assay Reagents Others
    Mal-PEG10000-SCM is a linear hetero-bifunctional PEG product with maleimide and succinimidyl NHS ester groups. Mal-PEG10000-SCM is an important cross-linker with PEG chains. Maleimide reacts with thiols, SH, sulfhydryls or sulfhydryls, and SCM stands for succinimidyl carboxymethyl ester, which reacts with primary amines. Maleimide contains a reactive C=C double bond and is sensitive to light or oxygen .
    Mal-PEG10000-SCM
  • HY-W1048572A

    PROTAC Linkers Others
    N3-PEG2000-NH2 is a hetero-bifunctional PEG product with an azide and an amine group at the PEG terminus. N3-PEG2000-NH2 is an important cross-linker with PEG chains. The azide can be used for molecular conjugation through chemical reactions, and the amine can react with carboxylic acid or NHS ester .
    N3-PEG2000-NH2
  • HY-W1048555

    Biochemical Assay Reagents Others
    Mal-PEG1000-SCM is a linear hetero-bifunctional PEG product with maleimide and succinimidyl NHS ester groups. Mal-PEG1000-SCM is an important cross-linker with PEG chains. Maleimide reacts with thiols, SH, sulfhydryls or sulfhydryls, and SCM stands for succinimidyl carboxymethyl ester, which reacts with primary amines. Maleimide contains a reactive C=C double bond and is sensitive to light or oxygen .
    Mal-PEG1000-SCM
  • HY-W1048572H

    Azide-PEG10000-Amine

    PROTAC Linkers Others
    N3-PEG10000-NH2 (Azide-PEG10000-Amine) is a hetero-bifunctional PEG product with an azide and an amine group at the PEG terminus. N3-PEG10000-NH2 is an important cross-linker with PEG chains. The azide can be used for molecular conjugation through chemical reactions, and the amine can react with carboxylic acid or NHS ester .
    N3-PEG10000-NH2
  • HY-W1048572I

    Azide-PEG20000-Amine

    PROTAC Linkers Others
    N3-PEG20000-NH2 (Azide-PEG20000-Amine) is a hetero-bifunctional PEG product with an azide and an amine group at the PEG terminus. N3-PEG20000-NH2 is an important cross-linker with PEG chains. The azide can be used for molecular conjugation through chemical reactions, and the amine can react with carboxylic acid or NHS ester .
    N3-PEG20000-NH2
  • HY-D3279

    Biochemical Assay Reagents Others
    SMCC-PE is a dipalmitoylphosphatidylethanolamine derivative modified with the heterobifunctional crosslinker SMCC. SMCC-PE is an intermediate formed by conjugating the SMCC linker with R-phycoerythrin for antibody conjugation .
    SMCC-PE
  • HY-W1049071C

    Biochemical Assay Reagents Others
    HO-PEG20000-SCM is a hetero-bifunctional hydroxy PEG succinimidyl carboxymethyl ester product, which is commonly used as a cross-linker or spacer between two different chemical entities.
    HO-PEG20000-SCM
  • HY-W1049071A

    Biochemical Assay Reagents Others
    HO-PEG5000-SCM is a hetero-bifunctional hydroxy PEG succinimidyl carboxymethyl ester product, which is commonly used as a cross-linker or spacer between two different chemical entities.
    HO-PEG5000-SCM
  • HY-W1049071I

    Biochemical Assay Reagents Others
    HO-PEG3400-SCM is a hetero-bifunctional hydroxy PEG succinimidyl carboxymethyl ester product, which is commonly used as a cross-linker or spacer between two different chemical entities.
    HO-PEG3400-SCM
  • HY-W1049071B

    Biochemical Assay Reagents Others
    HO-PEG10000-SCM is a hetero-bifunctional hydroxy PEG succinimidyl carboxymethyl ester product, which is commonly used as a cross-linker or spacer between two different chemical entities.
    HO-PEG10000-SCM
  • HY-W1049071H

    Biochemical Assay Reagents Others
    HO-PEG2000-SCM is a hetero-bifunctional hydroxy PEG succinimidyl carboxymethyl ester product, which is commonly used as a cross-linker or spacer between two different chemical entities.
    HO-PEG2000-SCM
  • HY-W1049071E

    Biochemical Assay Reagents Others
    HO-PEG1000-SCM is a hetero-bifunctional hydroxy PEG succinimidyl carboxymethyl ester product, which is commonly used as a cross-linker or spacer between two different chemical entities.
    HO-PEG1000-SCM
  • HY-174364B

    Biochemical Assay Reagents Others
    Alkyne-PEG3400-COOH is a heterobifunctional PEG crosslinker that can be used to attach functional PEG to biomolecules, particles, and other material surfaces. The carboxyl group can react with the amine group to form a stable amide bond .
    Alkyne-PEG3400-COOH
  • HY-174364

    Biochemical Assay Reagents Others
    Alkyne-PEG1000-COOH is a heterobifunctional PEG crosslinker that can be used to attach functional PEG to biomolecules, particles, and other material surfaces. The carboxyl group can react with the amine group to form a stable amide bond .
    Alkyne-PEG1000-COOH
  • HY-174364H

    Biochemical Assay Reagents Others
    Alkyne-PEG40000-COOH is a heterobifunctional PEG crosslinker that can be used to attach functional PEG to biomolecules, particles, and other material surfaces. The carboxyl group can react with the amine group to form a stable amide bond .
    Alkyne-PEG40000-COOH
  • HY-174364D

    Biochemical Assay Reagents Others
    Alkyne-PEG10000-COOH is a heterobifunctional PEG crosslinker that can be used to attach functional PEG to biomolecules, particles, and other material surfaces. The carboxyl group can react with the amine group to form a stable amide bond .
    Alkyne-PEG10000-COOH
  • HY-174364A

    Biochemical Assay Reagents Others
    Alkyne-PEG2000-COOH is a heterobifunctional PEG crosslinker that can be used to attach functional PEG to biomolecules, particles, and other material surfaces. The carboxyl group can react with the amine group to form a stable amide bond .
    Alkyne-PEG2000-COOH
  • HY-W1049061B

    Biochemical Assay Reagents Others
    Boc-NH-PEG10000-COOH is a linear hetero-bifunctional PEG product with one Boc-protected amine and one carboxyl group. Boc-NH-PEG10000-COOH is an important cross-linker with PEG chains .
    Boc-NH-PEG10000-COOH
  • HY-W1049061C

    Biochemical Assay Reagents Others
    Boc-NH-PEG20000-COOH is a linear hetero-bifunctional PEG product with one Boc-protected amine and one carboxyl group. Boc-NH-PEG20000-COOH is an important cross-linker with PEG chains .
    Boc-NH-PEG20000-COOH
  • HY-W1048555H

    Biochemical Assay Reagents Others
    Mal-PEG40000-SCM is a linear hetero-bifunctional PEG product with maleimide and succinimidyl NHS ester groups. Mal-PEG40000-SCM is an important cross-linker with PEG chains. Maleimide reacts with thiols, SH, sulfhydryls or sulfhydryls, and SCM stands for succinimidyl carboxymethyl ester, which reacts with primary amines. Maleimide contains a reactive C=C double bond and is sensitive to light or oxygen .
    Mal-PEG40000-SCM
  • HY-W1048572E

    PROTAC Linkers Others
    N3-PEG5000-NH2 is a hetero-bifunctional PEG product with an azide and an amine group at the PEG terminus. N3-PEG5000-NH2 is an important cross-linker with PEG chains. The azide can be used for molecular conjugation through chemical reactions, and the amine can react with carboxylic acid or NHS ester .
    N3-PEG5000-NH2

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