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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
25 Results for "
human CK1
" in MedChemExpress (MCE) Product Catalog:
Products (25)
25 Results for "human CK1" in MCE Product Catalog:
Target:
Research Areas:
VRK1/CK1-IN-1 (compound 36) is a dual VRK1 and CK1 family inhibitor, with a Ki of 37.9 nM against human VRK1, 8.3 nM against human CK1δ, and 7.8 nM against human CK1ε. VRK1/CK1-IN-1 exhibits extremely low activity against VRK2. VRK1/CK1-IN-1 can be used in studies related to p53-deficient tumors .
Cat. No.: HY-148837
CAS No.: 2883535-99-5
Target:
PROTACs c-Myc CD276/B7-H3 IAP Casein Kinase Eukaryotic Release Factor (eRF) Oxidative Phosphorylation Apoptosis
Research Areas:
GT19630 is an orally active c-Myc PROTAC targeted degrader based on the cereblon E3 ubiquitin ligase, with an IC50 of 1.5 nM against human c-Myc. GT19630 mediates the degradation of MYC, GSPT1, GSPT2, CK1 alpha, N-Myc, B7-H3 and XIAP, and disrupts the MYC-GSPT1 synergistic regulatory feedback loop. GT19630 inhibits cell proliferation, blocks S-phase progression of the cell cycle, promotes cell apoptosis, reduces cell migration capacity, induces integrated stress response, and blocks oxidative phosphorylation by inhibiting the TCA cycle. GT19630 can be used in the research of Myc-driven hematological cancers, small cell lung cancer, breast cancer, TP53-mutant cancers, and venetoclax-resistant cancers .
Cat. No.: HY-W599279
CAS No.: 2761170-84-5
Research Areas:
ABS-752 is an orally active prodrug targeting CRBN-modulating molecular glue with selectivity in protein degradation. ABS-752 preferentially degrades GSPT1 and induces cytotoxicity through this degradation, while it also degrades NEK7, SALL4 and CK1α, with weaker degradation potency against CK1α. As a prodrug, ABS-752 requires metabolic activation to ABT-002 to form the active complex; VAP-1 mediates its conversion to an aldehyde intermediate. ABS-752 induces cell death, reduces cell viability, and exhibits antitumor activity, leading to regression and inhibition of tumor growth. ABS-752 shows no cytotoxicity in primary human hepatocytes. ABS-752 can be used in the research of hepatocellular carcinoma .
Cat. No.: HY-178335
CAS No.: 3125107-49-2
SGC-CK1γ-1 is a potent and selective probe for the CK1γ subfamily. SGC-CK1γ-1 can inhibit LRP6 phosphorylation levels. SGC-CK1γ-1 can selectively inhibit the CK1γ kinases in living cells and inhibit both WNT signaling and human cytomegalovirus (CMV) replication. SGC-CK1γ-1 can be used for the research of infection .
Cat. No.: HY-181586
CAS No.: 1397706-29-4
Target:
Research Areas:
CK1γ-IN-1 is a non-selective CK1 kinase inhibitor with IC50 values of 780 nM, 570 nM and 990 nM against human CK1γ1, CK1γ2, CK1γ3, respectively. The non-specific binding of CK1γ-IN-1 to multiple kinases enables its application in biological studies of specific CK1γ .
Cat. No.: HY-181585
CAS No.: 1403557-08-3
Target:
Research Areas:
FP1-24 is a non-selective CK1 kinase inhibitor, with IC50 values of 40 nM, 10 nM, 10 nM, and 40 nM against human CK1γ1, CK1γ2, CK1γ3 and CK1δ, respectively. FP1-24 exerts its activity by reducing the phosphorylation level of LRP5/6 at the T1479 site during WNT signaling pathway activation. The non-specific binding of FP1-24 to multiple kinases can be used for biological studies of specific CK1γ .
Cat. No.: HY-171278
CAS No.: 1095750-94-9
Target:
Research Areas:
Casein kinase 1δ-IN-28 (Compound 4) is the inhibitor for CK1ε with an IC50 of 0.0146 μM. Casein kinase 1δ-IN-28 exhibits a metabolite rate in human liver microsomes of 52% .
Cat. No.: HY-P72872
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: CSNK1A1; CKIalpha; Casein Kinase 1 Alpha 1; Epididymis Secretory Sperm Binding Protein Li 77p; CK1; Non-Specific Serine/Threonine Protein Kinase; Casein Kinase I Isoform Alpha; Down-Regulated In Lung Cancer; CK1a; Casein Kinase 1, Alpha 1; CKIa; HEL-S-77p
Species:
Human
Source:
Sf9 insect cells
Cat. No.: HY-P702668
Purity: ≥ 80%, as determined by reducing SDS-PAGE.
Synonyms: CSNK1A1; CKIalpha; Casein Kinase 1 Alpha 1; Epididymis Secretory Sperm Binding Protein Li 77p; CK1; Non-Specific Serine/Threonine Protein Kinase; Casein Kinase I Isoform Alpha; Down-Regulated In Lung Cancer; CK1a; Casein Kinase 1, Alpha 1; CKIa; HEL-S-77p
Species:
Human
Source:
Sf9 insect cells
Cat. No.: HY-123859
CAS No.: 1454584-91-8
Target:
Research Areas:
SR-2890 is a highly selective, ATP-competitive inhibitor of casein kinase CK1δ and CK1ε, with IC50 values of 4 nM and 44 nM, respectively, and a Ki of 14 nM for CK1δ. SR-2890 exhibits antiproliferative effects. SR-2890 blocks the serine/threonine kinase activity of CK1δ and weakly inhibits a few off-target kinases such as FLT3, CDK4. SR-2890 has an oral bioavailability of 10% and a blood-brain barrier penetration rate of <1%. SR-2890 demonstrates stable in vitro metabolism and favorable in vivo pharmacokinetic properties, effectively inhibiting the growth of human A375 melanoma cells. SR-2890 can be used in melanoma research and is also a useful compound for studying CK1δ/ε-related diseases such as Alzheimer's disease .
Cat. No.: HY-W998347
CAS No.: 2922884-90-8
Research Areas:
ABS-752 hydrochloride is an orally active prodrug targeting CRBN-modulating molecular glue with selectivity in protein degradation. ABS-752 hydrochloride preferentially degrades GSPT1 and induces cytotoxicity through this degradation, while it also degrades NEK7, SALL4 and CK1α, with weaker degradation potency against CK1α. As a prodrug, ABS-752 hydrochloride requires metabolic activation to ABT-002 to form the active complex; VAP-1 mediates its conversion to an aldehyde intermediate. ABS-752 hydrochloride induces cell death, reduces cell viability, and exhibits antitumor activity, leading to regression and inhibition of tumor growth. ABS-752 hydrochloride shows no cytotoxicity in primary human hepatocytes. ABS-752 hydrochloride can be used in the research of hepatocellular carcinoma .
Cat. No.: HY-P7741
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: CSNK1G2; Non-Specific Serine/Threonine Protein Kinase; Casein Kinase 1 Gamma 2; Casein Kinase 1, Gamma 2; CK1g2; Casein Kinase I; Casein Kinase I Isoform Gamma-2; CK1G2; CKI-Gamma 2
Species:
Human
Source:
E. coli
Cat. No.: HY-P72873
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: CSNK1G2; Non-Specific Serine/Threonine Protein Kinase; Casein Kinase 1 Gamma 2; Casein Kinase 1, Gamma 2; CK1g2; Casein Kinase I; Casein Kinase I Isoform Gamma-2; CK1G2; CKI-Gamma 2
Species:
Human
Source:
Sf9 insect cells
Cat. No.: HY-P702667
Purity: ≥ 80%, as determined by reducing SDS-PAGE.
Synonyms: CSNK1G2; Non-Specific Serine/Threonine Protein Kinase; Casein Kinase 1 Gamma 2; Casein Kinase 1, Gamma 2; CK1g2; Casein Kinase I; Casein Kinase I Isoform Gamma-2; CK1G2; CKI-Gamma 2
Species:
Human
Source:
Sf9 insect cells
Cat. No.: HY-P705797
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: CSNK1G2; Non-Specific Serine/Threonine Protein Kinase; Casein Kinase 1 Gamma 2; Casein Kinase 1, Gamma 2; CK1g2; Casein Kinase I; Casein Kinase I Isoform Gamma-2; CK1G2; CKI-Gamma 2
Species:
Human
Source:
sf9 insect cells
Cat. No.: HY-P705798
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: CSNK1G2; Non-Specific Serine/Threonine Protein Kinase; Casein Kinase 1 Gamma 2; Casein Kinase 1, Gamma 2; CK1g2; Casein Kinase I; Casein Kinase I Isoform Gamma-2; CK1G2; CKI-Gamma 2
Species:
Human
Source:
sf9 insect cells
Cat. No.: HY-P705484
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: CSNK1D; CKI-Delta; Casein Kinase 1 Delta; Non-Specific Serine/Threonine Protein Kinase; HCKID; Casein Kinase 1, Delta; CKIdelta; Casein Kinase I; CKID; FASPS2; Casein Kinase I Isoform Delta; ASPS; Tau-Protein Kinase CSNK1D; CKId
Species:
Human
Source:
E. coli
Cat. No.: HY-P701658
Purity: ≥ 80%, as determined by reducing SDS-PAGE.
Synonyms: CSNK1D; CKI-Delta; Casein Kinase 1 Delta; Non-Specific Serine/Threonine Protein Kinase; HCKID; Casein Kinase 1, Delta; CKIdelta; Casein Kinase I; CKID; FASPS2; Casein Kinase I Isoform Delta; ASPS; Tau-Protein Kinase CSNK1D; CKId
Species:
Human
Source:
Sf9 insect cells
Cat. No.: HY-P702669
Purity: ≥ 80%, as determined by reducing SDS-PAGE.
Synonyms: CSNK1G1; Non-Specific Serine/Threonine Protein Kinase; Casein Kinase 1 Gamma 1; Casein Kinase 1, Gamma 1; CK1gamma1; CKI-Gamma 1; Casein Kinase I Isoform Gamma-1
Species:
Human
Source:
Sf9 insect cells
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
