2761170-84-5
Chemical Structure
ABS-752
- CAS No.: 2761170-84-5
- Formula:C14H14FN3O3
- Molecular Weight:291.28
IUPAC Name: 3-(5-(aminomethyl)-6-fluoro-1-oxoisoindolin-2-yl)piperidine-2,6-dione
InChIKey: VHUZYSKPEQGBJP-UHFFFAOYSA-N
SMILES: O=C(C(N(CC1=C2C=C(F)C(CN)=C1)C2=O)CC3)NC3=O
Biological Activity: ABS-752 is a potent and orally active GSPT1 and NEK7 molecular glue degrader. ABS-752 shows cytotoxicity. ABS-752 decreases the protein expression of GSPT1 and SALL4, NEK7. ABS-752 is a prodrug activated by the monoamine oxidase, VAP-1, to an aldehyde intermediate and subsequently to the active molecule, ABT-002 (HY-175283). ABS-752 has the potential for the research of hepatocellular carcinoma[1].
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ABS-752 | ABS-752 is a potent and orally active GSPT1 and NEK7 molecular glue degrader. ABS-752 shows cytotoxicity. ABS-752 decreases the protein expression of GSPT1 and SALL4, NEK7. ABS-752 is a prodrug activated by the monoamine oxidase, VAP-1, to an aldehyde intermediate and subsequently to the active molecule, ABT-002 (HY-175283). ABS-752 has the potential for the research of hepatocellular carcinoma. | |||||||||||||||||||||
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Keywords
