SGC-CK1γ-1
Based on 1 Customer Validation
SGC-CK1γ-1 is a potent and selective probe for the CK1γ subfamily. SGC-CK1γ-1 can inhibit LRP6 phosphorylation levels. SGC-CK1γ-1 can selectively inhibit the CK1γ kinases in living cells and inhibit both WNT signaling and human cytomegalovirus (CMV) replication. SGC-CK1γ-1 can be used for the research of infection.
For research use only. We do not sell to patients.
- Purity : 99.33%
- CAS No.: 3125107-49-2
- Formula: C18H16ClN5O
- Molecular Weight:353.81
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Storage:
4°C, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Protocols
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
In Vitro
SGC-CK1γ-1 (5-10 μM, 2h) inhibits LRP6 phosphorylation levels in HEK293 cells[1].
SGC-CK1γ-1 (10 μM, 24-48 h) does not impact cell viability in HEK293 cells[1].
SGC-CK1γ-1 (1-10 μM) elicits anti-HCMV replication effects in HFF cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 3125107-49-2
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Appearance Solid
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Molecular Weight 353.81
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Formula C18H16ClN5O
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Color White to light yellow
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SMILES
N#CC1=CC=C2C(N=C(NC3=CC=C(N4CCOCC4)C(Cl)=C3)N2)=C1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
Solvent & Solubility
In Vitro:
DMSO : 105 mg/mL (296.77 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (272 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.8264 mL | 14.1319 mL | 28.2638 mL | 70.6594 mL |
| 5 mM | 0.5653 mL | 2.8264 mL | 5.6528 mL | 14.1319 mL | |
| 10 mM | 0.2826 mL | 1.4132 mL | 2.8264 mL | 7.0659 mL | |
| 15 mM | 0.1884 mL | 0.9421 mL | 1.8843 mL | 4.7106 mL | |
| 20 mM | 0.1413 mL | 0.7066 mL | 1.4132 mL | 3.5330 mL | |
| 25 mM | 0.1131 mL | 0.5653 mL | 1.1306 mL | 2.8264 mL | |
| 30 mM | 0.0942 mL | 0.4711 mL | 0.9421 mL | 2.3553 mL | |
| 40 mM | 0.0707 mL | 0.3533 mL | 0.7066 mL | 1.7665 mL | |
| 50 mM | 0.0565 mL | 0.2826 mL | 0.5653 mL | 1.4132 mL | |
| 60 mM | 0.0471 mL | 0.2355 mL | 0.4711 mL | 1.1777 mL | |
| 80 mM | 0.0353 mL | 0.1766 mL | 0.3533 mL | 0.8832 mL | |
| 100 mM | 0.0283 mL | 0.1413 mL | 0.2826 mL | 0.7066 mL |
SGC-CK1γ-1 Related Classifications
HY-178335 Related Classifications
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