1079 Results for "

human Fc

" in MedChemExpress (MCE) Product Catalog:
Products (1079)

1079 Results for "human Fc" in MCE Product Catalog:

9
9 Publications Verification
Cat. No.: HY-P70453B
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: WNT3A; Wnt Family Member 3A; Wingless-Type MMTV Integration Site Family, Member 3A; Protein Wnt-3a
Species:  
Human
Source:  
HEK293
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6
6 Cited Publications
Cat. No.: HY-N0762
CAS No.: 31524-62-6
Isobavachin is an orally active, blood-brain barrier-penetrating prenylated flavonoid present in Psoralea corylifolia. Isobavachin inhibits human CYP2B6, CYP2C9, CYP2C19, UGT1A1, UGT1A9, and UGT2B7. Isobavachin suppresses MAPK activation, NF-κB nuclear translocation, overexpression of iNOS/COX-2, FcεRI-mediated signaling pathways, and RANKL-induced osteoclastogenesis. Isobavachin induces autophagy, cytotoxicity, neuronal differentiation, and NRF2 activation; it alleviates oxidative damage, inflammatory responses, apoptosis, iron accumulation, mitochondrial biogenesis, and mast cell degranulation. Isobavachin is applicable to research related to liver injury, inflammatory diseases, osteoporosis, liver cancer, prostate cancer, glioma, periodontitis-induced bone loss, and Alzheimer's disease .
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5
5 Cited Publications
Cat. No.: HY-P74133
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: CGA; Anterior Pituitary Glycoprotein Hormones Common Subunit Alpha; Glycoprotein Hormones, Alpha Polypeptide; Follicle-Stimulating Hormone Alpha Subunit; Glycoprotein Hormones Alpha Chain; Chorionic Gonadotropin, Alpha Polypeptide; GPA1; Follicle-Stimulat
Species:  
Human
Source:  
HEK293
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5
5 Cited Publications
Cat. No.: HY-N2259
CAS No.: 19431-84-6
Synonyms: (+)-Curcumenol
Curcumenol ((+)-Curcumenol) is a natural compound with oral efficacy, exhibiting an IC50 of 12.6 μM and a Ki of 10.8 μM against human CYP3A4. Curcumenol inhibits TNFα-induced phosphorylation/degradation of IκBα, phosphorylation/nuclear translocation of NF-κB p65, as well as the upregulation of MMP3, MMP9, MMP13, TRAF3, IL1RL1, TNFα and IL-1β. Curcumenol suppresses LPS-induced phosphorylation of Akt and p38 MAPK, as well as the production of pro-inflammatory mediators/proteins, and downregulates the SLC7A11/NF-κB/TGF-β pathway. Curcumenol binds to and inhibits the activation of Fyn and Lyn, blocks the function of downstream FcεRI signaling components, and reduces the release of allergic mediators/cytokines. Curcumenol upregulates the expression of KDM6B, and promotes chondrocyte proliferation and cartilage repair. Curcumenol induces ferroptosis and apoptosis, regulates the EMT process, and inhibits tumor growth and metastasis of triple-negative breast cancer. Curcumenol possesses anti-inflammatory, neuroprotective, antioxidant, antitumor, antiviral and hepatoprotective activities. Curcumenol can be used in research related to intervertebral disc degeneration, cancer, inflammation, central nervous system neurodegenerative diseases, allergic reactions and knee osteoarthritis .
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5
5 Cited Publications
Cat. No.: HY-P72968
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: DKK1; Dickkopf 1 Homolog (Xenopus Laevis); Dickkopf Wnt Signaling Pathway Inhibitor 1; Dickkopf 1 Homolog; SK; Dickkopf-1 Like; DKK-1; Dickkopf-1; Dickkopf-Related Protein 1; HDkk-1; Dickkopf-Like Protein 1; Dkk-1; Dickkopf (Xenopus Laevis) Homolog 1
Species:  
Human
Source:  
HEK293
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4
4 Cited Publications
Cat. No.: HY-P99667
CAS No.: 1391727-24-4
Synonyms: OMP-54F28; FZD8-Fc

Target:  

Wnt

Research Areas:  

Cancer

Ipafricept (OMP-54F28; FZD8-Fc) is a first class recombinant fusion protein with the extracellular part of the human frizzled-8 receptor fused to a human IgG1 Fc fragment that binds Wnt ligands, which blocks Wnt signaling. Ipafricept reduces tumor growth and results in a decrease in both liver and lung metastases combined with Gemcitabine (HY-17026) in pancreatic cancer mouse models. Ipafricept shows solid tumor inhibition activity with well tolerance, such as desmoid tumor, germ cell cancer, ovarian cancer .
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4
4 Cited Publications
Cat. No.: HY-P70665
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: FNDC5; Fibronectin Type III Domain-Containing Protein 5; Fibronectin Type III Domain Containing 5; Fibronectin Type III Repeat-Containing Protein 2; FRCP2; Irisin
Species:  
Rat Mouse Human
Source:  
HEK293
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3
3 Cited Publications
Cat. No.: HY-P9977
CAS No.: 2171511-58-1
Synonyms: JNJ-61186372

Target:  

EGFR

Research Areas:  

Cancer

Amivantamab (JNJ-61186372) is a human EGFR-MET bispecific antibody with immune anticancer activity. Amivantamab inhibits ligand binding, promotes endocytosis and degradation of receptor-antibody complexes, and induces Fc-dependent cytokinesis in macrophages and antibody-dependent cytotoxicity in natural killer cells .
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3
3 Cited Publications
Cat. No.: HY-108829
CAS No.: 332348-12-6
Purity:  ≥99.0%
Synonyms: CTLA4lg; BMS-188667

Target:  

CTLA-4

Abatacept (CTLA4lg) is a soluble fusion protein consisting of the extra-cellular domain of human CTLA4 and a fragment of the Fc portion of human IgG1 (hinge and CH2 and 3 domains) . Abatacept is a selective T-cell co-stimulation modulator and a protein agent for the autoimmune diseases .
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3
3 Cited Publications
Cat. No.: HY-108829A
CAS No.: 332348-12-6
Purity:  95.00%
Synonyms: CTLA4lg (powder); BMS-188667 (powder); Orencia
Abatacept (CTLA4lg; BMS-188667) powder is a soluble fusion protein consisting of the extra-cellular domain of human CTLA4 and a fragment of the Fc portion of human IgG1 (hinge and CH2 and 3 domains). Abatacept powder is a selective T-cell co-stimulation modulator and a protein agent for the autoimmune diseases .
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3
3 Cited Publications
Cat. No.: HY-P72431
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: VEGFB; Vascular Endothelial Growth Factor B; VRF; VEGF-Related Factor; VEGFL; VEGF-B
Species:  
Human
Source:  
HEK293
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3
3 Cited Publications
Cat. No.: HY-P75951
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: GPNMB; Glycoprotein Nonmetastatic Melanoma Protein B; Glycoprotein Nmb; Osteoactivin; HGFIN; Hematopoietic Growth Factor Inducible Neurokinin-1; NMB; Transmembrane Glycoprotein HGFIN; Glycoprotein (Transmembrane) Nmb; Uncharacterized Protein GPNMB; Transm
Species:  
Human
Source:  
HEK293
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3
3 Cited Publications
Cat. No.: HY-P7395
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: PDCD1; Systemic Lupus Erythematosus Susceptibility 2; Prev. SLEB2; HPD-1; PD1; Programmed Cell Death 1 Protein; Programmed Cell Death Protein 1; CD279 Antigen; CD279; ADMIO4; HSLE1; AIMTBS; PD-1; HPD-L; Programmed Cell Death 1; Protein PD-1
Species:  
Human
Source:  
CHO
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2
2 Cited Publications
Cat. No.: HY-P99930
CAS No.: 2375240-92-7
Synonyms: AKR-001; AMG-876

Target:  

FGFR

Research Areas:  

Inflammation/Immunology

Efruxifermin is an Fc-FGF21 fusion protein (human IgG1 Fc domain linked to a modified human FGF21). Efruxifermin has prolonged half-life and enhanced receptor affinity compared with native human FGF21. Efruxifermin can be used for the research of non-alcoholic steatohepatitis .
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2
2 Cited Publications
Cat. No.: HY-P9981
CAS No.: 1422527-84-1
Synonyms: XmAb5574; MOR00208; Tafasitamab-cxix; MOR-208

Target:  

Apoptosis

Research Areas:  

Inflammation/Immunology Cancer

Tafasitamab (XmAb5574) is an Fc-modified, humanized monoclonal antibody that binds to the human B-cell surface antigenCD19 .
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2
2 Cited Publications
Cat. No.: HY-108801A
CAS No.: 862111-32-8
Purity:  97.66%

Target:  

VEGFR

Research Areas:  

Cardiovascular Disease Cancer

Aflibercept (VEGF Trap) is a soluble decoy VEGFR constructed by fusing the Ig domains of VEGFR1 and VEGFR2 with the Fc region of human IgG1. Aflibercept inhibits VEGF signaling by reducing VEGF-regulated processes. Aflibercept can be used for thr research of age-related macular degeneration (AMD) and cardiovascular disease .
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2
2 Cited Publications
Cat. No.: HY-108801
CAS No.: 862111-32-8
Synonyms: VEGF Trap; VEGF-TRAPR1R2; VEGF-trapR1

Target:  

VEGFR

Aflibercept is a soluble decoy VEGFR constructed by fusing the Ig domains of VEGFR1 and VEGFR2 with the Fc region of human IgG1. Aflibercept inhibits VEGF signaling by reducing VEGF-regulated processes. Aflibercept can be used for thr research of age-related macular degeneration (AMD) and cardiovascular disease .
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2
2 Cited Publications
Cat. No.: HY-P9979
CAS No.: 1584645-37-3
Synonyms: UCB7665

Target:  

TNF Receptor

Research Areas:  

Inflammation/Immunology

Rozanolixizumab (UCB7665), a humanized high-affinity anti-human neonatal Fc receptor (FcRn) monoclonal antibody (IgG4P), is used to the research of reducing pathogenic IgG in autoimmune and alloimmune diseases .
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2
2 Cited Publications
Cat. No.: HY-P70669
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: High affinity immunoglobulin gamma Fc receptor I; Fcgr1; FcRI; CD64; Fc receptor; IgG; high affinity I
Species:  
Human
Source:  
HEK293
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2
2 Cited Publications
Cat. No.: HY-P99008
CAS No.: 2417175-94-9
Synonyms: IC14
Atibuclimab (IC14), is a chimeric monoclonal antibody directed against CD14 and is composed of murine variable and human IgG4 Fc regions. Atibuclimab attenuates Lipopolysaccharides (HY-D1056) (LPS)-induced symptoms and strongly inhibits LPS-induced proinflammatory cytokine release, while only delaying the release of the anti-inflammatory cytokines soluble TNF receptor type I and IL-1 receptor antagonist. Atibuclimab can be used for the research of amyotrophic lateral sclerosis, sepsis, community-acquired pneumonia, or acute lung injury .
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